Congratulations!! Drs. Jin-Young Jeong and Namsuk Kim's paper titled "Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology" has been published (npj Parkinson's disease, Aug. 4th, 2025)

We are also pleased to share that this work was featured on "Bioengineer.org" and "Scienmag", websites that provide comprehensive daily coverage of advancements in science, technology, and medicine (https://scienmag.com/alpha-synuclein-levels-unnecessary-for-parkinsons-pathology/)

: In a groundbreaking study that challenges long-standing assumptions in neurodegenerative research, scientists have unveiled compelling evidence indicating that elevated levels of alpha-synuclein protein in the plasma are not a requisite factor for the development or progression of Parkinson’s disease pathology. This revelation, published in the prestigious npj Parkinson’s Disease journal, marks a significant departure from decades of prevailing thought that positioned alpha-synuclein accumulation as a central driver and biomarker of Parkinson’s disease (........)

The study’s findings underscore an evolving paradigm in Parkinson’s disease research where the pathophysiological landscape is perceived with greater sophistication, recognizing the limitations of oversimplified biomarkers. They stimulate a broader conversation about the reliability of peripheral fluid markers in reflecting brain-specific disease processes across neurodegenerative diseases, inviting comparative studies and cross-disease insights (........)

Ultimately, this study charts a new course for future investigations aiming to identify truly representative biomarkers and develop precision therapies. By challenging entrenched dogma, it empowers researchers to think beyond conventional frameworks and embrace new scientific horizons that promise better diagnostic and therapeutic outcomes for patients afflicted by Parkinson’s disease (........)