papers

近五年研究

1. Yu-Chi Chen, Bu-Miin Huang, Wei-Chang Lee, Yung-Chia Chen* 16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: Involvement of focal adhesion disassembly and signaling. OnCoTarget and Therapy. 2018. 2018:11 7679-7690. IF=4.147. Biotech & applied microbiology. 52/159=(32.7%)

2. Yung-Chia Chen*, Hsin-Ju Chen, Bu-Miin Huang, Yu-Chi Chen, Chi-Fen Chang. Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. Journal of Clinical Medicine. 2019, 8(10):1664. IF=4.241. MEDICINE, GENERAL & INTERNAL 39/169=23.7% 

3. Yung-Chia Chen*, Bu-Miin Huang Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions. Journal of visualized experiments. 2019. (145), e59016. IF=1.355. MULTIDISCIPLINARY SCIENCES 49/73=67.12%

4. Fu-Chi Kang, Shu-Chun Wang, Edmund Cheung So, Ming-Min Chang, Kar-Lok Wong, Ka Shun Cheng, Yung-Chia Chen*, Bu-Miin Huang*. Propofol could increase caspases and MAPKs pathways and suppress Akt pathway to induce apoptosis in MA-10 mouse Leydig tumor cells. Oncology Reports, 2019. 41 (6):3565-3574. IF=3.906. Oncology. 133/242=54.95%

5. Yi-Fen Mu, Ying-Hui Chen , Ming-Min Chang , Yung-Chia Chen, Bu-Miin Huang . 2019. Arsenic compounds induce apoptosis through the caspase pathway in MA-10 Leydig tumor cells. Oncology Letters, 18 (1): 944-954. IF=2.967  192/308=62.3%  

6. Fu-Chi Kang, Yung-Chia Chen, Shu-Chun Wang, Edmund Cheung So, Bu-Miin Huang.  Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the Akt pathway in TM3 mouse Leydig stem/progenitor cells. Int J Mol Med. 46 (1):439-448. 2020 Apr 21. 68/140=48.57%  IF:  4.101  

7. Ching-Feng Chiu, Yu-Qiang Lin, Ji Min Park, Yung-Chia Chen, Shao-Wen Hung, Chien-Chao Chiug, Chi-Fen Chang*.  The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer. Biomedicine & Pharmacotherapy. 2020. 128 (2020):110309. IF=6.529. pharmacology 24/275 =8.7%

8.  Yu-Chi Chen, Po-Yu, Wang, Bu-Miin Huang, Wei-Chang Lee, Yung-Chia Chen* 16-hydroxycleroda-3,13-dien-15,16-olide induces apoptosis in human bladder cancer cells through cell cycle arrest, mitochondria ROS overproduction and inactivation of EGFR-related signalling pathways. Molecules. 2020, 25(17):3958. IF= 4.411. BIOCHEMISTRY & MOLECULAR BIOLOGY. 63/178=(35.39%)

9.  Yu-Chi Chen, Chiao-Ling Hsieh, Bu-Miin Huang, Yung-Chia Chen*. Induction of mitochondrial-dependent apoptosis by essential oil of Toona sinensis root through Akt, mTOR and NF-kB signalling pathways in human renal cell carcinoma cells. Journal of Food and Drug Analysis. 2021. 29(3):433-447. IF=6.079. Food science and technology. 12/144=8.3% 

10.  Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang,  and Rong-Jane Chen. (2021) The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules, 26(16), 4954. Special Issue: Phytochemicals in Cancer Prevention and Therapy. doi.org/10.3390/molecules26164954 

11. Yung-Chia Chen, Yi-Chen Chia, Bu-Miin Huang. (2021) Invited review. Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities. Molecules, 26(17), 5369. doi.org/10.3390/molecules26175369 

12. Yu-Chi Chen, Chih-I Chen, Chao-Yuan Chang, Bu-Miin Huang, and Yung-Chia Chen*  Clerodane diterpene induces apoptosis/anoikis and suppresses migration and invasion of human bladder cancer cells through the histone deacetylases, integrin–focal adhesion kinase, and matrix metalloproteinase 9 signalling pathways. Human & Experimental Toxicology, 2022, 41. doi:10.1177/09603271221143040

13. Hsin-Ju Chen, Yu-Chi Chen, Bu-Miin Huang, Chih-I Chen, Cheng-Hsun Wu, Yung-Chia Chen*. 2023 Investigation of Eurycoma longifolia Extract on Alleviating Steatosis by Using in vivo and in vitro Steatotic Models: Mechanisms Through Activation of AMPK and Autophagic Flux. Revista Brasileira de Farmacognosia. published online 2023.11.15. doi.org/10.1007/s43450-023-00490-8 

14. Wan-Yi Ho, Chao-Yuan Chang, Yung-Chia Chen*. 2022. Self-directed learning through online tag exam improves the learning outcomes of osteology in undergraduate students. 投稿中

15. Wan-Yi Ho, Hsin-Ju Chen, Chao Yuan Chang,  Yung-Chia Chen*.  骨學解剖的教學實踐在護理系的運用。 撰寫中

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過去發表研究

1. Chen YC, Huang YL, Huang BM. Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumor cells. Int J Biochem Cell Biol. 2005; 37(1):214-23. IF: 4.956, ranking 58/286, at biochemistry and molecular biology 引用次數 63

2. Chien CL, Chen YC, Chang MF, Greenberg AS, Wang SM. Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochem Cell Biol. 2005; 123(4-5):429-39. IF: 4.727, ranking 1/9, at microscopy.

3. Chen YC, Chang MF, Chen Y, Wang SM. Signaling pathways of magnolol-induced adrenal steroidogensis. FEBS Lett. 2005; 579(20):4337-43. IF:3.263, ranking 24/73, at Biophysics.

4. Chen YC, Huang SH, Wang SM. Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2- mitogen-activated protein kinase kinase- extracellular signal-related regulated kinase signaling pathway. Int J Biochem Cell Biol. 2008 40(12):2815-25. 

5. Hsu KL, Fan HJ, Chen YC, Huang YS, Chen CH, Wu JC, Wang SM. Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions. Int J Biochem Cell Biol. 2009 Jan 8.

6. Chen YC, Huang BM. Regulatory mechanisms of Cordyceps sinensis on steroidogenesis in MA-10 mouse Leydig tumor cells. Biosci Biotechnol Biochem. 2010 Sep 23;74(9):1855-9.

7. Chen YC, Chen Y, Huang SH, Wang SM Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. FEBS Lett. 2010 Nov 5;584(21):4442-8.

8. Chen Y, Chen YC, Lin YT, Huang SH, Wang SM. Cordycepin Induces Apoptosis of CGTH W-2 Thyroid Carcinoma Cells through the Calcium-Calpain-Caspase 7-PARP Pathway. J Agric Food Chem. 2010 Nov 24;58(22):11645-52.IF:2.816 rank:2/55

9. Yang SH, Jeng CJ, Chen CH, Chen Y, Chen YC*, Wang SM*. Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. J Sci Food Agric. 2011; 91:694-702. (co-corresponding author) IF:1.36 rank:9/55

10. Chen Y, Chen YC. Oleic acid induces adherens junction disassembly in rat neonatal cardiomyocytes through mechanisms involving Fyn kinase and casein kinase 1. J of Medical Sciences. 2013; 33:011-019. 具審查制度論文

11. Yung-Chia Chen*, Ling-Hui Chien, Bu-Miin Huang, Yi-Chen Chia. Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells. J Func Food. 2014 IF:2.632 16% corresponding author. 優秀論文

12. Chih-Jen Yang, Yung-Chia Chen, Yee-Jean Tsai, Ming-Shyan Huang, Chao-Chuan Wang* Toona Sinensis leaf aqueous extract displays activity against sepsis in both in vitro and in vivo models.The Kaohsiung Medical Sciences. 2014

13. Yung-Chia Chen *, Yi-Lin Liang , Yuan-Li Huang , Bu-Miin Huang. Mechanism of Toona sinensis-stimulated adrenal steroidogenesis in primary rat adrenal cells. J Func Foods. 2015 優秀論文

14. Fu-Chi Kang, Pei-jung Chen, Bo-Syong Pan, Meng-Shao Lai, Yung-Chia Chen*, Bu-Miin Huang*.  Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells. 2015, Aug. 2015:8 2345-2360.

15. Yung-Chia Chen & Paige Mayleen True. Editors: Graham A. Colditz. Book Title: The SAGE Encyclopedia of Cancer and Society. Chapter Title: "Taiwan" Pub. Date: 2015 Access Date: November 10, 2015. Publishing Company: SAGE Publications, Inc. City: Thousand Oaks, Print ISBN: 9781483345734 Online ISBN: 9781483345758 DOI: http://dx.doi.org/10.4135/9781483345758.n555. Print pages: 1138-1140 專書論文

16. Yung-Chia Chen, Ling-Hui Chien, Bu-Miin Huang, Yi-Chen Chia, Hui-Fen Chiu*  Aqueous extracts of Toona sinensis leaves inhibits renal carcinoma cell growth and migration through JAK2/stat3, Akt, MEK/ERK, and mTOR/HIF-2a pathways. 2015.12.29 accepted. Nutrition And Cancer: An International Journal. 2016. 68(4):654-66.

17. Edmund Cheung So, Yung-Chia Chen, Shu-Chun Wang, Chia-Ching Wu, Man-Chi Huang, Meng-Shao Lai, Bo-Syong Pan, Fu-Chi Kang, Bu-Miin Huang*. Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells. OncoTargets and Therapy. 2016. 2016 (9): 2519–2533. IF=4.147. Biotech & applied microbiology. 52/159=(32.7%)

18. Meng-Shao Lai, Chia-Yih Wang, Shang-Hsun Yang, Chia-Ching Wu, Sunny Sun, Shaw-Jenq Tsai, Jih-Ing Chuang, Yung-Chia Chen*, Bu-Miin Huang** The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis. 2016. 12 (2):61-77. IF=2.5. Developmental biology 21/41=(51%) 

19. Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang* Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Journal of food and drug analysis 25 (2017):197-205. IF=6.079. Food science and technology. 12/144=8.3%

20. Cheng Liu, Wei-Chang Lee, Bu-Miin Huang, Yi-Chen Chia, Yu-Chi Chen, Yung-Chia Chen* 16-hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells. 2017. 36 (2017): 95-107. PHYTOMEDICINE. IF=5.340 PLANT SCIENCES 22/235=9.36%