Publications

近五年研究

1. Yu-Chi Chen, Bu-Miin Huang, Wei-Chang Lee, Yung-Chia Chen* 16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: Involvement of focal adhesion disassembly and signaling. OnCoTarget and Therapy. 2018. 2018:11 7679-7690. IF=4.147. Biotech & applied microbiology. 52/159=(32.7%)

2. Yung-Chia Chen*, Hsin-Ju Chen, Bu-Miin Huang, Yu-Chi Chen, Chi-Fen Chang. Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. Journal of Clinical Medicine. 2019, 8(10):1664. IF=4.241. MEDICINE, GENERAL & INTERNAL 39/169=23.7% 

3. Yung-Chia Chen*, Bu-Miin Huang Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions. Journal of visualized experiments. 2019. (145), e59016. IF=1.355. MULTIDISCIPLINARY SCIENCES 49/73=67.12%

4. Fu-Chi Kang, Shu-Chun Wang, Edmund Cheung So, Ming-Min Chang, Kar-Lok Wong, Ka Shun Cheng, Yung-Chia Chen*, Bu-Miin Huang*. Propofol could increase caspases and MAPKs pathways and suppress Akt pathway to induce apoptosis in MA-10 mouse Leydig tumor cells. Oncology Reports, 2019. 41 (6):3565-3574. IF=3.906. Oncology. 133/242=54.95%

5. Yi-Fen Mu, Ying-Hui Chen , Ming-Min Chang , Yung-Chia Chen, Bu-Miin Huang . 2019. Arsenic compounds induce apoptosis through the caspase pathway in MA-10 Leydig tumor cells. Oncology Letters, 18 (1): 944-954. IF=2.967  192/308=62.3%  

6. Fu-Chi Kang, Yung-Chia Chen, Shu-Chun Wang, Edmund Cheung So, Bu-Miin Huang.  Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the Akt pathway in TM3 mouse Leydig stem/progenitor cells. Int J Mol Med. 46 (1):439-448. 2020 Apr 21. 68/140=48.57%  IF:  4.101  

7. Ching-Feng Chiu, Yu-Qiang Lin, Ji Min Park, Yung-Chia Chen, Shao-Wen Hung, Chien-Chao Chiug, Chi-Fen Chang*.  The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer. Biomedicine & Pharmacotherapy. 2020. 128 (2020):110309. IF=6.529. pharmacology 24/275 =8.7%

8.  Yu-Chi Chen, Po-Yu, Wang, Bu-Miin Huang, Wei-Chang Lee, Yung-Chia Chen* 16-hydroxycleroda-3,13-dien-15,16-olide induces apoptosis in human bladder cancer cells through cell cycle arrest, mitochondria ROS overproduction and inactivation of EGFR-related signalling pathways. Molecules. 2020, 25(17):3958. IF= 4.411. BIOCHEMISTRY & MOLECULAR BIOLOGY. 63/178=(35.39%)

9.  Yu-Chi Chen, Chiao-Ling Hsieh, Bu-Miin Huang, Yung-Chia Chen*. Induction of mitochondrial-dependent apoptosis by essential oil of Toona sinensis root through Akt, mTOR and NF-kB signalling pathways in human renal cell carcinoma cells. Journal of Food and Drug Analysis. 2021. 29(3):433-447. IF=6.079. Food science and technology. 12/144=8.3% 

10.  Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang,  and Rong-Jane Chen. (2021) The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules, 26(16), 4954. Special Issue: Phytochemicals in Cancer Prevention and Therapy. doi.org/10.3390/molecules26164954 

11. Yung-Chia Chen, Yi-Chen Chia, Bu-Miin Huang. (2021) Invited review. Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities. Molecules, 26(17), 5369. doi.org/10.3390/molecules26175369 

12. Yu-Chi Chen, Chih-I Chen, Chao-Yuan Chang, Bu-Miin Huang, and Yung-Chia Chen*  Clerodane diterpene induces apoptosis/anoikis and suppresses migration and invasion of human bladder cancer cells through the histone deacetylases, integrin–focal adhesion kinase, and matrix metalloproteinase 9 signalling pathways. Human & Experimental Toxicology, 2022, 41. doi:10.1177/09603271221143040

13. Hsin-Ju Chen, Yu-Chi Chen, Bu-Miin Huang, Chih-I Chen, Cheng-Hsun Wu, Yung-Chia Chen*. 2023 Investigation of Eurycoma longifolia Extract on Alleviating Steatosis by Using in vivo and in vitro Steatotic Models: Mechanisms Through Activation of AMPK and Autophagic Flux. Revista Brasileira de Farmacognosia. published online 2023.11.15. doi.org/10.1007/s43450-023-00490-8 

14. Chen, YC., Chan, YC., Chang, YC. et al. Mitigation of high-fat diet-induced sarcopenia by Toona sinensis fruit extracts via autophagic flux and mitochondrial quality control. Food Sci Biotechnol 34, 245–256 (2025). https://doi.org/10.1007/s10068-024-01610-3

15. Sue-Joan Chang,*†, Yung-Chia Chen †, Yun-Ching Chang, Chung-Che Cheng and Yin-Ching Chan. (2025) ETAS®, a Standardized Extract of Asparagus officinalis Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality. Pharmaceuticals 2025, 18(9), 1243. https://doi.org/10.3390/ph18091243. co-first author.

16. Yung-Chia Chen*, Hsin-Hui Wang, Li-Syang Chen, Zuway-R Hong*. Inquiry-Based Practice-Oriented Teaching and Anatomy Self-Efficacy in Health Sciences Students: A Mixed-Methods Study. editing.

17. 陳永佳*。護理學系解剖學實驗課創新教學模式：以大體構造影片製作為核心之專題導向合作學習與同儕教學十年縱貫評估。Yung-Chia Chen*. An Innovative Teaching Model in Nursing Anatomy Laboratory Course: A Ten-Year Longitudinal Evaluation of Project-Based Cooperative Learning and Peer Teaching through Cadaveric Video Production. (Accepted and In press). 大學教學實務與研究學刊 ，2026。教學歷程文章 (已接受)

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過去發表研究

1. Chen YC, Huang YL, Huang BM. Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumor cells. Int J Biochem Cell Biol. 2005; 37(1):214-23. IF: 4.956, ranking 58/286, at biochemistry and molecular biology 引用次數 70

2. Chien CL, Chen YC, Chang MF, Greenberg AS, Wang SM. Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochem Cell Biol. 2005; 123(4-5):429-39. IF: 4.727, ranking 1/9, at microscopy.

3. Chen YC, Chang MF, Chen Y, Wang SM. Signaling pathways of magnolol-induced adrenal steroidogensis. FEBS Lett. 2005; 579(20):4337-43. IF:3.263, ranking 24/73, at Biophysics.

4. Chen YC, Huang SH, Wang SM. Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2- mitogen-activated protein kinase kinase- extracellular signal-related regulated kinase signaling pathway. Int J Biochem Cell Biol. 2008 40(12):2815-25. 

5. Hsu KL, Fan HJ, Chen YC, Huang YS, Chen CH, Wu JC, Wang SM. Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions. Int J Biochem Cell Biol. 2009 Jan 8.

6. Chen YC, Huang BM. Regulatory mechanisms of Cordyceps sinensis on steroidogenesis in MA-10 mouse Leydig tumor cells. Biosci Biotechnol Biochem. 2010 Sep 23;74(9):1855-9.

7. Chen YC, Chen Y, Huang SH, Wang SM Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. FEBS Lett. 2010 Nov 5;584(21):4442-8.

8. Chen Y, Chen YC, Lin YT, Huang SH, Wang SM. Cordycepin Induces Apoptosis of CGTH W-2 Thyroid Carcinoma Cells through the Calcium-Calpain-Caspase 7-PARP Pathway. J Agric Food Chem. 2010 Nov 24;58(22):11645-52.IF:2.816 rank:2/55

9. Yang SH, Jeng CJ, Chen CH, Chen Y, Chen YC*, Wang SM*. Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. J Sci Food Agric. 2011; 91:694-702. (co-corresponding author) IF:1.36 rank:9/55

10. Chen Y, Chen YC. Oleic acid induces adherens junction disassembly in rat neonatal cardiomyocytes through mechanisms involving Fyn kinase and casein kinase 1. J of Medical Sciences. 2013; 33:011-019. 具審查制度論文

11. Yung-Chia Chen*, Ling-Hui Chien, Bu-Miin Huang, Yi-Chen Chia. Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells. J Func Food. 2014 IF:2.632 16% corresponding author. 優秀論文

12. Chih-Jen Yang, Yung-Chia Chen, Yee-Jean Tsai, Ming-Shyan Huang, Chao-Chuan Wang* Toona Sinensis leaf aqueous extract displays activity against sepsis in both in vitro and in vivo models.The Kaohsiung Medical Sciences. 2014

13. Yung-Chia Chen *, Yi-Lin Liang , Yuan-Li Huang , Bu-Miin Huang. Mechanism of Toona sinensis-stimulated adrenal steroidogenesis in primary rat adrenal cells. J Func Foods. 2015 優秀論文

14. Fu-Chi Kang, Pei-jung Chen, Bo-Syong Pan, Meng-Shao Lai, Yung-Chia Chen*, Bu-Miin Huang*.  Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells. 2015, Aug. 2015:8 2345-2360.

15. Yung-Chia Chen & Paige Mayleen True. Editors: Graham A. Colditz. Book Title: The SAGE Encyclopedia of Cancer and Society. Chapter Title: "Taiwan" Pub. Date: 2015 Access Date: November 10, 2015. Publishing Company: SAGE Publications, Inc. City: Thousand Oaks, Print ISBN: 9781483345734 Online ISBN: 9781483345758 DOI: http://dx.doi.org/10.4135/9781483345758.n555. Print pages: 1138-1140 專書論文

16. Yung-Chia Chen, Ling-Hui Chien, Bu-Miin Huang, Yi-Chen Chia, Hui-Fen Chiu*  Aqueous extracts of Toona sinensis leaves inhibits renal carcinoma cell growth and migration through JAK2/stat3, Akt, MEK/ERK, and mTOR/HIF-2a pathways. 2015.12.29 accepted. Nutrition And Cancer: An International Journal. 2016. 68(4):654-66.

17. Edmund Cheung So, Yung-Chia Chen, Shu-Chun Wang, Chia-Ching Wu, Man-Chi Huang, Meng-Shao Lai, Bo-Syong Pan, Fu-Chi Kang, Bu-Miin Huang*. Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells. OncoTargets and Therapy. 2016. 2016 (9): 2519–2533. IF=4.147. Biotech & applied microbiology. 52/159=(32.7%)

18. Meng-Shao Lai, Chia-Yih Wang, Shang-Hsun Yang, Chia-Ching Wu, Sunny Sun, Shaw-Jenq Tsai, Jih-Ing Chuang, Yung-Chia Chen*, Bu-Miin Huang** The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis. 2016. 12 (2):61-77. IF=2.5. Developmental biology 21/41=(51%) 

19. Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang* Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Journal of food and drug analysis 25 (2017):197-205. IF=6.079. Food science and technology. 12/144=8.3%

20. Cheng Liu, Wei-Chang Lee, Bu-Miin Huang, Yi-Chen Chia, Yu-Chi Chen, Yung-Chia Chen* 16-hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells. 2017. 36 (2017): 95-107. PHYTOMEDICINE. IF=5.340 PLANT SCIENCES 22/235=9.36%