Dopamine Neurons Video

Cohorts of neurons are organized into anatomically specialized regions that are functionally connected by neural circuits. Allocating distinct types of neurons from uncommitted progenitor cells and the precision of neuronal connectivity requires the coordination of cell fate programming, differentiation, and neural circuit formation. I am interested in how genes and signaling pathways function at specific developmental stages to control these processes. My lab studies these mechanisms in the thalamus, striatum, and dopamine system because these regions regulate perception, sensation, sleep, motivation, and movement and are affected in complex brain disorders including autism, epilepsy, and schizophrenia. Using genetic approaches in mice, we ascertain how neuronal subtypes are established and become functionally connected. We also determine how mutations induced at specific embryonic stages affect brain development and cause complex behavioral phenotypes. Our knowledge of developmental mechanisms is being used to advance stem cell and pharmacological therapies to ameliorate brain disease.

Midbrain Dopamine Neuron Video (click link to open in new window)