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DropLab was built based on a simple tapered capillary and an automatic sample feeding device, which could either be a gear-driven slotted vial array or a 384-well plate placed on a 3-D translation stage. The 384-well plate can hold a larger number of samples to be tested. DropLab has high controllability and versatility to generate droplets with varied size, composition and concentration. It is a true capillary-based microfluidic analysis system (CBMAS) for droplet generation without any microfabrication technique involved. The storage, incubation and analysis of the droplets can be performed in capillaries or on an oil-immersed nanowell plate. Pictures on the right show a train of 2-nL droplets in a capillary and a 2-D nanowell array holding 12-nL dye drops.
DropLab has been tested in various types of screening assays, including but not limited to the following examples:
Protein crystallization
Protein crystallization
Carbohydrate identification
Carbohydrate identification
Enzyme inhibition assay
Enzyme inhibition assay
Interphase material exchange
Interphase material exchange
Precipitate morphology
Precipitate morphology
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