JSPS Post-Doctoral Researcher, Dept. of Mechanical Engineering, Toyohashi University of Technology, JAPAN 2019-2021
Post-Doctoral Researcher, Department of Engineering Design, Indian Institute of Technology-Madras (IIT-M) 2017-2019
Project Scientist, Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore, India 2016
Research Fellow, Department of Chemistry, Anna University, Chennai, India 2013-2015
Project Scientist, Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore, India 2012-2013
Project Assistant, Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore, India 2010-2012
Researcher, Centre for Biomaterials, Cellular and Molecular Theranostics [CBCMT], VIT University, Vellore, India 2009
JSPS Post-Doctoral Researcher, Nanomaterials, Dept. of Mechanical Engineering, Toyohashi University of Technology, JAPAN (2019-2021)
Post-Doctoral Researcher, Dept. of Engineering Design, Indian Institute of Technology-Madras (IIT-M), INDIA (2017-2019)
Ph.D. Biomaterials (Engineering), Anna University, Chennai, Tamilnadu, INDIA (2014-2016)
M.Tech Biomedical Engineering, Vellore Institute of Technology (VIT), Vellore, INDIA (2007-2009)
B.Pharm Pharmacy, Tamilnadu Dr. M.G.R Medical University Chennai, INDIA (2002-2006)
Intracellular delivery
Single-cell technology
Biomaterials and medical devices
3D printing
Photoporation
Electroporation
Mechanoporation
Magnetoporation
Nanomaterials and drug delivery applications
Surface modifications of bio-metals
Bio-NEMS / MEMS
Intracellular delivery of PI Dye and Dextran in HeLa cells (Cervical Cancer Cells)
Intracellular delivery in
MG 63 cells (Bone Cancer Cells)
Intracellular delivery
Photoporation / Electroporation / Mechanoporation / Magnetoporation
3D-Printing
Nano/microstructures formation (nanotubes, micro-spikes, flowers, cones) - Anodization
Photolithography
Plasma Immersion Ion implantation (PIII), Plasma Nitriding (PN), Diamond Like carbon coatings (DLC), Electrophoretic Deposition Techniques (EPD), Electrospinning (Nanofibers) for Bio-medical applications
Electrospinning
X-Ray Photoelectron Spectroscopy (XPS or ESCA) for surface analysis
Potentiodynamic polarization and EIS for Bio-Corrosion analysis
In-Vitro cell culture studies / Fluorescence microscopic imaging
Nanosecond pulsed laser
Micro hardness tester
Scratch tester for adhesion studies
Wear tester – To study Bio-Metals wear rate
Characterization Techniques- micro Raman, XRD, FESEM, EDS, AFM and XPS
Vacuum systems (CVD / PVD)
(On-going)
Project - 8 (TUT)
Title : Photoporation: Development of massively parallel intracellular delivery using nanostructures
2019 - 2021
(Completed)
Project - 7 (IITM)
Title : Development of Nanostructures and Bioactive Coatings on Magnesium Alloys for Medical Implants (2017 - 2019)
Magnesium oxide nanostructures fabricated on magnesium alloy using electrochemical anodization technique and incorporation/coating of bioactive materials.
Project - 6 (Anna University)
Title : Development of Nanostructured Titanium alloys for Bio-medical Applications (2013-2015)
The formation of titanium oxide nano structures (nano pores / nano tubes) by anodic oxidation on biomedical titanium alloys, CP Ti, Ti-6Al-4V, Ti-6Al-7Nb, Ti-13Nb-13Zr and Ti-15Mo-3Nb-3Al-0.2Si (β-21S) were investigated. Anodization parameters such as electrolyte composition, concentration, voltage, time and temperature were optimized to get well organized titanium oxide nanotube arrays. Nanotubes with pore diameters 35, 100 and 125 nm have been formed on titanium alloy Ti-6Al-7Nb at different voltages (10, 20 and 30 V) in electrolyte solution containing sulfuric acid and hydrofluoric acid. The dependence of pore diameter, wall thickness of nanotube arrays on different anodization temperature ranging from 5 ˚C to 70˚C was also investigated. Self-organized TNTs with pore diameter of 100 nm have been formed on titanium alloy Ti-6Al-7Nb by anodic oxidation and were nitrided in a nitrogen plasma. Quercetin and quercetin with chitosan were loaded into TNT successfully. Drug release profiles of samples were studied in Hanks’ solution for 192 h.
Project - 5 (CSIR-NAL)
Surface modification of NiTi alloy for Biomedical Applications (2016)
Modification of NiTi alloy by Plasma immersion ion implantation with nitrogen, carbon, oxygen, and DLC. To enhances the corrosion resistance of NiTi alloy for Biomedical applications.
Project - 4 (CSIR-NAL)
Plasma Immersion Ion Implantation and Plasma Nitriding of Beta stabilized Titanium Alloys for Aerospace applications (2013)
Modification of Titanium alloys such as Ti-6Al-4V, Ti-15-3-3 by Plasma immersion ion implantation and RF Plasma nitriding with different dilutions of nitrogen, hydrogen, and argon gas compositions. To enhances the tribological properties of Ti alloys for Aerospace applications.
Project - 3 (CSIR-NAL)
Surface Modifications of Titanium alloys for Bio-medical Applications (2010 – 2012)
Surface modification of Titanium alloys such as Ti-6Al-4V, Ti-Mo (Beta-21S) and Ti-13Nb-13Zr by Plasma immersion ion implantation (Nitrogen Carbon and Oxygen), Plasma nitriding (with different dilutions of nitrogen, Hydrogen and Argon), Diamond-like Carbon Coatings (DLC) interlayered and doping with zirconium, titanium, and molybdenum to enhance the corrosion and wear resistance properties of Ti alloys for Bio-medical applications.
Project - 2 (VIT University)
Electrophoretic Deposition of Nano Composite Powders (HAp + TiO2) on Titanium Alloys For Bio-medical Applications (2009)
The objective of this work is to coat the bio-medical implants to enhance the Osseointegration to increase the service period of implants, using Electrophoretic Deposition (EPD) technique. As cell adhesion is observed to be high on nanosurfaces, an attempt is made to deposit nanocrystalline composite powders (HAp / TiO2) using EPD technique on commercially pure Titanium and Ti-13Nb-13Zr alloy.
Project - 1 (PPC)
Pharmacognostical, preliminary phytochemical & pharmacological investigation of the leaves of SOLANUM TRILOBATUM.linn. (2006)
Solanum Trilobatum leaves were characterized for its Pharmacognostical and phytochemical properties. Pharmacological activities were investigated by animal studies using Albino rat. Solanum Trilobatum leaves are well known in the use of asthma and bronchial disorders. In our studies, we confirmed that it also has anti-inflammatory activity. Five sets of albino rats about 120 – 150 gm were studied by hind paw edema method injecting carrageenan and compared with the leaves extract of Solanum Trilobatum and Indomethacin.
Plasma Assisted Surface Modification of Titanium Alloy Ti-15V-3Al-3Cr-3Sn-Aviral Pandey, BE (hons. Mech. Engg.) BITS, Pilani December 2010.
Optimization of PECVD Process Parameters for Depositing DLC Film Using Doe Approach- Vijaykumar S, M.Tech (Mech.) NIT, Calicut, April, 2011.
Effects of chromium content on structure and electrical properties of chromium-doped diamond like carbon films- Raghavendra. M, M.Tech (nanotechnology), Kuvempu University, Shankaraghtta, June 2011.
Diamond-like Carbon Coatings Preparation and Characterization for Biomedical Applications- Prateek Kumar, BE (hons. Chem. Engg.) BITS, Pilani,December 2011.
Metal-Doped Amorphous Carbon Nanocomposite: Preparation and Characterization - Preetam Kumar Giri, BE (hons. Chem. Engg.) BITS, Pilani,December 2012.
Tribological Studies on Plasma Nitrided Ti-6Al-7Nb Alloy, Nishanth. N, (M.Tech) Visvesvaraya Technological University, Bengaluru, Karnataka,December 2013.
Studies on Copper Doped Diamond Like Carbon Films Synthesized By Plasma Enhanced Chemical Vapour Deposition, P. Mohan Raaj, (M.S) SRM University, Kattankulathur, Chennai, May 2013.
Preparation and Characterization of Zinc-doped DLC Coating on Titanium alloy for Biomedical Applications, Shivani Pandita, (M.Tech) Department of Chemical Engineering, Dayananda Sagar College of Engineering, Bengaluru, Karnataka, June 2014.
Synthesis and Characterization of Ti doped Vacuum Arc Deposited Tetrahedral Amorphous Carbon (ta-C) Coatings, Manjunath Reddy M, (M.Tech) Visvesvaraya Technological University, Belgaum, June 2014.
Ti doped DLC coatings deposited by PECVD for Biomedical Applications, K Saikumar, (M.Tech) Visvesvaraya Technological University, Belgaum, June 2014.
Drug release characteristics of EP-loaded TiO2 nanotubes coated with biopolymer, S. Zindahi (B.Tech), SRM Institute of Science and Technology, Chennai, India. March 2019
Controlled, localized drug delivery using titania nanotubes, Amogh Kumar Baranwal (MS), Indian Institute of Technology, Madras (IIT-M), Chennai, India. April 2019.
Fabrication of micro/nano structures for drug delivery applications, G. Keerthiga (M. Tech), Indian Institute of Technology, Madras (IIT-M), Chennai, India. Nov 2019.
Localized Electroporation with Titanium Oxide Nanotubes, Ahmad Zahid Fakhri Bin Zawawi, Toyohashi University of Technology, Japan, Febrauary 2021.