Cancer Biology Lab

Lab News

  • Hye-Kyung's paper was published in the Journal of Medicinal Chemistry TITLE: Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.ABSTRACT:Although Hsp90 inhibitors can inhibit multiple tumorigenic pathways in cancer cells, their anticancer activity has been disappointingly modest. However, by forcing Hsp90 inhibitors into the mitochondria with mitochondrial delivery vehicles, they were converted into potent drugs targeting the mitochondrial Hsp90 paralog TRAP1. Here, to improve mitochondrial drug accumulation without using the mitochondrial delivery vehicle, we increased freely available drug concentrations in the cytoplasm by reducing the binding of the drugs to the abundant cytoplasmic Hsp90. After analyzing X-ray cocrystal structures, the purine ring of the Hsp90 inhibitor 2 (BIIB021) was modified to pyrazolopyrimidine scaffolds. One pyrazolopyrimidine, 12b (DN401), bound better to TRAP1 than to ...
    Posted Sep 29, 2017, 11:32 AM by Byoung Heon Kang
  • Development of TRAP1 inhibitor (KDDF Interview) [UNIST] 새로운 기전으로 작용하는 항암 약물 개발 ‘도전’
    Posted Jun 7, 2016, 3:27 AM by Byoung Heon Kang
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Research Area

1) Cellular functions and molecular regulatory mechanism of the mitochondrial chaperone TRAP1.

2) TRAP1 and Client networks: implications for human diseases (Cancer & beyond)

3) Development of TRAP1 inhibitors as anticancer drugs: mitochondria-targeted "SMTINs" and in vivo pan-Hsp90 inhibitor "Panvotinibs".

4) Cancer stem cells and mechanism of resistance to chemo- and radio-therapies.

5) Tumor microenvironment: tumor cross-talk with inflammation and metabolism.

Position Available

암세포 미토콘드리아의 기능 연구 및 항암신약개발을 함께할 박사후 연구원을 상시 모집하고 있습니다.

[Graduate student]
미토콘드리아와 암생물학 연구에 관심있는 석박사통합/박사과정 대학원생을 모집합니다. 

[UNIST Undergraduate Research Internship]
UNIST 생명과학부 3, 4학년 학부생은 암생물학 실험실에서 실험을 배우거나 연구에 참여할 수 있습니다. 

암생물학실험실에 대학원생/연구원으로 지원하시고자 하는 분은 강병헌 교수에게 연락바랍니다.