This extended, online Table of Contents includes links to the full-text of each of the chapters comprising the thesis. It also includes, as relevant for any chapters, links to supplementary appendices; links to preliminary, preparatory work; and links to extended versions. Links to supplementary appendices are included for chapters 3, 7, and 9; links to preliminary, preparatory work published as either abstracts or journal articles are included for chapters 3, 4, and 9; links to earlier versions of thesis systematic reviews are included for chapters 8 and 9; a link to the complete, extended publication of the osteoarthritis Cochrane review, which has been substantially abridged for inclusion in the thesis, is included for Chapter 8; and a relevant Letter to the Editor and our response is included for Chapter 7. The full-text of each of these documents will open when the relevant item is clicked on this online Table of Contents page.