Links to Publications Supported by Provided Methodology

Methodological Publications:

1. Berdyshev, E.V., Gorshkova, I.A., Garcia, J.G.N., Natarajan, V., and Hubbard, W.C. (2005) Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal. Biochem., 339(1), 129-136.

2. Berdyshev, E.V., Gorshkova, I.A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W., Natarajan, V. (2006) De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell. Signaling, 18(10), 1779-1792.

3. Berdyshev E.V., Gorshkova I., Skobeleva A., Bittman R., Lu X., Dudek S.M., Mirzapoiazova T., Garcia J.G., Natarajan V. (2009) FTY720 inhibits ceramide synthases and upregulates dihydrosphingosine-1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 284(9):5467-5477.

4. Berdyshev E.V., Goya J., Gorshkova I., Prestwich G.D., Byun H.-S., Bittman R., Natarajan V. (2011) Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. Anal. Biochem., 408(1):12-18.

5. Berdyshev E.V. (2011) Mass spectrometry of fatty aldehydes. Biochim. Biophys. Acta. 1811(11):680-693.

Non-Methodological Publications:

1. Petrache I, Natarajan V, Zhen L, Medler TR, Richter A, Berdyshev EV, Tuder RM. (2006) Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells. Proc. Am. Thorac. Soc. 3(6):510.

2. Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. (2007) Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clin. Exp. Allergy 37(3):311-322.

3. Zhao, Y., Kalari, S.K., Usatyuk, P.V., Gorshkova, I., He, D., Watkins, T., Brindley, D.N., Sun, C., Bittman, R., Garcia, J.G., Berdyshev, E.V., Natarajan V. (2007) Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: Role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282(19):14165-14177.

4. Medler, T.R., Petrusca, D.N., Lee, P.J., Hubbard, W.C., Berdyshev, E.V., Skirball, J., Kamocki, K., Schuchman, E., Tuder, R.M., and Petrache, I. (2008) Apoptotic Sphingolipid Signaling by Ceramides in Lung Endothelial Cells. Am. J. Respir. Cell Mol. Biol., 38(6):639-646.

5. Gorshkova, I., He, D., Berdyshev, E., Usatyuk, P., Burns, M., Kalari, S., Zhao, Y., Pendyala, S., Garcia, J.G., Pyne, N.J., Brindley, D.N., Natarajan, V. (2008) Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta , and rac1. J. Biol. Chem., 283(17), 11794-11806.

6. Petrache, I., Medler, T., Richter, A. Kamocki, K.., Chukwueke, U., Zhen, L., Gu, Y., Adamowicz, J., Schweitzer, K., Hubbard, W., Berdyshev, E., Lungarella, G., Tuder, R.(2008) Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am. J. Physiol. Lung Cell. Mol. Physiol., 295(1):L44-53.

7. Kilkus J.P., Goswami R., Dawson S.A., Testai F.D., Berdyshev E.V., Han X., Dawson G. (2008) Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J. Neurochem. 106(4):1745-1757.

8. Dossumbekova A., Berdyshev E.V., Gorshkova I., Shao Z., Li C., Long P., Joshi A., Natarajan V., Vanden Hoek T.L. (2008) Akt activates NOS3 and separately restores barrier integrity in H₂O₂-stressed human cardiac microvascular endothelium. Am. J. Physio.l Heart Circ. Physiol. 295(6):H2417-H2426.

9. Kalari S.K., Zhao Y., Spannhake E.W., Berdyshev E.V., Natarajan V. (2008) Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 296(3):L328-336. PMCID: PMC2660210.

10. Pamuklar Z., Federico L., Liu S., Umezu-Goto M., Dong A., Panchatcharam M., Fulkerson Z., Berdyshev E., Natarajan V., Fang F., van Meeteren L.A., Moolenaar W.H., Mills G.B., Morris A.J., Smyth S.S. (2009) Autotaxin/lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis. // J. Biol. Chem. 284(11):7385-7394. PMCID: PMC2652269.

11. Noe J., Petrusca D., Rush N., Deng P., Vandemark M., Berdyshev E., Gu Y., Smith P., Schweitzer K., Pilewsky J., Natarajan V., Xu Z., Obhukov A.G., Petrache I. (2009) CFTR Regulation of Intracellular pH and Ceramides is Required for Lung Endothelial Cell Apoptosis. Am. J. Respir. Cell. Mol. Biol. 41(3):314-323. PMCID: PMC274275.

12. Tomsig J.L., Snyder A.H., Berdyshev E.V., Skobeleva A., Mataya C., Natarajan V., Brindley D.N., Lynch K.R. (2009) Lipid Phosphate Phosphohydrolase type 1 (LPP1) Degrades Extracellular Lysophosphatidic Acid in vivo. Biochem. J., 419(3):611-618. PMCID: PMC2677185.

13. Diab K.J., Adamowicz J.J., Kamocki K., Rush N.I., Garrison J., Gu Y., Schweitzer K.S., Skobeleva A., Rajashekhar G., Hubbard W.C., Berdyshev E.V., Petrache I. (2010) Stimulation of sphingosine 1 phosphate signaling as an alveolar cell survival strategy in emphysema. Am. J. Respir. Crit. Care Med. 181(4):344-352.

14. Qin J, Berdyshev E, Goya J, Natarajan V, Dawson G. (2010) Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. J. Biol. Chem. 285(19):14134-14143.

15. Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. (2010) A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. J. Biol. Chem. 285(21):15848-15857.

16. Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Pitson SM, Wattenberg BW. (2010) Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. J. Lipid Res. 51(9):2546-2559.

17. Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 22(9):1300-1307.

18. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen CT, Lariviere PJ, Mauceri H, Sammani S, Husain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JG. (2011) Simvastatin Attenuates Radiation-induced Murine Lung Injury and Dysregulated Lung Gene Expression. Am. J. Respir. Cell. Mol. Biol. 44(3):415-422.

19. Loveridge C., Tonelli F., Leclercq T., Lim K.G., Long J.S., Berdyshev E., Tate R.J., Natarajan V., Pitson S.M., Pyne N.J., Pyne S. (2010) The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J Biol Chem. 285(50):38841-38852.

20. Petrusca D.N., Gu Y., Adamowicz J.J., Rush N.I., Hubbard W.C., Smith P.A., Berdyshev E.V., Birukov K.G., Lee C.H., Tuder R.M., Twigg Iiird H.L., Vandivier R.W., Petrache I. (2010) Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J. Biol. Chem. 285(51):40322-40332.

21. Siow D.L., Anderson C.D., Berdyshev E.V., Skobeleva A., Natarajan V., Pitson S.M., Wattenberg B.W. (2011) Sphingosine kinase localization in the control of sphingolipid metabolism. Adv. Enzyme Regul. 51(1):229-244.

22. Zhao Y., Gorshkova I.A., Berdyshev E., He D., Fu P., Ma W., Su Y., Usatyuk P.V., Pendyala S., Oskouian B., Saba J.D., Garcia J.G., Natarajan V. (2011) Protection of LPS-Induced Murine Acute Lung Injury by Sphingosine-1-Phosphate Lyase Suppression. Am. J. Respir. Cell Mol. Biol. 45(2):426-435. PMCID: PMC3175568.

23. Berdyshev E.V., Gorshkova I., Usatyuk P., Kalari S., Zhao Y., Pyne N.J., Pyne S., Sabbadini R.A., Garcia J.G., Natarajan V. (2011) Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase. PLoS One. 6(1):e16571. PMCID: PMC3031585

24. Usatyuk P.V., He D., Bindokas V., Gorshkova I.A., Berdyshev E.V., Garcia J.G., Natarajan V. (2011) Photolysis of Caged Sphingosine-1-phosphate Induces Barrier Enhancement and Intracellular Activation of Lung Endothelial Cell Signaling Pathways. Am. J. Physiol. Lung Cell. Mol. Physiol. 300(6):L840-L850. PMCID: PMC3119122.

25. Véret J., Coant N., Berdyshev E., Skobeleva A., Therville N., Bailbé D., Gorshkova I., Natarajan V., Portha B., Le Stunff H. (2011) Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in gluco-lipotoxicity-induced apoptosis of INS-1 β-cells. Biochem. J. 438(1):177-189.

26. Zhao J., He D., Berdyshev E., Zhong M., Salgia R., Morris A.J., Smyth S.S., Natarajan V., Zhao Y. (2011) Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. Biochem J. 439(1):45-55.

27. Mathew B., Jacobson J.R., Berdyshev E., Huang Y., Sun X., Zhao Y., Gerhold L.M., Siegler J., Evenoski C., Wang T., Zhou T., Zaidi R., Moreno-Vinasco L., Bittman R., Chen C.T., Lariviere P.J., Sammani S., Lussier Y.A., Dudek S.M., Natarajan V., Weichselbaum R.R., Garcia JG. (2011) Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 25(10):3388-3400.

28. Selim S., Sunkara M., Salous A.K., Leung S.W., Berdyshev E.V., Bailey A., Campbell C.L., Charnigo R., Morris A.J., Smyth S.S. (2011) Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond). 121(12):565-572.

29. Zhao J., He D., Su Y., Berdyshev E.V., Chun J., Natarajan V., Zhao Y. (2011) Lysophosphatidic Acid Receptor 1 Modulates Lipopolysaccharide-Induced Inflammation in Alveolar Epithelial Cells and Murine Lungs. Am. J. Physiol. Lung Cell Mol. Physiol. 301(4):L547-L556. PMCID: PMC3191756

30. Li J, Beiser DG, Wang H, Das A, Berdyshev E, Li J, Leff AR, Stern SA, Vanden Hoek TL. (2011) Therapeutic Hypothermia Cardioprotection in Murine Hemorrhagic Shock/Resuscitation Differentially Affects p38α/p38γ, Akt, and HspB1. J. Trauma. 71(5):1262-1270.

31. Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson G. (2012) Neutral Sphingomyelinase 2 Deficiency Increases Hyaluronan Synthesis by Up-regulation of Hyaluronan Synthase 2 through Decreased Ceramide Production and Activation of Akt. J. Biol. Chem. 287(17):13620-13632.

32. Gorshkova I., Zhou T., Mathew B., Jacobson J.R., Takekoshi D., Bhattacharya P., Smith B., Aydogan B., Weichselbaum R.R., Natarajan V., Garcia J.G., Berdyshev E.V. (2012) Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J. Lipid Res. 53(8):1553-1568. PMCID: PMC3540856.

33. Lim K.G., Tonelli F., Berdyshev E., Gorshkova I., Leclercq T., Pitson S.M., Bittman R., Pyne S., Pyne N.J. (2012) Inhibition kinetics and regulation of sphingosine kinase 1 Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b. Int. J. Biochem. Cell. Biol. 44(9):1457-1464.

34. Testai F.D., Hillmann M., Amin-Hanjani S., Gorshkova I., Berdyshev E., Gorelick P.B., Dawson G. (2012) Changes in the Cerebrospinal Fluid Ceramide Profile After Subarachnoid Hemorrhage. Stroke, 43(8):2066-2070.

35. Poirier C., Berdyshev E.V., Dimitropoulou C., Bogatcheva N.V., Biddinger P.W., Verin A.D. (2012) Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema. Mamm Genome. 23(11-12):758-763.

36. Kalari S., Moolky N., Pendyala S., Berdyshev E.V., Rolle C., Kanteti R., Kanteti A., Ma W., He D., Husain A.N., Kindler H.L., Kanteti P., Salgia R., Natarajan V. (2012) Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation. PLoS One. 7(9):e45330.

37. Véret J, Coant N, Gorshkova IA, Giussani P, Fradet M, Riccitelli E, Skobeleva A, Goya J, Kassis N, Natarajan V, Portha B, Berdyshev EV, Le Stunff H. (2012) Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. Biochim. Biophys. Acta. 1831(2):251-262.

38. Kamocki K., Van Demark M., Fisher A., Rush N.I., Presson R.G. Jr, Hubbard W., Berdyshev E.V., Adamsky S., Feinstein E., Gandjeva A., Tuder R.M., Petrache I. (2013) RTP801 is Required for Ceramide-Induced Cell-Specific Death in the Murine Lung. Am. J. Respir. Cell. Mol. Biol. 48(1):87-93.

39. Watson DG, Tonelli F, Al Osaimi M, Williamson L, Chan E, Gorshkova I, Berdyshev E, Bittman R, Pyne NJ, Pyne S. (2013) The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal. 25(4):1011-1017. PMCID: PMC3595369

40. Huang LS, Berdyshev E, Mathew B, Fu P, Gorshkova IA, He D, Ma W, Noth I, Ma SF, Pendyala S, Reddy SP, Zhou T, Zhang W, Garzon SA, Garcia JG, Natarajan V. (2013) Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. FASEB J. 27(4):1749-1760. PMCID: PMC3606540.

41. Natarajan V, Dudek SM, Jacobson JR, Moreno-Vinasco L, Huang LS, Abassi T, Mathew B, Zhao Y, Wang L, Bittman R, Weichselbaum R, Berdyshev E, Garcia JG. (2013) Sphingosine-1-Phosphate, FTY720 and Sphingosine-1-Phosphate Receptors in the Pathobiology of Acute Lung Injury. Am J Respir Cell Mol Biol. 49(1):6-17.

42. Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV. (2013) Inhibition of sphingosine-1-phosphate lyase rescues spingosine kinase-1-knockout phenotype following murine cardiac arrest. Life Sci., 93(9-11):359-66.

43. Harijith A, Pendyala S, Reddy NM, Bai T, Usatyuk PV, Berdyshev E, Gorshkova I, Shuang Huang L, Mohan V, Garzon S, Kanteti P, Reddy SP, Raj U, Natarajan V. (2013) Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins. Am J Pathol. 183(4):1169-1182. PMCID: PMC3791871.

44. Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA, Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth SS, Ackerman SJ, Natarajan V, Christman JW. (2013) Autotaxin production of lysophosphatidic Acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med. 188(8):928-40. PMCID: PMC3906883

45. Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ. (2013) The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules; 3(2):316-33 . PMID: 24970170. PMCID: PMC4030851.

46. Montesi SB, Mathai SK, Brenner LN, Gorshkova IA, Berdyshev EV, Tager AM, Shea BS. (2014) Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis. BMC Pulm. Med. 14:5. PMCID: PMC3906883.

47. Chang Q, Berdyshev E, Cao D, Bogaard JD, White JJ, Chen S, Shah R, Mu W, Grantner R, Bettis S, Grassi MA. (2014) Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors. J. Biol. Chem. 289(12):8337-52.

48. Huang LS, Mathew B, Li H, Zhao Y, Ma SF, Noth I, Reddy SP, Harijith A, Usatyuk PV, Berdyshev EV, Kaminski N, Zhou T, Zhang W, Zhang Y, Rehman J, Kotha SR, Gurney TO, Parinandi NL, Lussier YA, Garcia JG, Natarajan V. (2014) The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Am J Respir Crit Care Med. 189(11):1402-1415.

49. Testai FD, Kilkus JP, Berdyshev E, Gorshkova I, Natarajan V, Dawson G. (2014) Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia. J Neurochem. 131(4):530-540.

50. Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang L, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. (2014) The Sphingosine Kinase 1 / Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 190(9):1032-43.

51. Lee YG, Jeong JJ, Nyenhuis S, Berdyshev E, Chung S, Ranjan R, Karpurapu M, Deng J, Qian F, Kelly EA, Jarjour NN, Ackerman SJ, Natarajan V, Christman JW, Park GY. (2015) Recruited Alveolar Macrophages, in Response to Airway Epithelial-derived MCP-1/CCL2, Regulate Airway Inflammation and Remodeling in Allergic Asthma. Am J Respir Cell Mol Biol. 52(6):772-84

52. Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I. (2015) Space Radiation Associated Lung Injury in a Murine Model. Am J Physiol Lung Cell Mol Physiol. 308(5):L416-L428.

53. Testai FD, Xu HL, Kilkus J, Suryadevara V, Gorshkova I, Berdyshev E, Pelligrino DA, Dawson G. (2015) Changes in the metabolism of sphingolipids after subarachnoid hemorrhage. J Neurosci Res. 93(5):796-805.

54. Huang LS, Berdyshev EV, Tran JT, Xie L, Chen J, Ebenezer DL, Mathew B, Gorshkova I, Zhang W, Reddy SP, Harijith A, Wang G, Feghali-Bostwick C, Noth I, Ma SF, Zhou T, Ma W, Garcia JG, Natarajan V. (2015) Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy. Thorax. 70(12):1138-48.

55. Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV. (2015) Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1. Am J Respir Cell Mol Biol. 53(4):555-562. PMCID: PMC4742897

56. Petrache I, Berdyshev EV. (2015) Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. Annu Rev Physiol. 2016;78:463-80.

57. Ackerman SJ, Park GY, Christman JW, Nyenhuis S, Berdyshev E, Natarajan V. (2016) Polyunsaturated lysophosphatidic acid as a potential asthma biomarker. Biomark Med. 10(2):123-135.

58. Oh MJ, Zhang C, LeMaster E, Adamos C, Berdyshev E, Bogachkov Y, Kohler EE, Baruah J, Fang Y, Schraufnagel DE, Wary KK, Levitan I. (2016) Oxidized-LDL Signals through Rho-GTPase to Induce Endothelial Cell Stiffening and Promote Capillary Formation. J. Lipid Res. 57(5):791-808. PMCID: PMC4847627.

59. Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. (2016) Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 30(6):2435-50. PMCID: PMC4871797.

60. Harijith A, Pendyala S, Ebenezer DL, Ha AW, Fu P, Wang YT, Ma K, Toth PT, Berdyshev EV, Kanteti P, Natarajan V. (2016) Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 311(2):L337-51. PMCID: PMC5142460.

61. Serban KA, Rezania S, Petrusca DN, Poirier C, Cao D, Justice MJ, Patel M, Tsvetkova I, Kamocki K, Mikosz A, Schweitzer KS, Jacobson S, Cardoso A, Carlesso N, Hubbard WC, Kechris K, Dragnea B, Berdyshev EV, McClintock J, Petrache I. (2016) Structural and functional characterization of endothelial microparticles released by cigarette smoke. Sci Rep. 6:31596. PMCID: PMC4987682

62. Fu P, Ebenezer DL, Berdyshev EV, Bronova IA, Shaaya M, Harijith A, Natarajan V. (2016) Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. J. Biol. Chem. 291(53):27187-27203. PMCID: PMC5207147

63. Ayee MA, LeMaster E, Shentu TP, Singh DK, Barbera N, Soni D, Tiruppathi C, Subbaiah PV, Berdyshev E, Bronova I, Cho M, Akpa BS, Levitan I. (2017) Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. Biophys. J. 112(2):325-338.

64. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. (2017) Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. (7):44867. doi: 10.1038/srep44867.

65. Ke Y, Zebda N, Oskokova O, Afonyushkin T, Berdyshev E, Tian Y, Meng F, Sarich N, Bochkov VN, Wang JM, Birukova AA, Birukov KG. (2017) Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell Mediated Generation of LXA4. Circ Res. 2017 121(3):244-257.

66. Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I. (2017) Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins. Arterioscler. Thromb. Vasc. Biol. 38(1):64-75.

67. Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I. (2017) Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 32(4):1880-1890.

68. Suryadevara V, Fu P, Ebenezer DL, Berdyshev E, Bronova IA, Huang LS, Harijith A, Natarajan V. (2018) Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase. Int. J. Mol. Sci. 2018, 19(1). pii: E114. doi: 10.3390/ijms19010114.

69. Oskolkova O, Sarich N, Tian Y, Gawlak G, Meng F, Bochkov VN, Berdyshev E, Birukova AA, Birukov KG. (2018) Incorporation of iloprost in phospholipase-resistant phospholipid scaffold enhances its barrier protective effects on pulmonary endothelium. Sci. Rep. 8(1):879.

70. Berdyshev E., Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DYM. Lipid abnormalities in atopic skin are driven by type-2 cytokines. (2018) JCI Insight, 1. Feb 22;3(4). 2018, pii: 98006.

71. Ke Y, Karki P, Kim J, Son S, Berdyshev E, Bochkov VN, Birukova AA, Birukov KG. Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. FASEB J. 33(3):3887-3900. PMID: 30521374

72. Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P. Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. Thorax. 2019 Feb 5. pii: thoraxjnl-2018-212378. doi: 10.1136/thoraxjnl-2018-212378. [Epub ahead of print]

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