Publications

2023

54. Tae-Hyun Kim, Dong Il Choi, Ja Eun Choi, Hoonwon Lee, Hyunsu Jung, Jooyoung Kim, Yongmin Sung, Hyo-Jin Park, Min Jung Kim, Dae Hee Han, Seung-Hee Lee, Bong-Kiun Kaang. (2023) Activated somatostatin interneurons orchestrate memory microcircuits. Neuron. https://doi.org/10.1016/j.neuron.2023.10.013

53. Ilsong Choi, Ilayda Demir, Seungmi Oh, Seung-Hee Lee. (2023) Multisensory integration in the mammalian brain: diversity and flexibility in health and disease. Phil Trans B 378(1886), DOI:https://doi.org/10.1098/rstb.2022.0338

52. Youkyeong Gloria Byun, Nam-Shik Kim, Gyuri Kim, Yi-Seon Jeon, Jong Bin Choi, Chan-Woo Park, Kyungdeok Kim, Hyunsoo Jang, Jinkyeong Kim, Eunjoon Kim, Yong-Mahn Han, Ki-Jun Yoon, Seung-Hee Lee, Won-Suk Chung. (2023) Stress induces behavioral abnormalities by increasing expression of phagocytic receptor, MERTK, in astrocytes to promote synapse phagocytosis. Immunity. S1074-7613(23)00318-7. doi: 10.1016/j.immuni.2023.07.005.

50. Seung-Hee Lee. (2023) Classifying inhibitory synapses in the cortex: beyond cell types. Nature Reviews Neuroscience. DOI:10.1038/s41583-023-00683-z  (Journal Club)

49. Kwang Wook Min, Namsuk Kim, Jae Hoon Lee, Younghoon Sung, Museong Kim, Eun Jung Lee, Jong-Myeong Kim, Jae-Hyun Kim, Jaeyoung Lee,  Wonjin Cho, Jee Myung Yang, Nury Kim, Jaehoon Kim, C. Justin Lee, Young-Gyun Park, Seung-Hee Lee, Han-Woong Lee, Jin Woo Kim. (2023) Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant. Experimental & Molecular Medicine. 55, 385-400. https://doi.org/10.1038/s12276-023-00930-4

2022

48. Jae Eun Choi, Doing Il Choi, Jisu Lee, Jooyoung Kim, Min Jung Kim, Ilgang Hong, Hyunsu Jung, Yongmin Sung, Ji-Il Kim, Taehyun Kim, Nam-Kyung Yu, Seung-Hee Lee, Han Kyoung Choe, Ja Wook Koo, Joung-Hun Kim, Bong-Kiun Kaang. (2022) Synaptic ensembles between raphe and D1R-containing accumbens shell neurons underlie postisolation sociability in males. Science Advances. 8, 41. https://doi.org/10.1126/sciadv.abo7527

47. Ilsong Choi, Seung-Hee Lee. (2022) Reduced activity of parvalbumin-positive interneurons in the posterior parietal cortex causes visually dominant multisensory decisions in freely navigating mice. Molecular Brain. 15, 82. https://doi.org/10.1186/s13041-022-00968-x

46. Mannkyu Hong, Mingeun Kim, Jiwon Yoon, Seung-Hee Lee*, Mu-Hyun Baik*, Mi Hee Lim*. (2022) Excited-state intramolecular hydrogen transfer of compact molecules controls amyloid aggregation profiles. JACS Au. 2, 2001-2012 (*co-corresponding)

45. Jiyeon Han, Jiwon Yoon, Jeongcheol Shin, Eunju Nam, Tongrui Qian, Yulong Li, Kiyoung Park*, Seung-Hee Lee*, Mi Hee Lim*. (2022) Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β. Nature Chemistry. 14, 1021-1030. https://doi.org/10.1038/s41557-022-00984-3 (*co-corresponding)

43. Jungjoo Park, Yeeun Choi, Eunji Jung, Seung-Hee Lee, Jong-Woo Sohn, Won-Suk Chung. (2021)  Microglial MERTK eliminates phosphatidylserine-displaying inhibitory post-synapses. EMBO. e107121. https://doi.org/10.15252/embj.2020107121 

42. You-Hyang Song*, Jiwon Yoon*, Seung-Hee Lee. (2021) The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders. Experimental & Molecular Medicine. 53, 328-338. https://doi.org/10.1038/s12276-021-00580-4  (*equal contribution)

41. Yang-Sun Hwang, Catherine Maclachlan, Jerome Blanc, Anaelle Dubois, Carl C.H. Petersen, Graham Knott, Seung-Hee Lee. (2021) 3D ultrastructure of synaptic inputs to distinct GABAergic neurons in the mouse primary visual cortex. Cerebral Cortex. 31(5), 2610-2624, https://doi.org/10.1093/cercor/bhaa378

40. Hanseul Kwon, Won Beom Jung, Geun Ho lm, Jia Ryoo, Joon-Hyuk Lee, Hogyeong Do, Yeonsoo Choi, You-Hyang Song, Hwajin Jung, Haram Park, Lily R. Qiu, Jacob Ellegood, Hyun-Ji Shim, Esther Yang, Hyun Kim, Jason P. Lerch, Seung-Hee Lee, Won-Suk Chung, Daesoo Kim, Seong-Gi Kim, Eunjoon Kim. (2021) Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors. Cell Reports. 34, 108780. https://doi.org/10.1016/j.celrep.2021.108780

2020

39. Jun Ho Song, Woochul Choi, You-Hyang Song, Jae-Hyun Kim, Daun Jeong, Seung-Hee Lee, Se-Bum Paik. (2020) Precise mapping of single neurons by calibrated 3D reconstruction of brain slices reveals topographic projection in mouse visual cortex. Cell Reports. 31, 107682. https://doi.org/10.1016/j.celrep.2020.107682

38. You-Hyang Song*, Yang-Sun Hwang*, Kwansoo Kim*, Hyoung-Ro Lee*, Jae-Hyun Kim, Catherine Maclachlan, Anaelle Dubois, Min Whan Jung, Carl C.H. Petersen, Graham Knott, Suk-Ho Lee, Seung-Hee Lee. (2020) Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1. Science Advances. http://doi.org/10.1126/sciadv.aaz0517 (*equal contribution)

2019

37. Yeonsoo Choi, Haram Park, Suwon Kang, Hwajin Jung, Hanseul Kweon, Seoyeong Kim, Ilsong Choi, Soo Yeon Lee, Ye-Eun Choi, Seung-Hee Lee, Eunjoon Kim. (2019) NGL-1/LRRC4C-mutant mice display hyperactivity and anxiolytic-like behavior associated with widespread suppression of neuronal activity. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2019.00250

36. Saeyeong Jeon, Jae-Hyun Kim, Hongkyun Lee, Yong-Kweon Kim, Sang Beom Jun, Seung-Hee Lee, Chang-Hyuon Ji. (2019) Multi-wavelength light emitting diode-based disposable optrode array for in vivo optogenetic modulation. Journal of Biophotonics. https://doi.org/10.1002/jbio.201800343

2018

35. Sylvain Crochet*, Seung-Hee Lee*, Carl C.H. Petersen*. (2018) Neural circuits for goal-directed sensorimotor transformations. Trends in Neuroscience. DOI: http://doi.org/10.1016/j.tins.2018.08.011 (*co-corresponding)

34.  Hee-Jun Rho, Jae-Hyun Kim, Seung-Hee Lee. (2018) Function of selective neuromodulatory projections in the mammalian cerebral cortex: comparison between the cholinergic and noradrenergic systems. Frontiers in Neural Circuits. doi: 10.3389/fncir.2018.00047

33.  Ilsong Choi, Jae-Yun Lee, Seung-Hee Lee. (2018) Bottom-up and top-down modulation of multisensory integration. Current Opinion in Neurobiology. 52, 115-122.  https://doi.org/10.1016/j.conb.2018.05.002

2017

32.   You-Hyang Song*, Jae-Hyun Kim*, Hye-Won Jeong, Ilsong Choi, Daun Jeong, Kwansoo Kim, Seung-Hee Lee. (2017) A neural circuit for auditory dominance over visual perception. Neuron. 93, 940-954. DOI: http://dx.doi.org/10.1016/j.neuron.2017.01.006 (*equal contribution)

    - Selected as Issue Highlights

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        Daniel B. Polley. (2017) Multisensory Conflict Resolution: Should I Stay or Should I Go? 93, 725-727.

31.   Kwansoo Kim, Jae-Hyun Kim, You-Hyang Song, Seung-Hee Lee. (2017) Functional dissection of inhibitory microcircuits in the visual cortex. Neuroscience Research. 116, 70-76. DOI: 10.1016/j.neures.2016.09.003. (Review article)

30.    Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song, Young-In Sohn, Dae-Jin Park, Sun-Soon Paik, Joo-ri Kim-Kaneyama, Mi-Ryoung Song, Amanda Leung, Edward M Levine, In-Beom Kim, Yong Sook Goo, Seung-Hee Lee, Kyung Hwa Kang, Jin Woo Kim. (2017) The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity. eLife. DOI: http://dx.doi.org/10.7554/eLife.21303.

29.   Soowon Shin, Jae-Hyun Kim, Joonsoo Jeong, Tae Mok Gwon, Seung-Hee Lee, Sung June Kim. (2017) Novel four-sided neural probe fabricated by a thermal lamination process of polymer films. Journal of Neuroscience Methods. 278, 25-35. DOI: http://dx.doi.org/10.1016/j.jneumeth.2016.12.017

2016

28.   Yong-Woo Jun, Seung-Hee Lee, Jaehoon Shim, Jin-A Lee, Chae-Seok Lim, Bong-Kiun Kaang, Deok-Jin Jang. (2016) Dual roles of the N-terminal coiled-coil domain for an Aplysia sec7 protein: homodimer formation and nuclear export. Journal of Neurochemistry. 139, 1102-1112. DOI: 10.1111/jnc.13875

27.    Seung-Hee Lee*, Jaehoon Shim*, Ye-Hwang Cheong*, Sun-Lim Choi, Yong-woo Jun, Sue-Hyun Lee, Yeon-Su Chae, Jin-Hee Han, Yong-Seok Lee, Jin-A Lee, Chae-Seok Lim, Kausik Si, Stephan Kassabov, Igor Antonov, Eric R. Kandel, Bong-Kiun Kaang, Deok-Jin Jang. (2016) ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation. Molecular Brain. DOI: 10.1186/s13041-016-0271-x (*equal contribution)

26.    Dohoung Kim, Huijeong Jeong, Juhyeong Lee, Jeong-Wook Ghim, Eun Sil Her, Seung-Hee Lee, Min Whan Jung. (2016) Distinct roles of parvalbumin- and somatostatin-expressing interneurons in working memory. Neuron. 92, 902-915. DOI: http://dx.doi.org/10.1016/j.neuron.2016.09.023.

25.    Johnny Phong Do*, Min Xu*, Seung-Hee Lee*, Wei-Cheng Chang, Siyu Zhang, Shinjae Chung, Tyler J Yung, Jiang Lan Fan, Kazunari Miyamichi, Liqun Luo, Yang Dan. (2016) Cell type-specific long-range connections of basal forebrain circuit. eLife.  DOI: http://dx.doi.org/10/7554/eLife.13214 (*equal contribution)

24.    Jae-Hyun Kim, A-Hyun Jung, Daun Jeong, Ilsong Choi, Kwansoo Kim, Soowon Shin, Sung June Kim, Seung-Hee Lee. (2016) Selectivity of neuromodulatory projections from the basal forebrain and locus ceruleus to primary sensory cortices. Journal of Neuroscience. May 11;36(19):5314-27. doi: 10.1523/JNEUROSCI.4333-15.2016.

23.    Ji Won Um, Tae-Young Choi, Hyeyeon Kang, Yi Sul Cho, Gayoung Choii, Pavel Uvarow, Dongseok Park, Daun Jeong, Sangmin Jeon, Dongmin Lee, Hyun Kim, Seung-Hee Lee, Yong-Chul Bae, Se-Young Choi, Matti S. Airaksinen, and Jaewon Ko. (2016) LRRTM3 regulates excitatory synapse development through alternative splicing and neurexin binding. Cell Reports.  14, 1-15.

~ 2014

22.    Lee, S.-H., Kwan, A.C., Dan, Y. (2014). Interneuron subtypes and orientation tuning. Nature.  508, E1-2.(Brief Communications Arising)

21.    Pinto, L., Goard, M.J., Estandian, D., Xu, M., Kwan, A.C., Lee, S.-H., Harrison, T.C., Feng, G., Dan, Y. (2013). Fast modulation of visual perceptionby basal forebrain cholinergic neurons. Nature Neurocience.  16, 1857-1863

20.    Park, A.Y., Chae, Y.S., Lee, S.H., Kaang, B.K., Lee, S. (2013). Presynaptic structure of Aplysia single live neuron by atomic force and confocal laser scanning microscope. Journal of Physical Chemistry B. 117, 4779-4788.

19.    Lee, S.-H., Shim, J., Kaang, B.-K. (2013). The role of cell adhesion molecules (CAMs) in defining synapse-specific function and plasticity. Animal Cells and Systems. 17, 1-6. (Review Paper)

18.    Lee, S.-H., Dan, Y. (2012). Neuromodulation of brainstates. Neuron. 76, 209-222. (Review Article)

17.    Lee, S.-H., Shim, J., Choi, S.-L., Lee, N., Lee, C.-H., Bailey, C.H., Kandel, E.R., Jang, D.-J., Kaang, B.-K. (2012). Learning-related synaptic growth mediated by internalization of Aplysia cell adhesion molecule is controlled by membrane PI(4,5)P2 synthetic pathway. Journal of Neuroscience. 32, 16296-16305.

16.    Lee, S.-H., Kwan, A.C., Zhang, S., Phoumthipphavong, V., Flannery, J.G., Masmanidis, S.C., Taniguchi, H., Huang, Z.J., Boyden, E.S., Deisseroth, K., and Dan, Y. (2012). Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature. 488, 379-383.

15.    Lee, Y.-S., Choi, S.-L., Jun, H., Yim, S.-J., Lee, J.-A., Kim, H.F., Lee, S.-H., Shim, J., Lee, K., Jang, D.-J., Kaang, B.-K. (2012). AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia. Proc Natl Acad Sci U S A. doi:10.1073   

14.    Park, J.W., Park, A.-Y., Lee, S., Yu, N.-K., Lee, S.-H., Kaang, B.-K. (2010). Detection of TrkB receptors distributed in cultured hippocampal neurons through bioconjugation between highly luminescent (quantum dot-neutravidin) and(biotinylated anti-TrkB antibody) on neurons by combined atomic forcemicroscope and confocal laser scanning microscope. Bioconjugate Chemistry. 21, 597-603.

13.    Chae, Y.-S., Lee, S.-H., Cheang, Y.-H., Lee, N., Rim, Y.-S., Jang, D.-J., Kaang, B.-K. (2010). Neuronal RNA granule contains ApCPEB1, a novelcytoplasmic polyadenylation element binding protein in Aplysia sensory neuron. Experimental and Molecular Medicine. 42, 30-37.

12.    Lee, Y.-S., Choi, S.-L., Lee, S.-H., Kim, H., Park, H., Lee, N., Lee, S.-H., Chae, Y.-S., Jang, D.-J., Kandel, E.R., Kaang, B.-K. (2009). Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. Proc Natl Acad Sci U S A. 106, 14634-14639. 

11.    Lee, S.-H., Choi, J.-H., Lee, N., Lee, H.-R., Kim, J.-I., Yu, N.-K., Choi, S.-L., Lee, S.-H., Kim, H., Kaang, B.-K. (2008). Synaptic protein degradation underlies destabilization of retrieved fear memory. Science. 319, 1253-1256. 

10.    Lee, S.-H.*, Lim, C.-S.*, Park, H.*, Lee, J.-A., Han, J.-H., Kim, H., Cheang, Y.-H., Lee, S.-H., Lee, Y.-S., Ko, H.-G., Jang, D.-H., Kim, H., Miniaci, M.C., Bartsch, D., Kim, E., Bailey, C.H., Kandel, E.R., Kaang, B.-K. (2007). Nucleartranslocation of apCAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell. 129, 801-812. (*equal contribution)

9.    Jang, D.-H., Han, J.-H., Lee, S.-H., Lee, Y.-S., Park, H., Lee. S.-H., Kim, H., Kaang, B.-K. (2005). Cofilin expression induces cofilin-actin rod formation and distrupts synaptic structure and function in Aplysia synapses. Proc Natl Acad Sci U S A.102, 16072-16077.

8.    Park, H., Lee, J.-A., Lee, C.-H., Kim, M.-J., Chang, D.-J., Kim, H., Lee, S.-H., Lee, Y.-S., Kaang, B.-K. (2005). An Aplysia type 4 phosphodiesterase homologlocalized at the presynaptic terminals of Aplysia neuron and regulatessynaptic facilitation. Journal of Neuroscience. 25, 9307-9045.

7.    Li, W., Lee, J., Vikis, H.G., Lee, S.-H., Liu, G., Aurandt, J., Sheng, T.L., Fearon, E.R., Guan, J.-L., Han, M., Rao, Y., Hong, K., Guan, K.-L. (2004). Activation of FAK and Src are receptor-proximal events required for Netrinsignaling. Nature Neuroscience. 7, 1213-1221.

6.    Chang, D.-J., Lee, S.-H., Lim, C.-S., Jang, D.-H., Lee, C.-H., Lee, Y.-D., Kaang, B.-K. (2004). Thioloxidation-mediated cell death in Aplysia cultured sensory neurons. Brain Research. 1007, 71-77.

5.    Akalal, D.G., Bottenstein, J.E., Lee, S.-H., Han, J.-H., Chang, D.-J., Kaang, B.-K., Nagle, G.T. (2003). Aplysia mollusk-derived growth factor is amitogen with adenosine deaminase activity and is expressed in the developingcentral nervous system. Brain Research Molecular Brain Research. 117, 228-236.

4.    Lee, S.-H., Han, J.-H., Choi, J.-H., Huh, E.-Y., K, Y.K., Kaang, B.-K. (2003). Effect of brain-derived neurotrophic factor(BDNF) on neuritogenesis and synaptic plasticity in Aplysia neurons and a hippocampal cell line HiB5. Molecules and Cells. 15, 233-239.

3.    Chang. D.-J., Lim, C.-S., Lee, S.-H., Kaang, B.-K. (2003). Hydrogen peroxidemodulates K+ ion currents in cultured Aplysia neurons. Brain Research. 970, 159-168. 

2.    Huh, M.-J., Han, J.-H., Lim, C.-S., Lee, S.-H., Kim, S-H., Kim, E.-J., Kaang, B.-K. (2003). Regulation of neuritogenesis and synaptic transmissionby msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons. Journal of Neurochemistry. 85, 282-285.

1.    Lee, J.-A., Lim, C.-S., Lee, S.-H., Kim, H., Nukina, N., Kaang, B.-K. (2003). Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysianeurons. Journal of Neurochemistry. 85, 160-169.