2024
[42] Jiseong Kim,† Insuk Byun,† Do Young Kim,† Hyunhi Joh, Hak Joong Kim,* Min Jae Lee,* Chem. Soc. Rev. 2024 Advance Article. DOI: 10.1039/D3CS00344B. Targeted protein degradation directly engaging lysosomes or proteasomes. [link] (†Three authors contributed equally)
2023
[41] Suyeon Yeom, Do Young Kim, Seungwoo Kim, Arjun Gontala, Jimin Park, Yong Ho Lee,* Hak Joong Kim,* Org. Lett. 2023, 25, 9008. DOI: 10.1021/acs.orglett.3c03616. Carboxylate-Directed Pd-Catalyzed β-C(sp3)–H Arylation of N-Methyl Alanine Derivatives for Diversification of Bioactive Peptides. [link]
[40] Suyeon Yeom,† Dowoon Nam,† Kwon Hee Bok, Hye Kyeong Kwon, SeungWoo Kim, Sang Won Lee,* Hak Joong Kim*, Anal. Chem. 2023, 95, 14413. DOI: 10.1021/acs.analchem.3c02768. Synthesis of S-Carbamidomethyl Cysteine and its Use for Quantification of Cysteinyl Peptides by Targeted Proteomics. (†Two authors contributed equally) [link]
[39] Eunji Cha, Jushin Kim, Lizaveta Gotina, Jaehwan Kim, Hyuon Jeong Kim, Seon Hee Seo, Jeong-Eun Park, Jeongmin Joo, Minsik Kang, Jaeick Lee, Hayoung Hwang, Hak Joong Kim, Ae Nim Pae, Ki Duk Park, Jong-Hyun Park, Sang Min Lim,* J. Med. Chem. 2023, 66, 10381. DOI: 10.1021/acs.jmedchem.3c00498. Exploration of Tetrahydroisoquinoline- and Benzo[c]azepine-Based Sphingosine 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis. [link]
[38] Namkyoung Kim, Sandip Sengupta, Jiwon Lee, Uttam Dash, Soojeung Kim, Hak Joong Kim, Chiman Song, Taebo Sim,* Eur. J. Med. Chem. 2023, 259, 115592. DOI: 10.1016/j.ejmech.2023.115592. Synthesis and Antibacterial Activities of Baulamycin A Inspired Derivatives. [link]
[37] Do Young Kim, Suyeon Yeom, Jimin Park, Heeyeong Lee, Hak Joong Kim,* ACS Infect. Dis. 2023, 9, 554. DOI: 10.1021/acsinfecdis.2c00556. Cytoplasmic Delivery of an Antibiotic, Trimethoprim, with a Simple Bidentate Catechol Analog as a Siderophore Mimetic. [link]
2022
[36] Doyoung Kim, Jieon Lee, Rina Kwag, Hyunbin Kim, Hyunji Oh, Bongjin Moon, Hak Joong Kim, Jihye Seong, Byungsun Jeon, Taek Kang, Hyunah Choo, Bull. Kor. Chem. Soc. 2022, 43, 73. in press. DOI: 10.1002/bkcs.12427. N-(Biphenyl-3-ylmethyl)ethanamines as G protein-biased agonists of 5-HT7R. [link]
2021
[35] Rina Kwag, Jieon Lee, Doyoung Kim, Haeun Lee, Miyoung Yeom, Jiwan Woo, Yakdol Cho, Hak Joong Kim, Jeongjin Kim, Gyochang Keum, Byungsun Jeon , Hyunah Choo, J. Med. Chem. 2021, 64, 13766. DOI: 10.1021/acs.jmedchem.1c01093. Discovery of G Protein-Biased Antagonists against 5-HT7R. [link]
[34] Mingi Kim,† Do Young Kim,† Woon Young Song, So Eun Park, Simone A. Harrison, Walter J. Chazin, Man Hwan Oh, and Hak Joong Kim, mBio 2021, 26, e02248-21. DOI: 10.1128/mBio.02248-21. Distinctive Roles of Two Acinetobactin Isomers in Challenging Host Nutritional Immunity. †These authors contributed to this manuscript equally. [link]
[33] Jieon Lee, Rina Kwag, Soyeon Lee, Doyoung Kim, Jiwan Woo, Yakdol Cho, Hak Joong Kim, Jeongjin Kim, Byungsun Jeon, Hyunah Choo, J. Med. Chem. 2021, 64, 7453. DOI: 10.1021/acs.jmedchem.1c00110. Discovery of G Protein-Biased Ligands against 5-HT7R. [link]
[32] Do Young Kim and Hak Joong Kim, Org. Lett. 2021, 23, 5256. DOI: 10.1021/acs.orglett.1c01786. Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle. [link]
2016-2020
[31] Soojeung Kim, Haeun Lee, Woon Young Song, and Hak Joong Kim, Org. Lett. 2020, 22, 2806. DOI: 10.1021/acs.orglett.0c00790. Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii. [link]
[30] Woon Young Song and Hak Joong Kim, Nat. Prod. Rep. 2020, 37, 477. DOI: 10.1039/C9NP00046A. Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon. [link] (#1 Journal in the Organic Chemistry & Medicinal Chemistry categories by JCR)
[29] Jihye Kim, Eunji Cha, Woo Kyu Park, Hye Yeon Lee, Sang Min Lim, Hak Joong Kim, Ae Nim Pae, Bioorg. Med. Chem. Lett. 2020, 30, 126882. DOI: 10.1016/j.bmcl.2019.126882. Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT2A, 5-HT2C, and the serotonin transporter. [link]
[28] Juhyeon Kim, Yihoon Kim, Ahmed Z. Abdelazem, Hak Joong Kim, Hyunah Choo, Hoon Seok Kim, Jung Ok Kim, Yeon-Joon Park, Sun-Joon Min, Bioorg. Chem. 2020, 94, 103405. DOI: 10.1016/j.bioorg.2019.103405. Development of carbapenem-based fluorogenic probes for the clinical screening of carbapenemase-producing bacteria. [link]
[27] Juhyeon Kim, Yoon Jung Kim, Ashwini M. Londhe, Ae Nim Pae, Hyunah Choo, Hak Joong Kim, and Sun-Joon Min, Molecules 2019, 24, 3234. Synthesis and biological evaluation of disubstituted pyrimidines as selective 5-HT2C agonists. [link]
[26] Haeun Lee, Woon Young Song, Minju Kim, Min Wook Lee, Soojeung Kim, Ye Song Park, Kyungwon Kwak, Man Hwan Oh, and Hak Joong Kim, Org. Lett. 2018, 20, 6476. Synthesis and characterization of anguibactin to reveal its competence to function as a thermally stable surrogate siderophore for a Gram-negative pathogen, Acinetobacter baumannii. [link]
[25] Sandip Sengupta, Munhyung Bae, Dong-Chan Oh, Uttam Dash, Hak Joong Kim, Woon Young Song, Injae Shin, and Taebo Sim, J. Org. Chem. 2017, 82, 12947. Structural revision of baulamycin A and structure-activity relationships of baulamycin A derivatives. [link]
[24] Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, and Sun-Joon Min, Molecules 2017, 22, 1416. Identification of optically active pyrimidine derivatives as selective 5-HT2C modulators. [link]
[23] Juhyeon Kim, Byung Seok Moon, Byung Chul Lee, Ho-Young Lee, Hak Joong Kim, Hyunah Choo, Ae Nim Pae, Yong Seo Cho, and Sun-Joon Min, ACS Chem. Neurosci. 2017, 8, 996. A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine. [link]
[22] Seung Kyun Shin, Ji Hyeon Kim, Jung Hoon Lee, Young Hoon Son, Min Wook Lee, Hak Joong Kim, Sue Ah Noh, Kwang Pyo Kim, In-Gyu Kim, Min Jae Lee, Exp. Mol. Med. 2017, 49, e287. Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro. [link]
[21] Sandip Sengupta, Hak Joong Kim, Kyung Seon Cho, Woon Young Song, and Taebo Sim, Tetrahedron 2017, 73, 1182. Highly stereoselective synthesis of Mupirocin H. [link]
[20] Woon Young Song, Dawa Jeong, Jimin Kim, Min Wook Lee, Man Hwan Oh, Hak Joong Kim, Org. Lett. 2017, 19, 500. The key structural elements for cellular uptake of acinetobactin, a major siderophore of Acinetobacter baumannii. [link]
[19] Hyun Lee, Jung-Jin Park, Nga Nguyen, Jun Sub Park, Jin Hong, Seung-Hyeob Kim, Woon Young Song, Hak Joong Kim, Kwangman Choi, Sungchan Cho, Jae-Seon Lee, Bong-Woo Kim, Young-Gyu Ko, J. Biol. Chem. 2016, 291, 26627. MG53-IRS-1 interaction disruptor sensitizes insulin signaling in skeletal muscle. [link]
[18] Youngjae Kim, Hyeri Park, Jeongeun Lee, Jinsung Tae, Hak Joong Kim, Sun-Joon Min, Hyewhon Rhim, Hyunah Choo, Eur. J. Med. Chem. 2016, 123, 180. 5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity. [link]
[17] So Yeon Lee, Kyoung-Ran Kim, Duhee Bang, Se Won Bae, Hak Joong Kim, Dae-Ro Ahn, Biomater. Sci. 2016, 4, 1314. Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification. [link]
2012–2015
[16] Hwisoo Ree, Jimin Kim, Woon Young Song, Jae Eun Lee, Hak Joong Kim, Bull. Kor. Chem. Soc. 2015, 36, 1520. Total syntheses and evaluation of the siderophore functions of fimsbactin B and its analogues. [link]
[15] Jimin Kim, Jae Eun Lee, Hwisoo Ree, Hak Joong Kim, Bull. Kor. Chem. Soc. 2015, 36, 439. Total synthesis of acinetobactin. [link]
[14] Hyeon Seok Kim, Woon Young Song, Hak Joong Kim, Org. Biomol. Chem. 2015, 13, 73. Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates. [link]
[13] Matinder Kaur, Byungkwon Yoon, Rajesh Kumar, Min Ju Cho, Hak Joong Kim, Jong Seung Kim, Dong Hoon Choi, Bull. Kor. Chem. Soc. 2014, 35, 3437. A carbazole based bimodal "turn-on" fluorescent probe for biothiols (cysteine/homocysteine) and fluoride: Sensing, imaging and its applications. [link]
[12] Hak Joong Kim, Sei-hyun Choi, Byung-sun Jeon, Namho Kim, Rongson Pongdee, Qingquan Wu, Hung-wen Liu, Angew. Chem. Int. Ed. 2014, 53, 13553. Chemoenzymatic synthesis of spinosyn A. [link]
Prior to 2012
[11] Chan Hyuk Kim, Mingchao Kang, Hak Joong Kim, Abhishek Chatterjee, Peter G. Schultz, Angew. Chem. Int. Ed. 2012, 51, 7246. Site-specific incorporation of ε-N-crotonyllysine into histones. [link]
[10] Hak Joong Kim,* Mark W. Ruszczycky,* Hung-wen Liu, Curr. Opin. Chem. Biol. 2012, 16, 124-131. Current developments and challenges in the search for a naturally selected Diels-Alderase. [link]
* These two authors equally contributed.
[9] Hak Joong Kim, Mark W. Ruszczycky, Sei-hyun Choi, Hung-wen Liu, Nature 2011, 473, 109-112. Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A.* [link]
* This article was highlighted in Nature [link], C&EN [link], and Chembiochem[link].
[8] Svetlana A. Borisova, Sanjeeva R. Guppi, Hak Joong Kim, Bulan Wu, John H. Penn, Hung-wen Liu, George A. O’Doherty, Org. Lett. 2011, 12, 5150-5153, A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity. [link]
[7] Hak Joong Kim, Jess A. White-Phillip, Yasushi Ogasawara, Nara Shin, Eta A. Isiorho, Hung-wen Liu, J. Am. Chem. Soc. 2010, 132, 2901-2903. The biosynthesis of spinosyn in Saccharopolyspora spinosa: Synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK. [link]
[6] Jeffrey W. Munos, Xiaotao Pu, Steven O. Mansoorabadi, Hak Joong Kim, Hung-wen Liu, J. Am. Chem. Soc. 2009, 131, 2048-2049. A secondary isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: Evidence for a retroaldol-aldol rearrangement. [link]
[5] Svetlana A. Borisova, Hak Joong Kim, Xiaotao Pu, Hung-wen Liu,ChemBioChem 2008, 9, 1554-1558. Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications. [link]
[4] Hak Joong Kim, Rongson Pongdee, Qingquan Wu, Lin Hong, Hung-wen Liu, J. Am. Chem. Soc. 2007, 129, 14582-14584. The biosynthesis of spinosyn in Saccharopolyspora spinosa: Synthesis of the cross-bridging precursor and identification of the function of SpnJ. [link]
[3] Chai-Lin Kao, Svetlana A. Borisova, Hak Joong Kim, Hung-wen Liu, J. Am. Chem. Soc. 2006, 128, 5606-5607. Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis. [link]
[2] Eun Lee, Eun Jeong Jeong, Sun Joon Min, Sukwon Hong, Jaehong Lim, Sang Kyun Kim, Hak Joong Kim, Bum Gyu Choi, Ki Chul Koo, Org. Lett. 2000, 2, 2169-2171. Radical cyclization of β-aminoacrylates: Synthesis of (-)-indolizidine 223AB. [link]
[1] Eun Lee, Cheol Hwan Yoon, Young Jin Lee, Hak Joong Kim, Bull. Kor. Chem. Soc. 1997, 18, 1247-1248. Synthesis of iridolactones via stereoselective Favorskii rearrangement: (+)-dolicholactone, (+)-alyxialactone, and (-)-4-epi-alyxialactone. [link]