Research

Nuclear Envelope Instability in Cancer and Senescence

The nuclear envelope safeguards genome integrity, but its stability is frequently compromised in cancer and senescent cells. Transient ruptures of the nuclear envelope expose genomic DNA to the cytoplasm, causing DNA damage and triggering inflammatory responses. We investigate the mechanisms maintaining nuclear envelope integrity and explore how its breakdown drives disease to identify novel therapeutic targets.

High-Throughput Imaging-Based Screening

To understand and control organelle homeostasis at a systems level, our laboratory conducts functional genomics and compound library screenings. In particular, we perform high-throughput imaging-based screenings and develop and utilize state-of-the-art AI-based image and data analysis pipelines to analyze the results.