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Welcome to the page of the research group of Dr. Jun Nakanishi, group leader.
The activity of cells is highly dependent on their extracellular environments. Our group develops new materials for chemically and mechanically engineering cellular environments and look at how they regulate cellular functions. Such material biological approach is important not only for fundamental understanding of life phenomena, but also for a number of biomedical applications including stem cell regulation, tissue engineering and drug testing. Currently, we are focusing on cell adhesion and cell migration signaling, which is essential for various physiological and pathological processes.
 
Topics
1) Our new paper has been accepted to Polymers.
Y.S. Huang, J.K. Chen, S.W. Kuo, Y.A. Hsieh, S. Yamamoto, J. Nakanishi, and C.F. Huang,
"Synthesis of Poly(N-vinylpyrrolidone)-Based Polymer Bottlebrushes by ATRPA and RAFT Polymerization: Toward Drug Delivery Application"

2) Our new paper has been accepted to Acta Biomaterialia.
S. Yamamoto, Y. Iwamaru, Y. Shimizu, Y. Ueda, M. Sato, K. Yamaguchi, and J. Nakanishi*
"Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts"

3) Our new paper has been accepted to Small.
X. Jia,* K. Minami, K. Uto, A. C. Chang, J. P. Hill, T. Ueki, J. Nakanishi,* K. Ariga*
"Modulation of Mesenchymal Stem Cells Mechanosensing at Fluid Interfaces by Tailored Self-Assembled Protein Monolayers"

4) Our new paper has been accepted to Langmuir.
S. Yamamoto, K. Okada, N. Sasaki, A. Chang, K. Yamaguchi, J. Nakanishi,*
"Photoactivatable hydrogel interfaces for resolving the interplay of chemical, mechanical, and geometrical regulation of collective cell migration"



 
Nakanishi group, WPI-MANA, National Institute for Materials (NIMS), Tsukuba, JAPAN
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