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Welcome to the page of the research group of Dr. Jun Nakanishi, group leader.
The activity of cells is highly dependent on their extracellular environments. Our group develops new materials for chemically and mechanically engineering cellular environments and look at how they regulate cellular functions. Such material biological approach is important not only for fundamental understanding of life phenomena, but also for a number of biomedical applications including stem cell regulation, tissue engineering and drug testing. Currently, we are focusing on cell adhesion and cell migration signaling, which is essential for various physiological and pathological processes.
 
Topics
1) We will organize an International Symposium on Material-based Mechanobiology.
Symposium: 3rd International Symposium on Nanoarchitectonics for Mechanobiology
Date: March 7th-8th
Place: NIMS, Tsukuba, Japan
Plenary speakers: Adam Engler (UCSD), Khalid Salaita (Emory), Cole DeForest (Washington))
Invited speakers: James Gimzewski (UCLA), Naotaka Nakazawa (Kyoto), Hiroaki Hirata (Nagoya), Keitaro Yoshimoto (Tokyo), Yoshibumi Ueda (AMED-PRIME), Tadahiro Yamashita (Keio)
Organizers: Jun Nakanishi, Koichiro Uto, Cole DeForest

2) Our new paper has been accepted to Langmuir.
S. Yamamoto, K. Okada, N. Sasaki, A. Chang, K. Yamaguchi, J. Nakanishi,*
"Photoactivatable hydrogel interfaces for resolving the interplay of chemical, mechanical, and geometrical regulation of collective cell migration"

3) Our new paper has been accepted to Analytical Sciences.
J. Nakanishi,* K. Sugiyama, H. Matsuo, Y. Takahashi, S. Ōmura, and T. Nakashima
"An application of photoactivatable substrate for the evaluation of epithelial-mesenchymal transition inhibitors"

4) Our new paper has been accepted to Journal of Bioscience and Bioengineering.
H. Matsuo, Y. Noguchi, A Také, J. Nakanishi, K. Shigemura, T. Sunazuka, Y. Takahashi, S. Ōmura, and T. Nakashima*
"Nanaomycin I and J: new nanaomycins generated by mycothiol-mediated compounds from “Streptomyces rosa subsp. notoensis” OS-3966"

5) Our new paper has been appeared in ChemPhotoChem.
S. Yamamoto, H. Ikegami, K. Yamaguchi, and J. Nakanishi*
"A dynamic biomaterial based on a 2-nitrobenzyl derivative with a tert-butyl substituent at the benzyl position: rapid response and minimized phototoxicity"
The paper was selected as the outside cover!





 
Nakanishi group, WPI-MANA, National Institute for Materials (NIMS), Tsukuba, JAPAN
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