Takemoto, J. Y.; Hintze, K. J.; Grilley, M. M.; Chang, C.-W. T. (2025) Mesobiliverdin IXα-enriched microalgal feed supplement promotes beneficial gut microbiota in rabbits. World Rabbit Sci. (internet) 33 (1), 73-83. DOI: https://doi.org/10.4995/wrs.2025.20748.
Liao, T.-S.; Chang, P.-E.; Chen, Y.-T.; Chen, C.-Y.; Chang, T. C.-W.; Takemoto, J.Y.; Lin, Y.-Y. (2025) Mesobiliverdin IXα-enriched microalgae feed improves gut health in weaned piglets under LPS challenge. Czech Journal of Animal Science 70 (4), 139-146.
Poudyal, N.; Takemoto, J. Y.; Lin, Y. Y.; Chang, C. T. (2025) An Alternative to Biliverdin, Mesobiliverdin IXalpha and Mesobiliverdin-Enriched Microalgae: A Review on the Production and Applications of Mesobiliverdin-Related Products. Molecules 30 (6). DOI: 10.3390/molecules30061379 From NLM Medline.
Chang, C.-W. T.; Takemoto, J. Y. (2024) Amphiphilic kanamycin compositions and methods. Patent Issued US 12,119,310 B2. Oct 8, 2024, U.S. Patent and Trademark Office.
Poudyal, N.; Subedi, Y. P.; Shakespear, M.; Grilley, M.; Takemoto, J. Y.; Chang, C.-W. T. (2024) Synthesis of kanamycin-azole hybrids and investigation of their antifungal activities. Bioorganic & Medicinal Chemistry 114, 117947. https://doi.org/10.1016/j.bmc.2024.117947.
Liao T.-S. Chen C.-Y. Lin C.-S. Chang C.-W. T. Takemoto J. Y. and Lin Y.-Y. (2023). Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets. Journal of Animal Physiology and Animal Nutrition 107(6):1368-1375 https://doi.org/10.1111/jpn.13867
Lin, Y. Y.; Chang, C. W. T.; Takemoto, J. Y. (2023) Mesobiliverdin IXα ameliorate DSS-induced colitis by inhibiting inflammation and oxidative stress in mice. IOP Conference Series: Earth and Environmental Science 1286 (1), 012018. DOI: 10.1088/1755-1315/1286/1/012018.
Lin Y.-Y. Takemoto J. Y. Chang C.-W. T. and Peng C.-A. (2022). Mesobiliverdin IXα ameliorates osteoporosis via promoting osteogenic differentiation of mesenchymal stem cells. Biochemical and Biophysical Research Communications 619, 56-61.
Takemoto, J. Y., Altenberg, G. A., Poudyal, N., Subedi, Y. P. and Chang, C.-W. T. (2022) Amphiphilic aminoglycosides: Modifications that revive old natural product antibiotics. Frontiers in Microbiology, 13:1000199. https://www.frontiersin.org/articles/10.3389/fmicb.2022.1000199
Wood J. L. Takemoto J. Y. and Sims R. C. (2022). Rotating algae biofilm reactor for management and valorization of produced wastewater. Frontiers in Energy Research 10.774760. https://www.frontiersin.org/article/10.3389/fenrg.2022.774760
Chang, C.T, Takemoto, J.Y, Chang, P., Alfindee, M.N, Lin, Y., (2021). Effects of mesobiliverdin IX alpha-enriched microalgae feed on gut health and microbiota of broilers. Front Vet Sci, 7, doi: 10.3389/fvets.2020.586813
Hamill, P.G, Stevenson, A., McMullan, P.E, Williams, J.P, Lewis, A.D, S, S., Stevenson, K.E, Farnsworth, K.D, Khroustalyova, G., Takemoto, J.Y, Quinn, J.P, Rapoport, A., Hallsworth, J.E, (2020). Microbial lag phase can be indicative of, or independent from, cellular stress. Sci Rep, 10:1, 5948.
Zhang, W., Rhodes, J., Garg, A., Takemoto, J.Y, Qi, X., Harihar, S., Chang, C.T, Moon, K., Zhou, A., (2020). Label-free discrimination and quantitative analysis of oxidative stress induced cytotoxicity and potential protection of antioxidants using Raman spectroscopy and machine learning algorithms . Anal Chem Acta, 1128, 221-230. doi: https://doi.org/10.1016/j.aca.2020.06.074
Subedi, Y. P., Pandey, U., Alfindee, M. N., Montgomery, H., Roberts, P., Wight, J., Nichols, G., Grilley, M., Takemoto, J. Y., and Chang, C. T. (2019) Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6''-Modified amphiphilic kanamycins. Eur J Med Chem 182, 111639
Alfindee, M. N, Subedi, Y.P, Grilley, M.M, Takemoto, J.Y, Chang, C.T. (2019) Antifungal activities of 4″,6″-disubstituted amphiphilic kanamycins. Molecules, 24 (10), 1882.
Subedi, Y.P, Paul, R., Grilley, M.M, Takemoto, J.Y, Chang, C.T. (2019). Development of fungal selective amphiphilic kanamycin: cost effective synthesis and use of fluorescent analogs for mode of action investigation. ACS Infect Diseases, 5, 473-483.
Chang, C.T, Takemoto, J.Y, Zhan, J. (2019). Natural Bioactive Compounds. Isr J Chem, 59, 325-326.
Takemoto, J.Y, Chang, C.T, Chen, D., Hinton, G. (2019). Heme-derived bilins. Isr J Chem 59, 378-386.
Takemoto, J.Y, Wegulo, S., Yuen, G.Y, Stevens, J.A, Jochum, C.C, Chang, C.T, Kawasaki, Y., Miller, G.A. 2018. Suppression of wheat fusarium head blight by novel amphiphilic aminoglycoside fungicide K20 . Fungal Biol 122:465-470.
AlFindee, M.N, Zhang, Q., Subedi, Y.P, Shrestha, J.P, Kawasaki, Y., Grilley, M.M, Takemoto, J.Y, Chang, C.T. 2018. One-step synthesis of carbohydrate esters as antibacterial and antifungal agents. Bioorg Med Chem 26:765-774.
Subedi, Y. P., AlFindee, M. N., Takemoto, J. Y., Chang, C.-W. T. 2018. Antifungal amphiphilic kanamycins: new life for an old drug. Med Chem Comm 9:909-919.
Alder-Rangel, A., Bailao, A.M, da Cunha, A.F, Soares, C.M, Wang, C., Bonatto, D., Dadachova, E., Hakalehto, E., Eleutherio, E.C, Fernandes, E.K, Gadd, G.M, Braus, G.H, Braga, G.U, Goldman, G.H, Malavazi, I., Hallsworth, J.E, Takemoto, J.Y, Fuller, K.K, Selbmann, L., Corrochano, L.M, von Zeska Kress, Marcia R., , Bertolini, M.C, Schmoll, M., Pedrini, N., Loera, O., Finlay, R.D, Peralta, R.M, Rangel, D.E. 2018. The second international symposium on fungal stress: ISFUS. Fungal Biol, 122:386-399 doi.org/10.1016/j.funbio.2017.10.011
Xu, F., Napan, K., Zhang, S., Gladwin, T., Takemoto, J.Y, Zhan, J., 2017. New insights into pradimicin biosynthesis revealed by two O-methyltransferases. Bioorg Med Chem Lett, 27:15, 3499-3502.
Shrestha, J.P., C. Baker, Y. Kawasaki, Y. P. Subedi, N.N. Vincent de Paul, J.Y. Takemoto, C-W.T. Chang. 2017. Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. Eur Med Chem 126:696-704.
Zhang, Q., M. N. Alfindee, J. P. Shrestha, V. d. P. Nziko, Y. Kawasaki, X. Peng, J. Y. Takemoto, C-W. T. Chang. 2016. Divergent synthesis of three classes of antifungal amphiphilic kanamycin derivatives. J Org Chem 81:10651-10663.
Kawasaki Y, Nischwitz C, Grilley MM, Jones J, Brown JD, Takemoto JY. 2016. Production and application of syringomycin E as an organic fungicide seed protectant against pythium damping-off. J Phytopathol 164:801-810.
Takemoto J., D. Chen, C-W. T. Chang. 2016. Meso-biliverdin compositions and methods. Patent Issued, US 9,242,932 B2, Jan 26, 2016, U.S. Patent and Trademark Office
Takemoto, J. Y., D. Chen, C-W. T. Chang and *J. Wood, 2015. Therapeutic meso-biliverdin IXα compositions and associated methods, Patent assigned, US 14/028,313, Sept 1, 2015, U.S. Patent and Trademark Office
Shrestha S. K., M. Grilley, T. Anderson, C. Dhiman, J. Oblad, C.-W. T. Chang, K.N.Sorensen, and J. Y. Takemoto. 2015. In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Med Mycol DOI:10.1093/mmy/myv063.
Wood, J.L., C. D. Miller, R. C. Sims, R. C., and J. Y.Takemoto. 2015. Biomass and phycocyanin production from cyanobacteriadominated biofilm reactors cultured using oilfield and natural gas extractionproduced water. Algal Res 11:165-168. DOI:10.1016/j.algal.2015.06.015
Fosso, M., AlFindee, M. N., Zhang, Q., Nziko, V.de., P, Kawasaki, Y., Shrestha, S.K., Bearss, J., Gregory, R., Takemoto, J. Y., and Chang, C. W. 2015. Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem 80:4398-4411. DOI:10.1021/acs.joc.5b00248
Zhang, Q., Peng, X., Grilley, M., Takemoto, J.Y., and Chang, C.W.T. (2015). Using fluorogenic probes for the investigation of selective biomass degradation by fungi. Green Chem 17, 1918-1925. doi: DOI: 10.1039/c4gc01659a
Napan, K.L., S. Zhang, T. Anderson, J.Y. Takemoto and J. Zhan. 2015. Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Bioorg Med Chem Lett DOI: http://dx.doi.org/10.1016/j.bmcl.2015.01.043
Shrestha, S.K., C.-W. T. Chang, N. Meissner, J. Oblad, J.P. Shrestha, K.N. Sorensen, M.M. Grilley, and J.Y.Takemoto. 2014. Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action. Front Microbiol DOI: 10.3389/fmicb.2014.00671
Chang, C.-W. T. and J.Y. Takemoto. 2014. Antifungal amphiphilic aminoglycosides (review article). Med Chem Commun DOI: 10.1039/C4MD00078A
Napan, K., S. Zhang, W. Morgan, T. Anderson, J.Y. Takemoto, and J. Zhan. 2014. Synergistic actions of tailoring enzymes in pradimicin biosynthesis. ChemBioChem 15: 2289-2296. DOI: 10.1002/cbic.201402306
Golo, P. S., D. R. Gardner, M. M. Grilley, J. Y. Takemoto, S. B. Krasnoff, M. S. Pires, E. K. Fernandes, V. R. Bittencourt, D. W. Roberts. 2014. Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants. PLoS One 9:e104946.
Takemoto, J., C.-W. Chang, S. Shrestha and M. Grilley. 2014. Aminoglycoside and azole compositions and methods. Nov. 20, 2014. Non-provisional Patent Application, PCT/US2014/038649, WIPO/PCT, filed 19/05/2014,
Shrestha, S., M. Grilley, M. Y. Fosso, C.-W. T. Chang, and J. Y. Takemoto. 2013. Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08. PLoS One 8:e73843.
Takemoto, J.Y. and D. Chen. 2013. Biliverdin from a Non-Animal Source, Patent No. US 8,455,222 B2, issued June 4, 2013, U.S. Patent and Trademark Office
Ito, T., D. Chen, C.W.T. Chang, T. Kenmochi, T. Saito, S. Suzuki, and J.Y.Takemoto. 2013. Mesobiliverdin-IXα enhances rat pancreatic islet yield and function. Front. Pharmacol. 4:50 DOI10.3389/fphar.2013.00050
Chang, C-W. T., J. Takemoto. 2012. Aminoglycosides: synthesis and use as antifungals, Appl. No. 13/316,720, US 2012/0316125 A1, U.S. Patent and Trademark Office
Chen, D., J. D. Brown, Y. Kawasaki, J. Bommer, and J. Y. Takemoto. 2012. Scalable production of biliverdin IXalpha by Escherichia coli. BMC Biotechnol.12:89. DOI:10.1186/1472-6750 12-89
Bessonov, A., J. Y. Takemoto, and F. C. Simmel. 2012. Probing DNA-lipid membrane interactions with a lipopeptide nanopore. ACS Nano 6:3356-3363 doi:10.1021/nn3003696
Napan, K.L., J. Zeng, J.Y. Takemoto, and J. Zhan. 2012. A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorg Med Chem Lett 22:606-609, doi:10.1016/j.bmcl.2011.10.075