PUBLICATIONS

Publications (*: corresponding author; †: equal contribution; **: undergraduate student)

71) Kittur FS, Wright C, Hung C-Y, Xie JH* (2024) Tobacco plants as a versatile host for the expression of glycoproteins. In: Kole, C., Chaurasia, A., Hefferon, K.L., Panigrahi, J. (eds) Applications of Plant Molecular Farming. Concepts and Strategies in Plant Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-97-0176-6_19 

70) Hung C-Y, Kittur FS, Wharton KN**, Umstead ML**, Burwell DB**, Thomas M**, Qi Q, Zhang J, Oldham CE, Burkey KO, Chen J*, Xie JH* (2023) A rapid alkalinization factor-like peptide EaF82 impairs tapetum degeneration during pollen development through induced ATP deficiency. Cells. 12(11):1542. DOI: 10.3390/cells12111542 

69) Kittur FS*, Hung C-Y, Li PA, Sane DC, Xie JH* (2023) Asialo-rhuEPO as a potential neuroprotectant for ischemic stroke treatment. Pharmaceuticals (Basel). 16(4):610. DOI: 10.3390/ph16040610.  

68) Xie JH*, Kittur FS, Hung C-Y, Ding TT (2023) Regulation of one-carbon metabolism may open new avenues to slow down the initiation and progression of Huntington’s disease. Neural Regen Res. DOI: 10.4103/1673-5374.371363.  

67) Hung CY†, Zhu CS†, Kittur FS†, He MT†, Arning E†, Zhang JH, Johnson AJ**, Jawa GS**, Thomas MD**, Ding TT*, Xie JH* (2022) A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR. Cellular and Molecular Life Sciences. 79(11):553.  

66) Xie JH*, Kittur FS, Li PA, Hung CY (2022) Rethinking the necessity of low glucose intervention for cerebral ischemia/reperfusion injury. Neural Regen Res. 17(7):1397-1403. 

65) He M†, Kittur FS†, Hung CY, Zhang J, Jing L, Sane DC, Li PA*, Xie JH* (2022) A novel plant-produced asialo-rhuEPO protects brain from ischemic damage without erythropoietic action. Transl Stroke Res. 13: 338–354. https://doi.org/10.1007/s12975-021-00943-z (https://rdcu.be/cygJ7 ).

64) Hung CY†, Zhang J†, Bhattacharya C, Li H, Kittur FS, Oldham CE, Wei X, Burkey KO, Chen J, Xie JH* (2021) Transformation of long-lived albino Epipremnum aureum 'Golden Pothos' and restoring chloroplast development. Front Plant Sci. 12:647507. 

63) Li H, Kittur FS, Hung C-Y, Li PA, Ge XH, Sane DC, Xie JH* (2020) Quantitative proteomics reveals beneficial effects of low glucose on neuronal cell survival in an in vitro ischemic penumbral model. Front. Cell. Neurosci. 14: 272.

62) Kittur FS, Hung C-Y, Zhu C, Shajahan A, Azadi P, Thomas MD**, Pearce JL**, Gruber C, Kallolimath S, Xie JH* (2020) Glycoengineering tobacco plants to stably express recombinant human erythropoietin with different N-glycan profiles. Int. J. Biol. Macromolec. 157: 158-169.

61) Kittur FS, Lin Y, Arthur E, Hung C-Y, Li PA, Sane DC, Xie JH* (2019) Recombinant asialoerythropoetin protects HL-1 cardiomyocytes from injury via suppression of Mst1 activation. Biochemistry and Biophysics Reports. 17: 157-168.

60) Lin Y, Hung C-Y, Bhattacharya C, Nichols S, Rahimuddin H, Kittur FS,  Leung T-C, Xie JH* (2018) An effective way of producing fully assembled antibody in transgenic tobacco plants by linking heavy and light chains via a self-cleaving 2A peptide. Front. Plant Sci. 9: 1379.

59) Arthur E, Kittur FS, Lin Y, Hung C-Y, Sane DC, Xie JH* (2017) Plant-produced asialo-erythropoietin restores pancreatic beta-cell function by suppressing mammalian sterile-20-like kinase (MST1) and caspase-3 activation. Front. Pharmacol. 8: 208. doi: 10.3389/fphar.2017.0020858.

58) Guan XY, Li ZJ, Zhang ZL, Wei XY, Xie JH, Chen JJ*, Chen QX* (2017) Overexpression of an RaZIP gene devoid of transit peptide sequence induced leaf variegation in tobacco. PLoS ONE 12(4): e0175995. https://doi.org/10.1371/journal.pone.0175995.

57) Sun Y-H, Hung C-Y, Qiu J,  Chen JJ, Kittur FS, Oldham CE, Henny RJ, Burkey KO, Fan LJ, Xie JH* (2017) Accumulation of high OPDA level correlates with reduced ROS and elevated GSH benefiting white cell survival in variegated leaves. Scientific Reports | 7:44158 | DOI: 10.1038/srep44158.  

56) Abijo T*, Xie JH (2016) Preliminary study of selenium (Se) toxicity in human prostate carcinoma (PC3) cells with the overexpression of selenocysteine synthase (SecS) gene. Open Journal of Genetics. 6: 79-86.   

55) Hung C-Y, Qiu J, Sun Y-H, Chen JJ, Kittur FS, Henny RJ, Jin GL, Fan LJ*, Xie JH* (2016) Gibberellin deficiency is responsible for shy-flowering nature of Epipremnum aureum. Scientific Reports | 6:28598 | DOI: 10.1038/srep28598.    

54) Xie JH*, Fan LJ (2016) Nicotine biosynthesis is regulated by two more layers: small and long non-protein-coding RNAs. Plant Signaling & Behavior. DOI:10.1080/15592324.2016.1184811. 

53) Li FF, Wang WD, Zhao N, Xiao BG, Cao PJ, Wu XF, Ye CY, Shen EH, Qiu J, Zhu Q-H, Xie JH, Zhou XP*, Fan LJ* (2015) Regulation of nicotine biosynthesis by endogenous target mimicry of miRNA in tobacco. Plant Physiol. 169:1062-1071.

52) Kittur FS, Lalgondar M, Hung C-Y, Sane DC, Xie JH* (2015) C-Terminally fused affinity Strep-tag II is removed by proteolysis from recombinant human erythropoietin expressed in transgenic tobacco plants. Plant Cell Rep. 34: 507-516.  

51) Kittur FS, Arthur E, Nguyen M**, Hung C-Y, Sane DC, Xie JH* (2015) Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants. Int. J. Biol. Macromolec. 72: 1111-1116. 

50) Vallentine P, Hung C-Y, Xie JH, Van Hoewyk D* (2014) The ubiquitin-proteasome pathway protects Chlamydomonas reinhardti against selenite toxicity, but is impaired as mitochondrial superoxide accumulates. AoB PLANTS, 6: plu062. 

49) Qiu J, Wang Y, Wu SL, Wang YY, Ye CY, Bai XF, Li ZF, Yan CH, Wang ZQ, Shu QY, Xie JH, Lee SH, Fan LJ* (2014) Genome re-sequencing of semi-wild soybean reveals a complex Soja population structure and deep introgression. PLoS One. 9: e108479.   

48) Hung C-Y, Umsteada ML**, Chen JJ, Holliday BM**, Kittura FS, Henny RJ, Burkey KO, Xie JH* (2014) Differential expression of a novel gene EaF82a in green and yellow sectors of variegated Epipremnum aureum leaves is related to uneven distribution of auxin. Physiol. Plant.  doi: 10.1111/ppl.12219. 

47) Zhu CS, Miao GP, Huo YB, Zhang X, Xie JH, Juntao Feng* (2014) Establishment of Tripterygium wilfordii Hook.f. hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J. Microbiol. Biotech. 24: 823-834. 

46) Tetteh AY, Sun KH**, Hung C-Y, Kittur FS, Ibeanu GC, Williams D, Xie JH* (2014) Genome-wide investigation of selenite-responsive genes in Escherichia coli K12 under toxic and beneficial selenite conditions. Int. J. Microbiol. 2014, Article ID 394835.  

45)  Kittur FS, Bah M, Archer-Hartmann S, Hung C-Y, Azadi P, Ishihara M, Sane DC, Xie JH* (2013) Cytoprotective effect of recombinant human erythropoietin produced in transgenic tobacco plants. PLoS One. 8(10): e76468. doi:10.1371/journal.pone.0076468. 

44)  Dewey RE*, Xie JH (2013) Molecular Genetics of Alkaloid Biosynthesis in Nicotiana tabacum. Phytochemistry. 94: 10-27.   

43)    Zhao JT, Li ZT, Cui J, Henny RJ, Gray DJ, Xie JH, Chen JJ* (2013) Efficient somatic embryogenesis and Agrobacterium-mediated transformation of pothos (Epipremnum aureum) ‘Jade’. Plant Cell Tiss. Organ Cult. 114: 237-247.  

42)     Hung C-Y, Fan LJ, Kittur FS, Sun K, Qiu J, Tang S, Holliday MB**, Xiao BG, Burkey KO, Bush LP, Conkling MA, Roje S, Xie JH* (2013) Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. Plant Physiol. 161:1049-1060.

41)     Hung C-Y, Holliday MB**, Kaur H, Yadav R, Kittur FS, Xie JH* (2012) Identification and characterization of selenate- and selenite-responsive genes in a Se-hyperaccumulator Astragalus racemosu. Mol. Biol. Rep. 39: 7635-7645. 

40)     Tang S, Wang Y, Li ZF, Gui YJ, Xiao BG, Xie JH, Zhu QH, Fan LJ* (2012) Identification of wounding and topping responsive small RNAs in tobacco (Nicotiana tabacum). BMC Plant Bio. 12: 28.

39)     Kittur FS, Hung C-Y, Darlington DE**, Sane DC, Xie JH* (2012) N-Glycoengineering of tobacco plants to produce cytoprotective asialoerythropoietin. Plant Cell Rep. 31:1233-1243.

38)     Zhao JT, Zhang Q, Xie JH, Hung C-Y, Cui J, Henny RJ, Chen JJ* (2012) Plant regeneration via direct somatic embryogenesis from leaf and petiole explants of Epipremnum aureum ‘Marble Queen’. Acta Physiol. Plant. 34: 1461-1469. 

37)     Liu JX, Deng M, Henny RJ, Chen JJ*, Xie JH (2010) Regeneration of Dracaena surculosa through indirect shoot organogenesis. HortSci. 45(8): 1250-1254. 

36)     Hung C-Y, Sun Y-H, Chen JJ, Darlington DE**, Alfred L. Williams AL, Burkey KO, Xie JH* (2010)  Identification of a Mg-protoporphyrin IX monomethyl ester cyclase homologue, EaZIP, involved in variegation of Epipremnum aureum ‘Golden Pothos’ is achieved through a unique method of comparative study using tissue regenerated plants. J. Exp. Bot. 61: 1483-1493. 

35)  Leng XD, Xiao BG, Wang S, Gui YJ, Wang Y, Lu XP, Xie JH, Li YP, Fan LJ* (2010) Identification of NBS-type resistance gene homologs in tobacco genome. Plant Mol. Biol. Rep. 28: 152-161. 

34)  Darlington DE**, Hung C-Y, Xie JH* (2009) Developing an Agrobacterium tumefaciens–mediated genetic transformation for a selenium-hyperaccumulator Astragalus racemosus. Plant, Cell, Tiss. & Org. Cult. 99:157-165.  

33)  Musa TA**, Hung C-Y, Darlington DE**, Sane DC, Xie JH* (2009) Overexpression of human erythropoietin in tobacco does not affect plant fertility or morphology. Plant Biotechnol. Rep. 3: 157-165. 

32)  Hung CY, Xie JH* (2009) A comparison of plants regenerated from a variegated Epipremnum aureum. Biologia Plantarum. 53: 610-616. 

31) Cheng XY*, Liu GZ, Ye GY, Wang HJ, Shen XJ, Wu KC, Xie JH, Altosaar I (2009) Screening and cloning of antimicrobial DNA sequences using a vital staining method. Gene. 430: 132-139. 

30)  Hung CY, Xie JH* (2008) Development of an efficient plant regeneration system for the selenium-hyperaccumulator Astragalus recemosus and the nonaccumulator Astragalus canadensis. HortSci. 43: 2138-2142. 

Prior to 2006 

29)  Xie JH, Song W, Maksymowicz W, Jin W, Cheah K, Chen WX, Carnes C, Ke J, Conkling MA. (2004) Biotechnology: A tool for reduced risk tobacco products - The nicotine experience from test tube to cigarette pack. Recent Adv. Tob. Sci. 30: 17-37. 

28)  Xie JH, Wehner TC, Wollenberg K, Purugganan MD, Conkling MA. (2003) Intron and polypeptide evolution of conserved NPA to NPA motif regions in plant aquaporins. J. Amer. Soc. Hort. Sci. 128: 591-59. 

27)  Xie JH, Wehner TC, Conkling MA. (2002) PCR-based single-strand conformation polymorphism (SSCP) analysis to clone nine aquaporin genes in cucumber. J. Amer. Soc. Hort. Sci. 127: 925-930.  

26)  Afza R., Xie JH, Shen M, Zapata - Arias FJ. (2001) Detection of androclonal variation in anther-cultured rice lines using RAPDs. In Vitro Cell. Dev. Biol. - Plant 37: 644-647.  

25)  Xie JH, Shen M, Afza R, Zapata-Arias FJ. (2000) Study the genetic diversity in relation to salt tolerance in four rice varieties using RAPD. Euphytica 116: 105-110. 

24)  Afza R, Shen M, Zapata-Arias FJ, Xie JH, Fundi HK, Lee KS, Bobadilla-Mucino E, Kodym A. (2000) Effect of spikelet position on rice anther culture efficiency. Plant Sci. 153: 155-159. 

23)  Shu QY, Xu DX, Gao MW, Tong HJ, Xie JH, Xu GF, Zhu HH, Wu DX, Shen YW. (1999)  Preliminar The first hybrid rice –“Shan you 371” developed by using somaclonal variation techniques in the world. Sci. Agric. Sin. 32: 108. 

22)  Xu SY, Xiang SN, Xie JH, Yan YH, Wu CG. (1999) Breeding rice blast resistant restorer lines by modifying back - cross and selection of new hybrid rice combinations. J. of Zhejiang Agric. Univ. 25: 5-9. 

21)  Xie JH, Gao MW, Xue QZ, Liang ZQ. (1998) Preliminary studies on the isolation of protoplast from microspore in rice. J. of  Zhejiang Agric. Univ. 24: 59-62.  

20)  Xie JH, Gao MW, Liang ZQ, Cheng CY, Xue QZ. (1997)The effect of cool-pretreatment on the isolated microspore culture and free amino acid change of anthers in Japonica rice (Oryza sativa L.). J. of Plant Physiol. 151: 79-82.  

19)  Xie JH, Lu J, Zhuang JY, Lin HX, Qian HR, Gao MW, Zheng KL.(1997) Identifying different types of dedifferentiated microspores from indica-japonica F1 hybrids with subspecies differentiating RFLP probes in rice. Theor. Appl. Genet. 94: 34-38. 

18)  Xie JH, Gao MW, Cai QH, Liang ZQ, Xue QZ. (1996) Effects of donor plant growth status and preculture temperature on isolated microspore culture ability in japonica rice (Oryza sativa L.). Cereal Res. Commun. 24: 133-138. 

17)  Hua JW, Xie JH. 1996. Analysis of characters and evaluation of the use on autumn soybean in Zhejiang. J. of Zhejiang Agric. Sci. 3: 126-128. 

16)  Xie JH, Gao MW, Cai QH, Cheng XY, Shen YW, Liang ZQ. (1995) Improved isolated microspore culture efficiency by medium with maltose and optimal growth regulator combination in japonica rice. Plant, Cell, Tiss. & Org. Cult. 42: 245-250. 

15)  Xie JH, Li SK, Zhou JH, Gao MW. (1995) The effect of gamma rays irradiation on isolated microspore culture in barley. Acta Agric. Nucl. Sin. 10: 57-60. 

14)  Hua JW, Xie JH, Pan XY. (1995) Characteristics and characters of a new good quality soybean variety, Liuqiu-1, and key points of its culture. J. of Zhejiang Agric. Sci. 2:205-206. 

13)  Xia YW, Liu GF, Shu QY, Jiang RH, Xie JH. (1995) A preliminary study on induction and identification of chlorophyll mutants of indica type temperature sensitive genic male-sterile rice. Acta Agric. Nucl. Sin. 9: 129-133. 

12)  Wu DX, Xia YW, Shu QY, Xie JH. (1995) Study on plantlet direct formation of rice young panicles with electron beam implantation. Plant Physiol. Commun. 6:431-432. 

11)  Xia YW, Wu DX, Shu QY, Xie JH. (1995) Brief report of electron beam implantation on young spike culture of rice. J. Nucl. Agric. Sci. 16: 67-70.  

10)  Xie JH, Gao MW, Cai QH. (1994) Effects of maltose and growth regulators on callus formation and plant regeneration in isolated microspore culture of japonica rice. International Rice Res. Note. 19: 7-8. 

9)  Xie JH, Pan XY. (1994) Analysis of disease-resistance and quality of autumn soybean in Zhejiang province. Crop Genet. Resource. 3:32-33. 

8)  Xia, YW, Xie JH, Shu QY, Xie XM. (1994) Biological effects of nitrogen ion implantation on rice. Acta Agric. Nucl. Sin. 1:1-6. 

7)  Xie JH, Xia YW, Shu QY. (1994) Advances and expectation in application ion implantation technique to improve crop. J. Nucl. Agric. Sci. 2: 96-98. 

6)  Xia YW, Xie JH, Shu QY (1994) Studies on the mutagenic effects of nitrogen ion implantation on rice. J. of  Zhejiang Agric.Univ. 20: 249-253.  

5)  Xie JH, Xia YW, Shu QY. (1994) Studies on biological effects of nitrogen ion implantation on different genotype rice. Nucl. Techniques. 17: 508-512. 

4)  Xie JH, Xia YW, Shu QY. (1993) The biological effects of ion implantation combine with NaN3 treatment on rice. J. Nucl. Agric. Sci. 2: 84-87. 

3)  Xie JH, Pan XY. (1992) Characteristics and characters of a soybean variety, “Qiu 7-1”, and key points of its culture. J. of Zhejiang Agric. Sci. 4: 159-160. 

2)  Xie JH, Dong ZG. (1990) A study on the benefit of Multi-Effects-Triazole treatment for autumn soybean yield. J. of Cult. 3: 38-41. 

1)  Pan XY, Xie JH. (1989) A study on autumn soybean germplasm resources in Zhejiang province. Crop Genet. Resource. 2: 15-16.