Imaging Molecules and Protein Interactions in Neurons
Imaging Molecules and Protein Interactions in Neurons
My research uses cutting-edge optical imaging and engineered protein technologies to detect signaling molecules in real-time. I develop novel genetically encoded biosensors and optical imaging systems to monitor in-vivo G protein coupled receptors (GPCRs) signaling cascades in behaving mice (link). For example, I measure intracellular second messenger such as cAMP using genetically engineered fluorescence proteins and fluorescence lifetime imaging microscopy (FLIM). These tools are crucial for elucidating the molecular and circuit-level mechanisms that underlie neuronal plasticity and gene expression, with the potential to provide new insights into the treatment of neurological and psychiatric disorders.
My research uses cutting-edge optical imaging and engineered protein technologies to detect signaling molecules in real-time. I develop novel genetically encoded biosensors and optical imaging systems to monitor in-vivo G protein coupled receptors (GPCRs) signaling cascades in behaving mice (link). For example, I measure intracellular second messenger such as cAMP using genetically engineered fluorescence proteins and fluorescence lifetime imaging microscopy (FLIM). These tools are crucial for elucidating the molecular and circuit-level mechanisms that underlie neuronal plasticity and gene expression, with the potential to provide new insights into the treatment of neurological and psychiatric disorders.