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(February 18, 2025) Our work on expansion microscopy imaging of whole mouse embryo bodies has been published in ACS Nano. Link to the paper: https://pubs.acs.org/doi/10.1021/acsnano.4c14791
(January 13, 2025) Our work on the fabrication of SERS devices using market-sourced meat has been published in Advanced Science. Link to the paper: https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202406492
(December 30, 2024) Our work on wavelength-selective heating of hydrogel structures has been published in Materials Horizons. Link to the paper: https://pubs.rsc.org/en/content/articlelanding/2025/mh/d4mh01294a
(February 16, 2024) Chang Woo Song has been honored with the Best Academic Paper Award by the Department of Materials Science and Engineering at KAIST.
(December 16, 2023) Our work has been featured on the cover of Advanced Sciences.
(October 31, 2023) Our research on the novel hydrogel assembly technique has been published in Materials Horizons.
(October 18, 2023) Our study on the creation of conductive meshes from extracellular matrix has been published in Advanced Sciences.
(July 24, 2023) Our work on a new super-resolution imaging technique has been published in Scientific Reports.
(March 8, 2023) Our research on the development of a hydrogel gripper inspired by the human hand has been published in Materials Horizons.
(2023.04.21) Our group member has won the Best Poster Award at the Samsung Global Technology Symposium 2023.
(2022.09.30) Our group members have won the Best Poster Awards at the Korean Society for Biomaterials Annual Meeting 2022.
(2022.09.01) Our biotemplating approach has been highlighted on the frontispiece of Advanced Materials
(2022.08.11) Our biotemplating approach has been featured in numerous media outlets: 전자신문
(2022.07.05) Our paper on the new biotemplating approach has been accepted to Advanced Materials
(2022.05.05) Our paper on the ultra-multiplexed imaging technique has been published in Nature Communications.
(2022.05.24) Our ultra-multiplexed imaging method has been featured in numerous media outlets: 전자신문
(2022.06.13) 한빛사 인터뷰
(2021.09.29) Check out our preprints on multiplexed imaging and whole-zebrafish embryo expansion!
PICASSO: Ultra-multiplexed fluorescence imaging of biomolecules through single-round imaging and blind source unmixing [Link]
Whole-ExM: Expansion microscopy imaging of all anatomical structures of whole larval zebrafish [Link]
(2021.08.13) Check out our Instagram!
(2021.05.21) Our group members have won the Best Poster Awards at the Korean Society for Brain and Neural Sciences.
Our lab members have won the Best Poster Awards at the Optical Society Korea 2020.
Our URP student has won an Excellent Award at the URP program.
Our current research topics:
(1) Ultra-multiplexed imaging of proteins in tissue
For the understanding of the molecular heterogeneity of tumor and development of better immunotherapy
(2) Super-resolution imaging of the whole vertebrates via hydrogel-based tissue expansion
For the systematic understanding of biological systems and biological phenomena
(3) Highly heterogeneous & programmable hydrogels
For the development of human-like hydrogel robots, programmable hydrogel folding, and hydrogel electronics
(4) Molecular printing and fabrication on hydrogel surfaces
For the development of low-cost ultra-high resolution sensors and tissue engineering
(5) Synthesis and growth of inorganic materials using biological systems as templates
For the development of materials with superior performance than man-made materials
우리 연구실에서 대학원생을 모집합니다.
(우리 연구실은 생명과학과, 신소재공학과에 모두 소속되어 있어서 두 학과로 모두 입학 가능합니다.)
새로운 이미징 기술을 개발하고, 이를 이용 하여 기존보다 더 높은 해상도로, 더 많은 분자 정보를 얻어 암 및 뇌 연구를 할 학생을 기다립니다.
(1) 초다중 단백질 이미징 및 이를 이용한 암의 분자적 다양성 연구 (Spatially resolved proteomics) (Bric 세미나)
최근 암 연구에서는 기존의 genomics, proteomics, transcriptomics에서 한발 더 나아간 spatially resolved omics 기술들이 각광을 받고 있습니다.
이러한 기술들로 암 환자 조직을 분석하고, 기존에는 몰랐던 새로운 암 subtype을 발굴하거나 면역항암제의 반응성을 예측할 수 있습니다.
우리 연구실에서는 한번에 40개 이상의 단백질을 동시에 이미징 할 수 있는 spatial proteomics 기술인 PICASSO를 개발한 바 있습니다.
우리 연구실은 더 뛰어난 성능의 spatial omics 기술을 개발하며, 이를 암 환자 샘플에 적용하여 더 정확한 암 진단, 새로운 면역항암제 개발 등을 위한 연구를 하고 있습니다.
(2) 팽창현미경을 이용한 전유기체 초고해상도 이미징 (Super-resolution imaging of the whole vertebrates)
최근 뇌 및 신경 연구에서는 뇌 뿐만이 아니라 온 몸에서 서로 연결된 신경을 모두 같이 연구하려는 움직임이 주목을 받고 있습니다.
우리 연구실은 세계 최초로 뼈를 가진 전유기체(whole organism)를 팽창시킬 수 있는 기술을 개발한 바 있습니다.
이 기술을 활용하여 생명체의 몸 전체에서 단백질의 분포 및 생체 구조를 초고해상도로 이미징 할 수 있습니다.
이를 통해 생명체의 발생 과정, 온 몸에서 신경의 분포, 장기들간의 상호작용을 연구합니다.
Contact Prof. Jae-Byum Chang for questions!
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