Y Ding, A Fernández-Montero, A Mani, E Casadei, Y Shibasaki, F Takizawa, R Miyazawa, I Salinas*, JO Sunyer* (co-corresponding authors). Secretory IgM (sIgM) is an ancient master regulator of microbiota homeostasis and metabolism. bioRxiv 2023.02.26.530119; doi: https://doi.org/10.1101/2023.02.26.530119
B Garcia, F Dong, E Casadei, J Rességuier, J Ma, KD Cain, PA Castrillo, ...2022. A Novel Organized Nasopharynx-Associated Lymphoid Tissue in Teleosts That Expresses Molecular Markers Characteristic of Mammalian Germinal Centers. The Journal of Immunology 209 (11), 2215-2226.
A Mani, I Salinas. 2022. The knowns and many unknowns of CNS immunity in teleost fish. Fish & Shellfish Immunology 131, 431-440.
A Kraus, M Huertas, L Ellis, P Boudinot, JP Levraud, I Salinas. 2022. Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Brain, Behavior, and Immunity 102, 341-359
J Ma, E Casadei, TJ Bruce, A Sepahi, KD Cain, I Salinas. 2022. Long-term efficacy of nasal vaccination against enteric red mouth (ERM) disease and infectious hematopoietic necrosis (IHN) in juvenile rainbow trout (Oncorhynchus mykiss). Vaccine 40 (2), 229-238
DB Herbert, I Salinas, EM Oltz. 2022. The Importance of Diversity in Immunology. The Journal of Immunology 208 (2), 191-193.
V Laghi, V Rezelj, L Boucontet, M Frétaud, B Da Costa, P Boudinot, ...2022. Exploring zebrafish larvae as a COVID-19 model: probable abortive SARS-CoV-2 replication in the swim bladder. Frontiers in Cellular and Infection Microbiology, 172
A Dornburg, T Ota, MF Criscitiello, I Salinas, JO Sunyer, S Magadán, ...2022. From IgZ to IgT: a call for a common nomenclature for immunoglobulin heavy chain genes of ray-finned fish. Zebrafish 18 (6), 343-345
RD Heimroth, E Casadei, O Benedicenti, CT Amemiya, P Muñoz, I Salinas. 2021. The lungfish cocoon is a living tissue with antimicrobial functions. Science Advances 7 (47), eabj0829
I Salinas, Á Fernández-Montero, Y Ding, JO Sunyer. 2021. Mucosal immunoglobulins of teleost fish: A decade of advances. Developmental & Comparative Immunology 121, 104079.
A Kraus, KM Buckley, I Salinas. Sensing the world and its dangers: An evolutionary perspective in neuroimmunology. Elife 10, e66706.
AS Dalum, A Kraus, S Khan, E Davydova, D Rigaudeau, H Bjørgen, .... 2021. High-resolution, 3D imaging of the zebrafish gill-associated lymphoid tissue (GIALT) reveals a novel lymphoid structure, the amphibranchial lymphoid tissue. Frontiers in Immunology, 4724
R Brown, L Moore, A Mani, S Patel, I Salinas. 2021. Effects of ploidy and salmonid alphavirus infection on the skin and gill microbiome of Atlantic salmon (Salmo salar). Plos one 16 (2), e0243684
RD Heimroth, E Casadei, I Salinas. 2020. Molecular drivers of lymphocyte organization in vertebrate mucosal surfaces: revisiting the TNF superfamily hypothesis. The Journal of Immunology 204 (10), 2697-2711.
RD Miller, I Salinas. Phylogeny of the mucosal immune system. Principles of Mucosal Immunology, 23-32
Xu Z, Takizawa F, Casadei E, Shibasaki Y, Ding Y, Sauters TJC, Yu Y, Salinas I*, Sunyer JO*. 2020. Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. Sci Immunol. 2020 Feb 7;5(44):eaay3254. doi: 10.1126/sciimmunol.aay3254.
Magadan S, Jouneau L, Boudinot P, Salinas I. 2019. Nasal vaccination drives modifications of nasal and systemic antibody repertoires in rainbow trout. J Immunol. 2019 Aug 14. pii: ji1900157.
Casadei E, Tacchi L, Lickwar CR, Espenschied ST, Davison JM, Muñoz P, Rawls JF, Salinas I. Commensal bacteria regulate gene expression and differentiation in vertebrate olfactory systems through transcription factor REST. Chem Senses. 2019 Aug 12. pii: bjz050.
Sepahi A, Kraus A, Casadei E, Johnston CA, Galindo-Villegas J, Kelly C, García-Moreno D, Muñoz P, Mulero V, Huertas M, Salinas I. 2019. Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. Proc Natl Acad Sci U S A.;116(25):12428-12436.
Brown RM, Wiens GD, Salinas I. 2019. Analysis of the gut and gill microbiome of resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 86:497-506.
Casadei E, Salinas I. 2019. Comparative models for human nasal infections and immunity. Dev Comp Immunol. 92:212-222.
Sanchez M, Sepahi A, Casadei E, Salinas I. 2018. Symbiont-derived sphingolipids regulate inflammatory responses in rainbow trout (Oncorhynchus mykiss). Aquaculture. 495:932-939.
Yu YY, Kong W, Yin YX, Dong F, Huang ZY, Yin GM, Dong S, Salinas I, Zhang YA, Xu Z. 2018. Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection. PLoS Pathog. 14(11):e1007251.
Heimroth RD, Casadei E, Salinas I. 2018. Effects of Experimental Terrestrialization on the Skin Mucus Proteome of African Lungfish (Protopterus dolloi). Front Immunol. 9:1259.
Sepahi A, Tacchi L, Casadei E, Takizawa F, LaPatra SE, Salinas I. 2017. CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout. J Immunol. 199(11):3900-3913.
Barnhart K, Forman ME, Umile TP, Kueneman J, McKenzie V, Salinas I, Minbiole KPC, Woodhams DC. 2017. Identification of Bufadienolides from the Boreal Toad, Anaxyrus boreas, Active Against a Fungal Pathogen. Microb Ecol. 74(4):990-1000.
Kelly C, Salinas I. 2017. Under Pressure: Interactions between Commensal Microbiota and the Teleost Immune System. Front Immunol. 15;8:559.
Salinas I, Magadán S. 2017. Omics in fish mucosal immunity. Dev Comp Immunol. 75:99-108.
Reid KM, Patel S, Robinson AJ, Bu L, Jarungsriapisit J, Moore LJ, Salinas I. 2017. Salmonid alphavirus infection causes skin dysbiosis in Atlantic salmon (Salmo salar L.) post-smolts. PLoS One. 12(3):e0172856.
Kelly C, Takizawa F, Sunyer JO, Salinas I. 2017. Raibow trout (Oncorhynchus mykiss) secretory component binds commensal bacteria and pathogens. Sci Rep 7:41753.
Sepahi A, Cordero H, Goldfine MA, Salinas I. 2016. Symbiont-derived sphingolipids modulate mucosal homeostasis and B cells in teleost fish. Sci Rep 6:39054.
Sepahi A, Casadei E, Tacchi L, Munoz P, LaPatra SE, Salinas I. 2016. Tissue microenvironments in the nasal epithelium of rainbow trout (Oncorhynchus mykiss) define two distinct CD8a+ T cell populations and establish regional immunity. J Immunol. 197(11): 4453-4563.
Larragoite ET, Tacchi L, LaPatra SE, Salinas I. An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery. Fish Shellfish Immunol. 49:351-4.
Sepahi A, Salinas I. 2015. The evolution of nasal immune systems in vertebrates. Mol Immunol. pii: S0161-5890(15)30071-7.
Salinas I. 2015. The mucosal immune system of fish. Biology (Basel) 4(3):525-39.
Lowrey L, Woodhams DC, Tacchi L, Salinas I. 2015. Topographical mapping of the rainbow trout (Oncorhynchus mykiss) micro biome reveals a diverse bacterial community with anti fungal properties in the skin. App Env Microbiol. 81(19):6915-25.
Tacchi L, Larragoite ET, Muñoz P, Amemiya CT, Salinas I. 2015. African lungfish reveal the evolutionary origins of organized mucosal lymphoid tissue in vertebrates. Curr Biol. 5(18):2417-24.
Salinas I, Erhardt EB, LaPatra SE. 2015. Nasal vaccination of young rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis and enteric red mouth disease. Dev Comp Immunol. 53(1):105-11.
LaPatra S, Kao S, Erhardt EB, Salinas I. 2015. Evaluation of dual nasal delivery of infectious hematopoietic necrosis virus and enteric red mouth vaccines in rainbow trout (Oncorhynchus mykiss). Vaccine 33(6):771-6.
Tacchi L, Lowrey L, Musharrafieh R, Crossey K, Larragoite ET, Salinas I. 2015. Effects of transportation stress and addition of salt to transport water on the skin mucosal homeostasis of rainbow trout (Oncorhynchus mykiss). Aquaculture 435:120–27.
Tacchi L, Musharrafieh R, Larragoite ET, Crossey K, Erhardt EB, Martin SA, LaPatra SE, Salinas I. 2014. Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nat Commun. 5:5205.
Zhang T, Tacchi L, Wei Z, Zhao Y, Salinas I. 2014. Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish. Immunogenetics 66(5):335-51.
Musharrafieh R, Tacchi L, Trujeque J, LaPatra S, Salinas I. 2014. Staphylococcus warneri, a resident skin commensal of rainbow trout (Oncorhynchus mykiss) with pathobiont characteristics. Vet Microbiol. 169(1-2), 80-8.
Gomez-Atria D, Sunyer JO, Salinas I. 2013. The mucosal immune system of teleost fish: tolerating commensals while fighting pathogens. Fish Shellfish Immunol. 35(6): 1729-39.
Tacchi L, Misra M, Salinas I. 2013. Anti-viral immune responses in a primitive lung: characterization and expression analysis of interferon-inducible immunoproteasome subunits LMP2, LMP7 and MECL-1 in a sarcopterygian fish, the Nigerian spotted lungfish (Protopterus dolloi). Dev Comp Immunol. 41(4):657-665.
Xu Z, Parra D, Gómez D, Salinas I, Zhang Y-A, von Gersdorff Jørgensen L, Heinecke RD, Buchmann K, LaPatra S, Sunyer JO. 2013. Teleost skin, an ancient mucosal surface that elicits gut-like immune responses. PNAS 110(32):13097-102.
Tacchi L, Larragoite E, Salinas I. 2013. Discovery of J chain in African lungfish (Protopterus dolloi, Sarcopterygii) using high throughput transcriptome sequencing: implications in mucosal immunity. PLOS ONE 8(8):e70650.
Parker S, La Flamme A, Salinas I. 2012. The ontogeny of New Zealand groper (Polyprion oxygeneios) lymphoid organs and IgM. Dev Comp Immunol. 38(2):215-23.
Salinas I, Anderson SA, Wright J, Webb V. 2012. In vivo innate immune responses of groper (Polyprion oxygeneios) against Miamiensis avidus infection and lack of protection following dietary vitamin C administration. Fish Shellfish Immunol. 32(1), 8-15.
Anderson SA, Salinas I, Walker SP, Gublin Y, Pether S, Kohn YY, Symonds JE. 2012. Early development of New Zealand hapuku Polyprion oxygeneios eggs and larvae. J Fish Biol. 80(3), 555-71.
Salinas I, Maas EW, Munoz P. 2011. Characterization of acid pho sphatases from marine scuticociliate parasites and their activation by host's factors. Parasitol. 18, 1-12.
Salinas I, Zhang YA, Sunyer JO. 2011. Mucosal immunoglobulins and B cells in teleosts. A review. Dev Comp Immunol. 35(12), 1346-65.
Zhang YA, Salinas I, Sunyer JO. 2011. Recent findings on the structure and function of IgT, a teleost immunoglobulin specialized in mucosal immunity. Fish Shellfish Immunol. 31(5), 627-34.
Zhang YA*, Salinas I*, Li J, Parra D, Bjork S, Xu Z, LaPatra SE, Bartholomew J, Sunyer JO. 2010. IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol. 11, 827-835.
Ringø E, Løvmo L, Kristiansen M, Bakken Y, Salinas I, Myklebust R, Olsen RE, Mayhew TM. 2009. Lactic acid bacteria vs pathogens in the gastrointestinal tract of fish: a review. Aquaculture Res. 41, 451-467.
Cuesta A, Salinas I, Esteban MA, Meseguer J. 2008.Unmethylated CpG motifs mimicking bacterial DNA trigger the local and systemic innate immune parameters and expression of immune-relevant genes in gilthead seabream. Fish Shellfish Immunol. 25, 617-624.
Salinas I, Abelli L, Bertoni F, Picchietti S, Roque A, Furones D, Cuesta A, Meseguer J, Esteban MA. 2008. Monospecies and multispecies probiotic formulations produce different systemic and local immunostimulatory effects in the gilthead seabream (Sparus aurata L.). Fish Shellfish Immunol. 25, 114-123.
Reyes-Becerril M, Salinas I, Cuesta A, Meseguer J, Tovar-Ramirez D, Ascencio-Valle F, Esteban MA. 2008. Oral delivery of live yeast Debaryomyces hansenii modulates the main innate immune parameters and the expression of immune-relevant genes in the gilthead seabream (Sparus aurata L.) Fish Shellfish Immunol. 25, 731-739.
Salinas I, Meseguer J, Esteban MA. 2008. Antiproliferative effects and apoptosis induction by probiotic cytoplasmic extracts in fish cell lines. Vet Microbiol. 126, 287-294.
Salinas I, Myklebust R, Esteban MA, Olsen RE, Meseguer J, Ringø E. 2007. In vitro studies of Lactobacillus delbrueckii ssp. lactis in Atlantic salmon (Salmo salar L.) foregut: tissue responses and evidence of protection against Aeromonas salmonicida ssp. salmonicida epithelial damage. Vet Microbiol. 128, 167-177.
Salinas I, Meseguer J, Esteban MA. 2007. Assessment of different protocols for the isolation and purification of gut associated lymphoid cells from the gilt head sea bream (Sparus aurata L.). Biol Proc Online. 9, 43-55.
Salinas I, Rodríguez A, Meseguer J, Esteban MA. 2007. Adenosine arrests apoptosis in lymphocytes but not in phagocytes from primary leucocyte cultures of the teleost fish, Sparus aurata L. Dev Comp Immunol. 31, 1233-1241.
Ringo E, Salinas I, Olsen RE, Nyhaug A, Myklebust R, Mayhew TM. 2007. Histological changes in intestine of Atlantic salmon (Salmo salar L.) following in vitro exposure to pathogenic and probiotic bacterial strains. Cell Tissue Res. 328, 109-116.
Cuesta A, Salinas I, Rodriguez A, Munoz P, Sitga-Bobadilla A, Alvarez-Pellitero P, Meseguer J, Esteban MA. 2006. Cell-mediated cytotoxicity is the main innate immune mechanism involved in the cellular defence of gilthead seabream (Teleostei: Sparidae) against Enteromyxum leei (Myxozoa) Parasite Immunol. 28, 657–665.
Salinas I, Diaz-Rosales P, Rodríguez A, Cuesta A, Meseguer J, Chabrillon M, Morinigo MA, Esteban MA. 2006. Effect of heat-inactivated fish and non-fish derived probiotics on the innate immune parameters of a teleost fish (Sparus aurata L.). Vet Immunol Immunopathol. 111, 279-286.
Cuesta A, Munoz P, Rodriguez A, Salinas I, Sitges-Bobadilla A, Alvarez-Pellitero P, Esteban MA, Meseguer J. 2006. Gilthead seabream (Sparus aurata L.) innate defence against the parasite Enteromyxum leei (Myxozoa). Parasitol. 132, 95-104.
Diaz-Rosales P, Salinas I, Rodríguez A, Cuesta A, Chabrillon M, Balebona MC, Morinigo MA, Esteban MA, Meseguer J. 2006. Gilthead seabream (Sparus aurata L.) innate immune response after dietary administration of heat-inactivated potential probiotics. Fish Shellfish Immunol. 20, 482-492.
Salinas I, Rodríguez A, Esteban MA, Meseguer J. 2005. N6-Cyclohexyl-adenosine but not adenosine is a modulator of teleost fish innate immune activities. Dev Comp Immunol. 30, 325-334.
Salinas I, Cuesta A, Esteban MA, Meseguer J. 2005. Dietary administration of Lactobacillus delbrüeckii and Bacillus subtilis, single or combined, on gilthead seabream cellular innate immune responses Fish Shellfish Immunol. 19, 67-77.
Salinas I, Lockhart K, Bowden TJ, Collet B, Secombes CJ, Ellis AE. 2004. An assessment of immunostimulants as Mx inducers in Atlantic salmon (Salmo salar L.) parr and the effect of temperature on the kinetics of Mx responses. Fish Shellfish Immunol. 17, 159-170.