研究業績

【学術論文】

八木 秀樹

  1. Jomen W, Ohtake T, Akita T, Suto D, Yagi H, Osawa Y, Kohgo Y, Iron chelator deferasirox inhibits NF-κB activity in hepatoma cells and changes sorafenib-induced programmed cell deaths. Biomedicine & pharmacotherapy, 153:113363, 2022. IF=7.419.

  2. Otsuka H, Endo Y, Ohtsu H, Inoue S, Kuraoka M, Koh M, Yagi H, Nakamura M, Soeta S, Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice. Anatomical record, 304: 1136-1150 , 2021. IF=1.634.

  3. 中村雅典、八木秀樹、大塚裕忠、遠藤康男．造血組織と骨、ビスフォスフォネートの関与、炎症と免疫、27: 463-468, 2019.

  4. Niwa K, Tanaka N, Tatano Y, Yagi H, Kashiwada Y. Hypascyrins A–E, Prenylated Acylphloroglucinols from Hypericum ascyron. J Nat Prod, 82: 2754−2760, 2019. IF=4.257

  5. Haraguchi K, Kumamoto H, Konno K, Yagi H, Tatano Y, Odanaka Y, Shimbara Matsubayashi S, Snoeck R, Andrei G, Synthesis of 4′-substituted 2′-deoxy-4′-thiocytidines and its evaluation for antineoplastic and antiviral activities, Tetrahedron 75: 4542-4555, 2019. IF=2.379

  6. Funayama, H., Tashima, I., Okada, S., Ogawa T., Yagi, H., Tada, H., Wakita R., Asada, Y., Endo, Y., Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide. Biological & Pharmaceutical Bulletin 42: 929-936, 2019. IF=1.694

  7. Ueda, S., Hayashi, H., Miyamoto, T., Abe, S., Hirai, K., Matsukura, K., Yagi, H., Hara, Y., Yoshida, K., Okazaki, S., Tamura, M., Abe, Y., Agatsuma, T., Niwa, S., Masuko, K., Masuko, T., Anti-tumor effects of antibodies to L-type amino-acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes. Cancer Sci., 110: 674-685, 2019. IF= 4.372

  8. Hara, Y., Torii, R., Ueda, S., Kurimoto, E., Ueda, Eri; Okura, H., Tatano, Y., Yagi, H., Ohno, Y., Tanaka, T., Masuko, K., Masuko, T.: Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1. Cancer Sci., 109: 3171-3182, 2018. IF= 4.372

  9. 藤井幹雄、紺野奇重、加藤芳徳、多田納豊、八木秀樹、渡邊敏子、武田弘志：化学教育へのTeam Based Learning (TBL) の導入―アクティブラーニングによる問題解決能力の育成を目指して―．国際医療福祉大学学会誌、23:16-27, 2018.

  10. Tanaka N, Jia Y, Niwa K, Imabayashi K, Tatano Y, Yagi H, Kashiwada Y. Phloroglucinol derivatives and a chromone glucoside from the leaves of Myrtus communis. Tetrahedron. 74: 117-123, 2018. IF=2.379

  11. Ookura, M., Fujii, T., Yagi, H., Ogawa, T., Kishi, S., Hosono, N., Shigemi, H., Yamauchi, T., Ueda, T. and Yoshida, A. YM155 exerts potent cytotoxic activity against quiescent (G0/G1) multiple myeloma and bortezomib resistant cells via inhibition of survivin and Mcl-1. Oncotarget, 8:111535-111550, 2017. IF=5.168

  12. Suyama Y, Higashino Y, Tanaka N, Tatano Y, Yagi H, Kawazoe K, Murakami K, Li SL, Sun HD, Kashiwada Y. Stereochemical assignments of rubiaquinones A–C, naphthoquinone derivatives from Rubia yunnanensis. Tetrahedron Lett. 58: 4568-4571, 2017. IF=2.193

  13. Otsuka, H., Yagi, H., Endo, Y., Soeta, S., Nonaka, N., and Nakamura, M., Nitrogen-containing bisphosphonate induced a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production. Cell Tissue Res., 367: 297−309, 2017. IF=3.043

  14. Takamura, S., H. Yagi, Y. Hakata, C Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier and M. Miyazawa, Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance. J. Exp. Med., 213: 3057-3073, 2016. IF=10.79

  15. Arai, H., Otsuka, H., Takito,J., Yagi, H., Inoue, S., Yanagisawa, N., Nonaka, N., Endo, Y., and Nakamura, M., Effect of minodronate, a nitrogen-containing bisphosphonate, on collagen-induced arthritis in mice. Cell. Immunol. Immunother. 1: 1-7, 2016.

  16. Otsuka, H., J. Takito, Y. Endo, H. Yagi, S. Soeta, N. Yanagisawa, N. Nonaka and M. Nakamura, The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate. BMC Hematol, 16: 4, 2016.

  17. Yamasoba Daichi, Seki Yukari, Yamanishi Hiroki, Tsubota Maho, Sekiguchi Fumiko, Yagi Hideki, Masuko Takashi, Nishibori Masahiro, Kawabata Atsufumi, Macrophage-derived HMGB1 contributes to the inflammatory hyperalgegia through the NF-kappa B pathway. JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S104, 2015.

  18. Takechi M, Wada T, Yagi H, Masuko T and Kawabata A: Ouabain exerts cytoprotection by diminishing the intracellular K+ concentration increase caused by distinct stressful stimuli in human leukemic cells. J. Pharm. Pharmacol., 67: 126-32, 2015. IF=2.309

  19. Maeda Y, Yagi H, Takemoto K, Utsumi H, Fukunari A, Sugahara K, Masuko T and Chiba K: S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. Int. Immunol., 26: 245-255, 2014. IF=5.189

  20. 丹羽眞一郎、林秀美、八木秀樹、益子高：癌幹細胞の研究開発・機能解析ツールとしての抗CD44v抗体の開発. Meddical Science Digest, 40: 41-45, 2014.

  21. Nishiwaki K, Kawase A, Wada T, Yagi H, Kawasaki N, Ito E & Iwaki M.: Team-based learning (TBL) in the interdisciplinary lecture. Yakugaku Zasshi, 134: 171-177, 2014.

  22. Yagi H, and Masuko T: An Efficient Method for Producing Monoclonal Antibodies against Multi-pass Membrane Proteins. Yakugaku Zasshi,, 133: 939-945, 2013.

  23. Hidaka M, Nakamura M, Ohmichi Y, Itoh J, Fukuzawa K, Masuko T, and Yagi H: Involvement of intestinal intraepithelial lymphocytes in turnover of intestinal epithelial cells --Morphological and functional alterations due to daily administration of FK506--. Cell. Immunol., 279: 124-133, 2012. IF=2.955

  24. Hara K, Ueda S, Ohno Y, Tanaka T, Yagi H, Okazaki S, Kawahara R, Takechi M, Enomoto T, Hashimoto Y, Masuko K, and Masuko T: NIH3T3 cells over-expressing CD98 heavy chain resist early G1 arrest and apoptosis induced by serum starvation. Cancer Sci., 103: 1460-1466, 2012. IF= 4.372

  25. Masuko K, Okazaki S, Satoh M, Tanaka G, Ikeda T, Torii R, Ueda E, Nakano T, Danbayashi M, Tsuruoka T, Ohno Y, Yagi H, Yabe N, Yoshida H, Tahara T, Kataoka S, Oshino T, Shindo T, Niwa S, Ishimoto T, Baba H, Hashimoto Y, Saya H, and Masuko T: Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. PLoS One, 7: e29728. 2012. IF=2.766

  26. Otsuka H, Yagi H, Endo Y, Nonaka N, Nakamura M. Kupffer cells support extramedullary erythropoiesis induced by nitrogen-containing bisphosphonate in splenectomized mice. Cell. Immunol., 271: 197-204. 2011. IF=2.955

  27. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, and Saya H: CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth. Cancer Cell, 19: 387-400, 2011. IF=22.844

  28. Ohkawa M, Ohno Y, Masuko K, Takeuchi A, Suda K, Kubo A, Kawahara R, Okazaki S, Tanaka T, Saya H, Seki M, Enomoto T, Yagi H, and Masuko T: Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy. Biochem. Biophys. Res. Commun., 406: 649-55, 2011. IF=2.559

  29. Masuko T, Ohno Y, Masuko K, Yagi H, Uejima S, Takechi M, Hashimoto Y: Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein. Cancer Sci., 102: 25-35, 2011. IF= 4.372

  30. 安原智久, 川﨑直人, 八木秀樹, 伊藤栄次, 川瀬篤史, 大鳥徹, 和田哲幸, 松山賢治, 岩城正宏、初年次における分野横断的統合型薬学教育の試み、YAKUGAKU ZASSHI, 130:1647-1653, 2010.

  31. Ohno, Y., Suda, K., Masuko, K., Yagi, H., Hashimoto, Y., and Masuko, T., Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1. Cancer Sci 99:1000-1007, 2008. IF= 4.372

  32. Ohno, Y., Yagi, H., Nakamura, M., Masuko, K., Hashimoto, Y., and Masuko, T., Cell-death-inducing monoclonal antibodies raised against DT40 tumor cells: identification of chicken transferrin receptor as a novel cell-death receptor. Cancer Sci 99:894-900, 2008. IF= 4.372

  33. Ohno, Y., Yagi, H., Nakamura, M., Masuko, K., Hashimoto, Y., and Masuko, T., Simultaneous induction of apoptotic, autophagic, and necrosis-like cell death by monoclonal antibodies recognizing chicken transferrin receptor. Biochem. Biophys. Res. Commun., 367: 775-781, 2008. IF=2.559

  34. Tokunaga, M., Matsuda, H., Iwahashi, H., Naruto, S., Tsuruoka, T., Yagi, H., Masuko, T., and Kubo, M., Studies on Palauan Medicinal Herbs. IV. Immunopotentiatory activities of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. In diabetic mice. J Traditional Medicines 23: 24-26, 2006.

  35. Matsuda, H., Tokunaga, M., Iwahashi, H., Naruto, S., Yagi, H., Masuko, T., and Kubo, M., Studies on Palauan Medicinal Herbs. III. Antitumor and Immunostimulatory Activities of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. J Traditional Medicines 22: 314-320, 2005.

  36. Matsuda, H., Tokunaga, M., Iwahashi, H., Naruto, S., Yagi, H., Masuko, T., and Kubo, M., Studies on Palauan Medicinal Herbs. II. Activation of Mouse Macrophages RAW 264.7 by Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. and Its Acylglucosylsterols. Biol Pharm Bull 28: 929-933, 2005. IF=1.694

  37. Onoda, F., Takeda, M., Seki, M., Maeda, D., Tajima, J., Ui, A., Yagi, H., and Enomoto, T. SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair 3: 429 - 439, 2004. IF=4.461

  38. Yagi, H., Hidaka, M., Nakamura, M., and Masuko, T. Morphological and functional alteration of enterocytes by the daily administration of FK506: Application of UV-excited alkaline phosphatase substrate, ELF 97 phosphate. Cytometry Research, 14:41-46, 2004.

  39. Yagi, H., and Masuko, T. Expression of CD98 amino acid transporter on murine haematopoietic stem cells. Cytometry Research, 14:57-62, 2004.

  40. Wang, W., Seki, M., Narita, Y., Nakagawa, T., Yoshimura, A., Otsuki, M., Kawabe, Y., Tada, S., Yagi, H., Ishi, Y., and Enomoto, T. Functional relation among RecQ family helicases, RecQL1, RecQL5, and BLM in cell growth and SCE formation Mol. Cell. Biol., 23: 3527-3535, 2003. IF=3.813

  41. Mikami, Y., Takeda, K., Shibuya, K., Qiu-Feng, H., Shimamura, H., Yamauchi, J., Egawa, S., Sunamura, M., Yagi, H., Endo, Y., and Matsuno, S. Do Peritoneal Macrophages Play an Essential Role in the Progression of Acute Pancreatitis in Rats? Pancreas, 27:253-260, 2003. IF=2.958

  42. Hayashi, T., Seki, M., Maeda, D., Wang, W., Kawabe, Y., Seki, T., Saitoh, H., Fukagawa, T., Yagi, H., and Enomoto, T. Ubc9 is essential for viability of higher eukaryotic cells Exp. Cell Res., 280: 212-221, 2002. IF=3.309

  43. Branzei, D., Seki, M., Onoda, F., Yagi, H., Kawabe, Y., and Enomoto, T. Characterization of the slow-growth phenotype of S. cerevisiae whip/mgs1 sgs1 double deletion mutants. DNA Repair, 1: 671-682. 2002. IF=4.461

  44. Yagi, H., and Masuko, T. Multi-color flow cytometoric analysis using UV-excited fluorochromes: Study on the expression of CD98 amino-acid transporter. Cytometry Research, 12:65-72, 2002.

  45. Itoh, T., Nakamura, M., Yagi, H., Soga, H., Doi, H., Koja, S., Nanno, M., Suzuki, R., Satomi, S., and Kasahara, S. Establishment of a mouse thymic epithelial cell line, IT-76MHC and a brief review on cultured thymic epithelial cells. Cell. Mol. Biol., 47: 1-18, 2001. IF=1.372

  46. Ohtsu, S., Yagi, H., Nakamura, M., Ishii, T., Kayaba, S., Soga, H., Gotoh, T., Rikimaru, A., Kokubun, S., and Itoh, T. Enhanced neutrophilic granulopoiesis in rheumatoid arthritis. Involvement of neutrophils in disease progression. J. Rheumatol., 27: 1341-1351, 2000. IF=3.407

  47. Yagi, H., Kamba, R., Chiba, K., Soga, H., Yaguchi, K., Nakamura, M., and Itoh, T. Immunosuppressant FTY720 inhibits thymocyte emigration. Eur. J. Immunol., 30: 1435-1444, 2000. IF=4.248

  48. Nakamura, M., H. Yagi, Y. Endo, H. Kosugi, T. Ishii, and T. Itoh, A time kinetic study of the effect of aminobisphosphonate on murine haemopoiesis Br. J. Haematol., 107:779-790, 1999. IF=5.518

  49. Kimura, S., Hirasawa, T., Nakamura, K., Yagi, H., Matsumoto, M., Makino, S., and Harada, M. Genetic control of peripheral T-cell deficiency in the cataract Shionogi (CTS) mouse linked to chromosome 7. Immunogenetics, 47:278-280. 1998.

  50. Ishii, T., Nakamura, M., Yagi, H., Soga, H., Kayaba, S., Gotoh, T., Satomi, S., and Itoh, T. Glucocorticoid-induced thymocyte death in the murine thymus: the effect at later stages. Arch Histol Cytol, 60:65-78. 1997.

  51. Nakamura, M., Yagi, H., Ishii, T., Kayaba, S., Soga, H., Gotoh, T., Ohtsu, S., Ogata, M., and Itoh, T. DNA fragmentation is not the primary event in glucocorticoid-induced thymocyte death in vivo. Eur J Immunol, 27:999-1004. 1997. IF=4.248

  52. Soga, H., Nakamura, M., Yagi, H., Kayaba, S., Ishii, T., Gotoh, T., and Itoh, T. Heterogeneity of mouse thymic macrophages: I. Immunohistochemical analysis. Arch Histol Cytol, 60:53-63. 1997.

  53. Yagi, H., Nakamura, M., Ishii, T., Kasahara, S., and Itoh, T. Ultrastructural analysis of mouse thymocyte subpopulations. Eur J Immunol, 27:2680-2687. 1997. IF=4.248

  54. 石井正、中村雅典、八木秀樹、曽我浩之、萱場尚一、後藤孝浩、大津進、尾形雅君、伊藤恒敏, ステロイド投与による胸腺リンパ球の細胞死. 臨床免疫, 29: 55-62, 1997.

  55. Nakamura, M., Yagi, H., Kayaba, S., Ishii, T., Gotoh, T., Ohtsu, S., and Itoh, T. Death of germinal center B cells without DNA fragmentation. Eur J Immunol, 26:1211-1216. 1996. IF=4.248

  56. Yagi, H., Matsumoto, M., Nakamura, M., Makino, S., Suzuki, R., Harada, M., and Itoh, T. Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. J Immunol, 157:3412-3419. 1996. IF=4.539

  57. Nakamura, M., Yagi, H., Kayaba, S., Ishii, T., Ohtsu, S., Gotoh, T., and Itoh, T. Most thymocytes die in the absence of DNA fragmentation. Arch Histol Cytol, 58:249-256. 1995.

  58. Nanno, M., Hata, M., Shimada, S., Doi, H., Satomi, S., Yagi, H., Nakamura, M., Sakata, T., Suzuki, R., and Itoh, T. Induction of TCR-gamma delta+ cells from thymocytes stimulated by a fetal liver-derived hepatocyte clone. J Immunol, 155:2918-2927. 1995. IF=4.539

  59. 伊藤恒敏、中村雅典、八木秀樹, リンパ節ー免疫反応とＢリンパ球最終分化の「場」, 生体の科学, 1995.

  60. Nanno, M., Hata, M., Doi, H., Satomi, S., Yagi, H., Sakata, T., Suzuki, R., and Itoh, T. Stimulation of in vitro hematopoiesis by a murine fetal hepatocyte clone through cell-cell contact. J Cell Physiol, 160:445-454. 1994.

  61. Arimura, A., Asanuma, F., Yagi, H., Kurosawa, A., and Harada, M. Involvement of thromboxane A2 in bronchial hyperresponsiveness but not lung inflammation induced by bacterial lipopolysaccharide in guinea pigs. Eur J Pharmacol, 231:13-21. 1993.

  62. Matsumoto, M., Yagi, H., Kunimoto, K., Kawaguchi, J., Makino, S., and Harada, M. Transfer of autoimmune diabetes from diabetic NOD mice to NOD athymic nude mice: the roles of T cell subsets in the pathogenesis. Cell Immunol, 148:189-197. 1993. IF=2.995

  63. Yagi, H., Matsumoto, M., Kunimoto, K., Kawaguchi, J., Makino, S., and Harada, M. Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur J Immunol, 22:2387-2393. 1992. IF=4.248

  64. Takemoto, H., Yagi, H., Harada, M., and Ide, M. Two distinct P70 interleukin-2 receptors on a murine large granular lymphocyte clone Y479. Immunol Invest, 20:461-474. 1991. IF=2.588

  65. 原田稔, 松本光史, 八木秀樹, & 牧野進, NODマウスの病態発生におけるL3T4+およびLyt2+T細胞サブセットの役割： 発症NODマウスからの各細胞移入によるNODヌードマウスでの病態誘導. 糖尿病動物, 糖尿病動物研究会, 医薬ジャーナル社, 1991.

  66. 原田稔, 八木秀樹, & 牧野進, サイクロフォスファマイド処置によるNOD雄マウスの糖尿病発症に及ぼすBCG処置マウス血清の抑制効果, 糖尿病動物, 糖尿病動物研究会, 医薬ジャーナル社, 1991.

  67. Yagi, H., Matsumoto, M., Kishimoto, Y., Makino, S., and Harada, M. Possible mechanism of the preventive effect of BCG against diabetes mellitus in NOD mouse. II. Suppression of pathogenesis by macrophage transfer from BCG-vaccinated mice. Cell Immunol, 138:142-149. 1991. IF=2.995

  68. Yagi, H., Matsumoto, M., Suzuki, S., Misaki, R., Suzuki, R., Makino, S., and Harada, M. Possible mechanism of the preventive effect of BCG against diabetes mellitus in NOD mouse. I. Generation of suppressor macrophages in spleen cells of BCG-vaccinated mice. Cell Immunol, 138:130-141. 1991. IF=2.995

  69. Tatsumi, Y., Kumanogoh, A., Saitoh, M., Mizushima, Y., Kimura, K., Suzuki, S., Yagi, H., Horiuchi, A., Ogata, M., Hamaoka, T., and Fujiwara, H. Differentiation of thymocytes from CD3-CD4-CD8- through CD3-CD4-CD8+ into more mature stages induced by a thymic stromal cell clone. Proc Natl Acad Sci U S A, 87:2750-2754. 1990.

  70. 松本光史, 八木秀樹, 原田稔, & 牧野進, NODマウスの膵島炎、ならびに糖尿病発症におけるL3T4+、およびLyt2+T細胞の役割 無胸腺コンジェニックマウスへの細胞移入による解析, 糖尿病動物, 糖尿病動物研究会, 医薬ジャーナル社, 1990.

  71. 八木秀樹, 松本光史, 原田稔, & 牧野進, NODマウスの糖尿発症に及ぼすBCGの抑制作用とその機序, 糖尿病動物, 糖尿病動物研究会, 医薬ジャーナル社, 1990.

  72. Yagi, H. [Mechanisms of the pathogenesis of overt diabetes in NOD mouse]. Seikagaku, 62:1263-1268. 1990.

  73. Yagi, H., Nagata, M., Takeuchi, M., Watanabe, A., Arimura, A., Hashimoto, S., Makino, S., and Harada, M. Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in vivo T cell-mediated immune response. Immunol Invest, 19:493-505. 1990. IF=2.588

  74. Yagi, H., Suzuki, S., Matsumoto, M., Makino, S., and Harada, M. Immune deficiency of the CTS mouse. I. Deficiency of in vitro T cell-mediated immune response. Immunol Invest, 19:279-295. 1990. IF=2.588

  75. Hashimoto, Y., Kato, K., Sato, N., Yagi, H., Yagita, H., and Nishimura, T. (1988) Properties of target molecule of murine lymphokine-activated killer (LAK) cells and the clones. Princess Takamatsu Symp, 19:315-322.

  76. Sugihara, S., Izumi, Y., Yoshioka, T., Yagi, H., Tsujimura, T., Tarutani, O., Kohno, Y., Murakami, S., Hamaoka, T., and Fujiwara, H. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. J Immunol, 141:105-113. 1988. IF=4.539

  77. Nishimura, T., Yagi, H., and Hashimoto, Y. The role of lymphokine-activated cell-associated antigen. II. Distribution and correlation with cell cycle. Cell Immunol, 107:24-31. 1987. IF=2.995

  78. Nishimura, T., Yagi, H., Sato, N., Ohta, S., and Hashimoto, Y. The role of lymphokine-activated cell-associated antigen. III. Inhibition of T-cell activation by monoclonal killer-blocking antibody. Cell Immunol, 107:32-39. 1987. IF=2.995

  79. Nishimura, T., Yagi, H., Uchiyama, Y., and Hashimoto, Y. The precursor cells of mouse lymphokine-activated killer (LAK) cells. Thymus, 9:131-139. 1987.

  80. Yagi, H., Nishimura, T., and Hashimoto, Y. Characteristics of mouse thymocyte-derived, interleukin 2-activated killer cells and their precursors. Jpn J Cancer Res, 78:721-728. 1987.

  81. Nishimura, T., Togashi, Y., Goto, M., Yagi, H., Uchiyama, Y., and Hashimoto, Y. Augmentation of the therapeutic efficacy of adoptive tumor immunotherapy by in vivo administration of slowly released recombinant interleukin 2. Cancer Immunol Immunother, 21:12-18. 1986.

  82. Nishimura, T., Uchiyama, Y., Yagi, H., and Hashimoto, Y. Administration of slowly released recombinant interleukin 2. Augmentation of the efficacy of adoptive immunotherapy with lymphokine-activated killer (LAK) cells. J Immunol Methods, 91:21-27. 1986. IF=2.190

  83. Nishimura, T., Yagi, H., Uchiyama, Y., and Hashimoto, Y. Generation of lymphokine-activated killer (LAK) cells from tumor-infiltrating lymphocytes. Cell Immunol, 100:149-157. 1986. IF=2.995

  84. Nishimura, T., Yagi, H., Uchiyama, Y., and Hashimoto, Y. Recombinant interleukin 2 allows the differentiation of Thy 1.2+ LAK cells from nude mouse spleen cells. Immunol Lett, 12:77-82. 1986.

  85. Nishimura, T., Uchiyama, Y., Yagi, H., and Hashimoto, Y. Use of Millipore diffusion chambers to assay in vivo IL-2 activity. J Immunol Methods, 78:239-245. 1985. IF=2.190

  86. Nishimura, T., Yagi, H., Yagita, H., Uchiyama, Y., and Hashimoto, Y. Lymphokine-activated cell-associated antigen involved in broad-reactive killer cell-mediated cytotoxicity. Cell Immunol, 94:122-132. 1985. IF=2.995

【国際学会発表】

八木 秀樹

  1. Tatano Y, Kanehiro Y, Yamabe S, Sano C, Shimizu T, H. Yagi, Tomioka H. ATP has antimicrobial activity based on the chelating action of the ferric ions and shows its combined effect with anti-Mycobacterium avium complex drugs. 30th International Congress of Chemotherapy and Infection (ICC 2017), Taipei, 2017

  2. Yagi H., J. Itoh, H. Otsuka, Y. Nakamoto, S. Yamazaki, J. Komeda, H. Kaminaka, T. Masuko, Y. Endo, M. Nakamura. Kupffer cells support emergent erythropoiesis caused by nitrogen-containing bisphosphonate in splenectomized mice. The 22nd International Symposium on Molecular Cell Biology of Macrophages (Kobe), 2014.

  3. Komeda J., H. Yagi, M. Umemura, J. Itoh, H. Kaminaka, N. Isaka, K. Sugahara, K. Chiba, T. Masuko. Expression of mouse S1P3 receptor on dendritic cells and macrophages. The 22nd International Symposium on Molecular Cell Biology of Macrophages (Kobe), 2014.

  4. Takamura S., Kohlmeier J.E., Yagi H., Nakayama T., Tomura M., Matsushima K., Woodland D.L. & Miyazawa M., CD69 controls a balance between S1P- and CXCL16-induced chemotaxes during the process of memory CD8+ T cell recruitment to the lung airways. Keystone Symposia, Viral Immunity and Host Gene Influence (X6) （Keystone）, 2012年3月21 – 26日

  5. Yagi H., A. Kyusai, Y. Endo, K. Tateishi, M. Masutani, K. Sugahara, & K. Chiba, Production and characterization of the functional monoclonal antibodies against mouse sphingosine 1-phosphate receptor-1 (S1P1)．14th International Congress of Immunology (Kobe), 2010, Aug

  6. Itoh, T., H. Yagi, H. Soga, & M. Nakamura, Differentiation of thymocyte subsets and their morphology. XV International Symposium on Morphological Sciences (Kyoto), 2000.

  7. Yagi, H., M. Matsumoto, M. Harada, & S. Makino, Flow cytometric analysis of lymphocytes infiltrating pancreas of NOD female mouse. The 11th International Immunology and Diabetes Workshop (Nagasaki), 1991.

  8. Harada, M., M. Matsumoto, H. Yagi, & S. Makino, Role of CD4+ and CD8+ T cells in the pathogenesis of NOD mice – analysis by means of T cell transfer from diabetic NOD mice to athymic nude congenic mice. The 11th International Immunology and Diabetes Workshop (Nagasaki), 1991.

  9. Harada, M., H. Yagi, M. Matsumoto, & S. Makino, Mechanism of suppressive action of BCG against diabetes in NOD mice. Frontiers in diabetes research,1990.

  10. Harada, M., H. Yagi, M. Matsumoto, & S. Makino, Analysis of the roles of L3T4+ and Lyt 2+ T-cells in the pathogenesis of NOD mice by means of cell transfer to athymic nude congenic mice. Frontiers in diabetes research,1990.

  11. Hashimoto, Y., K. Kato, N. Sato, H. Yagi, H. Yagita, & T. Nishimura, Properties of target molecule of murine lymphokine-activated killer (LAK) cells and the clones. International Symposium Princess Takamatsu Cancer Research Fundation, 1988.

  12. Yagi, H., & M. Harada, Possible mechanism of preventive effect of BCG on diabetes mellitus in NOD mice. 4th International Conference on Immunopharmacology (Osaka) 1988.

  13. Harada, M., M. Matsumoto, & H. Yagi, Reduction of natural killer activity in athymic nude mice by transfer of T cells. 6th International Workshop on Immune-Deficient Animals (Beijing) 1988.

  14. Nishimura, T., Y. Uchiyama, Y. Togashi, H. Yagi, & Y. Hashimoto, Slow-release administration of recombinant interleukin-2: a strategy for adoptive-tumor immunotherapy. The 7th Symposium on Host Defense Mechanisms Against Cancer (Hakone) 1985.

【学会発表（シンポジウム）】

八木 秀樹

  1. 菅井一真、高野みどり、太田智之、常田百合、多田納豊、八木秀樹、フローサイトメトリーによる細胞傷害試験法の開発、第29回日本サイトメトリー学会学術集会（東京）、2019年5月 学術奨励賞を受賞

  2. 八木秀樹、多田納豊、リンパ節高転移ヒト乳癌細胞由来リンパ管新生因子の同定の試み、第8回 国際医療福祉大学学会学術大会（東京）、2018年8月 優秀演題賞を受賞

  3. 八木秀樹、益子高、抗体医薬品のシーズ創出を目指して, 生体機能2014シンポジウム（東大阪）、2014年8月

  4. 八木秀樹、益子高、千葉健治: GPCRに対する機能的モノクローナル抗体の作製．第85回日本生化学会学術集会シンポジウム（福岡）、2012年12月

  5. 八木秀樹、益子高: 複数回膜貫通タンパク質に対する効率的モノクローナル抗体の作製．第132年会日本薬学会シンポジウム（札幌）、2012年3月（オーガナイザー）

  6. 鳥居良太、岡本広世、葛本佳世、八木秀樹、ヒアルロン酸受容体LYVE-1の細胞外領域を認識する新規モノクローナル抗体を用いたリンパ節転移機構の解析、第19回日本がん転移学会学術集会（金沢）、2010年6月 優秀演題賞を受賞

  7. 八木秀樹、Rheumatoid arthritis (RA)の骨破壊への滑膜細胞v-ATPase関与の可能性、第33回日本臨床免疫学会総会（京都）、2005年10月

  8. 八木秀樹、中村雅典、曽我浩之、伊藤恒敏、 分化マーカーによる胸腺リンパ球サブセットの超微形態学的解析、第56回日本電子顕微鏡学会・学術講演会シンポジウム（東京）、2000年５月

  9. 中村雅典、八木秀樹、曽我浩之、伊藤恒敏、 リンパ球の分化過程における細胞死 —胸腺とリンパ節—、第105回日本解剖学会総会・全国学術集会シンポジウム（横浜）、2000年３月

  10. 曽我浩之、中村雅典、八木秀樹、神波力也、後藤孝浩、伊藤恒敏、マウス胸腺に見られる小型Mac-2ポジティブマクロファージ亜群：免疫電顕による検索、第23回日本リンパ学会総会シンポジウム（鹿児島）、1999年７月

  11. 伊藤恒敏、大津進、中村雅典、八木秀樹、曽我浩之、 多形核白血球による骨破壊とその抑制、第25回日本医学会総会シンポジウム（東京）、1999年4月

  12. 八木秀樹、神波力也、中村雅典、曽我浩之、伊藤恒敏、 免疫抑制剤FTY720投与の胸腺リンパ球への影響、第104回日本解剖学会総会・全国学術集会シンポジウム（東京）、1999年３月

  13. 中村雅典、八木秀樹、遠藤康男、大津進、力丸暘、伊藤恒敏、骨吸収抑制薬Aminobisphosphonate (ABP) の造血機構への影響、第３９回日本リウマチ学会総会シンポジウム（福島）1995年５月

  14. 八木秀樹、中村雅典、伊藤恒敏、胸腺リンパ球の移出機構について、第100回日本解剖学会ミニシンポジウム（東京）、1995年4月

  15. 中村雅典、八木秀樹、伊藤恒敏、胸腺リンパ球の細胞死について、第100回日本解剖学会ミニシンポジウム（東京）、1995年4月

【著書等】

八木 秀樹

  1. スタンダード薬学シリーズⅡ ４ 生物系薬学 III.生体防御と微生物、日本薬学会編、東京化学同人、2016（分担）

  2. 保健医療福祉のための臨床推論 －チーム医療・チームケアのための実学－ 北島政樹 編集、朝倉書店、2016（分担）

  3. Nakamura M, Otsuka H, Yagi H, & Endo Y, The functional diversity of Kupffer cells. Handbook of Macrophages (Eds, Takahashi, R. & Kai, H.), Nova Science, pp.329-344, 2012.

  4. リアリスティック 続 複合問題、岩城正宏、齋藤浩司、灘井雅行 編著、京都廣川、2011（分担）

  5. リアリスティック 複合問題、岩城正宏、齋藤浩司、灘井雅行 編著、京都廣川、2011（分担）

  6. くすり，痛み，病気から薬学ってものを考えて 薬学概論、岩城正宏、安原智久著、京都廣川、2011（分担）

  7. スタンダード薬学シリーズ４ 生物系薬学 III.生体防御、日本薬学会編、東京化学同人、2006（分担）

  8. 臓器別アポトーシス証明法（大槻勝紀、小路武彦、渡辺慶一編）、胸腺・リンパ節、南江堂、2000（分担）

  9. Itoh, T., M. Nakamura, H. Yagi, H. Soga, & T. Ishii, Thymocyte and B-cell death without DNA fragmentation. Handbook of Experimental Pharmacology, Vol. 142, Apoptosis and its modulation by drugs (Eds, Cameron, R.G. & Feuer, G.), Springer-Verlag, 2000

  10. 〔疾患別〕モデル動物の作製と新薬開発のための試験・実験法 薬理・薬効評価と安全性試験への応用、Ⅰ型糖尿病（NOD）マウス, 技術情報協会, 1993

  11. 溶連菌製剤OK-432 その作用と臨床応用, Lymphokine-activated killer (LAK)細胞の性状とその抗腫瘍免疫への応用, Excerpta Medica, 1986（分担）