CH40022 Organic Reactions and Synthesis

CH40022: Organic Reactions and Synthesis

Instructor: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: TTh 14:30-16:00

Class Lecture Hall: Lectures will be delivered at Building E6-4 Room# 3130. In case the hybrid Zoom class is needed, the following Zoom meeting room will be used: https://zoom.us/j/4217755535 , Meeting ID: 421-775-5535

Website: https://synthesis.kaist.ac.kr/ch40022-organic-reactions-and-synthesis

Office Hours: by appointment via email

Teaching Assistant: Hangyoung Kim (김한경, hangyoung23@kaist.ac.kr)

Course Prerequisites:

Organic Chemistry I (CH20021), Organic Chemistry II (CH20022), Bioorganic Chemistry (CH30021, encouraged but not compulsory), Physical Organic Chemistry (CH30022, encouraged but not compulsory)

Course Description:

- Essential topics in organic chemistry will be discussed in depth with a spectrum ranging drawing arrow pushing mechanism to the state-of-the-art topics.

- This course discusses representative name reactions, their mechanism, and synthetic applications in organic chemistry.

- This course is designed to be complementary to other organic chemistry courses such as Organometallic Chemistry (CH50032), Organic Synthesis I (CH50022), and Organic Synthesis II (CH50023). In other words, pericyclic reactions and carbonyl chemistry (1,2 and 1,4 addition, stereochemistry) won’t be discussed in details in this course.

- Details in drawing arrow-pushing mechanisms, heterocycles syntheses, detailed olefin synthesis methods, various olefin functionalization reactions, practical metal catalyzed cross-coupling reactions, metal catalyzed allylations, organolithium chemistry, Aggarwal chemistry, olefin metathesis, radical chemistry, strategies in complex molecules synthesis will be discussed.

Textbook:

- Strategic Applications of Named Reactions in Organic Synthesis, 1st Edition, by Laszlo Kurti and Barbara Czako

Lecture Slides:

Supplementary Resources:

- Andrew G. Myers Chemistry 115 Handouts (Harvard University)

- Phil Baran Group Seminar Lecture (The Scripps Research Institute)

- David MacMillan Group Seminar Presentation (Princeton University)

- Alison Frontier Not Voodoo (University of Rochester)

- Jon Njardarson Top-Selling Pharmaceuticals (University of Arizona)

- Jon Njardarson Chemistry by Design (University of Arizona)

Grading Policy

Course Participation & Homework: 10 (Attendance + Questions for Questions)