Publications

2. Structure prediction-based insights into the patatin family of Mycobacterium tuberculosis. P V Ragavendran, Vaishnavi Tripathi  Sheetal Gandotra. Microbiology (Reading) 2022 Dec;168(12). doi: 10.1099/mic.0.001270.

3. The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy. Deepthi Shankaran , Anjali Singh, Stanzin Dawa, Prabhakar Arumugam, Sheetal Gandotra, Vivek Rao. Elife. 2023 Jan 11:12:e64834. doi: 10.7554/eLife.64834.

4.  Modern Clinical Mycobacterium tuberculosis Strains Leverage Type I IFN Pathway for a Proinflammatory Response in the Host. Shankaran D, Arumugam P, Vasanthakumar RP, Singh A, Bothra A, Gandotra S, Rao V. J Immunol. 2022 Nov 1;209(9):1736-1745. doi: 10.4049/jimmunol.2101029. Epub 2022 Sep 23.

5. Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses. Dawa S, Menon D, Arumugam P, Bhaskar AK, Mondal M, Rao V, Gandotra S*. Front Immunol. 2021 Sep 15;12:722735. doi: 10.3389/fimmu.2021.722735. eCollection 2021. 

6. High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next-generation sequencing. Bhoyar et al PLoS One2021 Feb 17;16(2):e0247115. doi: 10.1371/journal.pone.0247115. eCollection 2021. 

7. Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Singh RK, Jayarajan R, Varshney S, Upadrasta S, Singh A, Yadav R, Scaria V , Sengupta S, Shanmugam D, Shalimar, Sivasubbu S, Gandotra S, Sachidanandan C.Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May;1866(5):158905. doi: 10.1016/j.bbalip.2021.158905. Epub 2021 Feb 12. 

8. Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis.De Majumdar S, Sikri K, Ghosh P, Jaisinghani N, Nandi M, Gandotra S, Mande S, Tyagi JS.BMC Genomics. 2019 Feb 12;20(1):129. doi: 10.1186/s12864-019-5482-y.

9. Quantitative Lipid Droplet Proteomics Reveals Mycobacterium tuberculosis Induced Alterations in Macrophage Response to Infection. Menon D, Singh K, Pinto SM, Nandy A, Jaisinghani N, Kutum R, Dash D, Prasad TSK, Gandotra S*. ACS Infect Dis. 2019 Feb 4. doi: 10.1021/acsinfecdis.8b00301. 

10. Tuning the Mycobacterium tuberculosis Alternative Sigma Factor SigF through the Multidomain Regulator Rv1364c and Osmosensory Kinase Protein Kinase D. M isra R, Menon D, Arora G, Virmani R, Gaur M, Naz S, Jaisinghani N, Bhaduri A, Bothra A, Maji A, Singhal A, Karwal P, Hentschker C, Becher D, Rao V, Nandicoori VK, Gandotra S*, Singh Y*. J Bacteriol. 2019 Mar 13;201(7). pii: e00725-18. doi: 10.1128/JB.00725-18. Print 2019 Apr 1.

11. The MmpS6-MmpL6 Operon Is an Oxidative Stress Response System Providing Selective Advantage to Mycobacterium tuberculosis in Stress.Arumugam P, Shankaran D, Bothra A, Gandotra S, Rao V. J Infect Dis. 2019 Jan 9;219(3):459-469. doi: 10.1093/infdis/jiy526.

12. Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection Neetika Jaisinghani, Stanzin Dawa, Kaurab Singh, Ananya Nandy, Dilip Menon, Purva Deepak Bhandari, Garima Khare, Anil Tyagi and Sheetal Gandotra*. Front Immunol. 2018 July 9:1490 doi.org/10.3389/fimmu.2018.01490

13. Integrated Multi-Omic Analysis of Mycobacterium tuberculosis H37Ra Redefines Virulence Attributes. Pinto SM, Verma R, Advani J, Chatterjee O, Patil AH, Kapoor S, Subbannayya Y, Raja R, Gandotra S, Prasad TSK. Front Microbiol. 2018 Jun 19;9:1314. doi: 10.3389/fmicb.2018.01314. eCollection 2018.

14. Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function. Bothra A, Arumugam P, Panchal V, Menon D, Srivastava S, Shankaran D, Nandy A, Jaisinghani N, Singh A, Gokhale RS, Gandotra S, Rao V. Sci Rep. 2018 May 29;8(1):8317. doi: 10.1038/s41598-018-26710-z.

15. Adipocyte model of Mycobacterium tuberculosis infection reveals differential iron availability to bacilli in the lipid rich caseous environment.Nandy A, Mondal AK, Pandey R, Arumugam P, Dawa S, Jaisinghani N, Rao V, Dash D, Gandotra S*. Infect Immun. 2018 Apr 9. pii: IAI.00041-18. doi: 10.1128/IAI.00041-18. 

16. Quantitative Proteomic and Phosphoproteomic Analysis of H37Ra and H37Rv Strains of Mycobacterium tuberculosis. Verma R, Pinto SM, Patil AH, Advani J, Subba P, Kumar M, Sharma J, Dey G, Ravikumar R, Buggi S, Satishchandra P, Sharma K, Suar M, Tripathy SP, Chauhan DS, Gowda H, Pandey A, Gandotra S*, Prasad TS*. J Proteome Res. 2017 Apr 7; 16(4):1632-1645.

17. A network map of Interleukin-10 signaling pathway. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, Tripathy SP, Suar M, Pandey A, Gandotra S, Prasad TS, Shankar S. J Cell Commun SIgnal, 2016 Mar; 10(1):61-7.

18. Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host. Nagarajan SN, Updahyay S, Chawla Y, Khan S, Naz S, Subramanian J, Gandotra S, Nandicoori VK. J Biol Chem. 2015 Apr 10; 290(15):9626-45.

19. Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Kozuko K, Tsang VH, Bottomley W, Cho YH, Gandotra S, Mimmack M, Lim K, Isaac I, Patel S, Saudek V, O'Rahilly S, Srinivasan S, Greenfield JR, Barroso I, Campbell LV, Savage DB. Diabetes. 2015 Jan; 64(1):299-310.

20. clpC operon regulates cell architecture and sporulation in Bacillus anthracis. Singh LK, Dhasmana N, Sajid A, Kumar P, Bhduri A, Bharadwaj M, Gandotra S, Kalia VC, Das TK, Goel AK, Pomerantsev AP, Misra R, Gerth U, Leppla SH, Singh Y. Environ Microbiol. 2014 Jun 20

21. Secretory phosphatase deficient mutant of Mycobacterium tuberculosis imparts protection at thh primary site of infection in guinea pigs. Chauhan P, Reddy PV, Singh R, Jaisinghani N, Gandotra S, Tyahi AK. PLoS One. 2013 Oct 18:8(10)e77930.