Installation troubleshooting:
This application is deployed using MS .NET 2.0 "ClickOnce" technology. If you are using a non-IE browser as your default browser, you might be experiencing installation and update difficulties.
Opera browser:
This post claims to have found a workaround for the Opera 8 and ClickOnce .NET 2 technology. I haven't tested it, but the suggested steps seem logical, so it's up to you if you decide to try them. If you do, please let me know of your experience.
Firefox browser:
Here's an extension which may solve ClickOnce and Firefox issues. Once again, I haven't tested it myself so use it at your own risk (and let me know the results...).