Publications

Publications in international peer-reviewed journals

2025

• Lanore A, Tesson C, Basset A, Lejeune FX, Cogan G, Mangone G, Sambin S, Bertille N, Anheim M, Arnulf I, Ansquer S, Brandel JP, Brefel-Courbon C, Defebvre L, Drapier S, Eusebsio A, Fabbri M, Giordana C, Hainque E, Lehericy S, Marques A, Moreau C, Moro E, Ory F, Rolland AS, Thobois S, Vidailhet M, Devos D, Mariani LL, Lesage S, Brice A, Corvol JC; Predistim study group; Iceberg study group; NSPark study group, Classification of GBA1 variants and their impact on Parkinson's disease: an in silico score analysis, NPJ Parkinsons Dis, 2025. DOI pubmed

• Bottemanne H, Dobler L, Martet G, Lejeune FX, Crinière-Boizet B, Colle R, Fossati P, Corruble E, Joly L, Echoes of Pregnancy: Maternal Perception of Phantom Foetal Movements After Childbirth, BJOG, 2025. DOI pubmed

• Gaurav R, Lejeune FX, Santin MD, Valabrègue R, Pérot JB, Pyatigorskaya N, Mangone G, Leu-Semenescu S, Villain N, Habert MO, Vidailhet M, Arnulf I, Corvol JC, Lehéricy S, Early brain iron changes in Parkinson's disease and isolated rapid eye movement sleep behaviour disorder: a four-year longitudinal multimodal quantitative MRI study, Brain Commun, 2025. DOI pubmed

• Pérot JB, Ruze A, Gaurav R, Rebbah S, Cadin C, Le Troter A, Soustelle L, Mouton L, Valabrègue R, Parent A, Mangone G, Lejeune FX, Arnulf I, Corvol JC, Vidailhet M, Santin MD, Vila M, Lehéricy S, Longitudinal neuromelanin changes in prodromal and early Parkinson's disease in humans and rat model, Brain Commun, 2025. DOI pubmed  

• Lanore A, Gaurav R, Lejeune FX, Basset A, Tesson C, Kodjovi G, Sambin S, Mangone G, Arnulf I, Vidailhet M, Mariani LL, Brice A, Lesage S, Lehericy S, Corvol JC; Iceberg study group, Linking polygenic risk scores to dopaminergic neuron loss using neuromelanin-sensitive imaging, Brain, 2025. DOI pubmed 

• Vargas Gonzalez E, Yang Z, Dodet P, Leu-Semenescu S, Brink-Kjaer A, Roujansky P, Jennum PJ, Lejeune FX, Vidailhet M, Arnulf I, Rapid Eye Movements (REMs) during Non-REM Sleep as a Marker of Alpha-Synucleinopathies, Mov Disord, 2025. DOI pubmed

• Chougar L, Coarelli G, Lejeune FX, Ziegner P, Gaurav R, Biondetti E, Sayah S, Hilab R, Dagher A, Durr A, Lehéricy S, Substantia nigra degeneration in spinocerebellar ataxia 2 and 7 using neuromelanin-sensitive imaging, Eur J Neurol, 2025. DOI pubmed

2024

• Daghsen L, Checkouri T, Wittwer A, Valabregue R, Galanaud D, Lejeune FX, Doulazmi M, Lamy JC, Pouget P, Roze E, Rosso C, The relationship between corticospinal excitability and structural integrity in stroke patients, J Neurol Neurosurg Psychiatry, 2024. DOI pubmed

• Rohaut B, Calligaris C, Hermann B, Perez P, Faugeras F, Raimondo F, King JR, Engemann D, Marois C, Le Guennec L, Di Meglio L, Sangaré A, Munoz Musat E, Valente M, Ben Salah A, Demertzi A, Belloli L, Manasova D, Jodaitis L, Habert MO, Lambrecq V, Pyatigorskaya N, Galanaud D, Puybasset L, Weiss N, Demeret S, Lejeune FX, Sitt JD, Naccache L, Multimodal assessment improves neuroprognosis performance in clinically unresponsive critical-care patients with brain injury, Nat Med, 2024. DOI pubmed

• Kacher R, Lejeune FX, David I, Boluda S, Coarelli G, Leclere-Turbant S, Heinzmann A, Marelli C, Charles P, Goizet C, Kabir N, Hilab R, Jornea L, Six J, Dommergues M, Fauret AL, Brice A, Humbert S, Durr A, CAG repeat mosaicism is gene specific in spinocerebellar ataxias, Am J Hum Genet, 2024. DOI pubmed

• Menon PJ, Sambin S, Criniere-Boizet B, Courtin T, Tesson C, Casse F, Ferrien M, Mariani LL, Carvalho S, Lejeune FX, Rebbah S, Martet G, Houot M, Lanore A, Mangone G, Roze E, Vidailhet M, Aasly J, Gan Or Z, Yu E, Dauvilliers Y, Zimprich A, Tomantschger V, Pirker W, Álvarez I, Pastor P, Di Fonzo A, Bhatia KP, Magrinelli F, Houlden H, Real R, Quattrone A, Limousin P, Korlipara P, Foltynie T, Grosset D, Williams N, Narendra D, Lin HP, Jovanovic C, Svetel M, Lynch T, Gallagher A, Vandenberghe W, Gasser T, Brockmann K, Morris HR, Borsche M, Klein C, Corti O, Brice A, Lesage S, Corvol JC; French Parkinson disease Genetics Study Group (PDG), Genotype-phenotype correlation in PRKN-associated Parkinson's disease, NPJ Parkinsons Dis, 2024. DOI pubmed 

• Chougar L, Faucher A, Faouzi J, Lejeune FX, Gama Lobo G, Jovanovic C, Cormier F, Dupont G, Vidailhet M, Corvol JC, Colliot O, Lehéricy S, Grabli D, Degos B, Contribution of MRI for the Early Diagnosis of Parkinsonism in Patients with Diagnostic Uncertainty, Mov Disord, 2024. DOI pubmed

2023

• Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart C, Lehtinen MK, SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation, Fluids Barriers CNS, 2023. DOI pubmed

• Guieysse T, Lamothe R, Houot M, Razafimahatratra S, Medani T, Lejeune FX, Dreyfus G, Klarsfeld A, Pantazis D, Koechlin E, Andrade K, Detecting Anosognosia from the Prodromal Stage of Alzheimer's disease, J Alzheimers Dis, 2023. DOI pubmed

• Gassama S, Garmendia A, Lejeune FX, Boudot de la Motte M, Louapre C, Papeix C, Maillart E, Roux T, A short washout period from fingolimod to anti-CD20 therapy is safe and decreases the risk of reactivation, Rev Neurol (Paris), 2023. DOI pubmed

• Razafimahatratra S, Guieysse T, Lejeune FX, Houot M, Medani T, Dreyfus G, Klarsfeld A, Villain N, Raposo Pereira F, La Corte V, George N, Pantazis D, Andrade K, Can a failure in the error-monitoring system explain unawareness of memory deficits in Alzheimer’s disease?, Cortex, 2023. DOI pubmed

• Heinzmann A, Sayah S, Lejeune FX, Hahn V, Teichmann M, Monin ML, Marchionni E, Gérard F, Charles P, Pariente J, Durr A, Huntington disease with small CAG repeat expansions, Mov Disord, 2023. DOI pubmed

• Lakhlifi C, Lejeune FX, Rouault M, Khamassi M, Rohaut B, Illusion of knowledge in statistics among clinicians: evaluating the alignment between objective accuracy and subjective confidence, an online survey, Cog Res Princ Implic, 2023. DOI pubmed

• Prendergast AE, Jim KK, Marnas H, Desban L, Quan FB, Djenoune L, Laghi V, Hocquemiller A, Lunsford ET, Roussel J, Keiser L, Lejeune FX, Dhanasekar M, Bardet PL, Levraud JP, van de Beek D, Vandenbroucke-Grauls CMJE, Wyart C, CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection, Curr Biol, 2023. DOI pubmed

• Chougar L, Lejeune FX, Faouzi J, Morino B, Faucher A, Hoyek N, Grabli D, Cormier F, Vidailhet M, Corvol JC, Colliot O, Degos B, Lehéricy S, Comparison of mean diffusivity, R2* relaxation rate and morphometric biomarkers for the clinical differentiation of parkinsonism, Parkinsonism Relat Disord, 2023. DOI pubmed

• Nobileau A, Gaurav R, Chougar L, Faucher A, Valabrègue R, Mangone G, Leu-Semenescu S, Lejeune FX, Corvol JC, Arnulf I, Vidailhet M, Grabli D, Degos B, Lehéricy S, Neuromelanin-Sensitive Magnetic Resonance Imaging Changes in the Locus Coeruleus/Subcoeruleus Complex in Patients with Typical and Atypical Parkinsonism, Mov Disord, 2023. DOI pubmed

2022

• Genovese G, Diaz-Fernandez B, Lejeune FX, Ronen I, Marjańska M, Yahia-Cherif L, Lehéricy S, Branzoli F, Rosso C, Longitudinal Monitoring of Microstructural Alterations in Cerebral Ischemia with in Vivo Diffusion-weighted MR Spectroscopy, Radiology, 2022. DOI pubmed

• Parodi L, Barbier M, Jacoupy M, Pujol C, Lejeune FX, Lallemant-Dudek P, Esteves T, Pennings M, Kamsteeg EJ, Guillaud-Bataille M, Banneau G, Coarelli G, Oumoussa BM, Fraidakis MJ, Stevanin G, Depienne C, van de Warrenburg B, Brice A, Durr A, The mitochondrial seryl-tRNA synthetase SARS2 modifies onset in spastic paraplegia type 4, Genet Med, 2022. DOI pubmed

• Fouad A, Azizollahi H, Le Douget JE, Lejeune FX, Valderrama M, Mayor L, Navarro V, Le Van Quyen M, Interictal epileptiform discharges show distinct spatiotemporal and morphological patterns across wake and sleep, Brain Commun, 2022. DOI pubmed

• Peltier C, Lejeune FX, Jorgensen  LGT , Rametti-Lacroux A , Tanguy D, Godefroy V, Bendetowicz D, Carle G, Cognat E, Bombois S, Migliaccio R, Levy R, Marin F, Batrancourt B, ECOCAPTURE study group, A temporal classification method based on behavior time series data in patients with behavioral variant of frontotemporal dementia and apathy, J Neurosci Methods, 2022. DOI pubmed

• Lejeune FX, Ichou F, Camenen E, Colsch B, Mauger F, Peltier C, Moszer I, Gilson E, Pierre-Jean M, Le Floch E, Sabarly V, Tenenhaus A, Deleuze JF, Ewenczyk C, Vidailhet M, Mochel F, A Multimodal Omics Exploration of the Motor and Non-Motor Symptoms of Parkinson's Disease, Int J Transl Med, 2022. DOI

• Chougar L, Arsovic E, Gaurav R, Biondetti E, Faucher A, Valabrègue R, Pyatigorskaya N, Dupont G, Lejeune FX, Cormier F, Corvol JC, Vidailhet M, Degos B, Grabli D, Lehéricy S, Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism, Mov Disord, 2022. DOI pubmed

• Orts-Del'Immagine A, Dhanasekar M, Lejeune FX, Roussel J, Wyart C, A norepinephrine-dependent glial calcium wave travels in the spinal cord upon acoustovestibular stimuli, Glia, 2022. DOI pubmed

2021

• Ronzano R, Roux T, Thetiot M, Aigrot MS, Richard L, Lejeune FX, Mazuir E, Vallat JM, Lubetzki C, Desmazières A, Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination, Nat Commun, 2021. DOI pubmed

• Lemercier P, Vergallo A, Lista S, Zetterberg H, Blennow K, Potier MC, Habert MO, Lejeune FX, Dubois B, Teipel S, Hampel H, INSIGHT-preAD study group and the Alzheimer Precision Medicine Initiative (APMI), Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease, Neurobiol Aging, 2021. DOI pubmed

• Paris A, Labrador B, Lejeune FX, Canlet C, Molina J, Guinot M, Mégret A, Rieu M, Thalabard JC, Le Bouc Y, Metabolomic signatures in elite cyclists: differential characterization of a seeming normal endocrine status regarding three serum hormones, Metabolomics, 2021. DOI pubmed

• Wu MY, Carbo-Tano M, Mirat O, Lejeune FX, Roussel J, Quan FB, Fidelin K, Wyart C, Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed, Curr Biol, 2021. DOI pubmed

• Kacher R, Lejeune FX, Noël S, Cazeneuve C, Alexis A, Humbert S, Durr A, Propensity for somatic expansion increases over the course of life in Huntington disease, Elife, 2021. DOI pubmed

• Boeri J, Meunier C, Le Corronc H, Branchereau P, Timofeeva Y, Lejeune FX, Mouffle C, Arulkandarajah H, Mangin JM, Legendre P, Czarnecki A, Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity, Elife, 2021. DOI pubmed

• Poirion E, Tonietto M, Lejeune FX, Ricigliano VAG, Boudot de la Motte M, Benoit C, Bera G, Kuhnast B, Bottlaender M, Bodini B, Stankoff B, Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis, Neurology, 2021. DOI pubmed

• Penner G, Lecocq S, Chopin A, Vedoya X, Lista S, Vergallo A, Cavedo E, Lejeune FX, Dubois B, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI), Aptamarker prediction of brain amyloid-β status in cognitively normal individuals at risk for Alzheimer's disease, PLoS One, 2021. DOI pubmed

2020

• Voisin J, Farina F, Naphade S, Fontaine M, Tshilenge KT, Galicia Aguirre C, Lopez-Ramirez A, Dancourt J, Ginisty A, Sasidharan Nair S, Lakshika Madushani K, Zhang N, Lejeune FX, Verny M, Campisi J, Ellerby LM, Neri C, FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 INK4a increase, Aging Cell, 2020. DOI pubmed

• Guesdon A, Lejeune FX, Rotgé JY, George N, Fossati P, Mind-wandering changes in dysphoria, Front Psychiatry, 2020. DOI pubmed 

• Quan FB, Desban L, Mirat O, Kermarquer M, Roussel J, Koëth F, Marnas H, Djenoune L, Lejeune FX, Tostivint H, Wyart C, Somatostatin 1.1 contributes to the innate exploration of zebrafish larva, Sci Rep, 2020. DOI pubmed 

• Marie-Claire C, Lejeune FX, Mundwiller E, Ulveling D, Moszer I, Bellivier F, Etain B, A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1, Sci Rep, 2020. DOI pubmed

• Besse A, Astord S, Marais T, Roda M, Giroux B, Lejeune FX, Relaix F, Smeriglio P, Barkats M, Biferi MG, AAV9-Mediated Expression of SMN Restricted to Neurons Does Not Rescue the Spinal Muscular Atrophy Phenotype in Mice, Mol Ther, 2020. DOI pubmed

• Jachiet M, Bieuvelet S, Argoud AL, Vallée M, Zinaï S, Lejeune FX, Leger D, Bouaziz JD, Elbaz M, Bagot M, Sleep disturbance in atopic dermatitis: a case-control study using actigraphy and smartphone-collected questionnaires, Br J Dermatol, 2020. DOI pubmed

• Thetiot M, Freeman SA, Roux T, Dubessy AL, Aigrot MS, Rappeneau Q, Lejeune FX, Tailleur J, Sol-Foulon N, Lubetzki C, Desmazières A, An alternative mechanism of early nodal clustering and myelination onset in GABAergic neurons of the central nervous system, Glia, 2020. DOI pubmed

• Orts-Del'Immagine A, Cantaut-Belarif Y, Thouvenin O, Roussel J, Baskaran A, Langui D, Koëth F, Bivas P, Lejeune FX, Bardet PL, Wyart C, Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo, Curr Biol, 2020. DOI pubmed

• Bigan E, Sasidharan Nair S, Lejeune FX, Fragnaud H, Parmentier F, Mégret L, Verny M, Aaronson J, Rosinski J, Neri C, Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington's disease mice synchronous to symptoms, Bioinformatics, 2020. DOI pubmed

2019

• Xicota L, Ichou F, Lejeune FX, Colsch B, Tenenhaus A, Leroy I, Fontaine G, Lhomme M, Bertin H, Habert MO, Epelbaum S, Dubois B, Mochel F, Potier MC, INSIGHT study group, Multi-omics signature of brain amyloid deposition in asymptomatic individuals at-risk for Alzheimer's disease: The INSIGHT-preAD study, EBioMedicine, 2019. DOI pubmed

• Penner G, Lecocq S, Chopin A, Vedoya X, Lista S, Vergallo A, Lejeune FX, Hampel H, Blood-based diagnostics of Alzheimer's disease, Expert Rev Mol Diagn, 2019. DOI pubmed

2018

• Boeri J, Le Corronc H, Lejeune FX, Le Bras B, Mouffle C, Angelim MKSC, Mangin JM, Branchereau P, Legendre P, Czarnecki A, Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks, J Neurosci, 2018. DOI pubmed

• Dréan A, Rosenberg S, Lejeune FX, Goli L, Nadaradjane AA, Guehennec J, Schmitt C, Verreault M, Bielle F, Mokhtari K, Sanson M, Carpentier A, Delattre JY, Idbaih A, ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma, J Neurooncol, 2018. DOI pubmed

2017

• Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bièche I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP, Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness, Acta Neuropathol, 2017. DOI pubmed

• Farina F, Lambert E, Commeau L, Lejeune FX, Roudier N, Fonte C, Parker JA, Boddaert J, Verny M, Baulieu EE, Neri C, The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease, Sci Rep, 2017. DOI pubmed

2016

• El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, Fareh M, Mahfoudhi E, Janin M, Narayanan A, Morvan-Dubois G, Schmitt C, Verreault M, Oliver L, Sharif A, Pallud J, Devaux B, Puget S, Korkolopoulou P, Varlet P, Ottolenghi C, Plo I, Moura-Neto V, Virolle T, Chneiweiss H, Junier MP, A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma, Acta Neuropathol, 2016. DOI pubmed

2015

• Achour M, Le Gras S, Keime C, Parmentier F, Lejeune FX, Boutillier AL, Neri C, Davidson I, Merienne K, Neuronal identity genes regulated by super-enhancers are preferentially downregulated in the striatum of Huntington’s disease mice, Hum Mol Genet, 2015, 24(12) :3481-96. DOI pubmed

2013

• Parmentier F, Lejeune FX, Neri C, Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington’s disease : of gene prioritization and context dependence, Front Aging Neurosci, 2013, 5 :22. DOI pubmed

2012

• Lejeune FX, Mesrob L, Parmentier F, Bicep C, Vazquez-Manrique R, Parker JA, Vert JP, Tourette C, Neri C, Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons, BMC Genomics, 2012, 13 :91. DOI pubmed

2011

• Lejeune FX, Piecewise linear density estimation for sampled data, Mathematical Methods of Statistics, 2011, Vol. 20, No. 2, p. 106–124. springer

2006

• Lejeune FX, Propriétés des estimateurs par histogrammes et polygones de fréquences de la densité marginale d’un processus à temps continu, Ann. I.S.U.P., 2006, Vol. 50, Fasc. 1, p. 47–77. pdf

2005

• Lejeune FX, Vitesses optimale et suroptimale des polygones de fréquences pour les processus à temps continu, C. R. Acad. Sci. Paris Sér. I Math., 2005, 341, p. 59–62. sciencedirect

PhD Thesis. Histogramme, régressogramme et polygone de fréquences en temps continu, Thèse de doctorat de l’Université Pierre et Marie Curie, 2007, 108 pages. pdf