Конечно-диастолическое отношение объема и давления

End diastolic pressure-volume relationship (EDPVR)

EDPVR describes the passive filling curve for the ventricle and thus the passive properties of the myocardium. The slope of the EDPVR at any point along this curve is the reciprocal of ventricular compliance (or ventricular stiffness).

• if ventricular compliance is ↓ (such as in ventricular hypertrophy), the ventricle is stiffer → results in ↑ ventricular end-diastolic pressures (EDP) at any given end-diastolic volume (EDV).

  • Alternatively, for a given EDP, a less compliant ventricle would have a smaller EDV due to impaired filling.

• If ventricular compliance ↑ (such as in dilated cardiomyopathy - the ventricle becomes highly dilated without appreciable thickening of the wall), the EDV may be very high but the EDP may not be greatly elevated.