Time-series and causality analysis of neurophysiological data
Pathophysiology of movement disorders and influences of deep brain stimulation on electrophysiology
Electrophysiological correlates of resting state networks
Real-time neurofeedback
“Pain processing in Parkinson’s disease: motivational-emotional vs. sensory-discriminative components”, funded by the German Research Foundation (DFG)
"MEG-based neurophysiological markers of optimized STN-DBS in PD" (with A. Schnitzler) within the CRC "Retuning dynamic motor network disorders using neuromodulation" funded by the German Research Foundation (DFG)
"Predicting task performance based on electrophysiological resting state networks", funded by the German Research Foundation (DFG)
"Spontaneous brain activity in healthy subjects and Parkinson's disease", funded by Volkswagen Foundation
R.K. Spooner, B.H. Bahners, A. Schnitzler, E. Florin (2023): DBS-Evoked Cortical Responses Index Optimal Contact Orientations and Motor Outcomes in Parkinson’s Disease, NPJ Parkinson’s disease, accepted
M. Krösche, S. Kannenberg, M. Butz, C. J. Hartmann, E. Florin, A. Schnitzler, J. Hirschmann (2023): Slowing of Frontal Beta Oscillations in Atypical Parkinsonism, Movement Disorders, accepted.
B.H. Bahners, R.K. Spooner, C.J. Hartmann, A. Schnitzler, E. Florin (2023): Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson's disease. Brain Stimulation, accepted.
M. Sure, S. Mertiens, J. Vesper, A. Schnitzler, E. Florin (2023): Alterations of resting-state networks of Parkinson's disease patients after subthalamic DBS surgery. NeuroImage Clinical, 37:103317.
K. Jung, E. Florin, K.R. Patil, J. Caspers, C. Rubbert, S.B. Eickhoff, O.V. Popovych OV (2022): Whole-brain dynamical modelling for classification of Parkinson's disease. Brain Communication, 5(1):fcac331.
M. Sure, J. Vesper, A. Schnitzler, E. Florin (2022): Neural-event triggered analysis reveals cortical activity time-locked to subthalamic beta bursts, NeuroImage, 263:119619.
J. Hirschmann, A. Steina, J. Vesper, E. Florin, A. Schnitzler (2022): Neuronal oscillations predict deep brain stimulation outcome in Parkinson's disease, Brain stimulation, 15(3): 792-802.
L.K. Feldmann, R. Lofredi, W.J. Neumann, D. Al-Fatly, J. Roediger, B.H. Bahners, P. Nikolov, T. Denison, A. Saryyeva, J.K. Krauss, E. Florin, A. Schnitzler, G.H. Schneider, A.A. Kühn (2022): Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings, NPJ Parkinson’s Disease, 8(1):44.
M. Gerster, G. Waterstraat, V. Litvak, K. Lehnert, A. Schnitzler, E. Florin, G. Curio, V. Nikulin (2022): Separating neural oscillations from aperiodic 1/f activity: Challenges and recommendations, Neuroinformatics, 20(4):991-1012 .
S. Samiee, D. Vuvan, E. Florin, P. Albouy, I. Peretz, S. Baillet (2022): Cross-frequency brain network dynamics support pitch change detection, Journal of Neuroscience, 42(18): 3823-3835.
B.H. Bahners, G. Waterstraat, S. Kannenberg, G. Curio, A. Schnitzler, V. Nikulin, E. Florin (2022): Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation, Experimental Neurology, 352: 114031.
A.C. Zapf, A.K. Folkerts, L. Kahler, A. Schnitzler, P. Reker, M.T. Barbe, E. Florin*, E. Kalbe* (2022): No higher risk-seeking tendencies of altered self-estimation in a social decision-making task in patients with Parkinson’s disease, Journal of Parkinson’s disease, 12(3): 1045-1057.
M. Sure, J. Vesper, A. Schnitzler, E. Florin (2021): Dopaminergic modulation of spectral and spatial characteristics of parkinsonian STN beta bursts, Frontiers in Neuroscience, 15: 724334.
A. Sharma, D. Vidaurre, J. Vesper, A. Schnitzler, E. Florin (2021): Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease, ELife, 10: e66057.
J. Rosenberg, Q. Dong, E. Florin, P. Spirad, F. Boers, M. Reske, N.J. Shah, J. Dammers (2021): Conflict processing networks: A directional analysis of stimulus-response compatibilities using MEG, PLoS One, 16(2):e0247408.
V. Litvak; E. Florin, G. Tamásc, S. Groppad, M. Muthuramand (2021): EEG and MEG primers for tracking DBS network effects, NeuroImage, 224: 117447, pdf
E. Florin, K.C. Koschmieder, A. Schnitzler, S. Becker (2020): Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease, Movement Disorders, forthcoming, pdf.
A. L. Kandemir, V. Litvak, E. Florin (2020): The comparative performance of DBS artefact rejection methods for MEG recordings, NeuroImage, 219: 117057. pdf
B. H. Bahners, E. Florin, J. Rohrhuber, H. Krause, J. Hirschmann, R. van de Vijver, A. Schnitzler, M. Butz (2020): Deep Brain Stimulation does not modulate auditory-motor integration of speech in Parkinson's Disease, Frontiers in Neurology, 11:655, pdf.
L. Schneider, V. Seeger, L. Timmermann, E. Florin (2020): Electrophysiological resting state networks of predominantly akinetic-rigid Parkinson patients: Effects of dopamine therapy, NeuroImage Clinical, 25:102147. pdf
I. Weber, E. Florin, M. von Papen, V. Visser-Vandewalle, L. Timmermann (2020): Characterization of information processing in the subthalamic area of Parkinson's patients, NeuroImage, 209: 116518. pdf
J. Hirschmann, S. Baillet, M. Woolrich, A. Schnitzler, D. Vidaurre, E. Florin (2020): Spontaneous network activity <35 Hz accounts for variability in stimulus-induced gamma responses, NeuroImage, 207: 116374. pdf
E. A. Pelzer, E. Florin, A. Schnitzler (2019): Quantitative susceptibility mapping and resting state network analyses in Parkinsonian phenotypes – a systematic review of the literature, Frontiers in Neural Circuits, 13:50. pdf
P.W. Donhauser, E. Florin, S. Baillet (2018): Imaging of neural oscillations with embedded inferential and group prevalence statistics, PLoS Compuational Biology, 14(2): e1005990. pdf
E. Florin, S. Baillet (2018): Commentary: Evaluation of phase-amplitude coupling in resting state magnetoencephalographic signals: Effect of surrogates and evaluation approach, Frontiers in Computational Neuroscience.
I. Weber, E. Florin, M. von Papen, L. Timmermann (2017): The influence of filtering and downsampling on the estimation of transfer entropy, PLoS One, 12(11): e0188210. pdf
M. von Papen, H. Dafsari, E. Florin, F. Gerick, L. Timmermann, J. Saur (2017): Phase-coherence classification: A new wavelet-based method to separate local field potentials into local (in)coherent and volume-conducted components, Journal of Neuroscience Methods, 291: 198-212. pdf
E. Florin, D. Vuvan, I. Peretz, S. Baillet (2017): Pre-target neural oscillations predict variability in the detection of small pitch changes, PLoS One, 12(5): e0177836. pdf
E. Florin, J. Pfeifer, V. Visser-Vandewalle, A. Schnitzler, L. Timmermann (2016): Parkinson subtype-specific Granger-causal coupling and coherence frequency in the subthalamic area, Neurosciene, 332: 170-180. pdf
E. Florin, S. Baillet (2015): The brain's resting-state activity is shaped by synchronized cross-frequency coupling of neural oscillations, NeuroImage, 111:26-35. pdf
E. Florin, M. Watanabe, N.K. Logothetis (2015): The role of sub-second neural events in spontaneous brain activity, Current Opinion in Neurobiology, 32: 24–30. pdf
E. Florin, E. Bock, S. Baillet (2014): Targeted Reinforcement of Neural Oscillatory Activity with Real-time Neuroimaging Feedback, NeuroImage, 88:54–60. pdf
D.M. Herz, E. Florin, M.S. Christensen, C. Reck, M.T. Barbe, M.K. Tscheuschler, M. Tittgemeyer, H.R. Siebner, L. Timmermann (2014): Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease, Cerebral Cortex, 24: 2873–83. pdf
D.M. Herz, H.R. Siebner, O. Hulme, E. Florin, M.S. Christensen, L. Timmermann (2014): Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease, NeuroImage, 90:15–23. pdf
M.T. Barbe, M. Amarell, A.H. Snijders, E. Florin, E.-L. Quatuor, E. Schönau, G.R. Fink, B.R. Bloem, L.Timmermann (2014): Gait and upper limb variability in Parkinson’s disease patients with and without freezing of gait, Journal of Neurology, 216(2): 330–342. pdf
E. Florin, D. Müller, J. Pfeifer, M.T. Barbe, G.R. Fink, L. Timmermann (2013): Subthalamic stimulation modulates self-estimation of Parkinson patients and induces risk-seeking behavior, Brain, 136(11): 3271–3281. pdf
L.M. Bettray, C. Eggers, E.L. Quatuor, E. Florin, C. Reck, A.K. Pauls, M.T. Barbe, G.R. Fink, L. Timmermann (2013): Discontinuities in slow finger movements in patients with Parkinson’s disease, Neuroscience Letters, 548: 10–14. pdf
E. Florin, H. Salimi Dafsari, C. Reck, M.T. Barbe, K.A.M. Pauls, M. Maarouf, V. Sturm, G.R. Fink, L. Timmermann (2013): Modulation of local field potential power of the subthalamic nucleus during incremental isometric force generation in patients with Parkinson’s disease, Neuroscience, 240: 106–116. pdf
E. Florin, R. Erasmi, C. Reck, M. Maarouf, A. Schnitzler, G.R. Fink, L. Timmermann (2013): Does increased gamma activity in patients suffering from Parkinson’s disease counteract the movement inhibiting beta activity?, Neuroscience, 237: 42–50. pdf
E. Florin, J. Pfeifer (2013): Statistical pitfalls in the comparison of multivariate causality measures for effective causality, Computers in Biology and Medicine, 43(2): 131–134. pdf
C. Reck, M.Maarouf, L. Wojtecki, S.J. Groiss, E. Florin, V. Sturm, G.R. Fink, A. Schnitzler, L. Timmermann (2012): Clinical Outcome of Subthalamic Stimulation in Parkinson’s Disease is Improved by Intraoperative Multiple Trajectories Microelectrode Recording, Journal of Neurological Surgery Part A Central European Neurosurgery, 73(6): 377–86. pdf
D.J. Pedrosa, C. Reck, E. Florin, K.A. Pauls, M. Maarouf, L. Wojtecki, H.S. Dafsari, V. Sturm, A. Schnitzler, G.R. Fink, L. Timmermann (2012): Essential tremor and tremor in Parkinson’s disease are associated with distinct ‘tremor clusters’ in the ventral thalamus, Experimental Neurology, 237(2):435–43. pdf
E. Florin, M. Himmel, C. Reck, M. Maarouf, A. Schnitzler, V. Sturm, G.R. Fink, L. Timmermann (2012): Subtype-specific statistical causalities in parkinsonian tremor. Neuroscience, 210: 353–362. pdf
D.M. Herz, M.S. Christensen, C. Reck, E. Florin, M. T. Barbe, C. Stahlhut, K.A.M. Pauls, M. Tittgemeyer, H.R. Siebner, L. Timmermann (2012): Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study. NeuroImage 59(4): 3187–3193. pdf
L. Timmermann, E. Florin (2012): Parkinson’s disease and pathological oscillatory activity: Is the beta band the bad guy? - New lessons learned from low-frequency deep brain stimulation. Experimental Neurology, 233: 123–125. pdf
E. Florin, J. Gross, J. Pfeifer, G.R. Fink, L. Timmermann (2011): Reliability of multivariate causality measures for neural data. Journal of Neuroscience Methods, 198(2): 344–58. pdf
M.T. Barbe, L. Liebhart, M. Runge, J. Deyng, E. Florin, L. Wojtecki, A. Schnitzler, N. Allert, V. Sturm, G.R. Fink, L. Timmermann (2011): Deep brain stimulation of the ventral intermediate nucleus in patients with essential tremor: Stimulation below intercomissural line is more efficient but equally effective as stimulation above. Experimental Neurology, 230(1): 131–137. pdf
C. Reck, M. Himmel, E. Florin, M. Maarouf, V. Sturm, L. Wojtecki, A. Schnitzler, G.R. Fink, L. Timmermann (2010): Coherence analysis of local field potentials in the subthalamic nucleus: differences in Parkinsonian rest and postural tremor, European Journal of Neuroscience. 32(7):1202–14. pdf
E. Florin, J. Gross, J. Pfeifer, G.R. Fink, L. Timmermann (2010): The effect of filtering on Granger causality derived multivariate causality measures. NeuroImage, 50(2): 577–588. pdf
E. Florin, J. Gross, C. Reck, M. Maarouf, A. Schnitzler, V. Sturm, G.R. Fink, L. Timmermann (2010): Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson's disease. European Journal of Neuroscience, 31: 491–498. pdf
C. Reck, E. Florin, L. Wojtecki, S. Groiss, J. Voges, V. Sturm, A. Schnitzler, L. Timmermann (2009): Differential distribution of coherence between beta-band subthalamic oscillations and forearm muscles in Parkinson’s disease during isometric contraction. Clinical Neurophysiology, 120: 1601–1609. pdf
C. Reck, E. Florin, L. Wojtecki, H. Krause, S. Groiss, J. Voges, M. Maarouf, V. Sturm, A. Schnitzler, L. Timmermann (2009): Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson’s disease. European Journal of Neuroscience, 29: 599–612. pdf
E. Florin, C. Reck, L. Burghaus, R. Lehrke, J. Gross, V. Sturm, G.R. Fink, L. Timmermann (2008): 10 Hz thalamus stimulation increases tremor activity in the subthalamic nucleus in a patient with Parkinson’s disease. Clinical Neurophysiology, 119: 2098–103. pdf
L.Timmermann, E. Florin, C. Reck (2007): Pathological cerebral oscillatory activity in Parkinson’s Disease: a critical review on methods, data and hypothesis. Expert Review on Medical Devices, 4(5): 651–661. pdf
E. Florin, H.S. Rangwala, S. Rudin (2007): Method to rotate an endovascular device around the axis of a vessel using an external magnetic field. Medical Physics, 34: 328–33. pdf
E. Florin (2017): Aufbau von Mikroelektroden bzw. Makroelektroden, Chapter 10, in: Voges/Timmermann (ed.) „Tiefe Hirnstimulation: Grundlagen, Indikation, Verfahren“, De Gruyter, Berlin.
F. Jung, E. Florin (2017): Zielareale und deren elektrophysiologische Eigenschaft, Chapter 11, in: Voges/Timmermann (ed.) „Tiefe Hirnstimulation: Grundlagen, Indikation, Verfahren“, De Gruyter, Berlin.
F. Jung, E. Florin (2017): Krankheitsspezifische elektrophysiologische Marker, Chapter 12, in: Voges/Timmermann (ed.) „Tiefe Hirnstimulation: Grundlagen, Indikation, Verfahren“, De Gruyter, Berlin.
E. Florin, F. Jung (2017): Intraoperative Vorgehensweise, Chapter 13 , in: Voges/Timmermann (ed.) „Tiefe Hirnstimulation: Grundlagen, Indikation, Verfahren“, De Gruyter, Berlin.
E. Florin (2010): Causality measures between neural signals from invasively and non-invasively obtained local field potentials in humans, Forschungszentrum Jülich GmbH, Jülich. pdf
E. Florin (2008): Implementation of a magnetic device to rotate a stent, Verlag Dr. Müller, Saarbrücken.