Project summary

The aim of this visit is to spend 6 weeks in genomics lab (New York University, Langone Medical Center’s Genome technology center) directed by professor Jiri Zavadil in order to gain knowledge and experience in the field of cancer genomics (molecular profiling). The focus will be on quantitative microRNA profiling of primary aristolochic-acid associated urothelial tumors of the upper urinary tract, that is still not well established in Croatia.

During the visit I will learn to perform novel laboratory techniques, perform analysis on my own material, participate in interpretation of results and prepare a paper to publish the obtained data. The gained knowledge will be transferable to other Croatian scientists, so the benefit would be notable. Additionally, it might be the basis for future collaborations and applications for European or American grants. This visit will also allow me to process and finalize the analysis of data needed for my PhD thesis.

The overall beneficiary would ultimately be the patients with endemic nephropathy and associated cancers as the obtained data might provide key insights into the complex aristolochic acid-induced carcinogenesis and lead to potential therapeutic interventions with the disease at the molecular level.

PROJECT LEADER:

Sandra Karanović, MD

INVOLVED INSTITUTIONS:

School of medicine University of Zagreb & New York University, Langone Medical Center's Genome Technology Center

TOTAL AMOUNT:

54.914,50 HRK (amount of matching funds: 12.600 HRK)