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Michael, C., Mendonça-Gomes, J.M., DePaolo, C.W., Di Cristofano, A*., and de Oliveira, S*. A zebrafish xenotransplant model of anaplastic thyroid cancer to study the tumor microenvironment and innate immune cell interactions in vivo. Endocr. Relat. Cancer, 31: e230195, 2024.
Michael, C., Mendonça-Gomes, J.M., DePaolo, C.W., Di Cristofano, A*., and de Oliveira, S*. A zebrafish xenotransplant model of anaplastic thyroid cancer to study the tumor microenvironment and innate immune cell interactions in vivo. Endocr. Relat. Cancer, 31: e230195, 2024.
Sugarman A.J., Huynh L.D., Shabro A., Di Cristofano A. Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability. Cancer Lett. 568: 216304, 2023.
Sugarman A.J., Huynh L.D., Shabro A., Di Cristofano A. Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability. Cancer Lett. 568: 216304, 2023.
Bible, K.C., Kebebew, E., Brierley, J., Brito, J.P., Cabanillas, M.E., Clark, T.J., Di Cristofano, A., Foote, R., Giordano, T., Kasperbauer, J., Newbold, K., Nikiforov, Y.E., Randolph, G., Rosenthal, M.S., Sawka, A.M., Shah, M., Smallridge, R., Wong-Clark, C.K. 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer. Thyroid, 31: 337-386, 2021.
Bible, K.C., Kebebew, E., Brierley, J., Brito, J.P., Cabanillas, M.E., Clark, T.J., Di Cristofano, A., Foote, R., Giordano, T., Kasperbauer, J., Newbold, K., Nikiforov, Y.E., Randolph, G., Rosenthal, M.S., Sawka, A.M., Shah, M., Smallridge, R., Wong-Clark, C.K. 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer. Thyroid, 31: 337-386, 2021.
Shanja-Grabarz, X., Coste-Abramson, A., Entenberg, D., and Di Cristofano, A. Real-time, high-resolution imaging of tumor cells in thyroid cancer mouse models. Endocr. Relat. Cancer, 27: 529-539, 2020.
Shanja-Grabarz, X., Coste-Abramson, A., Entenberg, D., and Di Cristofano, A. Real-time, high-resolution imaging of tumor cells in thyroid cancer mouse models. Endocr. Relat. Cancer, 27: 529-539, 2020.
Li, Y.Z., Di Cristofano, A., and Woo, M. Metabolic role of PTEN in insulin signaling and resistance. Cold Spring Harb. Perspect. Med. a036137: 265-281, 2020.
Li, Y.Z., Di Cristofano, A., and Woo, M. Metabolic role of PTEN in insulin signaling and resistance. Cold Spring Harb. Perspect. Med. a036137: 265-281, 2020.
Jezek, J. , Wang, K., Yan, R., Di Cristofano, A., Cooper, K., and Strich, R. Synergistic repression of thyroid hyperplasia by cyclin C and Pten. J. Cell Sci.132, jcs230029. doi:10.1242/jcs.230029, 2019.
Jezek, J. , Wang, K., Yan, R., Di Cristofano, A., Cooper, K., and Strich, R. Synergistic repression of thyroid hyperplasia by cyclin C and Pten. J. Cell Sci.132, jcs230029. doi:10.1242/jcs.230029, 2019.
Wong, K., Di Cristofano, F., Ranieri, M., De Martino, D., and Di Cristofano, A. PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer. Endocr. Relat. Cancer, 26: 425-436, 2019.
Wong, K., Di Cristofano, F., Ranieri, M., De Martino, D., and Di Cristofano, A. PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer. Endocr. Relat. Cancer, 26: 425-436, 2019.
De Martino, D., Yilmaz, E., Orlacchio, A., Ranieri, M., Zhao, K., and Di Cristofano, A. PI3K blockage synergizes with PLK1 inhibition preventing endoreduplication and enhancing apoptosis in anaplastic thyroid cancer. Cancer Lett.439: 56-65, 2018.
De Martino, D., Yilmaz, E., Orlacchio, A., Ranieri, M., Zhao, K., and Di Cristofano, A. PI3K blockage synergizes with PLK1 inhibition preventing endoreduplication and enhancing apoptosis in anaplastic thyroid cancer. Cancer Lett.439: 56-65, 2018.
Orlacchio, A., Ranieri, M., Brave, M., Antico Arciuch V., Forde, T., De Martino, D., Anderson, K.E., Hawkins, P., and Di Cristofano, A. SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance. Cancer Res., 77: 6914-6926, 2017.
Orlacchio, A., Ranieri, M., Brave, M., Antico Arciuch V., Forde, T., De Martino, D., Anderson, K.E., Hawkins, P., and Di Cristofano, A. SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance. Cancer Res., 77: 6914-6926, 2017.
Mio, C., Lavarone, E., Conzatti, K., Baldan, F., Toffoletto, B., Puppin, C., Filetti, S., Durante, C., Russo, D., Orlacchio, A., Di Cristofano, A., Di Loreto, C., and Damante, G. MCM5 as a target of BET inhibitors in thyroid cancer cells. Endocr. Relat. Cancer, 23:335-347, 2016.
Mio, C., Lavarone, E., Conzatti, K., Baldan, F., Toffoletto, B., Puppin, C., Filetti, S., Durante, C., Russo, D., Orlacchio, A., Di Cristofano, A., Di Loreto, C., and Damante, G. MCM5 as a target of BET inhibitors in thyroid cancer cells. Endocr. Relat. Cancer, 23:335-347, 2016.
Champa, D., Orlacchio, A., Patel, B. Ranieri, M., Shemetov, A.A., Verkhusha, V.V., Cuervo, A.M., and Di Cristofano, A. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget, 7:34453-34471, 2016.
Champa, D., Orlacchio, A., Patel, B. Ranieri, M., Shemetov, A.A., Verkhusha, V.V., Cuervo, A.M., and Di Cristofano, A. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget, 7:34453-34471, 2016.
Champa, D. and Di Cristofano, A. Modeling anaplastic thyroid carcinoma in the mouse. Horm Cancer. 6:37-44, 2015.
Champa, D. and Di Cristofano, A. Modeling anaplastic thyroid carcinoma in the mouse. Horm Cancer. 6:37-44, 2015.
Champa, D., Russo, M.A., Liao, X-H., Refetoff, S., Ghossein, R.A., and Di Cristofano, A. Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression. Endocr. Relat. Cancer, 21:755-767, 2014.
Champa, D., Russo, M.A., Liao, X-H., Refetoff, S., Ghossein, R.A., and Di Cristofano, A. Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression. Endocr. Relat. Cancer, 21:755-767, 2014.
Di Cristofano, A. Obesity And Thyroid Cancer: Is Leptin The (Only) Link? Endocrinology, 154:2567-2569, 2013
Di Cristofano, A. Obesity And Thyroid Cancer: Is Leptin The (Only) Link? Endocrinology, 154:2567-2569, 2013
Antico Arciuch V.G., Russo, M.A., Kang, K.S, and Di Cristofano, A. Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells. Cancer Res., 73: 5459-5472, 2013.
Antico Arciuch V.G., Russo, M.A., Kang, K.S, and Di Cristofano, A. Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells. Cancer Res., 73: 5459-5472, 2013.
Sponziello, M., Lavarone, E., Pegolo, E., Di Loreto, C., Puppin, C., Russo, M.A., Bruno, R., Filetti S., Durante, C., Russo, D., Di Cristofano, A., and Damante, G. Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. Endocrinology, 154:3043-3053, 2013.
Sponziello, M., Lavarone, E., Pegolo, E., Di Loreto, C., Puppin, C., Russo, M.A., Bruno, R., Filetti S., Durante, C., Russo, D., Di Cristofano, A., and Damante, G. Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. Endocrinology, 154:3043-3053, 2013.
Russo, M.A., Kang, K.S., and Di Cristofano, A. The PLK1 inhibitor GSK461364A is effective in poorly differentiated and anaplastic thyroid carcinoma cells, independent of the nature of their driver mutations.Thyroid, 23:1284-1293, 2013.
Russo, M.A., Kang, K.S., and Di Cristofano, A. The PLK1 inhibitor GSK461364A is effective in poorly differentiated and anaplastic thyroid carcinoma cells, independent of the nature of their driver mutations.Thyroid, 23:1284-1293, 2013.
Danescu, A., Herrero Gonzalez, S., Di Cristofano, A., Mai, S., and Hombach-Klonisch, S. Three-dimensional (3D) Nuclear Telomere Architecture Changes during Endometrial Carcinoma Development. Genes Chromosomes Cancer. 52:716-732, 2013.
Danescu, A., Herrero Gonzalez, S., Di Cristofano, A., Mai, S., and Hombach-Klonisch, S. Three-dimensional (3D) Nuclear Telomere Architecture Changes during Endometrial Carcinoma Development. Genes Chromosomes Cancer. 52:716-732, 2013.
Antico-Arciuch, V.G. and Di Cristofano, A. Estrogen signaling and thyrocyte proliferation. In Thyroid and Parathyroid Diseases, ISBN 978-953-51-0221-2, 2012.
Antico-Arciuch, V.G. and Di Cristofano, A. Estrogen signaling and thyrocyte proliferation. In Thyroid and Parathyroid Diseases, ISBN 978-953-51-0221-2, 2012.
Tiozzo, C., Danopoulos, S., Lavarreda-Pearce, M., Baptista, S., Varimezova, R., Al Alam, D., Warburton, D., Virender, R., De Langhe, S., Di Cristofano, A., Bellusci, S., and Minoo, P. Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain dependent manner. Endocr. Relat. Cancer, 19:111-122, 2012.
Tiozzo, C., Danopoulos, S., Lavarreda-Pearce, M., Baptista, S., Varimezova, R., Al Alam, D., Warburton, D., Virender, R., De Langhe, S., Di Cristofano, A., Bellusci, S., and Minoo, P. Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain dependent manner. Endocr. Relat. Cancer, 19:111-122, 2012.
Russo M.A., Antico Arciuch V.G. and Di Cristofano A. Mouse models of follicular and papillary thyroid cancer progression. Front. Endocrin. 2, 2012.
Russo M.A., Antico Arciuch V.G. and Di Cristofano A. Mouse models of follicular and papillary thyroid cancer progression. Front. Endocrin. 2, 2012.
Antico Arciuch V.G., Russo, M.A., Dima, M., Kang, K.S., Dasrath, F., Liao, X-H., Refetoff, S., Montagna, C., and Di Cristofano, A. Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget, 2:1109-1126, 2011.
Antico Arciuch V.G., Russo, M.A., Dima, M., Kang, K.S., Dasrath, F., Liao, X-H., Refetoff, S., Montagna, C., and Di Cristofano, A. Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget, 2:1109-1126, 2011.
Dima, M., Miller, K.A., Antico-Arciuch V.G., and Di Cristofano, A. Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research. Thyroid, 21:1001-1007, 2011.
Dima, M., Miller, K.A., Antico-Arciuch V.G., and Di Cristofano, A. Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research. Thyroid, 21:1001-1007, 2011.
Antico-Arciuch VG, Dima, M., Liao, X-H., Refetoff, S., and Di Cristofano, A. Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females. Oncogene, 29:5678-5686, 2010.
Antico-Arciuch VG, Dima, M., Liao, X-H., Refetoff, S., and Di Cristofano, A. Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females. Oncogene, 29:5678-5686, 2010.
Miller, K., Yeager, N., Baker, K., Liao, X-H., Refetoff, S., and Di Cristofano, A. Oncogenic Kras Requires Simultaneous PI3K Signaling to Induce ERK Activation and Transform Thyroid Epithelial Cells in Vivo.Cancer Res., 69:3689-3694, 2009.
Miller, K., Yeager, N., Baker, K., Liao, X-H., Refetoff, S., and Di Cristofano, A. Oncogenic Kras Requires Simultaneous PI3K Signaling to Induce ERK Activation and Transform Thyroid Epithelial Cells in Vivo.Cancer Res., 69:3689-3694, 2009.
Yeager, N., Brewer, C., Cai, KQ, Xu, XX., and Di Cristofano, A. mTOR is the key effector of PI3K-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res., 68:444-449, 2008.
Yeager, N., Brewer, C., Cai, KQ, Xu, XX., and Di Cristofano, A. mTOR is the key effector of PI3K-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res., 68:444-449, 2008.
Brewer, C., Yeager, N. and Di Cristofano, A. Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res. 67:8006-8006, 2007.
Brewer, C., Yeager, N. and Di Cristofano, A. Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res. 67:8006-8006, 2007.
Yeager, N., Klein-Szanto, A., Kimura, S. and Di Cristofano, A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 67:959-966, 2007.
Yeager, N., Klein-Szanto, A., Kimura, S. and Di Cristofano, A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 67:959-966, 2007.
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