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We are broadly interested in understanding the forces, structures, and dynamics that govern the interaction of biologically significant macromolecular assemblies to address problems in biology and biomedicine. Using interdisciplinary methodologies in chemistry, physics, and medicine, we focus currently on structure and dynamic measurements to address issues related primarily to DNA condensation in vitro and in vivo. Learning the strength, specificity, and reversibility in associates of biologically important macromolecules, typically in crowded environments, is crucial to our understanding of how gene and cellular function relates to packaging and for effective and rational drug design.