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Neuroimaging /EEG research in older adults with cognitive decline
Neuroimaging /EEG research in older adults with cognitive decline
認知衰退高齡者之神經影像/腦電生理研究
認知衰退高齡者之神經影像/腦電生理研究
Our lab primarily utilizes electrophysiological techniques, such as resting-state electroencephalography (rs-EEG) and event-related potentials (ERPs), to investigate the neural mechanisms underlying cognitive complaints in older adults. Our research focuses on individuals across the cognitive continuum, including those with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and various stages of dementia. By examining neural activity patterns, we aim to identify potential biomarkers that can aid in early detection and progression monitoring of neurodegenerative diseases, ultimately contributing to the development of more precise diagnostic tools and targeted interventions for AD.
Selected publications:
Hung CC#, Hsiao FJ#, Wang PN, Cheng CH*. Disconnection of alpha oscillations within default mode network associated with memory dysfunction in amnestic MCI. Clinical Neurophysiology 2024, 167: 221-228 (SCI, 2023 IF = 3.7, Q1)
Cheng CH*, Hung CC, Chao YP, Nouchi R, Wang PN. Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus. Clinical Neurophysiology 2023, 156: 281-289 (SCI, 2023 IF = 3.7, Q1)
Chao YP, Liu PT, Wang PN, Cheng CH*. Reduced inter-voxel white matter integrity in subjective cognitive decline: Diffusion tensor imaging with tract-based spatial statistics analysis. Frontiers in Aging Neuroscience 2022, 14: 810998 (SCI, 2023 IF = 4.1, Q2)
Chen PY, Hsu HY, Chao YP, Nouchi R, Wang PN, Cheng CH*. Altered mismatch response of inferior parietal lobule in amnestic mild cognitive impairment: A magnetoencephalographic study. CNS Neuroscience & Therapeutics 2021, 27: 1136-1145 (SCI, 2023 IF = 4.8, Q1)
Sun HH, Lin MY, Nouchi R, Wang PN, Cheng CH*. Neuromagnetic evidence of abnormal automatic inhibitory function in subjective memory complaint. European Journal of Neuroscience 2021, 53: 3350-3361 (SCI, 2023 IF = 2.7, Q3)
Cheng CH*, Chang CC, Chao YP, Lu H, Peng SW, Wang PN. Altered mismatch response precedes gray matter atrophy in subjective cognitive decline (SCD). Psychophysiology 2021, 58: e13820 (SCI, 2023 IF = 2.9, Q1)
Cheng CH*, Wang PN, Mao HF, Hsiao FJ*. Subjective cognitive decline detected by the oscillatory connectivity in the default mode network: A magnetoencephalographic study. Aging 2020, 12: 3911-3925 (SCI, 2023 IF = 3.9, Q2)
Non-pharmacological intervention to older adults with cognitive declines
Non-pharmacological intervention to older adults with cognitive declines
高齡者認知衰退之非藥物療法
高齡者認知衰退之非藥物療法
Our lab is actively engaged in research aimed at evaluating the effectiveness of non-pharmacological interventions for this population. Given the growing recognition of lifestyle factors in cognitive health, we have investigated the potential benefits of lifestyle-modifying therapies. Specifically, our studies have explored the combined effects of physical exercise and cognitive training in community-dwelling older adults with subjective cognitive decline (SCD). Building on this foundation, we are now expanding our research to include non-invasive brain stimulation techniques as a promising approach for cognitive enhancement.
Selected publications:
Cheng CH*, Hsieh YW, Chang CC, Hsiao FJ, Chen LF, Wang PN. Effect of 6-month combined physical exercise and cognitive training on neuropsychological and neurophysiological function in older adults with subjective cognitive decline: A randomized controlled trial. Journal of Alzheimer’s Disease 2024, 100: 175-192 (SCI, 2023 IF = 3.4, Q2)
Ito E, Nouchi R*, Dinet J, Cheng CH, Husebø BS. The effect of music therapy on general cognitive and executive functions, and episodic memory in people with mild cognitive impairment and dementia: A systematic review and meta-analysis of recent randomized controlled trials. Healthcare 2022, 10: 1462 (SCI, 2023 IF = 2.4, Q2)
Neural correlates of emotional traits or personality
Neural correlates of emotional traits or personality
情緒特質或人格特質之神經生理機制
情緒特質或人格特質之神經生理機制
Our lab also conducts research in biological psychology and psychophysiology, exploring the complex interactions between neural activity, cognitive processes, and individual differences in psychological traits. Recently, we have been investigating the genetic and environmental factors that contribute to high sensitivity in individuals classified as highly sensitive persons (HSP). HSPs are characterized by heightened sensory processing sensitivity and increased emotional reactivity. Using ERP techniques, we aim to identify the neural mechanisms underlying sensory and emotional processing in HSPs.
Our lab also conducts research in biological psychology and psychophysiology, exploring the complex interactions between neural activity, cognitive processes, and individual differences in psychological traits. Recently, we have been investigating the genetic and environmental factors that contribute to high sensitivity in individuals classified as highly sensitive persons (HSP). HSPs are characterized by heightened sensory processing sensitivity and increased emotional reactivity. Using ERP techniques, we aim to identify the neural mechanisms underlying sensory and emotional processing in HSPs.
Selected publications:
Cheng CH*, Chan PY, Chen SY, Chen YH, Lu H, Liu CY. Trait anxiety negatively modulates the coupling of motor event-related desynchronization and event-related synchronization. BMC Psychiatry 2025, 25: 447 (IF = 3.4, Q2)
Hsieh MT, Lu H, Chen LF, Liu CY, Hsu SC, Cheng CH*. Cancellation but not restraint ability is modulated by trait anxiety: An event-related potential and oscillation study using Go-Nogo and stop-signal tasks. Journal of Affective Disorders 2022, 299: 188-195 (SCI, 2023 IF = 4.9, Q1)
Jian JR#, Lin YY#, Connor L, Cheng CH*. Revisiting the relationship between neural correlates of sensory gating and self-reported sensory gating inventory: An MEG investigation. Neuroscience Letters 2022, 766: 136336 (SCI, 2023 IF = 2.5, Q3)
Hsieh MT, Lu H, Lin CI, Sun TH, Chen YR, Cheng CH*. Effects of trait anxiety on error processing and post-error adjustments: An event-related potential study with stop-signal task. Frontiers in Human Neuroscience 2021, 15: 650838 (SCI, 2023 IF = 2.4, Q2)
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