Kalyan S. Chakrabarti
Division of Science, Krea University
Sri City, AP 517646, India
Email: kalyan.chakrabarti@krea.edu.in
kalyansundar.chakrabarti@gmail.com
AFFILIATIONS
Krea University, Division of Science, Sri City, AP, India. (current)
Max Planck Institute for Biophysical Chemistry (MPIBPC), Department of NMR-based Structural Biology, Göttingen, Germany
National Cancer Institute (NCI/NIH), Structural Biophysics Laboratory, Frederick, MD, USA.
Howard Hughes Medical Institute and Brandeis University, MA, USA.
EDUCATION
Ph.D. : Molecular Biophysics Unit, Indian Institute of Science, India.
M.S. : Division of Biological Sciences, Indian Institute of Science
B.Sc. : Presidency College/University, University of Calcutta, India.
RESEARCH INTEREST
Structural biology
Biophysics
Biomolecular NMR spectroscopy
TEACHING
Carbon-based molecules (T4, CHEM206), Chemistry and Physics of molecules (T4, BIOS206), Biochemistry, molecular & cell biology (T5, BIOS211), Systems Biology: Molecular Approach (T6, CHEM211), Ways of knowing: Instrumentation in Biology (T7, BIOS231), Molecular Biophysics (T9, CHEM305).
Scientific reasoning (T2, foundational), Data analytics (T2, foundational), Design thinking (T3, foundational)
PUBLICATIONS
Kalyan S. Chakrabarti, Simon Olsson, Supriya Pratihar, Kerstin Overkamp, Ko On Lee, Vytautas Gapsys, Kyoung-Seok Ryu, Bert L. de Groot, Frank Noe, Stefan Becker, Donghan Lee, Thomas R.Weikl, Christian Griesinger, "A litmus test for classification of recognition mechanisms of transiently binding proteins" Nature communication (2022) 13: 3792.
Myeongkyu Kim, Jung-Hye Ha, Joonhyeok Choi, Bo-Ram Kim, Vytautas Gapsys, Ko On Lee, Jun-Goo Jee, Kalyan S Chakrabarti, Bert L de Groot, Christian Griesinger, Kyoung-Seok Ryu, Donghan Lee, "Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXβ Reductase B as a Novel Thrombocytopenia Therapeutic Target", Journal of Medicinal Chemistry (2021) DOI: 10.1021/acs.jmedchem.1c01664.
Abuthahir Abdulrahuman, Kalyan S Chakrabarti, Gaurav Raina, "Stability, Convergence and Bifurcation of a Reduced Boissonade-De Kepper Model with Delayed Feedback", 16th International Federation of Automation and Control (IFAC) Workshop on Time Delay Systems, TDS 2021, arXiv:2103.13016v1 (2021).
Karuna Dixit, N Megha Karanth, Smita Nair, Khushboo Kumari, Kalyan S Chakrabarti, Handanahal S Savithri, Siddhartha P Sarma, "Aromatic Interactions Drive the Coupled Folding and Binding of the Intrinsically Disordered Sesbania mosaic Virus VPg Protein" Biochemistry (2020) DOI:10.1021/acs.biochem.0c00721.
Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U. Mahajani, Kalyan S. Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bahr and Sebastian Kugler, "Dopamine promotes the neurodegenerative potential of beta-synuclein" Journal of Neurochemistry (2020) DOI:10.1111/jnc.15134.
Kalyan S. Chakrabarti, Jess Li, Ranabir Das and R. Andrew Byrd, “Conformational dynamics and allostery in E2:E3 interactions driving ubiquitination: gp78 and Ube2g2” Structure (2017) 25 : 794-805.
Kalyan S. Chakrabarti, David Ban, Supriya Pratihar, Jithender G. Reddy, Stefan Becker, Christian Griesinger, Donghan Lee, "High-power 1H composite pulse decoupling provides artifact free exchange-mediated saturation transfer (EST) experiments" Journal of Magnetic Resonance (2016) 269 : 65-69.
Kalyan S. Chakrabarti*, Roman Agafonov*, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F. X. Schertler, Daniel D. Oprian and Dorothee Kern, “Conformational selection in a protein-protein interaction by dynamic pathway analysis” Cell Reports (2016) 14: 32-42. (* contributed equally)
Matthew J. Ranaghan, Prem K. Ramasamy, Kalyan S. Chakrabarti, Vanessa Buosi, Dorothee Kern and Daniel D. Oprian, “A highly conserved cysteine of neuronal calcium sensing proteins controls cooperative binding of Ca+2 to recoverin” Journal of Biological Chemistry (2013) 288: 36160-36167.
Rikard Frederiksen, Nicholas P. Boyer, Benjamin Nickle, Kalyan S. Chakrabarti, Yiannis Koutalos, Rosalie K. Crouch, Daniel Oprian and M. Carter Cornwall, “Low aqueous solubility of 11-cis retinal limits rate of pigment formation and dark adaptation in salamander rods” Journal of General Physiology (2012) 139: 493-505.
Kalyan S. Chakrabarti, Krishan Gopal Thakur, B. Gopal and Siddhartha P. Sarma, “X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate” FEBS Journal (2010) 277: 697-712.
Kalyan S. Chakrabarti and Siddhartha P. Sarma, “NMR assignment of 2H, 13C, 15N labeled amino-terminal domain of apo-pantothenate synthetase from E. coli.” Journal of Biomolecular NMR (2006) 36: 38.
Ashima Mitra*, Kalyan S. Chakrabarti*, M.S. Shahul Hameed, Kalyan V. Srinivas, Ganesan Senthil Kumar and Siddhartha P. Sarma, “High level expression of peptides and proteins using cytochrome b5 as a fusion host” Protein Expression and Purification (2005) 41: 84-97. (*contributed equally)
Kalyan S. Chakrabarti, B. S. Sanjeev and Saraswathi Vishveshwara, “Stability and dynamics of domain-swapped bovine-seminal ribonuclease” Chemistry and Biodiversity (2004) 1: 802-818.
R. Padmashree, K. S. Chakrabarti, D. Sahal, R. Mahalakshmi, S. P. Sarma and S. K. Sikdar, “Functional characterization of the pentapeptide QYNAD on rNaυ1.2 channels and its NMR structure” European Journal of Physiology (2004) 447: 895-907.
Other technical writings:
"Conformational selection in vision" Kalyan S. Chakrabarti, www.sciwri.club (2016)
“Structure of invisible intermediate of a protein” Kalyan S. Chakrabarti, Current Science (Research News) (2011) 100 (1): 19-20.
SCHOLARSHIPS
Krea University Intramural research fellowship: 2019, 2022
Max Planck Society fellowship: 2014
NIH intramural visiting research scholar: USA 2012
2006-2008 Senior Research Fellow of the Council for Scientific and Industrial Research, Indian Institute of Science, India, 2006.
2006 Travel award from the organizers to attend ICMRBS XXII in Gottingen, Germany
2001-2006 Integrated PhD. fellowship, Indian Institute of Science.
2001 National Merit Scholarship, Government of India.
Updated 29th Apr 2022