Kalyan S. Chakrabarti
Welcome to my webpage. I am an associate professor of Biological science and Chemistry at the Krea University, Sri City, AP, India. Previously, I was affiliated with the Max Planck Institute for Biophysical Chemistry, in Germany, HHMI, Brandeis University and the National Cancer Institute / National Institute of Health, USA. I completed my PhD from the Indian Institute of Science, Bangalore, India.
I am part of "The Common Babbler" collaboration to discuss science pedagogy. The links of the episodes of Youtube podcasts are on the right.
Here is my complete list of publications/profiles at:
Recent work:
Rashmi Agrata, Priyesh Mohanty, Aravind Ravichandran, Sanju Kumari, Nishant Varshney, Arun GS, Kanchan Chauhan, Jess Li, Kalyan S. Chakrabarti, R. Andrew Byrd, Ranabir Das, "Bacterial deamidases modulate ubiquitin structure and dynamics to dysregulate ubiquitin signaling" bioRxiv (2023) doi: https://doi.org/10.1101/2023.05.22.541748.
Check Stenstrom et al. for a recent analysis of our works: Stenström, O., Diehl, C., Modig, K., & Akke, M. (2024). Ligand-induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit. Proceedings of the National Academy of Sciences, 121(14), e2317747121. https://doi.org/10.1073/pnas.2317747121
Kalyan S. Chakrabarti, Simon Olsson, Supriya Pratihar, Kerstin Overkamp, Ko On Lee, Vytautas Gapsys, Kyoung-Seok Ryu, Bert L. de Groot, Frank Noe, Stefan Becker, Donghan Lee, Thomas R.Weikl, Christian Griesinger, "A litmus test for classification of recognition mechanisms of transiently binding proteins" Nature communication (2022) doi: 10.1038/s41467-022-31374-5.
Selected publications:
From the National Cancer Institute (National Institute of Health, USA): "Conformational dynamics and allostery in E2:E3 interactions driving ubiquitination: gp78 and Ube2g2" Kalyan S. Chakrabarti, Jess LI, Ranabir Das, R. Andrew Byrd, Structure (2017) 25 : 794-805.
From the Howard Hughes Medical Institute/Brandeis University: “Conformational selection in a protein-protein interaction by dynamic pathway analysis” Kalyan S. Chakrabarti, Roman Agafonov, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F. X. Schertler, Daniel D. Oprian and Dorothee Kern, Cell Reports (2016) 14: 32-42.
Check Fabien Paul & Thomas R. Weikl (MPI, Potsdam, Germany) "How to distinguish conformational selection and induced fit based on chemical relaxation rates", Fabien Paul and Thomas R. Weikl (2016) PLOS Comput. Biol., 12(9):e1005067. doi:10.1371/journal.pcbi.1005067 for an important analysis of the results.
Contact address: kalyansundar.chakrabarti@gmail.com
Updated 21st Jan 2023