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Organocatalysis
Organocatalysis
Our approach involves the discovery and design of simple cost effective catalysts for highly enantioselective organic reactions. Typically our studies not only involve design and synthesis of the catalyst but also involves elucidation of the reaction mechanism underlying the catalytic activity and selectivity. We attempt to utilize such mechanistic insight in iterating the design of the catalyst to achieve higher selectivity and broad reaction scope.
Additionally, the group is interested in developing newer methodologies by utilizing well-proven organocatalyst. For instance, we have recently developed an iminium based methodology for generation of quaternary stereo centers via a powerful bifunctional catalysis.
Transition Metal catalyzed C-H activation
Transition Metal catalyzed C-H activation
Our group has developed reaction systems in the area of oxidative C-H coupling, potentially the most effective of all C-C bond formation. We are particularly interested in regioselective C-H bond activation of heterocycle under the ambient condition to construct a range of important molecular architectures.
Organo Photocatalysis
Organo Photocatalysis
A photocatalyst is a substance that absorbs light to get excited to higher energy level and provides such energy to a reacting substance to make a chemical reaction occur. Over the past few decades the research activity in this direction has experienced a massive non linear growth. Our laboratory deals with visible light promoted photocatalysis in remote bond activation, functional group transformations and functional group addition.
Total Synthesis of Small Molecules
Total Synthesis of Small Molecules
Our laboratory focusses on the total synthesis of certain small organic molecules having biological activity. There are two strategies for Combinatorial Synthesis and Diversity Oriented Synthesis (DOS). If we look at the structural diversity spectrum of all molecules , we can see combinatorial library provides the stock for the molecules having appendage and stereochemical diversity and on the other hand the DOS library opens the domain of molecules with skeletal diversity along with appendage and stereochemical diversity.
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