Publications
Peer reviewed publications
1. Hancock, B.C.*, York, P., Rowe, R.C. & Parker, M.D., Characterisation of wet masses using a mixer torque rheometer Part 1: Effect of instrument geometry, International Journal of Pharmaceutics 76 (1991) 239‑245 (Principal investigator) doi:10.1016/0378-5173(91)90276-T.
2. Hancock, B.C.*, York, P. & Rowe, R.C., Characterisation of wet masses using a mixer torque rheometer Part 2: Mixing kinetics, International Journal of Pharmaceutics 83 (1992) 147‑153 (Principal investigator) doi:10.1016/0378-5173(82)90017-5.
3. Hancock, B.C.*, York, P. & Rowe, R.C., An assessment of substrate‑binder interactions in model granule systems Part 1: Mixer torque rheometry, International Journal of Pharmaceutics 102 (1994) 167‑176 (Principal investigator) doi:10.1016/0378-5173(94)90052-3.
4. Hancock, B.C.*, York, P. & Rowe, R.C., An assessment of substrate‑binder interactions in model granule systems Part 2: Scanning electron microscopy, European Journal of Pharmaceutical Sciences 2 (1994) 205‑211 (Principal investigator) doi:10.1016/0928-0987(94)90024-8.
5. Hancock, B.C.*, York, P. & Rowe, R.C., An assessment of substrate‑binder interactions in model granule systems Part 3: Linear elastic fracture mechanics, Journal of Materials Science 28 (1993) 6729‑6736 (Principal investigator) doi:10.1007/BF00356423.
6. Hancock, B.C.* & Zografi, G., The use of solution theories for predicting water vapour absorption by amorphous pharmaceutical solids: a test of the Flory‑Huggins and Vrentas models, Pharmaceutical Research 10 (1993) 1262‑1267 (Principal investigator) doi:10.1023/A:1018901325842.
7. Zografi, G.* & Hancock, B.C., Water‑solid interactions in pharmaceutical systems, In Proceedings of 53rd International Congress of Pharmaceutical Sciences, Tokyo, Japan. Elsevier, New York (1993) (Co‑investigator).
8. Hancock, B.C.* & Zografi, G., The relationship between the glass transition temperature and water content of amorphous pharmaceutical solids, Pharmaceutical Research 11 (1994) 471‑477 (Principal investigator) doi:10.1023/A:1018941810744.
9. Yoshioka, M., Hancock, B.C. & Zografi, G.*, Crystallisation of indomethacin from the amorphous state below and above its glass transition temperature, Journal of Pharmaceutical Sciences 83 (1994) 1700‑1705 (Co‑investigator) doi:10.1002/jps.2600831211.
10. Yoshioka, M., Hancock, B.C. & Zografi, G.*, Inhibition of indomethacin crystallisation from PVP coprecipitates, Journal of Pharmaceutical Sciences 84 (1994) 983‑986 (Co‑investigator) doi:10.1002/jps.2600840814.
11. Hancock, B.C.*, Shamblin, S.L. & Zografi, G., The molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures, Pharmaceutical Research 12 (1995) 799‑806 (Principal investigator) doi:10.1023/A:1016292416526.
12. Hancock, B.C.* & Zografi, G., Effects of solid‑state processing on water vapour sorption by aspirin, Journal of Pharmaceutical Sciences 85 (1996) 246‑248 (Principal investigator).
13. Thibert, R.* & Hancock, B.C., Direct visualisation of superdisintegrant hydration using environmental scanning electron microscopy, Journal of Pharmaceutical Sciences 85 (1996) 1255‑1258 (Co‑investigator) doi:10.1021/js960188d.
14. Oshima, M., Dinchuk, J.E., Kargman, S., Oshima, H., Hancock, B.C., Kwong, E., Trzaskos, J.M., Evans, J.F. & Taketo, M.*, Suppression of intestinal polyposis in ApcD176 knockout mice by inhibition of cyclooxygenase 2 (COX‑2), Cell 87 (1996) 803‑809 (Co‑investigator) doi:10.1016/S0092-8674(00)81988-1.
15. Hancock, B.C.* & Zografi, G., Characteristics and significance of the amorphous state in pharmaceutical systems, Journal of Pharmaceutical Sciences 86 (1997) 1‑12 (Principal investigator) “The 2nd Most Highly Cited Article in Journal of Pharmaceutical Sciences in 2009” doi:10.1021/js9601896.
16. Hancock, B.C.*, York, P. & Rowe, R.C., The use of solubility parameters in pharmaceutical dosage form design, International Journal of Pharmaceutics 148 (1997) 1‑21 (Principal investigator) doi:10.1016/S0378-5173(96)04828-4.
17. Dalton, C.R. & Hancock, B.C.*, Processing and storage effects on water vapour sorption by some model pharmaceutical solid dosage formulations, International Journal of Pharmaceutics 156 (1997) 143‑151 (Principal investigator) doi:10.1016/S0378-5173(97)04983-1.
18. Shamblin, S.L.*, Hancock, B.C. & Zografi, G., Water vapour sorption by peptides, proteins and their formulations, European Journal of Pharmaceutics and Biopharmaceutics 45 (1997) 239‑247 (Co‑investigator) doi:10.1016/S0939-6411(98)00006-X.
19. Hancock, B.C.*, Dalton, C.R., Pikal, M.J. & Shamblin, S.L. A pragmatic test of a simple calorimetric method for determining the fragility of some amorphous pharmaceutical materials, Pharmaceutical Research 15 (1998) 762‑767 (Principal investigator) doi:10.1023/A:1011931305755.
20. Hancock, B.C.* Comments on “An approach to estimate the amorphous content of pharmaceutical powders using calorimetry with no calibration standards”, International Journal of Pharmaceutics 160 (1998) 131‑133 (Principal investigator) doi:10.1016/S0378-5173(97)00331-1.
21. Hancock, B.C.*, Christensen, K. & Shamblin, S.L. Estimating the critical molecular mobility temperature (TK) of amorphous pharmaceuticals, Pharmaceutical Research 15 (1998) 1649‑1651 (Principal investigator) doi:10.1023/A:1011983923386.
22. Hancock, B.C.* & Shamblin, S.L. Water vapour sorption by pharmaceutical sugars, Pharmaceutical Science and Technology Today 1 (1998) 345‑351 (Principal investigator).
23. Hancock, B.C.* & Rowe, R.C. Thermal expansion of pharmaceutical solids, S.T.P. Pharma 4 (1998) 213‑220 (Principal investigator).
24. Hancock, B.C.* & Dalton, C.R. The effect of temperature on water vapour sorption by some amorphous pharmaceutical sugars, Pharmaceutical Development and Technology 4 (1999) 125‑131 (Principal investigator).
25. Shamblin, S.L.*, Tang, X., Chang, L., Hancock, B.C. & Pikal, M.J. Characterisation of the timescales for molecular motions in pharmaceutically important glasses, Journal of Physical Chemistry B 103 (1999) 4113-4121 (Co‑investigator) doi:10.1021/jp983964+.
26. Hancock, B.C.*, Dupuis, Y. & Thibert, R. Determination of the viscosity of an amorphous drug using thermomechanical analysis (TMA), Pharmaceutical Research 16 (1999) 672-675 (Principal investigator)doi:10.1023/A:1018816406470.
27. Clas, S.-D.*, Dalton, C.R. & Hancock, B.C. Differential scanning calorimetry: applications in drug development, Pharmaceutical Science and Technology Today 2 (1999) 311-320 (Co‑investigator).
28. Shamblin, S.L.*, Hancock, B.C., Dupuis, Y. & Pikal, M.J. Interpretation of relaxation time constants for amorphous pharmaceutical systems, Journal of Pharmaceutical Sciences 89 (2000) 417-427. (Co‑investigator) doi:10.1002/(SICI)1520-6017(200003)89:3<417::AID-JPS12>3.0.CO;2-V.
29. Hancock, B.C.* & Parks, M. What is the true solubility advantage for amorphous pharmaceuticals?, Pharmaceutical Research 17 (2000) 397-404 (Principal investigator) doi:10.1023/A:1007516718048.
30. Hancock, B.C.*, Clas, S.-D. & Christensen, K. Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 1: The elasticity and fracture behavior of microcrystalline cellulose, International Journal of Pharmaceutics 209 (2000) 27-35 (Principal investigator) doi:10.1016/S0378-5173(00)00541-X.
31. Thibert, R.* & Hancock, B.C. The effects of milling upon the physicochemical properties and functional behavior of some disintegrants, S.T.P. Pharma 11 (2001) 123-128 (Co‑investigator).
32. Hancock, B.C.*, Carlson, G.T., Ladipo, D.D., Langdon, B.A. & Mullarney, M.P. The powder flow and compact mechanical properties of two recently developed matrix-forming polymers, Journal of Pharmacy and Pharmacology 53 (2001) 1193-1199 (Principal investigator) doi:10.1211/0022357011776630.
33. Hancock, B.C.* & Shamblin, S.L. Molecular mobility of amorphous pharmaceuticals determined using differential scanning calorimetry, Thermochimica Acta 380 (2001) 95-107 (Principal investigator).
34. Lal, G., Ash, C., Hay, K., Redston, M., Kwong, E., Hancock, B.C., Mak, T., Kargman, S., Evans, J.F. & Gallinger, S.* Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor, Cancer Research 61 (2001) 6131–6136 (Co‑investigator).
35. Hancock, B.C.* Disordered drug delivery: destiny, dynamics & the Deborah Number, Journal of Pharmacy & Pharmacology 54 (2001) 1-10 (Principal investigator).
36. Hancock, B.C.* Comparison of the mechanical properties of the crystalline and amorphous forms of a drug substance, International Journal of Pharmaceutics 241 (2001) 73-85 (Principal investigator) doi:10.1016/S0378-5173(02)00133-3.
37. Hancock, B.C.*, Shalaev, E.Y. & Shamblin, S.L. Polyamorphism: a pharmaceutical sciences perspective, Journal of Pharmacy & Pharmacology 54 (2001) 1151-1152 (Principal investigator) doi:10.1211/002235702320266343.
38. Hancock, B.C.*, Dalton, C.R. & Clas, S.-D. Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 2: The dynamic moduli of microcrystalline cellulose, International Journal of Pharmaceutics 228 (2001) 139-145 (Principal investigator) doi:10.1016/S0378-5173(01)00833-X.
39. Clas, S.-D.*, Dalton, C.R. & Hancock, B.C. Calorimetry in pharmaceutical research and development, Encyclopedia of Pharmaceutical Technology (2nd edition) (2002) (Co‑investigator).
40. Narayan, P.* and Hancock, B.C. The relationship between particle properties, mechanical behavior and surface roughness for pharmaceutical excipient compacts, Materials Science and Engineering A 355 (2003) 24-36 (Co‑investigator) doi:10.1016/S0921-5093(03)00059-5.
41. Cao, W.*, Mullarney, M.P., Hancock, B.C., Bates, S. & Morris, K.R. Modeling of transmitted X-ray intensity variation with sample thickness and solid fraction in glycine compacts, Journal of Pharmaceutical Sciences 92 (2003) 2345-2353 (Co‑investigator) doi:10.1002/jps.10480.
42. Mullarney, M.P.*, Hancock, B.C., Carlson, G.T., Ladipo, D.D. & Langdon, B.A. The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets, International Journal of Pharmaceutics 257 (2003) 227-236 (Co‑investigator) doi:10.1016/S0378-5173(03)00144-3.
43. Hancock, B.C.*, Colvin, J.T., Mullarney, M.P. & Zinchuk, A.V. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets, Pharmaceutical Technology 27 (2003) 64-80 (Principal investigator).
44. Zinchuk, A.V., Mullarney, M.P. & Hancock, B.C.* Simulation of roller compaction using a laboratory scale compaction simulator, International Journal of Pharmaceutics 269 (2004) 403-415 (Principal investigator) doi:10.1016/j.ijpharm.2003.09.034.
45. Narayan, P.* & Hancock, B.C. Response to Dr. Jurgen Malzbender’s comments on “The relationship between particle properties, mechanical behavior and surface roughness for pharmaceutical excipient compacts, Materials Science and Engineering A 364 (2004) 375-376 (Co‑investigator) doi:10.1016/j.msea.2003.08.001.
46. Hancock, B.C.*, Amorphous pharmaceutical systems, Encyclopedia of Pharmaceutical Technology (4th edition) (2004) (Principal investigator).
47. Hancock, B.C.*, Vukovinsky, K.E., Brolley, B., Grimsey, I., Hedden, D., Olsofsky, A. & Doherty, R.A. Development of a robust procedure for assessing powder flow using a commercial avalanche testing instrument, Journal of Pharmaceutical & Biomedical Analysis 35 (2004) 979–990 (Principal investigator) doi:10.1016/j.jpba.2004.02.035.
48. Mullarney, M.P.* & Hancock, B.C. Improving the prediction of exceptionally poor tableting performance: an investigation into Hiestand’s ‘special case’, Journal of Pharmaceutical Sciences 93 (2004) 2017-2021 (Co‑investigator) doi:10.1002/jps.20108.
49. Chen, R., Hancock, B.C.* & Shanker, R.M. Hypromellose acetate succinate monograph, Handbook of Pharmaceutical Excipients (5th edition) (2004) (Co‑investigator).
50. Hancock, B.C. & Mullarney, M.P.* Raffinose monograph, Handbook of Pharmaceutical Excipients (5th edition) (2004) (Co‑investigator).
51. Hancock, B.C.* & Mullarney, M.P. X-ray microtomography of solid dosage forms, Pharmaceutical Technology April (2005) 92-100 (Principal investigator).
52. Wu, C.*, Hancock, B.C., Elliott, J.A., Best, S.M., Bentham, A.C. & Bonfield, W. Finite element analysis of capping mechanisms during pharmaceutical powder compaction, Advances in Powder Metallurgy and Particulate Materials 1 (2005) 62 (Co‑investigator).
53. Wu, C.Y.*, Ruddy, O., Bentham, A.C., Hancock, B.C., Best, S.M. and Elliot, J.A. Modelling the mechanical behaviour of pharmaceutical powders during compaction, Powder Technology 152 (2005) 107-117 (Co‑investigator) doi:10.1016/j.powtec.2005.01.010.
54. Wu, C.Y.*, Best, S.M., Bentham, A.C., Hancock, B.C. and Bonfield, W. A simple predictive model for the tensile strength of binary tablets, European Journal of Pharmaceutical Sciences 25 (2005) 331‑336 (Co‑investigator).
55. Dutt, M. *, Hancock, B.C., Bentham, A.C. & Elliot, J.A. An implementation of granular dynamics for simulating frictional elastic particles based on the DL_POLY code, Computer Physics Communications 166 (2005) 26-44 (Co‑investigator) doi:10.1016/j.cpc.2004.10.006.
56. Zinchuk, A.V., Hancock, B.C.*, Shalaev, E.Y., Reddy, R.D., Govindarajan, R. & Novak, E. The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipient, European Journal of Pharmaceutics and Biopharmaceutics 61 (2005) 158‑170 (Principal investigator) doi:10.1016/j.ejpb.2005.04.008.
57. Clas, S.-D.*, Dalton, C.R. & Hancock, B.C. Calorimetry in pharmaceutical research and development, Encyclopedia of Pharmaceutical Technology (3rd edition) (2005) (Co‑investigator).
58. Kremer, D.K.* & Hancock, B.C. Process simulation in the pharmaceutical industry: a review of some basic physical models. Journal of Pharmaceutical Sciences 95 (2006) 517-529 (Co‑investigator) “The 10th Most Downloaded Article in Journal of Pharmaceutical Sciences in 2006” doi:10.1002/jps.20583.
59. Mullarney, M.P. * & Hancock, B.C. Mechanical property anisotropy of pharmaceutical excipient compacts. International Journal of Pharmaceutics 314 (2006) 9-14 (Co‑investigator) doi:10.1016/j.ijpharm.2005.12.052.
60. Fu, X.*, Elliot, J.A., Bentham, A.C., Hancock, B.C. & Cameron, R.E. Application of X-ray microtomography and image processing to the investigation of a compacted granular system. Particle and Particulate Systems Characterization 23 (2006) 1-8 (Co‑investigator).
61. Wildfong, P.L.D.*, Moore, M.D., Hancock, B.C. & Morris, K.R. Towards an understanding of the structurally based potential for mechanically activated disordering of small molecule organic crystals. Journal of Pharmaceutical Sciences 95 (2006) 2645-2656 (Co‑investigator) doi:10.1002/jps.20672.
62. Wu, C.Y.*, Best, S.M., Bentham, A.C., Hancock, B.C., Elliot, J.A. & Bonnfield, W. Predicting the tensile strength of multi-component pharmaceutical mixtures. Pharmaceutical Research 23 (2006) 898-1905 (Co‑investigator).
63. Boldyreva, E.V.*, Dmitriev, V. & Hancock, B.C. Effect of pressure up to 5.5 GPa on dry powder samples of chlorpropamide form-A. International Journal of Pharmaceutics 327 (2006) 51-57 (Co‑investigator) doi:10.1016/j.ijpharm.2006.07.019.
64. Elliot, J.A.* & Hancock, B.C. Pharmaceutical materials science: an active new frontier in materials research. Materials Research Society Bulletin 31 (2006) 869-873 (Principal investigator).
65. Narayan, P.*, Hancock, B.C., Hamel, R., Bergstom, T.S., Childs, B.E. & Brown, C.A. Differentiation of the surface topographies of pharmaceutical excipient compacts. Materials Science and Engineering A 430 (2006) 79-89 (Co‑investigator) doi:10.1016/j.msea.2006.05.135.
66. Govindarajan, R., Zinchuk, A., Hancock, B.C., Shalaev, E.Y. & Suryanarayanan, R. Ionization states in the microenvironment of solid dosage forms: effect of formulation variables and processing Pharmaceutical Research 23 (2006) 2454-2468 (Co‑investigator) doi:10.1007/s11095-006-9085-3.
67. Shamblin, S.L.*, Hancock, B.C. & Pikal, M.J. Coupling between chemical reactivity and structural relaxation in pharmaceutical glasses. Pharmaceutical Research 23 (2006) 2254-2268 (Co‑investigator) doi:10.1007/s11095-006-9080-8.
68. Hedden, D.B.*, Brone, D., Clement, S., McCall, M., Olsofsky, A. Patel, P., Prescott, J. & Hancock, B.C. Development of an improved fluidization segregation tester for use with pharmaceutical powders. Pharmaceutical Technology December (2006) 54-64 (Principal investigator).
69. Dutt, M.*, Elliot, J.A., Hancock, B.C. & Bentham, A.C. Granular templating: effects of boundary structure on particle packings under simultaneous shear and compression. European Physical Letters 77 (2007) 18001 (Co‑investigator).
70. Fu, X.*, Dutt, M., Bentham, A.C., Hancock, B.C., Cameron, R.E. & Elliot, J.E. Investigation of particle packing in model pharmaceutical powders using X-ray microtomography and discrete element analysis. Powder Technology 167 (2006) 134-140 (Co‑investigator) doi:10.1016/j.powtec.2006.06.011.
71. Carlson, G.T.* & Hancock, B.C. A comparison of physical and mechanical properties of common tableting diluents. In Excipient Development for Pharmaceutical, Biotechnology and Drug Delivery Systems. Edited by Katdare, A. & Chaubal, M.V., Informa Healthcare, New York (2006) 127-153 (Co‑investigator).
72. Ketterhagen, W.R.*, Curtis, J.S., Wassgren, C.R. & Hancock, B.C. Modeling granular segregation in flow from quasi-three-dimensional, wedge-shaped hoppers. Powder Technology 179 (2007) 126-143 (Co‑investigator) doi:10.1016/j.powtec.2007.06.023.
73. Ketterhagen, W.R.*, Curtis, J.S., Wassgren, C.R., Kong, A, Narayan, P.J. & Hancock, B.C. Granular segregation in discharging cylindrical hoppers: A discrete element and experimental study. Chemical Engineering Science 62 (2007) 6423-6439 (Co‑investigator) doi:10.1016/j.ces.2007.07.052.
74. Cao, X.*, Leyva, N., Anderson, S.R. & Hancock, B.C. Use of prediction methods to estimate true density of active pharmaceutical ingredients. International Journal of Pharmaceutics 355 (2007) 231-237 (Co‑investigator) doi:10.1016/j.ijpharm.2007.12.012.
75. Wu, C.Y.*, Hancock, B.C., Mills, A., Best, S.M., Bentham, A.C. & Elliot, J.A. Numerical and experimental investigation of capping mechanisms during pharmaceutical tablet compaction. Powder Technology 181 (2008) 121-129 (Co‑investigator) doi:10.1016/j.powtec.2006.12.017.
76. Yu, W.* & Hancock, B.C. Evaluation of dynamic image analysis for characterizing pharmaceutical excipient particles. International Journal of Pharmaceutics 361 (2008) 150-157 (Co‑investigator) doi:10.1016/j.ijpharm.2008.05.025.
77. Han, L.H.*, Elliott, J.A., Bentham, A.C., Mills, A., Amidon, G.E. & Hancock, B.C. A modified Ducker-Prager Cap model for die compaction simulation of pharmaceutical powders. International Journal of Solids and Structures 45 (2008) 3088-3106 (Co‑investigator) doi:10.1016/j.ijsolstr.2008.01.024.
78. Jewad, R.*, Bentham, A.C., Hancock, B.C., Bonfield, W. & Best, S.M. Dispersant selection for aqueous medium pressure injection moulding of anhydrous dicalcium phosphate. Journal of the European Ceramic Society 28 (2008) 547-553 (Co‑investigator) doi:10.1016/j.jeurceramsoc.2007.07.010.
79. Han, L.*, Elliott, J.A., Best, S.M., Cameron, R., Bentham, A.C., Mills, A., Amidon, G.E. & Hancock, B.C. Numerical simulation on pharmaceutical powder compaction. Materials Science Forum 575-578 (2008) 560 (Co‑investigator).
80. Vendola, T.* & Hancock, B.C. The effect of mill type on the performance of two dry granulated placebo formulations. Pharmaceutical Technology November (2008) 72-86 (Co‑investigator).
81. Anand, A.*, Curtis, J.S., Wassgren, C.R., Hancock, B.C. & Ketterhagen, W.R. Predicting discharge dynamics from a rectangular hopper using the discrete element method (DEM). Chemical Engineering Science 63 (2008) 5821-5830 (Co‑investigator) doi:10.1016/j.ces.2008.08.015.
82. Cao, X.*, Hancock, B.C., Leyva, N., Yu, W., Becker, J. & Masterson, V. Estimating the refractive index of pharmaceutical solids using predictive methods. International Journal of Pharmaceutics 368 (2009) 16–23 (Co‑investigator) doi:10.1016/j.ijpharm.2008.09.044.
83. Ketterhagen, W.R.*, am Ende, M.T. & Hancock, B.C. Process modeling in the pharmaceutical industry using the discrete element method. Journal of Pharmaceutical Sciences 98 (2009) 442–470 (Co‑investigator) doi:10.1002/jps.21466.
84. Hancock, B.C.*, Carlson, G.T., Langdon, B.A., Ladipo, D.L., Mullarney, M.P., & Vukovinsky K.E. Indentation measurements on compacted pharmaceutical powders: establishing the sources of variation in white light interferometer dent measurements. Journal of Testing & Evaluation 37 (2009) JTE102109 (Principal investigator) doi:10.1520/JTE102109.
85. Wasicki, J.*, Kozlenko, D.P., Pankov, S.E., Bilski, P., Pajzderska, A., Hancock, B.C., Medek, A., Nawrocik, W. & Savenko, B.N. NMR search for polymorphic phase transformations in chlorpropamide Form-A at high pressures. Journal of Pharmaceutical Sciences 98 (2009) 1426-1437 (Co‑investigator) doi:10.1002/jps.21471.
86. Hancock, B.C.* Achieving a perfect tablet formulation: evolution or intelligent design? American Pharmaceutical Review March (2009) 20-22 (Principal investigator).
87. Ketterhagen, W.R.*, Curtis, J.S., Wassgren, C.R. & Hancock, B.C. Predicting the flow mode from hoppers using the discrete element method (DEM). Powder Technology 195 (2009) 1-10 (Co‑investigator) doi:10.1016/j.powtec.2009.05.002.
88. Kodam, M.*, Bharadwaj, R., Curtis, J., Hancock, B.C. & Wassgren, C.R. Force model considerations for glued sphere DEM simulations. Chemical Engineering Science 64 (2009) 3466-3475 (Co‑investigator) doi:10.1016/j.ces.2009.04.025.
89. Akseli, I.*, Hancock, B.C. & Cetinkaya, C. Non-destructive determination of anisotropic mechanical properties of pharmaceutical solid dosage forms. International Journal of Pharmaceutics 377 (2009) 35-44 (Co‑investigator) doi:10.1016/j.ijpharm.2009.04.040.
90. Anand, A.*, Curtis, J.S., Wassgren, C., Hancock, B.C., & Ketterhagen, W.R. Predicting discharge dynamics of wet cohesive particles from a rectangular hopper using the discrete element method (DEM). Chemical Engineering Science 64 (2009) 5268-5275 (Co‑investigator) doi:10.1016/j.ces.2009.09.001.
91. Hancock, B.C.*, Mojica, N., St.John-Green, K., Elliott, J.A. & Bharadwaj, R. An investigation into the kinetic (sliding) friction of some tablets and capsules. International Journal of Pharmaceutics 384 (2010) 39-45 (Principal investigator) doi:10.1016/j.ijpharm.2009.09.038.
92. Sinha, T.*, Curtis, J.S., Hancock, B.C., & Wassgren, C. A study on the sensitivity of Drucker-Prager cap model parameters during the decompression phase of powder compaction simulations. Powder Technology 198 (2010) 315-324 (Co‑investigator) doi:10.1016/j.powtec.2009.10.025.
93. Ketterhagen, W.R.*, Bharadwaj, R. & Hancock, B.C. The coefficient of rolling friction (CoRR) of some pharmaceutical tablets. International Journal of Pharmaceutics 392 (2010) 107-110 (Co‑investigator) doi:10.1016/j.ijpharm.2010.03.039.
94. Cao, X.*, Morganti, M., Hancock, B.C. & Masterson, V.M. Correlating particle hardness with powder compaction performance. Journal of Pharmaceutical Sciences 99 (2010) 4307-4316 (Co‑investigator) doi:10.1002/jps.22130.
95. Rao, A.*, Curtis, J.S., Hancock, B.C. & Wassgren, C. The effect of column diameter and bed height on minimum fluidization velocity. AIChE Journal 56 (2010) 2304-2311 (Co‑investigator) doi:10.1002/aic.12161.
96. Sinha, T.*, Curtis, J.S., Hancock, B.C., Bharadwaj, R. & Wassgren, C. Finite element analysis of pharmaceutical tablet compaction using a modified material plasticity model. Powder Technology 202 (2010) 46-54 (Co‑investigator) doi:10.1016/j.powtec.2010.04.001.
97. Ketterhagen, W.R.* & Hancock, B.C. Optimizing the design of eccentric feed hoppers for tablet presses using DEM. Computers and Chemical Engineering 34 (2010) 1072-1081 (Co‑investigator) doi:10.1016/j.compchemeng.2010.04.016.
98. Anand, A.*, Curtis, J.S., Wassgren, C., Hancock, B.C. and Ketterhagen, W.R., 2010. Segregation of cohesive granular materials during discharge from a rectangular hopper. Granular Matter 12 (2010) 193 (Co‑investigator) doi:10.1007/s10035-010-0168-9.
99. Kodam, M.*, Bharadwaj, R., Curtis, J.S., Hancock, B.C. & Wassgren, C. Cylindrical object contact detection for use in discrete element method simulations. Part 1 – Contact detection algorithms. Chemical Engineering Science 65 (2010) 5852 (Co‑investigator) doi:10.1016/j.ces.2010.08.006.
100. Bharadwaj, R.*, Ketterhagen, W.R, & Hancock, B.C. Discrete element simulations of a powder rheometer: a study of particle property effects. Chemical Engineering Science 65 (2010) 5747 (Co‑investigator) doi:10.1016/j.ces.2010.04.002.
101. Kodam, M.*, Bharadwaj, R., Curtis, J.S., Hancock, B.C. & Wassgren, C. Cylindrical object contact detection for use in discrete element method simulations. Part 2 – Experimental validation. Chemical Engineering Science 65 (2010) 5863 (Co‑investigator) doi:10.1016/j.ces.2010.08.007.
102. Smith, C.J., Stephens, J.D., Hancock, B.C., Vahdat, A.S. & Cetinkaya, C. Acoustic assessment of mean grain size in pharmaceutical compacts. International Journal of Pharmaceutics 419 (2011) 137 (Co-investigator) doi:10.1016/j.ijpharm.2011.07.032.
103. Hancock, B.C. & Ketterhagen, W.R, Discrete Element Method (DEM) simulations of stratified sampling during solid dosage form manufacturing. International Journal of Pharmaceutics 418 (2011) 265 (Principal investigator) doi:10.1016/j.ijpharm.2011.05.042.
104. Antypov, D., Elliot, J.E. & Hancock, B.C. Effect of particle size on energy dissipation in viscoelastic granular collisions. Physical Review E 84 (2011) 021303 (Co-investigator) doi:10.1103/PhysRevE.84.021303.
105. Rao, A, Curtis, J.S., Hancock, B.C. & Wassgren, C. Classifying the fluidization and segregation behavior of binary mixtures using particle size and density ratios. AIChE Journal 57 (2011) 1446 (Co‑investigator) doi:10.1002/aic.12371.
106. Hancock, B.C., Morris, K.R. & Wildfong, P.L.D. Editorial: A priori performance predictions in the pharmaceutical sciences. International Journal of Pharmaceutics 418 (2011) 149 (Principal investigator) doi:10.1016/j.ijpharm.2011.06.023.
107. Kichanov, S,. Kozlenko, D., Bilski, P., Wąsicki, J., Nawrocik, W., Medec A., Hancock, B., Lukin, E., Lathe, C., Dubrovinsky, L. & Savenko, B. The polymorphic phase transformations in resorcinol at high pressure. Journal of Molecular Structure 1006 (2011) 337 (Co‑investigator) doi:10.1016/j.molstruc.2011.09.029.
108. Kodam, M., Curtis, J., Hancock, B.C. & Wassgren, C. Discrete element method modeling of bi-convex pharmaceutical tablets: Contact detection algorithms and validation. Chemical Engineering Science 69 (2012) 587 (Co-investigator) doi:10.1016/j.ces.2011.11.011.
109. Rao, A., Curtis, J.S., Hancock, B.C. & Wassgren, C. Numerical simulation of dilute turbulent gas-particle flow with turbulence modulation. AIChE Journal 58 (2012) 1381 (Co-investigator) doi:10.1002/aic.12673.
110. Guo, Y., Wassgren, C., Ketterhagen, W., Hancock, B., & Curtis, J. Some computational considerations associated with discrete element modeling of cylindrical particles. Powder Technology 228 (2012) 193 (Co‑investigator) doi:10.1016/j.powtec.2012.05.015.
111. Guo, Y., Wassgren, C., Ketterhagen, W., Hancock, B., James, B. & Curtis, J. A numerical study of granular shear flows of rod-like particles using the discrete element method. Journal of Fluid Mechanics 713 (2012) 1 (Co‑investigator) doi:10.1017/jfm.2012.423.
112. Maranzano, B.J., Kaul, G. & Hancock, B.C. Rapid method for measuring the mechanical properties of pharmaceutical compacts. Powder Technology 236 (2013) 205 (Co‑investigator) doi:10.1016/j.powtec.2012.02.002.
113. Stephens, J.D., Lakshmaiaha, M.V., Kowalczyk, B.R., Hancock, B.C. & Cetinkaya, C. Wireless transmission of ultrasonic waveforms for monitoring drug tablet properties and defects. International Journal of Pharmaceutics 442 (2013) 35 (Co‑investigator) doi:10.1016/j.ijpharm.2012.08.050.
114. Stephens, J.D., Kowalczyk, B.R., Hancock, B.C., Kaul, G. & Cetinkaya, C. Ultrasonic real-time in-die monitoring of the tablet compaction process - A proof of concept study. International Journal of Pharmaceutics 442 (2013) 20 (Co‑investigator) doi:10.1016/j.ijpharm.2012.09.014.
115. Hancock, B.C. & Garcia-Munoz, S. How do formulation and process parameters impact blend and unit dose uniformity? Further analysis of the PQRI BUWG industry survey. Journal of Pharmaceutical Sciences 102 (2013) 982 (Principal investigator) doi:10.1002/jps.23426.
116. Rao, A., Curtis, J.S., Hancock, B.C. & Wassgren, C. Effect of Stokes number on dilute turbulent liquid-solid flow. An experimental and numerical study. AIChE Journal In press (2013) (Co‑investigator).
117. Amidon, G.E.*, Bharadwaj, R, Hancock, B.C. & Sun, C. Mechanical performance of pharmaceutical products, Accepted to be published in Pharmaceutical Materials Science: Principles, Characterization Methods, and Applications, Edited by Li, J.X. & Lee, P.I. (2010) (Co‑investigator).
Patents and Regulatory Filings
1. Hancock, B.C., Winters, C., Gertz, B. & Gottesdiener, K. Pharmaceutical compositions containing sulfonylphenylfuranone derivatives for a once a day treatment of cyclooxygenase-2 mediated diseases, World Patent 9744027 (1997).
2. Hancock, B.C., Winters, C., Gertz, B. & Ehrich, E. Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases, World Patent 9744028 (1997).
3. Expert Report on the Pharmaceutical and Chemical Documentation for VIOXXä (rofecoxib) tablets (12.5, 25 & 50 mg strengths) Merck & Co., PA, USA. Contributing author (1998).
4. New Drug Application for VIOXXä (rofecoxib) tablets (12.5, 25 & 50 mg strengths), Merck & Co., PA, USA. Contributing author (1998).
5. Babcock, W., Friesen, D., Lorenz, D., Macri, C., Nightingale, J.S.A., Shanker, R., Hancock, B.C. & Crew, M.D. Inhibitor of glycogen phosphorylase, World Patent 168092 (2001).
6. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A., Prescott, J.K. & Troxell, T.G. Fluidization segregation tester, US Patent 6,487,921 (2002).
7. Hancock, B.C., Schadtle, S.C., Appel, L.E., Byers, J.E., Crew, M.D. & Friesen, D.T. Immediate release dosage forms containing solid drug dispersions, European Patent 1,469,829 (2004).
8. Crew, M.D., Friesen, D.T., Hancock, B.C., Macri, C., Nightingale, J.A.S., Shankar, R.M., Hancock, B. & Crew, M. Pharmaceutical compositions of a sparingly soluble glycogen phyosphorylase inhibitor, US Patent 7,235,260 (2007).
9. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A. & Prescott, J.K. Method and apparatus for the segregation testing of particulate solids, US Patent 7,240,575 (2007).
10. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A., Prescott, J.K. & Troxell, T.G. Segregation testing apparatus for powder and granular materials, US Patent 7,347,111 (2008).
11. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A., Prescott, J.K. & Troxell, T.G. Method of segregation testing a mixture of particulate solids, US Patent 7,461,566 (2008).
12. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A., Prescott, J.K. & Troxell, T.G. Method and apparatus for segregation testing of particulate solids, US Patent 7,581,458 (2009).
13. Brone, D.L., Clement, S.A., Hancock, B.C., Hedden, D.B., McCall, M.A., Prescott, J.K. & Troxell, T.G. Method of uniformly supplying a mixture of particulate solids, US Patent 7,651,007 (2010).
14. Friesen, D.T., Lyon, D.K. , Lorenz, D.A., Hancock, B.C., McDermott, T.J. & Shanker, R.M. Dosage forms comprising a CETP inhibitors and an HMG-CoA reductase inhibitor, US Patent 7,897,175 (2011).
15. Common Technical Document for XELJANZä (tofacitinib) tablets (5 & 10 mg strengths), Pfizer Inc., NY, USA. Contributing author (2012).