Publications
2024
YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
Joseph S Bowness, Mafalda Almeida, Tatyana B Nesterova, Neil Brockdorff
EMBO Reports (2024); https://doi.org/10.1038/s44319-024-00136-3 [Article]
RNA m6A modification, signals for degradation or stabilisation?
Guifeng Wei
Biochem Soc Trans 2024; BST20230574, doi: https://doi.org/10.1042/BST20230574 [Review]
2023
YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
Joseph S Bowness, Mafalda Almeida, Tatyana B Nesterova, Neil Brockdorff
BioRxiv DOI: https://doi.org/10.1101/2023.11.22.568288; 2023.11.22.568288 [Preprint]
2022
Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
Bowness J S, Nesterova T B, Wei G, Rodermund L, Almeida M, Coker H, Carter E J, Kadaster A, Brockdorff N
Cell Reports 2022, May 17, V.39, Issue 7 DOI:https://doi.org/10.1016/j.celrep.2022.1108308 [Article]
2021
Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
Bowness J S, Nesterova T B, Wei G, Rodermund L, Almeida M, Coker H, Carter E J, Kadaster A, Brockdorff N
BioRxiv DOI: https://doi.org/10.1101/2021.11.02.466758 [Preprint]
Acute depletion of METTL3 implicates N6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
Wei G, Almeida M, Pintacuda G, Coker H, Bowness J, Ule J, Brockdorff N
Genome Research 2021, published in advance June 15, 2021 doi: 10.1101/gr.271635.120 [Article]
Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading
Rodermund L, Coker H, Oldenkamp R, Wei G, Bowness J, Rajkumar B, Nesterova T, Pinto D, Schermelleh L, Brockdorff N
Science 2021, volume 372, Issue 6547, eabe7500 DOI: 10.1126/science.abe7500 [Article]
High throughput sequencing data generated in this study can be accessed via GSE154658
Xist repeats B and C, but not repeat A, mediate de novo recruitment of the Polycomb system in X chromosome inactivation
Wei G, Almeida M, Bowness JS, Nesterova TB, Brockdorff N
Developmental Cell 2021, volume 56, p.1234-1235 DOI: https://doi.org/10.1016/j.devcel.2021.04.009 [Letter]
2020
Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading
Rodermund L, Coker H, Oldenkamp R, Wei G, Bowness J, Rajkumar B, Nesterova T, Pinto D, Schermelleh L, Brockdorff N
BioRxiv DOI: https://doi.org/10.1101/2020.11.24.396473 [Preprint]
The PWWP2A histone deacetylase complex represses intragenic spurious transcription initiation in mESCs
Wei G, Brockdorff N, Zhang T
iSCIENCE Published: October 29, 2020 DOI:https://doi.org/10.1016/j.isci.2020.101741 [Article]
Progress toward understanding chromosome silencing by Xist RNA
Brockdorff N, Bowness J S, Wei G
Genes & Development 2020, volume 34, p.733-744 [Review]
The many faces of Polycomb regulation by RNA
Almeida A, Bowness J S, Brockdorff N
Current Opinion in Genetics and Development 2020, volume 61, p.53-61 [Review]
The role of the Xist 5’ m6a region and RBM15 in X chromosome inactivation
Coker H, Wei G, Moindrot B, Mohammed S, Nesterova T, Brockdorff N
Wellcome Open Res 2020, volume 5, Article number: 31 DOI: https://doi.org/10.12688/wellcomeopenres.15711.1 [Article]
2019
Localized accumulation of Xist RNA in X chromosome inactivation
Brockdorff N
Open Biology 2019, volume 9, Article number: 190213 DOI: http://dx.doi.org/10.1098/rsob.190213 [Review]
Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
Nesterova TB, Wei G, Coker H, Pintacuda G, Bowness JS, Zhang T, Almeida M, Bloechl B, Moindrot B, Carter EJ, Alvarez-Rodrigo I, Pan Q, Bi Y, Song C-X and Brockdorff N
Nature Communications 2019, volume 10, Article number: 3129 DOI: https://doi.org/10.1038/s41467-019-11171-3 [Article]
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N
Nature Communications 2019, volume 10, Article number: 30 DOI: https://doi.org/10.1038/s41467-018-07907-2 [Article]
2018
m6A modification of non-coding RNA and the control of mammalian gene expression
Coker H, Wei G, Brockdorff N
Biochim Biophys Acta Gene Regul Mech 2018, Dec 11;pii: S1874-9399(18)30319-5. doi: 10.1016/j.bbagrm.2018.12.002. [Epub ahead of print]. [Review]
Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
Nesterova TB, Wei G, Coker H, Pintacuda G, Bowness JS, Zhang T, Almeida M, Bloechl B, Moindrot B, Carter EJ, Alvarez Rodrigo I, Pan Q, Bi Y, Song C-X, Brockdorff N
BioRxiv DOI: https://doi.org/10.1101/477232 [Preprint]
Local tandem repeat expansion in Xist RNA as a model for the functionalisation of ncRNA
Brockdorff N
Noncoding RNA 2018, Oct 19;4(4). pii: E28. DOI: 10.3390/ncrna4040028. [Review]
Unbiased genetic screen to identify factors involved in X-chromosome inactivation using a pooled bar-coded shRNA library
Moindrot B and Brockdorff N
In: Sado T. (eds) X-Chromosome Inactivation: Methods and Protocols. Methods in Molecular Biology, 2018, vol 1861. Humana Press, New York, NY
http://doi.org/10.1007/978-1-4939-8766-5_2
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Zhang T, Wei G, Millard CJ, Fischer R, Konietzny R, Kessler BM, Schwabe JWR and Brockdorff N
Nature Communications 2018, volume 9, Article number: 3798 DOI: 10.1038/s41467-018-06235-9 [Article]
The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome
Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N
BioRxiv DOI: https://doi.org/10.1101/342147 [Preprint]
2017
hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish Polycomb-mediated chromosomal silencing
Pintacuda G, Wei G, Roustan C, Kirmizitas BA, Solcan N, Cerase A, Castello A, Mohammed S, Moindrot B, Nesterova TB and Brockdorff N
Molecular Cell 2017, 68: 955–969 https://doi.org/10.1016/j.molcel.2017.11.013 [Article]
Polycomb complexes in X chromosome inactivation
Brockdorff N
Phil. Trans. R. Soc. B 2017, 372: 20170021. http://dx.doi.org/10.1098/rstb.2017.0021 [Article]
PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation
Almeida M, Pintacuda G, Masui O, Koseki Y, Gdula M, Cerase A, Brown D, Mould A, Nakayama M, Schermelleh L, Nesterova TB, Koseki H, Brockdorff N
Science 2017, 356: 1081–1084 DOI: 10.1126/science.aal2512 [Article]
The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory
Ridings-Figueroa R, Stewart ER, Nesterova TB, Coker H, Pintacuda G, Godwin J, Wilson R, Haslam A, Lilley F, Ruigrok R, Bageghni SA, Albadrani G, Mansfield W, Roulson J-A, Brockdorff N, Ainscough JFX, Coverley D
Genes Dev. 2017, 31: 1–13 DOI: 10.1101/gad.295907.117 [Article]
2016
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N
Nature Communications. 2016, 7:13661 DOI: 10.1038/ncomms13661 [Article]
The molecular mechanism of X chromosome inactivation
Brockdorff, N
The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London . 2016. [Talk]
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
Grijzenhout A, Godwin J, Koseki H, Gdula M, Szumska D, McGouran JF, Bhattacharya S, Kessler BM, Brockdorff N, Cooper S
Development. 2016, Aug 1;143(15):2716-23 doi: 10.1242/dev.123935. [Article]
RNA binding proteins implicated in Xist-mediated chromosome silencing
Moindrot B, Brockdorff N
Semin Cell Dev Biol. 2016, Jan 24. pii: S1084-9521(16)30029-5.doi: 10.1016/j.semcdb.2016.01.029.[Epub ahead of print] [Article]
2015
The interplay of histone modifications – writers that read
Zhang T, Cooper S, Brockdorff N
EMBO reports 2015, Oct 15. pii: e201540945. [Epub ahead of print] [Article]
Independent mechanisms target SmcHD1 to H3K9me3-modified chromatin and the inactive X chromosome
Brideau NJ, Coker H, Gendrel A-V, Siebert A, Bezstarosti K, Demmers J, Poot RA, Nesterova TB, Brockdorff N
Molecular and Cellular Biology 2015, September, 21. doi:10.1128/MCB.00432-15. [Article]
A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing
Moindrot B, Cerase A, Coker H, Masui O, Grijzenhout A, Pintacuda G, Schermelleh L, Nesterova TB, Brockdorff N
Cell Reports 2015, July, V.12, Issue 4: p562–572. DOI: http://dx.doi.org/10.1016/j. [Article]
Illuminating Xist
Coker H, Moindrot B, Pintacuda G, Brockdorff N
Biochemist 2015, VOLUME 37 NO 2 April. [Abstract]
Dosage compensation in mammals
Brockdorff N, Turner BM
Cold Spring Harb Perspect Biol. 2015 Mar 2;7(3):a019406. doi: 10.1101/cshperspect.a019406. [Abstract]
2014
Targeting Polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge N P, De Marco V, Elderkin S, Koseki H, Klose R, Heger A, Brockdorff N
Cell Reports 2014, June, V.7, Issue 5:1456–1470. [Article]
SmcHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks
Coker H, Brockdorff N
J Cell Sci. 2014 May 1.127: 1869-1874. [Article]
Spatial separation of Xist RNA and Polycomb proteins revealed by superresolution microscopy
Cerase A, Smeets D, Tang YA, Gdula M, Kraus F, Spivakov M, Moindrot B, Leleu M, Tattermusch A, Demmerle J, Nesterova TB, Green C, Otte AP, Schermelleh L, Brockdorff N
Proc Natl Acad Sci U S A 2014 Feb 11;111(6):2235-40. [Article]
2013
Genome-wide shRNA screening to identify factors mediating Gata6 repression in mouse embryonic stem cells
Cooper S, Brockdorff N
Development 2013 Oct 1; 140: 4110-4115. [Article]
Chromatin sampling — an emerging perspective on targeting Polycomb repressor proteins
Klose RJ, Cooper S, Farcas AM, Blackledge NP, Brockdorff N
PLoS Genet. 2013 9(8): e1003717. doi:10.1371/journal.pgen.1003717 [Article]
Epigenetic functions of SmcHD1 repress gene clusters on the inactive X chromosome and on autosomes
Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N
Mol Cell Biol. 2013 Aug;33(16):3150-65. [Article]
Noncoding RNA and Polycomb recruitment
Brockdorff N
RNA 2013 Apr;19(4):429-42. doi: 10.1261/rna.037598.112. Epub 2013 Feb 19. Review [Article]
Advances in understanding chromosome silencing by the long non-coding RNA Xist
Sado T, Brockdorff N
Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368 (1609):20110325. Review [Article]
2012
SmcHD1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome
Gendrel AV, Apedaile A, Coker H, Termanis A, Zvetkova I, Godwin J, Tang YA, Huntley D, Montana G, Taylor S, Giannoulatou E, Heard E, Stancheva I, Brockdorff N
Dev Cell 2012, Volume 23, Issue 2, p265–279. [Article] [Supplementary files]
RYBP-PRC1 complexes mediate H2A ubiquitylation at Polycomb target sites independently of PRC2 and H3K27me3
Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J, Bezstarosti K, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N
Cell 2012 Feb 17;148(4):664-78. [Article]
2011
Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns
Brockdorff N
Development 2011 Dec;138(23):5057-65. Review [Article]
Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated ES cells
Nesterova TB, Senner CE, Schneider J, Alcayna-Stevens T, Tattermusch A, Hemberger M, Brockdorff N
Epigenetics Chromatin 2011 Oct 7;4(1):17. [Article]
A scaffold for X chromosome inactivation
Tattermusch A, Brockdorff N
Hum Genet. 2011 Aug;130(2):247-53. [Article]
Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation
Senner CE, Nesterova TB, Norton S, Dewchand H, Godwin J, Mak W, Brockdorff N
Development 2011 Apr;138(8):1541-50. [Article]
Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells
Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, Appanah R, Bezstarosti K, Demmers J, Koseki H, Brockdorff N
Development 2011 Apr;138(8):1471-82. [Article]
2010
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA polymerase II to developmental regulators
Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jorgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AG
Nat Cell Biol. 2010, 12:618-624. [Article]
Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
Tang YA, Huntley D, Montana G, Cerase A, Nesterova TB, Brockdorff N
Epigenetics Chromatin 2010, 3:10. [Article]
2009
Transcription initiation activity sets replication origin efficiency in mammalian cells
Sequeira-Mendes J, Diaz-Uriarte R, Apedaile A, Huntley D, Brockdorff N, Gomez M
PLoS Genet. 2009, 5:e1000446. [Article]
Xist gene regulation at the onset of X inactivation
Senner CE, Brockdorff N
Curr Opin Genet Dev. 2009, 19:122-126. [Abstract]
Fgf4 independent derivation of trophoblast stem cells from the common vole
Grigor'eva EV, Shevchenko AI, Mazurok NA, Elisaphenko EA, Zhelezova AI, Shilov AG, Dyban PA, Dyban AP, Noniashvili EM, Slobodyanyuk SY, Nesterova Tb, Brockdorff N, Zakian SM
PLoS ONE 2009, 4:e7161. [Article]
SAT in silence
Brockdorff N
Dev Cell 2009, 16:483-484. [Article]
2008
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a
Nesterova TB, Popova BC, Cobb BS, Norton S, Senner CE, Tang YA, Spruce T, Rodriguez TA, Sado T, Merkenschlager M, Brockdorff N
Epigenetics Chromatin 2008, 1:2 [Article]
Genome environment browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome features
Huntley D, Tang YA, Nesterova TB, Butcher S, Brockdorff N
BMC Bioinformatics 2008, 9:501. [Article]
A dual origin of the Xist gene from a protein-coding gene and a set of transposable elements
Elisaphenko EA, Kolesnikov NN, Shevchenko AI, Rogozin IB, Nesterova TB, Brockdorff N, Zakian SM
PLoS ONE 2008, 3:e2521. [Article]
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
Blewitt ME, Gendrel AV, Pang Z, Sparrow DB, Whitelaw N, Craig JM, Apedaile A, Hilton DJ, Dunwoodie SL, Brockdorff N, Kay GF, Whitelaw E
Nat Genet. 2008, 40:663-669. [Abstract]
2007
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
Stock JK, Giadrossi S, Casanova M, Brookes E, Vidal M, Koseki H, Brockdorff N, Fisher AG, Pombo A
Nat Cell Biol. 2007, 9:1428-1435. [Abstract]
Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials
Shevchenko AI, Zakharova IS, Elisaphenko EA, Kolesnikov NN, Whitehead S, Bird C, Ross M, Weidman JR, Jirtle RL, Karamysheva TV, Rubtsov, N. B., VandeBerg, J. L., Mazurok, N. A., Nesterova, T. B., Brockdorff N, Zakian SM
Chromosome Res. 2007, 15:127-136. [Article]
A phosphorylated form of mel-18 targets the ring1b histone h2a ubiquitin ligase to chromatin
Elderkin S, Maertens GN, Endoh M, Mallery DL, Morrice N, Koseki H, Peters G, Brockdorff N, Hiom K
Mol Cell 2007, 28:107-120. [Article]
Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cells
de Napoles M, Nesterova T, Brockdorff N
PLoS ONE 2007, 2:e860. [Article]
2006
Attenuated spread of X-inactivation in an X;autosome translocation
Popova BC, Tada T, Takagi N, Brockdorff N, Nesterova TB
Proc Natl Acad Sci U S A 2006, 103:7706-7711. [Article]
2005
Global hypomethylation of the genome in XX embryonic stem cells
Zvetkova I, Apedaile A, Ramsahoye B, Mermoud JE, Crompton LA, John R, Feil R, Brockdorff N
Nat Genet. 2005, 37:1274-1279. [Abstract]
Composition and histone substrates of Polycomb repressive group complexes change during cellular differentiation
Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, Ouyang X, Brockdorff N, Abate-Shen C, Farnham P, Reinberg D
Proc Natl Acad Sci U S A 2005, 102:1859-1864. [Article]
T cell lineage choice and differentiation in the absence of the RNnase III enzyme Dicer
Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale ST, Merkenschlager M
J Exp Med. 2005, 201:1367-1373. [Article]
2004
Reactivation of the paternal X chromosome in early mouse embryos
Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N
Science 2004, 303:666-669. [Article] [Supplementary files]
Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage
Gomez M, Brockdorff N
Proc Natl Acad Sci U S A 2004, 101:6923-6928. [Article]
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki, H., Brockdorff, N
Dev Cell 2004, 7:663-676. [Article]
2003
Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 Polycomb group complexes
Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N
Dev Cell. 2003, 4:481-495. [Article]
Skewing chromosome choice by modulating sense transcription across the Xist locus
Nesterova TB, Johnston CM, Appanah R, Newall AE, Godwin J, Alexiou M, Brockdorff N
Genes Dev. 2003, 17:2177-2190. [Article]
2002
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
Peters AH, Mermoud JE, O'Carroll D, Pagani M, Schweizer D, Brockdorff N, Jenuwein T
Nat Genet.2002, 30:77-80. [Abstract]
Xist expression and macroH2A1.2 localisation in mouse primordial and pluripotent embryonic germ cells
Nesterova TB, Mermoud JE, Hilton K, Pehrson J, Surani MA, McLaren A, Brockdorff N
Differentiation. 2002, 69:216-225. [Article]
Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation
Mermoud JE, Popova B, Peters AH, Jenuwein T, Brockdorff N
Curr Biol. 2002, 12:247-251. [Article]
Mitotically stable association of Polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells
Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N
Curr Biol. 2002, 12:1016-1020. [Article]
Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivation
Johnston CM, Newall AE, Brockdorff N, Nesterova TB
Genomics. 2002, 80:236-244. [Article]
Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes
Goto Y, Gomez M, Brockdorff N, Feil R
Cytogenet Genome Res. 2002, 99:66-74. [Article]
Functional analysis of the highly conserved exon IV of Xst RNA
Brockdorff N
Trends Genet. 2002, 18:352-358. [Abstract]
2001
Primary non-random X inactivation associated with disruption of Xist promoter regulation
Newall AE, Duthie S, Formstone E, Nesterova T, Alexiou M, Johnston C, Caparros ML, Brockdorff N
Hum Mol Genet.2001, 10:581-589. [Article]
Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence
Nesterova TB, Slobodyanyuk SY, Elisaphenko EA, Shevchenko AI, Johnston C, Pavlova ME, Rogozin IB, Kolesnikov NN, Brockdorff N, Zakian SM
Genome Res. 2001, 11:833-849. [Article]
Loss of Xist imprinting in diploid parthenogenetic preimplantation embryos
Nesterova TB, Barton SC, Surani MA, Brockdorff N
Dev Biol. 2001, 235:343-350. [Article]
Centrosomal association of histone macroH2A1.2 in embryonic stem cells and somatic cells
Mermoud JE, Tassin AM, Pehrson JR, Brockdorff N
Exp Cell Res. 2001, 268:245-251. [Article]
1999
Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation
Mermoud JE, Costanzi C, Pehrson JR, Brockdorff N
J Cell Biol.1999, 147:1399-1408. [Article]
Chromatin structure analysis of the mouse Xist locus
McCabe V, Formstone EJ, O'Neill LP, Turner BM, Brockdorff N
Proc Natl Acad Sci U S A. 1999, 96:7155-7160. [Article]
Xist RNA exhibits a banded localization on the inactive X chromosome and is excluded from autosomal material
in cis
Duthie SM, Nesterova TB, Formstone EJ, Keohane AM, Turner BM, Zakian SM, Brockdorff N
Hum Mol Genet 1999, 8:195-204. [Article]
1998
Repetitive DNA sequences in the common vole: cloning, characterization and chromosome localization of two novel complex repeats MS3 and MS4 from the genome of the East European vole Microtus rossiaemeridionalis
Elisaphenko EA, Nesterova TB, Duthie SM, Ruldugina OV, Rogozin IB, Brockdorff N, Zakian SM
Chromosome Res. 1998, 6:351-360. [Abstract]
Developmentally regulated Xist promoter switch mediates initiation of X inactivation
Johnston CM, Nesterova TB, Formstone EJ, Newall AE, Duthie SM, Sheardown SA, Brockdorff N
Cell. 1998, 94:809-817. [Article]
The role of Xxist in X-inactivation
Brockdorff N
Curr Opin Genet Dev. 1998, 8:328-333. [Abstract]
Comparative mapping of X chromosomes in vole species of the genus Microtus
Nesterova TB, Duthie SM, Mazurok NA, Isaenko AA, Rubtsova NV, Zakian SM, Brockdorff N
Chromosome Res 1998, 6:41-48. [Abstract]
X chromosome inactivation and the Xist gene
Brockdorff N, Duthie SM
Cell Mol Life Sci. 1998, 54:104-112. [Abstract]
1997
Regulatory elements in the minimal promoter region of the mouse Xist gene
Sheardown SA, Newall AE, Norris DP, Rastan S, Brockdorff N
Gene. 1997, 203:159-168. [Article]
Stabilization of Xist RNA mediates initiation of X chromosome inactivation
Sheardown SA, Duthie SM, Johnston CM, Newall AE, Formstone EJ, Arkell RM, Nesterova TB, Alghisi GC, Rastan S, Brockdorff N
Cell. 1997, 91:99-107. [Article]
1996
Requirement for Xist in chromosome inactivation
Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N
Nature 1996, 379:131-137. [Abstract]
The mouse Smcx gene exhibits developmental and tissue specific variation in degree of escape from X inactivation
Sheardown S, Norris D, Fisher A, Brockdorff N
Hum Mol Genet. 1996, 5:1355-1360. [Article]