The laboratory, headed by Neil Brockdorff, is a part of the Department of Biochemistry, University of Oxford. We count our age from 1994, when the group settled down in London at MRC Clinical Sciences Centre where it spent 14 interesting and productive years. The group moved to Oxford in 2008 to be a part of one of the UK's largest Biochemistry Department.
Our friendly international team consists of postdoctoral fellows, research assistants and postgraduate students and we also regularly provide a training ground for the University undergraduate students. We are interested in epigenetic processes and their role in determination and maintenance of cell identity in multicellular organisms. Much of our work is focused on X chromosome inactivation, the process mammals use to equalise levels of X linked genes in XX females relative to XY males. Beyond this we are interested in recruitment and function of polycomb repressor proteins and in regulation of DNA methylation at CpG islands. Further details are given on the Research page.
Our work uses a wide range techniques in genetics, cell biology, molecular biology, biochemistry, and embryology. The lab is affiliated with Micron Oxford, an initiative to develop and apply advanced microscopy in chromosome, cell and developmental biology.