The laboratory, headed by Neil Brockdorff, is a part
of the Department of Biochemistry, University of Oxford. We count our age from 1994,
when the group settled down in London at MRC Clinical Sciences
Centre where it spent 14 interesting and productive years. The group moved to Oxford in 2008 to be a part of one
of the UK's largest Biochemistry Department.
Our friendly international team consists of postdoctoral fellows, research assistants and postgraduate students and we also regularly provide a training ground for the University undergraduate students. We are interested in epigenetic regulation of the genome in the context of determining and maintaining cell identity in multicellular organisms. Much of our work is focused on X chromosome inactivation, the process that has evolved in mammals to equalise expression levels of X-linked genes in XX females relative to XY males. Through this work we have developed projects aimed at understanding recruitment and function of polycomb repressor proteins and the regulation of DNA methylation at CpG islands. Further details are given on the Research page.
Our work uses a wide range techniques in genetics, cell biology, molecular biology, biochemistry, and embryology. The lab is affiliated with Micron Oxford, an initiative to develop and apply advanced microscopy in chromosome, cell and developmental biology.