The Cooper lab started a new venture in large-scale, non-targeted metabolomics in 2022 with the acquisition of an Exploris 240 mass spectrometer. This technology will be used to identify compounds in plants that confer disease resistance and to determine how plant disease resistance compounds alter the metabolisms of plant pathogens. Coupled with proteomics data, metabolomics data will help extend biological systems information.
Papers:
Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans (2026). Bret Cooper, Ronghui Yang, and Kimberly B. Campbell. Scientific Reports. 16: 3606. Published on-line December 30, 2025. DOI: 10.1038/s41598-025-33515-4. [1,076 on-line accesses in the first 30 days of publication.]
A splicing regulator, SR45, suppresses plant immunity by regulating salicylic acid pathway in Arabidopsis thaliana (2025). Audrey Bui, Arden Bui, Iesh Gujral, Serena Fan, Anthony Long, Anna Hu, Christopher Chin, Jordan Powers, Ronghui Yang, Min Gao, Chong Zhang, Hua Lu, Bret Cooper, and Xiao-Ning Zhang. Front. Plant Sci. 16:1704701. DOI: 10.3389/fpls.2025.1704701.
Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway (2025). Dougherty, L., Cooper, B., Bunce, J., Vinyard, B., and Stommel, J. J. Amer. Soc. Hort. Sci. 150, 34-41. DOI: 10.21273/JASHS05448-24.
Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in Penicillium expansum and Penicillium chrysogenum (2025). Bartholomew, H.P., Gottschalk, C., Cooper, B., Bukowski, M.R., Yang, R., Gaskins, V.L., Luciano-Rosario, D., Fonseca, J.M., and Jurick, W.M., II. J. Fungi, 11, 14. Published on-line December 28, 2024. DOI: 10.3390/jof11010014.
Indole Alkaloid Production by the Halo Blight Bacterium Treated with the Phytoalexin Genistein (2024). Bret Cooper, Ronghui Yang and Kimberly B. Campbell. Phytopathology 114, 1196-1205. DOI: 10.1094/PHYTO-11-23-0445-R.
An assessment of AcquireX and Compound Discoverer software 3.3 for non-targeted metabolomics (2024). Bret Cooper and Ronghui Yang. Scientific Reports 14, 4841. DOI: 10.1038/s41598-024-55356-3 [Chemistry Top 100 of 2024 (ranked 37 out of 2,325 chemistry papers); 5,678 on-line accesses in the first year of publication.]
Disruptive Effects of Resveratrol on a Bacterial Pathogen of Beans (2023). Bret Cooper. Journal of Proteome Research 22, 204-214. Published on-line before print December 13, 2022. DOI: 10.1021/acs.jproteome.2c00633
The Detriment of Salicylic Acid to the Pseudomonas savastanoi pv. phaseolicola Proteome (2022). Bret Cooper. Molecular Plant-Microbe Interactions 9, 814-824. Published on-line before print May 25, 2022. DOI: 10.1094/MPMI-05-22-0104-R
Salicylic Acid and Phytoalexin Induction by a Bacterium that Causes Halo Blight in Beans (2022). Bret Cooper, Kimberly B. Campbell, and Wesley M. Garrett. Phytopathology 112, 1766-1775. Published on-line before print February 11, 2022. DOI: 10.1094/PHYTO-12-21-0496-R
Bacterial Immobilization and Toxicity Induced by a Bean Plant Immune System (2021). Bret Cooper, Hunter S. Beard, Ronghui Yang, Wesley M. Garrett, and Kimberly B. Campbell. Journal of Proteome Research 20, 3664-3677. DOI: 10.1021/acs.jproteome.1c00232
Benzothiadiazole Conditions the Bean Proteome for Immunity to Bean Rust (2020). Bret Cooper, Hunter Beard, Wesley M. Garrett, and Kimberly B. Campbell. Molecular Plant-Microbe Interactions. Published on-line before print January 30, 2020. DOI: 10.1094/MPMI-09-19-0250-R