Dr. rer. nat. habil. Boran Altincicek

Consultant for M & E, Statistics and Research

Background

Dr. rer. nat. habil. Boran Altincicek has been graduated from the University of Gießen in Germany. During preparing his Ph.D. thesis in Biology, he and his colleagues co-founded a biotech research spin-off company (Jomaa Pharmaka GmbH). Multidisciplinary research in host-pathogen-interactions and immunology, writing of patents and scientific publications were part of his work. After two years as Post-doc at the Institute of Biochemistry in Gießen, he took the opportunity to lead a research group and to investigate molecular adaptation of diverse insects to pathogens and the phenotypic plasticity and evolution of the insect immunity at the Institute of Phytopathology and Applied Zoology. Self-dependent teaching, own third-party funding, and numerous publications in international scientific journals resulted in his German “Habilitation” in the year 2009. Then, funded by the German Research Foundation-DFG with the Heisenberg fellowship in Zoology, he got the opportunity to work on insect ecology and evolution as a Visiting Scientist and Lecturer with Professor Nicole Gerardo at the Emory University in Atlanta, GA, USA. Prior to his current working as freelancer and consultant in Lilongwe, Malawi and later in Addis Ababa, Ethiopia, he was “Privatdozent” (equivalent to Assoc. Professor) in Zoology and Ecology at the Agricultural Faculty of the University of Bonn, Germany.

Since 2012, he works as a Consultant for M & E, Statistics and Research in Southern Africa (focus on Malawi), Horn of Africa (Ethiopia) and Germany, for the German Society for International Cooperation (GIZ), Food and Agriculture Organization of the United Nations (FAO), Research Triangle Institute (RTI), Concern Worldwide, Trocaire, C12, Comit, GFA and more.

Professional qualifications:

• Biologist (Dipl. Biol.) (1997)

• Doctorate in Life Sciences (Dr. rer. nat., Ph.D. equivalent) (2002)

• Habilitation in Agricultural Sciences (Dr. rer.nat. habil.) (2009)

•> 10 years of experience in leading own research projects in molecular biology, zoology and agricultural sciences starting from third-party funded research and budget management over team leading and statistical data analysis to writing publications and reports.

•> 7 years of experience as consultant in development cooperation as a monitoring and evaluation expert with deep knowledge on M&E systems, tablet-based data collection, sampling and statistical analysis of base, mid and endline studies and in evaluations in food security, rural development, energy, gender and education projects; capacity building and training of specialists and executives.

Research publications in international journals with the peer-review process:

2019

48. N Herndon et al. 2019. Enhanced genome assembly and a new official gene set for Tribolium castaneum-from a draft to a reference genome . BMC Genomics. in revision process.

2018

47. Z Guo, K Pfohl, P Karlovsky, HW Dehne, B Altincicek. 2018. Dissemination of Fusarium proliferatum by mealworm beetle Tenebrio molitor. PloS one 13 (9), e0204602

2016

46. Z Guo, K Pfohl, P Karlovsky, HW Dehne, B Altincicek. 2016. Fumonisin B1 and beauvericin accumulation in wheat kernels after seed-borne infection with Fusarium proliferatum . Agricultural and Food Science 25 (2), 138–145

2014

45. Z Guo, K Döll, R Dastjerdi, P Karlovsky, HW Dehne, B Altincicek. 2014. Effect of fungal colonization of wheat grains with Fusarium spp. on food choice, weight gain and mortality of meal beetle larvae (Tenebrio molitor) . PloS one 9 (6), e100112

2013

44. B. ter Braak, A.M. Laughton, B. Altincicek, B.J. Parker, N. M. Gerardo. 2013. Exposure to Bacterial Signals Does Not Alter Pea Aphids’ Survival upon a Second Challenge or In-vestment in Production of Winged Offspring. PLOS ONE 8: e73600. (IF 4.092)

43. Altincicek B., A. Elashry, N. Guz, F.M.W. Grundler, A. Vilcinskas, H.-W. Dehne. 2013. Next generation sequencing based transcriptome analysis of septic-injury responsive genes in the beetle Tribolium castaneum. PLOS ONE 8: e52004. (IF 4.092)

42. Parker B. J., C. J. Spragg, B. Altincicek, N. M. Gerardo. 2013. Symbiont-mediated protection against fungal pathogens in pea aphids: a role for pathogen specificity? Appl Environ Microbiol. 79, 2455-8. (IF 3.829)

2012

41. Altincicek B.*, J. L. Kovacs*, N. M. Gerardo. 2012. Horizontally-transferred fungal carotenoid genes in the two-spotted spider mite Tetranychus urticae. Biol Letters. 8: 253-7. (IF 3.651)

2011

40. Altincicek B*, Vogel H*, Glockner G, Vilcinskas A. 2011. A comprehensive transcriptome and immune-gene repertoire of the lepidopteran model host Galleria mellonella. BMC Genomics. 12: 308. (IF 4.206)

39. Altincicek, B., B. ter Braak, A. M. Laughton, K. I. Udekwu, N. M. Gerardo. 2011. Escherichia coliK-12 pathogenicity in the pea aphid, Acyrthosiphon pisum, reveals reduced antibacterial defense in aphids. Dev Comp Immunol. 35: 1091-7. (IF 3.293)

38. Laughton, A.M., J.R. Garcia, B. Altincicek, M.R. Strand, N.M. Gerardo. 2011. Characterisation of immune responses in the pea aphid, Acyrthosiphon pisum. J Insect Physiol. 57: 830-9. (IF 2.310)

2010

37. Altincicek, B., M. Fischer, M. Fischer, et al. 2010. Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans. Dev Comp Immunol. 34:1160-9. (IF 3.293)

36. The International Aphid Genomics Consortium (including B. Altincicek). 2010. Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biol. 8:e1000313. (IF 12.469)

35. Gerardo, N. M., B. Altincicek, C. Anselme et al. 2010. Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol. 11:R21 (IF 6.885)

34. Mukherjee, K., B. Altincicek, T. Hain, et al.2010. Galleria mellonella as model system to study Listeria pathogenesis. Appl Environ Microbiol. 76:310-7. (IF 3.778)

2009

33. Altincicek, B., A. Berisha, K. Mukherjee, et al. 2009. Identification of collagen IV derived danger/alarm signals in insect immunity by nanoLC-FTICR MS. Biol Chem. 390:1303-11. (IF 3.603)

32. Altincicek, B. and A. Vilcinskas.2009. Septic injury inducible genes in medicinal maggots of the green blow fly Lucilia sericata. Insect Mol Biol. 18:119-25. (IF 2.669)

31. Knorr, E., H. Schmidtberg, A. Vilcinskas, and B. Altincicek. 2009. MMPs regulate both development and immunity in the Tribolium model insect. PLoS ONE. 4(3):e4751. (IF 4.411)

30. Rahnamaeian, M., G. Langen, J. Imani, W. Khalifa, B. Altincicek, D. von Wettstein, K.H. Kogel, and A. Vilcinskas. 2009. Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens. J Exp Bot. 60: 4105-14. (IF 4.818)

2008

29. Altincicek, B., J. Gross, and A. Vilcinskas.2008. Wounding-mediated gene expression and accelerated viviparous reproduction of the pea aphid Acyrthosiphon pisum. Insect Mol Biol. 17:711-6. (IF 2.669)

28. Altincicek, B., E. Knorr, and A. Vilcinskas.2008. Beetle immunity: Identification of immune-inducible genes from the model insect Tribolium castaneum. Dev Comp Immunol. 32:585-95. (IF 3.293)

27. Altincicek, B., S. Stoetzel, M. Wygrecka, et al. 2008. Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects. J Immunol. 181:2705-12. (IF 5.745)

26. Altincicek, B. and A. Vilcinskas.2008. Comparative analysis of septic injury-inducible genes in phylogenetically distant model organsims of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris. Front Zool. 5:6. (IF 2.519)

25. Altincicek, B. and A. Vilcinskas.2008. Identification of a lepidopteran matrix metalloproteinase with dual roles in metamorphosis and innate immunity. Dev Comp Immunol. 32:400-9. (IF 3.293)

24. Altincicek, B. and A. Vilcinskas. 2008. Identification of immune inducible genes from the velvet worm Epiperipatus biolleyi(Onychophora). Dev Comp Immunol. 32:1416-21. (IF 3.293)

23. Tribolium Genome Sequencing Consortium (including B. Altincicek).2008. The first genome sequence of a beetle, Tribolium castaneum, a model for insect development and pest biology. Nature. 452:949-55. (IF 36.101)

2007

22. Altincicek, B., M. Linder, D. Linder, et al.2007. Microbial metalloproteinases mediate sensing of invading pathogens and activate innate immune responses in the lepidopteran model host Galleria mellonella. Infect Immun. 75:175-83. (IF 4.098)

21. Altincicek, B. and A. Vilcinskas.2007. Analysis of the immune-related transcriptome of a lophotrochozoan model, the marine annelid Platynereis dumerilii. Front Zool. 4:18. (IF 2.519)

20. Altincicek, B. and A. Vilcinskas.2007. Analysis of the immune-inducible transcriptome from microbial stress resistant, rat-tailed maggots of the drone fly Eristalis tenax. BMC Genomics. 8:326. (IF 4.206)

19. Altincicek, B. and A. Vilcinskas.2007. Identification of immune-related genes from an apterygote insect, the firebrat Thermobia domestica. Insect Biochem Mol Biol. 37:726-31. (IF 4.018)

18. Wedde, M., C. Weise, R. Nuck, B. Altincicek, and A. Vilcinskas.2007. The insect metalloproteinase inhibitor gene of the lepidopteran Galleria mellonellaencodes two distinct inhibitors. Biol Chem. 388:119-27. (IF 3.603)

2006

17. Altincicek, B., A. Shibamiya, H. Trusheim, et al. 2006. A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding. Biochem J. 394:687-92. (IF 5.016)

16. Altincicek, B. and A. Vilcinskas.2006. Metamorphosis and collagen-IV-fragments stimulate innate immune response in the greater wax moth, Galleria mellonella. Dev Comp Immunol. 30:1108-18. (IF 3.293)

15. Langen, G., J. Imani, B. Altincicek, et al.2006. Transgenic expression of gallerimycin, a novel antifungal insect defensin from the greater wax moth Galleria mellonella, confers enhanced resistance to phytopathogenic fungi in tobacco. Biol Chem. 387:549-57. (IF 3.603)

1999 – 2002

14. Altincicek, B., E.C. Duin, A. Reichenberg, R. Hedderich, A.K. Kollas, M. Hintz, S. Wagner, J. Wiesner, E. Beck and H. Jomaa.2002. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. FEBS Lett. 532:437-40. (IF 3.601)

13. Altincicek, B., A.K. Kollas, M. Eberl, S. Sanderbrand, U. Bahr, A. Reichenberg, E. Beck, F. Donald, J. Wiesner, M. Hintz, and H. Jomaa.2002. Accumulation of a potent gdT cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106:200-11. (IF 3.302)

12. Kollas, A.K., E.C. Duin, M. Eberl, B. Altincicek, M. Hintz, A. Reichenberg, D. Henschker, A. Henne, I. Steinbrecher, D.N. Ostrovsky, R. Hedderich, E. Beck, H. Jomaa and J. Wiesner. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Lett. 532:432-6. (IF 3.601)

11. Altincicek, B., A.K. Kollas, M. Eberl, J. Wiesner, S. Sanderbrand, M. Hintz, E. Beck, and H. Jomaa. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 499:37-40. (IF 3.601)

10. Altincicek, B., A.K. Kollas, S. Sanderbrand, J. Wiesner, M. Hintz, E. Beck, and H. Jomaa. 2001. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. J Bacteriol. 183:2411-6. (IF 3.726)

9. Altincicek, B., J. Moll, N. Campos, G. Foerster, E. Beck, J.F. Hoeffler, C. Grosdemange-Billiard, M. Rodriguez-Concepcion, M. Rohmer, A. Boronat, M. Eberl, and H. Jomaa. 2001. Cutting edge: human gdT cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. J Immunol. 166:3655-8. (IF 5.745)

8. Hintz, M., A. Reichenberg, B. Altincicek, U. Bahr, R. M. Gschwind, A.K. Kollas, E. Beck, J. Wiesner, M. Eberl, and H. Jomaa.2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gdT cells in Escherichia coli. FEBS Lett. 509:317-22. (IF 3.601)

7. Reichenberg, A., J. Wiesner, C. Weidemeyer, E. Dreiseidler, S. Sanderbrand, B. Altincicek, E. Beck, M. Schlitzer, and H. Jomaa.2001. Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity. Bioorg Med Chem Lett. 11:833-5. (IF 2.661)

6. Wiesner, J., S. Sanderbrand, B. Altincicek, E. Beck, and H. Jomaa.2001. Seeking new targets for antiparasitic agents. Trends Parasitol. 17:7-8. (IF 4.906)

5. Altincicek, B., M. Hintz, S. Sanderbrand, J. Wiesner, E. Beck, and H. Jomaa. 2000. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa. FEMS Microbiol Lett. 190:329-33. (IF 2.040)

4. Altincicek, B., S.P. Tenbaum, U. Dressel, D. Thormeyer, R. Renkawitz, and A. Baniahmad. 2000. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem. 275:7662-7. (IF 5.328)

3. Wiesner, J., M. Hintz, B. Altincicek, S. Sanderbrand, C. Weidemeyer, E. Beck, and H. Jomaa. 2000. Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity. Exp Parasitol. 96:182-6. (IF 1.869)

2. Dressel, U., D. Thormeyer, B. Altincicek, A. Paululat, M. Eggert, S. Schneider, S. P. Tenbaum, R. Renkawitz, and A. Baniahmad.1999. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol. 19:3383-94. (IF 6.188)

1. Jomaa, H., J. Wiesner, S. Sanderbrand, B. Altincicek, C. Weidemeyer, M. Hintz, I. Turbachova, M. Eberl, J. Zeidler, H. K. Lichtenthaler, D. Soldati, and E. Beck. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 285:1573-6. (IF 31.364)

Invited review article:

1. B. Altincicek. The innate immunity in the cnidarian Hydra vulgaris. 2009. Invertebrate Survival Journal. 6:106-113.

Monograph:

1. B. Altincicek: Zoologie und die Evolution vom Einzeller zum Menschen. (ISBN:978-1311588104)

2. B. Altincicek: Step by step practical guide with Statistics (from ANOVA to survival analysis) in Biological Sciences: Or: Help, how can I analyze my “damned” scientific data correctly and in an easy way with free R! (ISBN: 978-1301217069)

3. B. Altincicek: Identifizierung neuer Enzyme des Mevalonat-unabhaengigen Methylerythritol-4-phosphat Stoffwechselweges zur Isoprenoidbiosynthese (ISBN: 978-3835953017)

Patents:

1. WO2004035810; DE10247478: Determining activity of enzymes in non-mevalonate isoprenoid pathway, for screening for microbicides and herbicides, involves incubation with a substrate and electron-transfer agent.

2. WO2004019956; DE10237085: Treatment or prevention of parasitic helminth infections, especially filariasis, in humans or animals, using oxyamino-substituted phosphonic or phosphinic acid compounds.

3. WO2003009855; EP1408984; US020060030546, US020080249067, DE10135395; DE10134705: New acyclic or cyclic organophosphorus compounds, are gamma-delta-T cell activators useful e.g. as medicaments for treating asthma, chronic bronchitis, ulcerative colitis, autoimmune diseases or allergies.

4. WO200295011; EP1381686; US020080206267, DE10119905: Enriching intermediates in the mevalonate-independent pathway of isoprenoid synthesis, useful for therapeutic activation of T cells, comprises altering enzymatic activity in the pathway.

Theses:

1. Boran Altincicek (2008) Kumulative Habilitationsschrift: Comparative Immunology of Invertebrates : Molecular mechanisms and novel antimicrobial peptides.

2. Boran Altincicek (2002) Inaugural-Dissertation: Identifizierung neuer Enzyme des Mevalonat-unabhaengigen Methylerythritol-4-phosphat Stoffwechselweges zur Isoprenoidbiosynthese.

3. Boran Altincicek (1997) Diplomarbeit: Charakterisierung der Interaktion des Retinoblastoma-Tumorsuppressors und des Thyroidhormonrezeptors mit Alien, einem neuartigen Co-Repressor.

Details of publications and citations:

• Google Scholar “My citations”
• Researchgate page

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