Publications

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2. Ӧzgecan Şavluğ İpek, Bilgesu Onur Sucu, Saba Selvi, Fulya Koksalar Alkan, Büşra Tiryaki, Hilmi Kaan Alkan, Ehsan Sayyah, İlayda Tolu, Mustafa Güzel, Serdar Durdağı, Nuri Öztürk, Hasan Korkaya, Anti-cancer efficacy of novel lonidamine derivatives: Design, synthesis, in vitro, in vivo, and computational studies targeting hexokinase-2, European Journal of Medicinal Chemistry, Volume 296, 2025, 117890, https://doi.org/10.1016/j.ejmech.2025.117890.

3. Design, synthesis and in vitro evaluations of new cyclotriphosphazenes as safe drug candidates.YILDIZ GÜL E, Tiryaki B, Köse B, Ozturk N, Okutan E, Dedeoglu B, Tanrıverdi Eçik E - RSC Medicinal Chemistry, 2025, https://doi.org/10.1039/D4MD00885E

4. Ozcelik G, Koca MS, Sunbul B, Yilmaz-Atay F, Dem'rhan F, Tiryaki B, Cilenk K, Selvi S, Ozturk N. Interactions of drosophila  cryptochrome. Photochem Photobiol. 2024;00:1-20.  doi:10.1111/php.1391 (https://onlinelibrary.wiley.com/share/author/ZSRVQEMURSUSUPVZI9VT?target=10.1111/php.13916 )

5. Surme, S., Ergun, C., Gul, S., Akyel, Y. K., Gul, Z. M., Ozcan, O., Ipek, O. S., Akarlar, B. A., Ozlu, N., Taskin, A. C., Turkay, M., Gören, A. C., Baris, I., Ozturk, N., Guzel, M., Aydin, C., Okyar, A., & Kavakli, I. H. TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice. Biochem Pharmacol. 2023;218:115896. doi:10.1016/j.bcp.2023.115896

6.  Gul S, Akyel YK, Gul ZM, Isin S, Ozcan O, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Akarlar BA, Ozlu N, Ozturk N, Ozturk N, Ünal DÖ, Guzel M, Turkay M, Okyar A, Kavakli IH. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13(1):6742. doi: 10.1038/s41467-022-34582-1. PMID: 36347873; PMCID: PMC9643396. 

7. Kavakli IH, Ozturk N, Baris I. (2022) Protein interaction networks of the mammalian core clock proteins. Advances in Protein Chemistry and Structural Biology.;131:207-233. DOI: 10.1016/bs.apcsb.2022.04.001. PMID: 35871891.

8. Gul H, Selvi S, Yilmaz F, Ozcelik G, Olfaz-Aslan S, Yazan S, Tiryaki B, Gul S, Yurtseven A, Kavakli IH, Ozlu N, Ozturk N. (2022) Proteome analysis of the circadian clock protein PERIOD2. Proteins. 2022 Feb 4. doi: 10.1002/prot.26314. Epub ahead of print. PMID: 35122331.

9. Ozturk N. Light-dependent reactions of animal circadian photoreceptor cryptochrome. FEBS J. 2022 Nov;289(21):6622-6639. doi: 10.1111/febs.16273. Epub 2021 Nov 19. PMID: 34750956. 

10. Gul S., Rahim, F, Isin, S, Fatma Yilmaz, Ozturk N, Turkay M, Kavakli IH (2021) Structure-based design and classifications of small molecules regulating the circadian rhythm period. Sci Rep 11, 18510 

11. Gul S, Akyel YK, Gu Z.M.l, Isin S, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Ozturk N, Ozturk N, Unal DO, Guzel M,  Turkay M,  Okyar A,  Kavakli IH. (2021) Discovery of a small molecule that selectively destabilizes cryptochrome 1 and enhances life span in p53 knockout mice. bioRxiv, 2021.2007.2021.453206

12. Emisoglu-Kulahli H, Gul S, Morgil H, Ozcan O, Aygenli F, Selvi S. Kavakli IH, Ozturk N. (2021) Transcriptome analysis of the circadian clock gene BMAL1 deletion with opposite carcinogenic effects. Functional & integrative genomics 21, 1–16

13.  Doruk YU, Yarparvar D, Akyel YK, Gul S, Taskin AC, Yilmaz F, Baris I, Ozturk N, Türkay M, Ozturk N, Okyar A, Kavakli IH (2020) A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude.  J. Biol. Chem. 295 (11), 3518-3531 

14. Dikbas UM, Tardu M,Canturk A,Gul S, Özçelik G, Baris I, Ozturk N, Kavakli IH (2019) Identification and characterization of a new class of (6-4) photolyase from Vibrio cholerae. Biochemistry 56(43), 4352-4360

15.  Cavga AD, Tardu M., Korkmaz T, Keskin O, Ozturk N, Gursoy A, Kavakli IH. Funct Integr Genomics (2019) Cryptochrome deletion in p53 mutant mice enhances apoptotic and anti-tumorigenic responses to UV damage at the transcriptome level. Functional & integrative genomics 19 (5), 729-742

16. Kavakli, I.H., Ozturk, N., and Gul, S. (2019). DNA repair by photolyases. Advances in protein chemistry and structural biology 115, 1-19.

17. T Korkmaz, F Aygenli, H Emisoglu, G Ozcelik, A Canturk, S Yilmaz, Ozturk N (2018) Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1. Scientific reports 8 (1), 16023

18. N. Ozturk (2017) Phylogenetic and Functional Classification of the Photolyase/Cryptochrome Family. Photochemistry and Photobiology 93 (1), 104-111

19. A. Sancar, L.A  Lindsey-Boltz, S. Gaddameedhi, C.P. Selby, R. Ye, Y.Y. Chiou, M.G. Kemp, J. Hu, J.H. Lee, N. Ozturk (2015) Circadian Clock, Cancer, and Chemotherapy. Biochemistry 54(2):110-23

20. N. Ozturk, C. P. Selby, D. Zhong, A. Sancar (2014) Mechanism of Photosignaling by Drosophila Cryptochrome ROLE OF THE REDOX STATUS OF THE FLAVIN CHROMOPHORE, J Biol Chem. 289: 4634-4642.

21. N. Ozturk, S. J. VanVickle-Chavez, L. Akileswaran, R. N. Van Gelder, A. Sancar (2013) Ramshackle (Brwd3) Promotes Light-induced Ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 Complex. Proc Natl Acad Sci U S A. 110: 4980-4985.

22. I. Ozkan-Dagliyan, Y. Y. Chiou, R. Ye, B. H. Hassan, N. Ozturk, A. Sancar (2013) Formation and Characterization of Plant Cryptochrome Photobodies in Mammalian Cells. J Biol Chem. 288:23244-23251.

23. G. Yildiz, A. Arslan-Ergul, S. Bagislar, O. Konu, H. Yuzugullu, O. Gursoy-Yuzugullu, N. Ozturk, C. Ozen, H. Ozdag, E. Erdal, S. Karademir, O. Sagol, D. Mizrak, H. Bozkaya, H. G. Ilk, O. Ilk, B. Bilen, R. Cetin-Atalay, N. Akar, M. Ozturk (2013) Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis. PLoS ONE 8(5): e64016.

24. A. S. Rivera, N. Ozturk, B. Fahey, D. C. Plachetzki, B. M. Degnan, A. Sancar, T. H. Oakley (2012) Blue light-receptive Cryptochrome is expressed in a sponge eye lacking neurons and opsin. J Exp Biol. 215: 1278-1286.

25. S. Gaddameedhi, J. T. Reardon, R. Ye, N. Ozturk, A. Sancar (2012) Effect of circadian clock mutations on DNA damage response in mammalian cells. Cell Cycle 11: 3481-3491.

26. J. H. Lee, S. Gaddameedhi, N. Ozturk, R. Ye, A. Sancar (2013) DNA damage-specific control of cell death by cryptochrome in p53 mutant Ras-transformed cells. Cancer Res. 73: 785-791.

27. N. Ozturk, C. P. Selby, Y. Annayev, D. Zhong, A. Sancar (2011) Reaction Mechanism of Drosophila Cryptochrome. Proc Natl Acad Sci U S A. 108: 516-521.

28. R. Ye, C. P. Selby, N. Ozturk, Y. Annayev, A. Sancar (2011) Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock. J Biol Chem. 286: 25891-25902.

29. A. Sancar, L. A. Lindsey-Boltz, T. H. Kang, J. T. Reardon, J. H. Lee, N. Ozturk. (2010) Circadian clock control of the cellular response to DNA damage. FEBS Lett. 584: 2618-2625.

30. E. Kavak, A. Najafov, N. Ozturk, T. Seker, K. Cavusoglu, T. Aslan, A. D. Duru, T. Saygili, G. Hoxhaj, M. C. Hiz, D. O. Unal, N. Birgul-Iyison, M. Ozturk, A. Koman (2010) Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal. 22: 1523-1535.

31. N. Ozturk, J. H. Lee, S. Gaddameedhi, A. Sancar (2009) Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A. 106: 2841-2846.

32. N. Ozturk, C. P. Selby, S. H. Song, R. Ye, C. Tan, Y. T. Kao, D. Zhong, A. Sancar (2009) Comparative photochemistry of animal type 1 and type 4 cryptochromes. Biochemistry 48: 8585-8593.

33. H. Yuzugullu, K. Benhaj, N. Ozturk, S. Senturk, E. Celik, A. Toylu, N. Tasdemir, M. Yilmaz, E. Erdal, K. C. Akcali, N. Atabey, M. Ozturk (2009) Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer. 8: 90.

34. N. Ozturk, Y. T. Kao, C. P. Selby, I. H. Kavakli, C. L. Partch, D. Zhong, A. Sancar (2008) Purification and characterization of a type III photolyase from Caulobacter crescentus. Biochemistry 47: 10255-10261.

35. Y. T. Kao, C. Tan, S. H. Song, N. Ozturk, J. Li, L. Wang, A. Sancar, D. Zhong (2008) Ultrafast dynamics and anionic active states of the flavin cofactor in cryptochrome and photolyase. J Am Chem Soc. 130: 7695-7701.

36. N. Ozturk, S. H. Song, C. P. Selby, A. Sancar (2008) Animal type 1 cryptochromes. Analysis of the redox state of the flavin cofactor by site-directed mutagenesis. J Biol Chem. 283: 3256-3263.

37. N. Ozturk, S. H. Song, S. Ozgur, C. P. Selby, L. Morrison, C. Partch, D. Zhong, A. Sancar (2007) Structure and function of animal cryptochromes. Cold Spring Harb Symp Quant Biol. 72:119-131.

38. S. H. Song, N. Ozturk, T. R. Denaro, N. O. Arat, Y. T. Kao, H. Zhu, D. Zhong, S. M. Reppert, A. Sancar (2007) Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 282: 17608-17612.

39. N. Ozturk, E. Erdal, M. Mumcuoglu, K. C. Akcali, O. Yalcin, S. Senturk, A. Arslan-Ergul, B. Gur, I. Yulug, R. Cetin-Atalay, C. Yakicier, T. Yagci, M. Tez, M. Ozturk (2006) Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells. Proc Natl Acad Sci U S A. 103: 2178-2183.

40. E. Erdal, N. Ozturk, T. Cagatay, E. Eksioglu-Demiralp, M. Ozturk (2005) Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int J Cancer. 115: 903-10.