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We are a single molecule biophysics laboratory at the Physics Department of Kent State University. We study biological systems using high resolution fluorescence microscopy methods at the single molecule level. In particular, we are interested in studying DNA/RNA structures and DNA-protein interactions. Another aspect of our research is developing new methods to facilitate the study of such biological systems. Our research projects are at the interface of physics, biology, and chemistry and we collaborate with researchers from these disciplines.



A schematic of Total Internal Reflection Microscopy that we commonly use in the lab.

Overlap of Rep and UvrD helicase when bound to partial duplex DNA

An example of a protein-DNA interaction study in which structural information on a DNA helicase is obtained using a novel single molecule fluorescence method (Balci et al. Biophys Jour. 2011).
Lab News
  • 03/31/2014
Time for a very late update
Parastoo Maleki and Allan Leishman are the latest members of our lab. Chad Frutig graduated with a Physics BSc degree and is currently working towards an MBA at KSU. Haroon Qureshi is another official graduate from the lab. Haroon completed an MSc degree in Biological Sciences and is currently working towards a PhD in the Molecular Biology and Genetics Department at Koc University, Istanbul, Turkey. We wish both of them good luck in their new places.

A very good news on the publications front. Our paper on the competition between POT1/TPP1 and RPA to access telomeric DNA has been published in PNAS.
  • 05/24/2013
Both the Biophysical Journal and Nature Communications articles are available online now (see Publications page for links).

Thanks to Burroughs Wellcome Fund that recently selected Hamza's proposal for the Burroughs Wellcome Fund 2013 Collaborative Research Travel Grant.

  • 04/23/2013
Two important updates:
We have been awarded a College of Arts and Sciences Research Resources Award. We will finally have a Plasma Cleaner!

A study that Hamza contributed to construction of the setup while at UIUC has been accepted for publication at Nature Communications.   

  • 04/03/2013
Two good news!
Our paper on RPA-GQ interactions is accepted at Biophysical Journal.

The proposal by Chad and Hamza has been funded by University Research Council (undergraduate researcher category)

  • 03/20/2013
Undergraduate Physics major Thomas Buida joins the group.

  • 02/10/2013
Sujay presented our work in the Biophysical Society Meeting.

  • 06/05/2012
It has been a while since the last update so there are several good news from the lab members:

Dominic accepted the offer from University of Rochester Biomedical Engineering Department. The offer comes with full support for is graduate studies.

Chad was awarded an REU at University of California at Los Angelos for this summer.

Sujay is awarded the University Fellowship which is given to one graduate student from each department.

Congratulations to all.

Our first paper is published at Journal of Physical Chemistry.
http://pubs.acs.org/doi/abs/10.1021/jp300546u

  • 02/27/2012
Hamza and Sujay presented our work in Biophysical Society Meeting in San Diego, Ca

  • 01/09/2012
Chad Frutig joins the lab.

  • 12/13/2011
Sujay receives ICAM Junior Scientist Exchange Award to go to Prof. Ahmet Yildiz's lab at University of California Berkeley for a one month training.

  • 12/01/2011
Jagat Budhathoki joined the lab.

  • 11/28/2011
Dominic successfully defended his Honors Thesis. Congratulations.

  • 08/17/2011
Hamza's paper on Global Nanopositioning is published in Biophysical Journal.

  • 08/15/2011
Our work on thyrosine hydroxylase (in collaboration with Prof. Soumitra Basu) is funded by NIH.

  • 08/10/2011
Subrata defends his thesis and receives his masters degree.

  • 06/08/2011
Hamza receives Farris Family Innovation Award for Early Achievement.

  • 03/31/2011
Hamza received a travel award from KSU-ICAM to present our work in Third International Meeting on G-Quadruplex and G-assembly in Naples, Italy.

  • 03/29/2011
Hamza and Dominic receive funding for Dominic's Honors Thesis research from University Research Council.

  • 02/14/2011
Sujay receives travel award from ICAM to present his work in Biophysical Society Meeting, Baltimore MD.

  • 10/28/2009
Haroon receives ICAM Junior Scientist Exchange Award to go to Prof. Aziz Sancar's lab at University of North Carolina and get trained on protein purification.