When Chemistry Meets Biology!!!!

Our group mainly focusing on development of novel chromo-fluorogenic functional materials for analytical, bioanalytical (diagnostics) and therapeutic applications. 

Development of Novel Probes for Sustained Environmental and Analytical Applications 

In this domain, we are aiming to develop new chromo-fluorogenic materials for the recognition of biologically relevant ions, molecules (cell metabolites, xenobiotics, carcinogens, industrial wastes, explosives, etc.) in real samples such as terrestrial and marine water bodies, soil and various types of biological samples (blood, spleen, etc.).    

Novel Label Free and Labelled Methods for Diagnostics Applications 

Development of Novel Opto-Diagnostics Tools Based on Label Free Approach

• Development of non-classical chromo-fluorescent materials for the recognition of canonical and non-canonical forms of nucleic acids in in-vitro and in-vivo models.  

• Development of small and efficient materials for the recognition of cancer biomarkers such as proteins, nucleic acids, cell metabolites, cellular temperature and pathophysiological conditions in cells and tissues.   

• Development of non-classical chromo-fluorogenic functional materials for real-time monitoring of cellular pathophysiology. 

• Small and efficient organelle-specific chromo-fluorescent functional materials for cancer theranostics.

• Small and efficient chromo-fluorescent functional materials for the recognition of bacteria, fungi and viruses. 

• Development of novel NIR-responsive metal-organic frameworks (MOFs), covalent organic frameworks (COFs) and polymer-nanocomposites for bacterial, fungal PDT, PTT, chemotherapy and synergistic multimodal therapeutic (PTT + PDT, PTT + PDT + Chemotherapy) applications.   

Development of Novel Opto-Diagnostics Tools Based on Labelled Approach

• Post-synthetically labelled nucleic acids for the recognition of non-canonical forms of cancerous DNA and RNA's in invitro and in-cellulo models. 

• Fluorescent nucleotides for site-specific incorporation and their application in cancer-related noncanonical nucleic acids such as G-Quadruplexes (G4s), i-motifs, triplexes and three-way (3WJ) junctions. 

• Development of fluorescent nucleotides for the recognition of miRNAs and nucleic acid-related proteins.   

• Development of novel small peptidyl-fluorescent conjugates for real-time monitoring of pathophysiology in various forms of disease cells and in-vivo models.  

Development of Novel Materials for Drug Delivery and Therapeutics Applications

• Development of photosensitive materials for the treatment of cancer and neurological disorders based on PDT, PTT and synergistic multimodal photo-theranostic platform. 

• Development of novel photo-responsive nano-capsules for controlled drug/siRNA delivery and their therapeutic applications assessments in cancer cell and neurological disorders cell models.

• Development of novel dental biomaterials.  

• Development of self-assembled organic and inorganic nanohybrid photosensitizers for PDT and PTT applications.   

Computational Chemistry 

• Evaluation of photo-physical properties of chromo-fluorogenic materials based on quantum chemical calculations such as density functional theory (DFT), time dependent density functional theory (TD-DFT). 

• Evaluation of analyte oriented opto-analytical capabilities of new functional materials through DFT, TD-DFT, molecular docking and molecular dynamics (MD) studies. 

• Identification of the vital interactions sites in the probe-analyte complex along with their thermodynamic properties based on biological perspectives. 

Energy Materials for Biomedical-Electronic Devices

• We are at infant stage in this research, currently aiming to develop novel and simplest nano-materials for  energy related applications and their smart integration in biomedical-electronic devices. 

• We are currently open to collaborate with energy materials and biomedical instrumentation specialists to develop novel sustainable energy materials for biomedical electronic devices. 

Financial Support