(21) « Identification of New Key Players for Ferrous Iron Export in the Asymmetric Inner Gate of Human Ferroportin 1»
Marlène Le Tertre#, Ahmad Elbahnsi#, Cécile Ged, Kevin Uguen, Isabelle Gourlaouen, Claude Férec, Chandran Ka, Gérald Le Gac and Isabelle Callebaut
FASEB Journal (2025). LINK
(20) « ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches »
Ahmad Elbahnsi*, Balint Dudas, Isabelle Callebaut, Alexandre Hinzpeter and Maria A Miteva.
Pharmaceuticals (2024). LINK
(19) « Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation »
Solène Castanier#, Ahmad Elbahnsi#, Benoit Chevalier, Nesrine Baatallah, Iwona Pranke, Lynda Berri, Aleksander Edelman, Isabelle Sermet-Gaudelus, Jean-Paul Mornon, Isabelle Callebaut and Alexandre Hinzpeter.
Cell. Mol. Life Sci. (2024). LINK
(18) « The dual loss and gain of function of the FPN1 iron exporter results in the Ferroportin Disease phenotype »
Kevin Uguen, Marlène Le Tertre, Dimitri Tchernitchko, Ahmad Elbahnsi, Sandrine Maestri, Isabelle Gourlaouen, Claude Férec, Chandran Ka, Isabelle Callebaut and Gérald Le Gac.
Human Genetics and Genomics Advances (2024). LINK
(17) « Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations »
Ahmad Elbahnsi*, Balint Dudas, Salvatore Cisternino, Xavier Declèves and Maria A Miteva*.
Comput Struct Biotechnol J (2024). LINK
(16) « Insights into the role of glycerophospholipids on the iron export function of SLC40A1 and the molecular mechanisms of ferroportin disease »
Rim Debbiche#, Ahmad Elbahnsi#, Kévin Uguen, Chandran Ka, Isabelle Callebaut and Gérald Le Gac.
FASEB J (2024). LINK
(15) « Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels »
Ahmad Elbahnsi#, John Cowgill#, Verena Burtscher, Linda Wedemann, Luise Zeckey, Baron Chanda and Lucie Delemotte
ELife (2023). LINK
(14) « Ivacaftor-Mediated Potentiation of ABCB4 Missense Mutations Affecting Critical Motifs of the NBDs: Repositioning Perspectives for Hepatobiliary Diseases »
Jean-Louis Delaunay, Ahmad Elbahnsi, Alix Bruneau, Claire Madry, Anne-Marie Durand-Schneider, Anne Stary, Chantal Housset, Jérémie Gautheron, Isabelle Callebaut and Tounsia Aït-Slimane.
Int J Mol Sci. (2023). LINK
(13) « Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants »
Baatallah N#, Elbahnsi A#, Chevalier B, Castanier S, Mornon JP, Pranke I, Edelman A, Sermet-Gaudelus I, Callebaut I and Hinzpeter A.
Int J Mol Sci. (2022). LINK
(12) « Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium »
A. Mehregan, S. Pérez-Conesa, Y. Zhuang, A. Elbahnsi, D. Pasini, E. Lindahl, R. J Howard, C. Ulens and L. Delemotte.
Biochim Biophys Acta Biomembr. (2022). LINK
(11) « Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR »
N. Baatallah#, A. Elbahnsi#, J-P. Mornon, B. Chevalier, I. Pranke, N. Servel, R. Zelli, J-L. Décout, A. Edelman, I. Sermet- Gaudelus, I. Callebaut and A.Hinzpeter.
Cell. Mol. Life Sci. (2021). LINK
(10) « Insights into the Role of the Discontinuous TM7 Helix of Human Ferroportin through the Prism of the Asp325 Residue »
Marlène Le Tertre#, Ahmad Elbahnsi#, Chandran Ka, Isabelle Callebaut and Gérald Le Gac
Int. J. Mol. Sci. (2021). Link
(9) « Structure and sequence-based computational approaches to allosteric signal transduction: application to electromechanical coupling in voltage-gated ion channels »
Ahmad Elbahnsi and Lucie Delemotte.
JMB (2021). Link
(8) « New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation »
Bitam Sara#, Elbahnsi Ahmad#, Creste Geordie#, Pranke Iwona, Chevalier Benoit, Berhal Farouk, Hoffmann Brice, Servel Nathalie, Tondelier Danielle, Hatton Aurelie, Moquereau Christelle, Faria Da Cunha Mélanie, Lepissier Agathe, Hinzpeter Alexandre, Mornon Jean-Paul, Prestat Guillaume, Edelman Aleksander, Callebaut Isabelle, Gravier-Pelletier Christine, Sermet-Gaudelus Isabelle
Scientific Reports (2021). Link
(7) « A dynamic view of DNA structure within the nucleosome: biological implications »
Romain Retureau, Nicolas Foloppe, Ahmad Elbahnsi, Christophe Oguey and Brigitte Hartmann
JSB (2020). Link
(6) « Functional and pharmacological characterization of the rare CFTR mutation W361R »
Arnaud Billet, Ahmad Elbahnsi, Mathilde Jollivet-Souchet, Brice Hoffmann, Jean-Paul Mornon, Isabelle Callebaut and Frederic Becq
Front. Pharmacol. (2020). Link
(5) « Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity »
Lionel Froux#, Ahmad Elbahnsi#, Benjamin Boucherle#, Arnaud Billet, Nesrine Baatallah, Brice Hoffmann, Julien Alliot, Renaud Zelli, Wael Zeinyeh, Romain Haudecoeur, Benoit Chevalier, Antoine Fortuné, Sandra Mirval, Christophe Simard, Pierre Lehn, Jean-Paul Mornon, Alexandre Hinzpeter, Frédéric Becq, Isabelle Callebaut and Jean-Luc Décout
Eur. J. Med. Chem. (2020). Link
(4) « Molecular model of the ferroportin intracellular gate and implications for the human iron transport cycle and hemochromatosis type 4A »
Julie Guellec, Ahmad Elbahnsi, Marlène Le Tertre, Kévin Uguen, Isabelle Gourlaouen, Claude Férec, Chandran Ka, Isabelle Callebaut and Gérald Le Gac
Faseb (2019). Link
(3) « Combining theoretical and experimental data to decipher CFTR 3D structures and functions »
Brice Hoffmann#, Ahmad Elbahnsi#, Pierre Lehn, Jean-Luc Décout, Fabio Pietrucci, Jean-Paul Mornon and Isabelle Callebaut.
Cell. Mol. Life Sci. (2018). Link
(2) « Holding the nucleosome together: A quantitative description of the DNA-histone interface in solution »
Ahmad Elbahnsi#, Romain Retureau#, Marc Baaden, Brigitte Hartmann and Christophe Oguey.
J. Chem. Theory Comput. (2017). Link
(1) « Simulations meet experiment to reveal new insights into DNA intrinsic mechanics »
Akli Ben Imeddourene, Ahmad Elbahnsi, Marc Guéroult, Christophe Oguey, Nicolas Foloppe and Brigitte Hartmann.
Plos Comp. Biol. (2015). Link
#co-first author(s) / equal contribution
*co-correponding author
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(3) « Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels »
Ahmad Elbahnsi, John Cowgill, Verena Burtscher, Linda Wedemann, Luise Zeckey, Baron Chanda and Lucie Delemotte
bioRxiv (2022). LINK
(2) « Biophysical characterization of the SARS-CoV-2 E protein »
Aujan Mehregan, Sergio Pérez-Conesa, Yuxuan Zhuang, Ahmad Elbahnsi, Diletta Pasini, Erik Lindahl, Rebecca J Howard, Chris Ulens and Lucie Delemotte
bioRxiv (2021). LINK
(1) CFTR corrector efficacy is associated with occupancy of distinct binding sites
Nesrine Baatallah#, Ahmad Elbahnsi#, Jean-Paul Mornon, Benoit Chevalier, Iwona Pranke, Nathalie Servel, Renaud Zelli, Jean-Luc Décout, Aleksander Edelman, Isabelle Sermet-Gaudelus, Isabelle Callebaut and Alexandre Hinzpeter
bioRxiv (2021). LINK
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(11) « Understanding and fostering CFTR potentiation »
Ahmad Elbahnsi, Solène Castanier, Alexandre Hinzpeter, Jean-Paul Mornon, Isabelle Callebaut
20th ECFS Basic Science Conference, Lido di Camaiore, Italy, 26 March – 29 March 2025
presented by Dr. I. Callebaut
LINK
(10) « CFTR modulation: insight from 3D structures »
Ahmad Elbahnsi, Nesrine Baatallah, Jean-Paul Mornon, Alexandre Hinzpeter, Isabelle Callebaut
17th ECFS Basic Science Conference, Albufeira, Portugal, 30 March – 02 April 2022
presented by Dr. I. Callebaut
(9) « Haemochromatosis type 4: structure/function analysis of the newly identified p. Ser47Phe missense mutation provides new insights about the ferroportin biology and mechanisms of disease »
Kévin Uguen, Marlène Le Tertre, Ahmad Elbahnsi, Chandran Ka, Isabelle Gourlaouen, Claude Férec, Isabelle Callebaut, Gérald Le Gac
EUROPEAN JOURNAL OF HUMAN GENETICS, SWEDEN. October 2019.
presented by Dr. K. Uguen
(8) « The structure-function analysis of ferroportin 1 (FPN1) gating residues sheds new light on the pathogenic mechanisms involved in haemochromatosis type 4A (HC 4A) »
Marlène Le Tertre, Ahmad Elbahnsi, Cécile Ged, Chandran Ka, Kévin Uguen, Julie Guellec, Isabelle Gourlaouen, Claude Férec, Isabelle Callebaut and Gérald Le Gac.
8th CONGRESS OF THE INTERNATIONAL BIOIRON SOCIETY, EMBL Heidelberg, Germany. May 5-10 2019.
presented by Dr. M. Le Tertre
(7) « CFTR conformational landscape explored by computational approaches »
Ahmad Elbahnsi, Fabio Pietrucci, Brice Hoffmann, Benjamen Boucherle, Renaud Zelli, Lionel Froux, Arnaud Billet, Nesrine Baatallah, Pierre Lehn, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter, Frederic Becq, Jean-Luc Décout, Jean-Paul Mornon, Isabelle Callebaut.
16th Basic Science European Cystic Fibrosis Conference, Dubrovnik, Croatia. March 27-30 2018.
(6) « Conformational map of the CFTR channel to decipher impacts of mutations and modulators »
Ahmad Elbahnsi, Fabio Pietrucci, Brice Hoffmann, Benjamen Boucherle, Renaud Zelli, Lionel Froux, Arnaud Billet, Nesrine Baatallah, Pierre Lehn, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter, Frederic Becq, Jean-Luc Décout, Jean-Paul Mornon, Isabelle Callebaut.
13th European CF Young Investigators’ Meeting (EYIM), Institut Pasteur Paris, France. February 27-28 & March 1 2019.
(5) « Advanced molecular dynamics simulations for understanding the functions and dysfunctions of the CFTR channel »
Ahmad Elbahnsi, Fabio Pietrucci, Brice Hoffmann, Pierre Lehn, Jean-Luc Décout, Jean-Paul Mornon and Isabelle Callebaut.
41st European Cystic Fibrosis Conference, Belgrade, Serbia. June 6-9 2018.
presented by Dr. I. Callebaut
(4) « Metadynamics simulations to study the transition between open and closed forms of the CFTR channel »
Ahmad Elbahnsi, Fabio Pietrucci, Brice Hoffmann, Pierre Lehn, Jean-Luc Décout, Jean-Paul Mornon and Isabelle Callebaut.
15th Basic Science European Cystic Fibrosis Conference, Loutraki, Greece. March 21-24 2018.
(3) « Benefit of CFTR 3D structure and dynamics to identify modulators binding sites and develop new molecules »
Ahmad Elbahnsi, Fabio Pietrucci, Brice Hoffmann, Alexandre Hinzpeter, Nesrine Baatallah. L. Froux, Arnaud Billet, R. Zelli, Pierre Lehn, Isabelle Sermet-Gaudelus, Aleksander Edelman, Frédéric Becq, Jean-Luc Décout, Jean-Paul Mornon and Isabelle Callebaut.
12th European CF Young Investigators’ Meeting (EYIM), Institut Pasteur Paris, France. February 21-23 2018.
(2) « Structure and dynamics of human CFTR »
Ahmad Elbahnsi, Brice Hoffmann, Fabio Pietrucci, Benjamen Boucherle, Jean-Luc Décout, Pierre Lehn, Jean-Paul Mornon and Isabelle Callebaut.
20th GGMM, Reims, France. May 9-11 2017.
(1) «New insights on nucleic acids - protein interfaces revealed by VLDM, a geometrical approach »
Ahmad Elbahnsi, Olivier Mauffret, David Perahia, Brigitte Hartmann and Christophe Oguey.
19th Albany Conversation, Albany, United States. June 9-13 2015.
Journal of Biomolecular Structure and Dynamics (2015).
(2) « Structural Explorations of NCp7–Nucleic Acid Complexes Give Keys to Decipher the Binding Process »
Romain Retureau, Christophe Oguey, Olivier Mauffret and Brigitte Hartmann
Journal of Molecular Biology (2019)
(1) «High-resolution biophysical analysis of the dynamics of nucleosome formation »
Akiko Hatakeyama, Brigitte Hartmann, Andrew Travers, Claude Nogues & Malcolm Buckle.
Scientific Reports (2015).