Publications

Representative publications by the AdenoNet participants:

1. Alzuguren, P., Hervas-Stubbs, S., González-Aseguinolaza, G., Poutou, J., Fortes, P., Mancheno, U., Bunuales, M., Olague, C., Razquin, N., Van Rooijen, N., Enguita, M. and Hernández-Alcoceba, R. (2015) Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Liver Int, 35, 1274-1289. doi:10.1111/liv.12571.

2. Iker Ausejo-Mauleon, Sara Labiano, Daniel de la Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corpión, Laasya Dhandapani, Silvestre Vicent, Maria Collantes, Iván Peñuelas, Oren J. Becher, Mariella G. Filbin, Li Jiang, Jenna Labelle, Carlos A.O. de Biagi-Junior, Javad Nazarian, Sandra Laternser, Timothy N. Phoenix, Jasper van der Lugt, Mariette Kranendonk, Raoull Hoogendijk, Sabine Mueller, Carlos De Andrea, Ana C. Anderson, Elizabeth Guruceaga, Carl Koschmann, Viveka Nand Yadav, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Fernando Pastor, Marta M. Alonso (2023) TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Cancer Cell 412023, 1911-1926. doi:10.1016/j.ccell.2023.09.001.

3. Belmar-López, C., Mendoza, G., Oberg, D., Burnet, J., Simon, C., Cervello, I., Iglesias, M., Ramirez, J.C., López-Larrubia, P., Quintanilla, M. and Martín-Duque, P. (2013) Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth. BMC Med, 11, 139. doi:10.1186/1741-7015-11-139.

4. Bofill-De Ros, X., Gironella, M. and Fillat, C. (2014) miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. Mol Ther, 22, 1665-1677. doi:10.1038/mt.2014.98.

5. Bofill-De Ros, X., Villanueva, E. and Fillat, C. (2015) Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells. Oncotarget, 6, 6179-6190. doi:10.18632/oncotarget.3350.

6. Carratalà, A., Rusiñol, M., Rodriguez-Manzano, J., Guerrero-Latorre, L., Sommer, R. and Girones, R. (2013) Environmental Effectors on the Inactivation of Human Adenoviruses in Water. Food Environ Virol. doi:10.1007/s12560-013-9123-3.

7. Condezo, G.N. and San Martín, C. (2017) Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and packaging occur concurrently at the periphery of the replication center. PLoS Pathog 13(4): e1006320. doi:10.1371/journal.ppat.1006320.

8. Condezo, G.N., Marabini, R., Ayora, S., Carazo, J.M., Alba, R., Chillón, M. and San Martín, C. (2015) Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k. Journal of Virology, 89, 9653-9664. doi:10.1128/jvi.01453-15.

9. Costa-Garcia, M., Rojas, J., Ramos, M. et al. Oncolytic adenovirus coding for shedding-resistant MICA enhances immune responses against tumors. Cancer Immunol Immunother 73, 5 (2024). doi:10.1007/s00262-023-03611-3.

10. Crespo-Barreda, A., Encabo-Berzosa, M.M., González Pastor, R., Ortiz-Teba, P., Iglesias, M., Serrano, J.L. and Martín-Duque, P. (2015) Viral and nonviral vectors for in vivo and ex vivo gene therapies. In Laurence, J. (ed.), Translating Regenerative Medicine to the Clinic. Elsevier, pp. 155-178.

11. Fajardo, C.A., Guedan, S., Rojas, L., Moreno, R., Arias-Badia, M., de Sostoa, J., June, C. H.,  and Alemany, R. Oncolytic adenoviral delivery of an EGFR-targeting T cell engager improves antitumor efficacy. Cancer Res. 2017 Jan 31. doi: 10.1158/0008-5472.CAN-16-1708.

12. Martín, V., Pascual, E., Avia, M., Pena, L., Valcárcel, F. and Sevilla, N. (2015) Protective Efficacy in Sheep of Adenovirus-Vectored Vaccines against Bluetongue Virus Is Associated with Specific T Cell Responses. PLoS One, 10, e0143273. doi:10.1371/journal.pone.0143273.

13. Martín, V., Pascual, E., Avia, M., Rangel, G., de Molina, A., Alejo, A. and Sevilla, N. (2016) A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice. J Virol 90:3783–3788. doi:10.1128/JVI.03258-15.

14. Martínez-Aguado, P., Serna-Gallego, A., Marrugal-Lorenzo, J.A., Gómez-Marín, I. and Sánchez-Céspedes, J. (2015) Antiadenovirus drug discovery: potential targets and evaluation methodologies. Drug Discov Today, 20, 1235-1242. doi:10.1016/j.drudis.2015.07.007.

15. Martínez-Vélez, N., Xipell, E., Vera, B., Acanda de la Rocha, A., Zalacain, M., Marrodan, L., González-Huarriz, M., Toledo, G., Cascallo, M., Alemany, R., Patiño-García, A. and Alonso, M.M. (2015) The oncolytic adenovirus VCN-01 as therapeutic approach against pediatric osteosarcoma. Clin Cancer Res. doi:10.1158/1078-0432.CCR-15-1899.

16. Mato-Berciano, A., Raimondi, G., Victoria Maliandi, M., Alemany, R., Montoliu, L., and Fillat, C. (2017). A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel. Oncotarget, 5. doi: 10.18632/oncotarget.15169 

17. Menéndez-Conejero, R., Nguyen, T. H., Singh, A. K., Condezo, G. N., Marschang, R. E., van Raaij, M. J, and San Martín, C. (2017) Structure of a Reptilian Adenovirus Reveals a Phage Tailspike Fold Stabilizing a Vertebrate Virus Capsid. Structure, in press. doi: 10.1016/j.str.2017.08.007

18. Moreno, R., Rojas, L. A., Vilardell Villellas, F., Cervera Soriano, V., García-Castro, J., Fajardo, C. A. and Alemany, R.(2017) Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus. Stem Cells International, Article ID 3615729. http://dx.doi.org/10.1155/2017/3615729

19. Ortega-Esteban, A., Condezo, G.N., Pérez-Berná, A.J., Chillón, M., Flint, S.J., Reguera, D., San Martín, C. and de Pablo, P.J. (2015) Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus. ACS Nano, 9, 10826-10833. doi:10.1021/acsnano.5b03417.

20. Pénzes, J.J., Menéndez-Conejero, R., Condezo, G.N., Ball, I., Papp, T., Doszpoly, A., Paradela, A., Pérez-Berná, A.J., López-Sanz, M., Nguyen, T.H., van Raaij, M.J., Marschang, R.E., Harrach, B., Benkö, M. and San Martín, C. (2014) Molecular characterization of a lizard adenovirus reveals the first atadenovirus with two fiber genes and the first adenovirus with either one short or three long fibers per penton. J Virol, 88, 11304-11314. doi:10.1128/JVI.00306-14.

21. Pérez-Berná, A.J., Marion, S., Chichón, F.J., Fernández, J.J., Winkler, D.C., Carrascosa, J.L., Steven, A.C., Šiber, A. and San Martín, C. (2015) Distribution of DNA-condensing protein complexes in the adenovirus core. Nucleic Acids Res, 43, 4274-4283. doi:10.1093/nar/gkv187.

22. Pérez-Illana, M., Martínez, M., Condezo, G.N., Hernando-Pérez, M., Mangroo, C., Brown, M., Marabini, R. and San Martín, C. Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses. Science Advances, 7, eabd9421. doi:10.1126/sciadv.abd9421.

23. Piedra, J., Ontiveros, M., Miravet, S., Penalva, C., Monfar, M. and Chillón, M. (2015) Development of a rapid, robust, and universal picogreen-based method to titer adeno-associated vectors. Hum Gene Ther Methods, 26, 35-42. doi:10.1089/hgtb.2014.120.

24. Poutou, J., Bunuales, M., González-Aparicio, M., García-Aragoncillo, E., Quetglas, J.I., Casado, R., Bravo-Pérez, C., Alzuguren, P. and Hernández-Alcoceba, R. (2015) Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model. Gene Ther, 22, 696-706. doi:10.1038/gt.2015.45.

25. Reyes-Andrade, J., Sánchez-Céspedes, J., Olbrich, P., Falcon, L., Sánchez-Ganfornina, I., Tebruegge, M., Pérez-Romero, P. and Neth, O. (2014) Meningoencephalitis due to adenovirus in a healthy infant mimicking severe bacterial sepsis. Pediatr Infect Dis J, 33, 416-419. doi:10.1097/INF.0000000000000128.

26. Rodríguez-García, A., Giménez-Alejandre, M., Rojas, J.J., Moreno, R., Bazán-Peregrino, M., Cascallo, M. and Alemany, R. (2015a) Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression. Clin Cancer Res, 21, 1406-1418. doi:10.1158/1078-0432.CCR-14-2213.

27. Rodriguez-García, A., Svensson, E., Gil-Hoyos, R., Fajardo, C.A., Rojas, L.A., Arias-Badía, M., Loskog, A.S. and Alemany, R. (2015b) Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity. Gene Ther, 22, 596-601. doi:10.1038/gt.2015.41.

28. Rojas, L. A., Condezo, G. N., Moreno Olié, R., Fajardo, C. A., Arias-Badía, M., San Martín, C. and Alemany, R. (2016) Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery. J Control Release, 237, 78-88. doi:10.1016/j.jconrel.2016.07.004. 

29. Rojas, J. M., Barba-Moreno D., Avia M., Sevilla N. and  Martín V. (2021) Vaccination With Recombinant Adenoviruses Expressing the Bluetongue Virus Subunits VP7 and VP2 Provides Protection Against Heterologous Virus Challenge.  Front Vet Sci, 8, 158. doi:10.3389/fvets.2021.645561.

30. Rusiñol, M., Fernández-Cassi, X., Timoneda, N., Carratalà, A., Abril, J.F., Silvera, C., Figueras, M.J., Gelati, E., Rodó, X., Kay, D., Wyn-Jones, P., Bofill-Mas, S. and Girones, R. (2015) Evidence of viral dissemination and seasonality in a Mediterranean river catchment: Implications for water pollution management. J Environ Manage, 159, 58-67. doi:10.1016/j.jenvman.2015.05.019.

31. Sánchez-Céspedes, J., Moyer, C.L., Whitby, L.R., Boger, D.L. and Nemerow, G.R. (2014) Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative. Antiviral Res, 108, 65-73. doi:10.1016/j.antiviral.2014.05.010.

32. Singh, A.K., Menéndez-Conejero, R., San Martín, C. and van Raaij, M.J. (2014) Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1. PLoS One, 9, e114373. doi:10.1371/journal.pone.0114373.

33. Vera, B., Martínez-Vélez, N., Xipell, E., Acanda de la Rocha, A., Patiño García, A., Castresana, J.S., González-Huarriz, M., Cascallo, M., Alemany, R. and Alonso, M.M. (2016) Characterization of the antiglioma effect of the oncolytic adenovirus VCN-01. PLoS ONE 11(1): e0147211. doi:10.1371/journal.pone.0147211.

34. Villanueva E, Navarro P, Rovira-Rigau M, Sibilio A, Méndez R, and Fillat C. (2017) Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies. Nat Commun. 8:14833. doi: 10.1038/ncomms14833.