News

Representative publications by the AdenoNet participants:

  1. Alzuguren, P., Hervas-Stubbs, S., González-Aseguinolaza, G., Poutou, J., Fortes, P., Mancheno, U., Bunuales, M., Olague, C., Razquin, N., Van Rooijen, N., Enguita, M. and Hernández-Alcoceba, R. (2015) Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Liver Int, 35, 1274-1289. doi:10.1111/liv.12571.

  2. Belmar-López, C., Mendoza, G., Oberg, D., Burnet, J., Simon, C., Cervello, I., Iglesias, M., Ramirez, J.C., López-Larrubia, P., Quintanilla, M. and Martín-Duque, P. (2013) Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth. BMC Med, 11, 139. doi:10.1186/1741-7015-11-139.

  3. Bofill-De Ros, X., Gironella, M. and Fillat, C. (2014) miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. Mol Ther, 22, 1665-1677. doi:10.1038/mt.2014.98.

  4. Bofill-De Ros, X., Villanueva, E. and Fillat, C. (2015) Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells. Oncotarget, 6, 6179-6190. doi:10.18632/oncotarget.3350.

  5. Carratalà, A., Rusiñol, M., Rodriguez-Manzano, J., Guerrero-Latorre, L., Sommer, R. and Girones, R. (2013) Environmental Effectors on the Inactivation of Human Adenoviruses in Water. Food Environ Virol. doi:10.1007/s12560-013-9123-3.

  6. Condezo, G.N., Marabini, R., Ayora, S., Carazo, J.M., Alba, R., Chillón, M. and San Martín, C. (2015) Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k. Journal of Virology, 89, 9653-9664. doi:10.1128/jvi.01453-15.

  7. Crespo-Barreda, A., Encabo-Berzosa, M.M., González Pastor, R., Ortiz-Teba, P., Iglesias, M., Serrano, J.L. and Martín-Duque, P. (2015) Viral and nonviral vectors for in vivo and ex vivo gene therapies. In Laurence, J. (ed.), Translating Regenerative Medicine to the Clinic. Elsevier, pp. 155-178.

  8. Martín, V., Pascual, E., Avia, M., Pena, L., Valcárcel, F. and Sevilla, N. (2015) Protective Efficacy in Sheep of Adenovirus-Vectored Vaccines against Bluetongue Virus Is Associated with Specific T Cell Responses. PLoS One, 10, e0143273. doi:10.1371/journal.pone.0143273.

  9. Martín, V., Pascual, E., Avia, M., Rangel, G., de Molina, A., Alejo, A. and Sevilla, N. (2016) A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice. J Virol, in press. doi:10.1128/JVI.03258-15.

  10. Martínez-Aguado, P., Serna-Gallego, A., Marrugal-Lorenzo, J.A., Gómez-Marín, I. and Sánchez-Céspedes, J. (2015) Antiadenovirus drug discovery: potential targets and evaluation methodologies. Drug Discov Today, 20, 1235-1242. doi:10.1016/j.drudis.2015.07.007.

  11. Martínez-Vélez, N., Xipell, E., Vera, B., Acanda de la Rocha, A., Zalacain, M., Marrodan, L., González-Huarriz, M., Toledo, G., Cascallo, M., Alemany, R., Patiño-García, A. and Alonso, M.M. (2015) The oncolytic adenovirus VCN-01 as therapeutic approach against pediatric osteosarcoma. Clin Cancer Res. doi:10.1158/1078-0432.CCR-15-1899.

  12. Ortega-Esteban, A., Condezo, G.N., Pérez-Berná, A.J., Chillón, M., Flint, S.J., Reguera, D., San Martín, C. and de Pablo, P.J. (2015) Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus. ACS Nano, 9, 10826-10833. doi:10.1021/acsnano.5b03417.

  13. Pénzes, J.J., Menéndez-Conejero, R., Condezo, G.N., Ball, I., Papp, T., Doszpoly, A., Paradela, A., Pérez-Berná, A.J., López-Sanz, M., Nguyen, T.H., van Raaij, M.J., Marschang, R.E., Harrach, B., Benkö, M. and San Martín, C. (2014) Molecular characterization of a lizard adenovirus reveals the first atadenovirus with two fiber genes and the first adenovirus with either one short or three long fibers per penton. J Virol, 88, 11304-11314. doi:10.1128/JVI.00306-14 .

  14. Pérez-Berná, A.J., Marion, S., Chichón, F.J., Fernández, J.J., Winkler, D.C., Carrascosa, J.L., Steven, A.C., Šiber, A. and San Martín, C. (2015) Distribution of DNA-condensing protein complexes in the adenovirus core. Nucleic Acids Res, 43, 4274-4283. doi:10.1093/nar/gkv187.

  15. Piedra, J., Ontiveros, M., Miravet, S., Penalva, C., Monfar, M. and Chillón, M. (2015) Development of a rapid, robust, and universal picogreen-based method to titer adeno-associated vectors. Hum Gene Ther Methods, 26, 35-42. doi:10.1089/hgtb.2014.120.

  16. Poutou, J., Bunuales, M., González-Aparicio, M., García-Aragoncillo, E., Quetglas, J.I., Casado, R., Bravo-Pérez, C., Alzuguren, P. and Hernández-Alcoceba, R. (2015) Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model. Gene Ther, 22, 696-706. doi:10.1038/gt.2015.45.

  17. Reyes-Andrade, J., Sánchez-Céspedes, J., Olbrich, P., Falcon, L., Sánchez-Ganfornina, I., Tebruegge, M., Pérez-Romero, P. and Neth, O. (2014) Meningoencephalitis due to adenovirus in a healthy infant mimicking severe bacterial sepsis. Pediatr Infect Dis J, 33, 416-419. doi:10.1097/INF.0000000000000128.

  18. Rodríguez-García, A., Giménez-Alejandre, M., Rojas, J.J., Moreno, R., Bazán-Peregrino, M., Cascallo, M. and Alemany, R. (2015a) Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression. Clin Cancer Res, 21, 1406-1418. doi:10.1158/1078-0432.CCR-14-2213.

  19. Rodriguez-García, A., Svensson, E., Gil-Hoyos, R., Fajardo, C.A., Rojas, L.A., Arias-Badía, M., Loskog, A.S. and Alemany, R. (2015b) Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity. Gene Ther, 22, 596-601. doi:10.1038/gt.2015.41.

  20. Rusiñol, M., Fernández-Cassi, X., Timoneda, N., Carratalà, A., Abril, J.F., Silvera, C., Figueras, M.J., Gelati, E., Rodó, X., Kay, D., Wyn-Jones, P., Bofill-Mas, S. and Girones, R. (2015) Evidence of viral dissemination and seasonality in a Mediterranean river catchment: Implications for water pollution management. J Environ Manage, 159, 58-67. doi:10.1016/j.jenvman.2015.05.019.

  21. Sánchez-Céspedes, J., Moyer, C.L., Whitby, L.R., Boger, D.L. and Nemerow, G.R. (2014) Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative. Antiviral Res, 108, 65-73. doi:10.1016/j.antiviral.2014.05.010.

  22. Singh, A.K., Menéndez-Conejero, R., San Martín, C. and van Raaij, M.J. (2014) Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1. PLoS One, 9, e114373. doi:10.1371/journal.pone.0114373.

  23. Vera, B., Martínez-Vélez, N., Xipell, E., Acanda de la Rocha, A., Patiño García, A., Castresana, J.S., González-Huarriz, M., Cascallo, M., Alemany, R. and Alonso, M.M. (2016) Characterization of the antiglioma effect of the oncolytic adenovirus VCN-01. PLoS One, in press.