Publications

UK Research and Innovation policy on open access
All published research articles should have the funding acknowledgment in the form of a sentence as follows, with the funding agency written out in full, followed by the grant number in square brackets -

This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) [grant number EP/T002778/1]

2022

2021

Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics - PNAS November 2, 2021 118 (44) e2106022118; https://doi.org/10.1073/pnas.2106022118

Kanglemycin A Can Overcome Rifamycin Resistance Caused by ADP-Ribosylation by Arr Protein - John Harbottle, Hamed Mosaei, Nicholas Allenby, Nikolay Zenkin - Antimicrobial Agents and Chemotherapy, 04 Oct 2021, 65(12):e0086421 DOI: 10.1128/aac.00864-21

The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids - Kasper Mikkelsen, Wanchat Sirisarn, Ohood Alharbib, Mohanned Alharbib, Huayong Liu, Katrine Nøhr-Meldgaard, Katharina Mayer, Martin Vestergaard, Laura A. Gallagher, Jeremy P. Derrick, Andrew J McBain, Jacob Biboy, Waldemar Vollmer, James P. O'Gara, Tom Grunert, HanneIngmer, Guoqing Xia - https://doi.org/10.1016/j.ijantimicag.2021.106283 - Open Access

Two distinct pathways of RNA polymerase backtracking determine the requirement for the Trigger Loop during RNA hydrolysis - Hamed Mosaei, Nikolay Zenkin - Nucleic Acids Research, Volume 49, Issue 15, 7 September 2021, Pages 8777–8784, https://doi.org/10.1093/nar/gkab675 - Open Access

Septal Class A Penicillin-Binding Protein Activity and ld-Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii - Katie N. Kang, Misha I. Kazi, Jacob Biboy, Joe Gray, Hannah Bovermann, Jessie Ausman, Cara C. Boutte, Waldemar Vollmer, Joseph M. Boll - ASM Journals mBio Vol. 12, No. 1 - DOI https://doi.org/10.1128/mBio.02185-20

Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment - Michal Walczak, Ryan A. Brady, Leonardo Mancini, Claudia Contini, Roger Rubio-Sánchez, William T. Kaufhold, Pietro Cicuta & Lorenzo Di Michele - Nature Communications volume 12, Article number: 4743 (2021) - https://doi.org/10.1038/s41467-021-24989-7 - Open Access

2020

Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin - Beth M. Hayes, Atanas D. Radkov, Fauna Yarza, Sebastian Flores, Jungyun Kim, Ziyi Zhao, Katrina W. Lexa, Liron Marnin, Jacob Biboy, Victoria Bowcut, Waldemar Vollmer, H.F. Pedra, Seemay Chou - ARTICLE| VOLUME 183, ISSUE 6, P1562-1571.E12, DECEMBER 10, 2020 - DOI:https://doi.org/10.1016/j.cell.2020.10.042

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression - Viralkumar V. Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A. F. Sutton, Oliver T. Carnell, David P. Hornby, Jeffrey Green, Jamie K. Hobbs, William L. Kelley, Nikolay Zenkin, Simon J. Foster. Published: July 24, 2020 https://doi.org/10.1371/journal.ppat.1008672 - Open Access.

Cytosolic Crowding Drives the Dynamics of Both Genome and Cytosol in Escherichia coli Challenged with Sub-lethal Antibiotic Treatments - Michal Wlodarski, Leonardo Mancini, Bianca Raciti, Bianca Sclavi, Marco Cosentino Lagomarsino, Pietro Cicuta. Published September 14, 2020 - DOI:https://doi.org/10.1016/j.isci.2020.101560 - Open Access.

Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP - Estelle Crozat, Catherine Tardin, Maya Salhi, Philippe Rousseau, Armand Lablaine, Tommaso Bertoni, David Holcman, Bianca Sclavi, Pietro Cicuta & François Cornet. Nature Communications volume 11, Article number: 3796 (2020) - https://doi.org/10.1038/s41467-020-17606-6 - Open Access.

Stability of β-lactam antibiotics in bacterial growth media - Rebecca Brouwers, Hugh Vass, Angela Dawson, Tracey Squires,S harareh Tavaddod, Rosalind J. Allen. Published: July 20, 2020 - https://doi.org/10.1371/journal.pone.0236198 - Open Access.

Ureidothiophene inhibits interaction of bacterial RNA polymerase with –10 promotor element - John Harbottle, Nikolay Zenkin - Nucleic Acids Research, Volume 48, Issue 14, 20 August 2020, Pages 7914–7923 - https://doi.org/10.1093/nar/gkaa591

The architecture of the Gram-positive bacterial cell wall - Pasquina-Lemonche L, Burns J, Turner RD, Kumar S, Tank R, Mullin N, Wilson JS, Chakrabarti B, Bullough PA, Foster SJ, Hobbs JK - Nature, 29 Apr 2020, 582(7811):294-297 - https://doi.org/10.1038/s41586-020-2236-6

Immune factor of bacterial origin protects ticks against host microbial commensal - Beth M. Hayes, Atanas D. Radkov, Fauna Yarza, Sebastian Flores, Jungyun Kim, Ziyi Zhao, Katrina W Lexa, Liron Marnin, Jacob Biboy, Victoria Bowcut, Waldemar Vollmer, Joao HF Pedra, Seemay Choudoi - https://doi.org/10.1101/2020.04.10.036376. This article is a preprint and has not been certified by peer review

Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest - Flint Stevenson-Jones, Jason Woodgate, Daniel Castro-Roa, and Nikolay Zenkin - PNAS April 14, 2020 117 (15) 8462-8467; first published April 1, 2020 - https://doi.org/10.1073/pnas.1919985117

Scratching the Surface: Bacterial Cell Envelopes at the Nanoscale - Albertus Viljoen, Simon J. Foster, Georg E. Fantner, Jamie K. Hobbs, Yves F. Dufrêne - DOI: 10.1128/mBio.03020-19

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like Molecules - Hamed Mosaei, and Nikolay Zenkin - https://www.asmscience.org/content/journal/ecosalplus/10.1128/ecosalplus.ESP-0017-2019