Under preparation

L. Pasquina Lemonche, J. K. Hobbs, S. J. Foster.; Book chapter: Atomic force microscopy for the study of bacterial cell wall architecture: purified peptidoglycan and live cells. Methods in Molecular Biology (submitted 2022)

L. Pasquina-Lemonche*, O. Meacock*, A. Feyisara-Olulana, W. M. Durham, S. J. Foster, E. Garner and J. K Hobbs.; Automated Image segmentation and analysis to study fibres in AFM images. (To be submitted 2027) - *(Authors contributed equally)

Mathew Barker, S. Nuñez-Pertiñez, A. Adedeji, J. Wilson, A. Alomari, X. Chen, N. Mullin, J. K. Hobbs, L. Pasquina-Lemonche.; FIJI routine PoreAFM: an automatic tool to quantitatively analyse porous materials from topography AFM images and produce 3D tomography representations. (To be submitted 2026) - *(Authors contributed equally)

Lea Kupcova, Nishan Nathoo, Krishna S. Chellappa, Bartosz J. Michno, Thomas Lawson, Didier Ndeh, Jessica L. Davis, Pavithra Manivannan, Joshua S. Norwood, Robert E. Smith, Emmanuel Maes, Laia Pasquina-Lemonche, Tomasz K. Prajsnar, Michelle L. Rowe, Helge C. Dorfmueller, Graham Stafford, Mike P. Williamson, Stéphane Mesnage*, Loss of the rhamnan backbone in the Enterococcus faecalis ΔepaB mutant uncouples the Enterococcal Polysaccharide Antigen decorations from biological activity.  (In Preparation 2026)

Published

2026

Forty years of atomic force microscopy

Toshio Ando, Leo Gross, Melanie Koehler, Christine Kranz, Ioanna Mela, Ernst Meyer and L. Pasquina-Lemonche, Nature Reviews Physics, 8, 405–409 (2026)

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing

Benjamin O. Murray, Jinhui Gao, L. Pasquina-Lemonche, Katherine Swarbrick, Guy Simpson, Mark A. Chambers, Hardev Pandha, Alex Freeman and  Jennifer L. Rohn, British Journal of Cancer (2026)

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

Ramon Garcia Maset, Aaron Crowther, Victoria Chu, Davide Di Grande, Rizka O.A. Jariah, Jenny Yoon, Dalia Blumgart, Marloes A.E Hodek, Nicholas Yuen, Benjamin O. Murray, Laia Pasquina-Lemonche, Sara N.H Alghamd, Andrew D. Millard, Gareth LuTheryn, Melissa E.K. Haines, Martha R.J. Clokie, Eleanor Stride, Dario Carugo, Jennifer L. Rohn (BioRXiv accepted into Nature Communications, 2026).

2025

Control of morphogenesis during the Staphylococcus aureus cell cycle

Tinajero-Trejo, M., Aindow, M., Pasquina-Lemonche, L., Lafage, L., Adedeji-Olulana, A.F., Sutton, J.A., Wacnik, K., Jia, Y., Bilyk, B., Yu, W. and Hobbs, J.K., 2025. Science advances, 11(15), p.eadr5011. 

Assessing the Mechanism of Action of Synthetic Nanoengineered Antimicrobial Polymers against the Bacterial Membrane of Pseudomonas aeruginosa

R. Garcia-Maset, S. C. L. Hall, L. A. Clifton, A. Hapeshi, L. Pasquina-Lemonche, J. K. Hobbs, F. Harrison, S. Perrier.; Biomacromolecules (2025) 26 (10): 6854–6868. 

2024

Two codependent routes lead to high-level MRSA

Adedeji-Olulana, A.F., Wacnik, K., Lafage, L., Pasquina-Lemonche, L., Tinajero-Trejo, M., Sutton, J.A., Bilyk, B., Irving, S.E., Portman Ross, C.J., Meacock, O.J.,  Randerson, S.A., Beattie, E., Owen, D.S., Florence, J., Durham, W. M., Hornby, D. P., Corrigan, R. M., Green, J., Hobbs, J. K. and Foster, S. J., Science, 386(6721), pp.573-580.  (2024)

Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

V. Salgueiro, J. Bertol, C. Gutierrez, A. Palacios, L. Pasquina-Lemonche, A. Espalliat, L. Lerna, B. Weinrick, J. L. Lavin, F. Elortza, M. Azkalgorta, A. Prieto, P. Buendía-Nacarino, J. L. Luque-García, O. Neyrolles, F. Cava, J. K. Hobbs, J. Sanz, R. Prados-Rosales, eLife. 13, RP94982 (2024)

2023

Mechanism of Action of Oxazoline-Based Antimicrobial Polymers Against Staphylococcus aureus: In Vivo Antimicrobial Activity Evaluation

M. Concilio, R. Garcia-Maset, L. Pasquina-Lemonche, V. Kontrimas, J. Song, S. Rajendrakumar, F. Harrison, C. Remzi-Becer, S. Perrier, Adv. Healthcare Mater.12, 2301961 (2023)

2022

The Staphylococcus aureus cell division protein, DivIC, interacts with the cell wall and controls its biosynthesis.

M. Tinajero-Trejo,* O. Carnell*, A. F. Kabli, L. Pasquina-Lemonche, L. Lafage, A. Han, J. Hobbs, S. Foster.; Commun Biol 5, 1228 (2022) - (*Authors Equally Contributed)

2021

Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics.

B. Salamaga*, L. Kong*, L. Pasquina-Lemonche*, L. Lafage*, M. Muhlen*, J. Gibson, D. Grybchuk, A. Tooke, V. Panchal, E. Culp, E. Tatham, M. O’Kane, T. Catley, S. Renshaw, G. Wright, P. Plevka, P. Bullough, A. Han, J. Hobbs, S. Foster; PNAS, 118(44), e2106022118 (2021) -  (*Authors Equally Contributed)

Correlative Super-Resolution Optical and Atomic Force Microscopy Reveals Relationships Between Bacterial Cell Wall Architecture and Synthesis in Bacillus subtilis. 

R. Tank,* V. Lund,* S. Kumar, R. Turner, L. Lafage, L. Pasquina-Lemonche, P. Bullough, A. Cadby, S. Foster, J. Hobbs.;  ACS nano 15 (10), (2021) -  (*Authors Equally Contributed)

2020

The architecture of the Gram-positive bacterial cell wall. View this article in WRRO 

Pasquina-Lemonche L*, Burns J*, Turner RD, Kumar S, Tank R, Mullin N, Wilson JS, Chakrabarti B, Bullough PA, Foster SJ and Hobbs JK, Nature, 582, 294–297 (2020) (*Authors Equally Contributed)

Rational Design and Self-Assembly of Coiled-Coil Linked SasG Protein Fibrils.

L. Jasaitis, D. Silver, E. Rawlings, T. Peters, F. Whelan, L. Regan, L. Pasquina-Lemonche, J. Potts, S. Johnson, S. Staniland.; ACS Synthetic Biology 9 (7),1599-1607 (2020).

2018

Insights into the structure and nanomechanics of a quatsome membrane by force spectroscopy measurements and molecular simulations. View this article in WRRO

Gumí-Audenis, B., Illa-Tuset, S., Grimaldi, N., Pasquina-Lemonche, L., Ferrer-Tasies, L., Sanz, F., Veciana, J., Ratera, I., Faraudo, J., Ventosa, N., Giannotti, M. I.;  Nanoscale 10 (48), 23001-23011. (2018)