Programme

9 AM Arrival, registration & coffee

Session 1: Organelle and synaptic signalling

Session Chair: Noemie Hamilton

9:45 AM Introduction

9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation, function & plasticity"

10:10 AM Cahir J O'Kane, University of Cambridge, "Axonal ER: architecture, function and disease"

10:30 AM John Franklin, The Francis Crick Institute / King's College London, "A wave of ER calcium depletion and fragmentation determines cell fate in NMDAr-mediated excitotoxicity of rodent hippocampal neurons"

10:50 AM Diogo Candeias, University of York, "Using non-mammalian models to elucidate the pathology of a novel white matter disorder"

11:10 AM Coffee Break

Session 2:  Single molecule neurobiology

Session Chair: Rosalind Norkett

11:25 AM Emma Turner, University of Sheffield, "Altered molecular mechanisms of KIF5A in neurodegenerative disease"

11:45 AM Noelia Pelegrina-Hidalgo, University of Edinburgh, "VISTA: A promising new tool to detect biomarkers in blood"

12:05 PM Anna Bodzeta, University of Bristol, "Why so fast? The role of rapid diffusion of intramembrane proteases in shaping lateral organization of synapses"

12:25 PM Takeshi Kaizuka, University of Edinburgh, "Whole-brain single-synapse mapping of postsynaptic protein complex organisation"

Lunch, networking and poster session

12:45 PM Lunch & posters

Plenary speaker 

15:00 PM Cathy Abbott - The University of Edinburgh, "Approaches to understanding and treating EEF1A2 –related neurodevelopmental disorder"

Session 3: Molecular mechanisms of disease

Session Chair: Tobias Moll

15:40 PM Nicolas Marichal, King's College London, "Reprogramming epilepsy: glia-to-neuron conversion as an experimental strategy for the treatment of MTLE"

16:00 PM Molly Magarotto, University of York, "JNK-associated neuronal overgrowth in response to ALS/FTD-associated RNA-binding deficient TDP-43"

16:20 PM Brittany Ellis, The University of Sheffield, "STMN2, a potential therapeutic target in ALS, is tightly regulating during cellular stress"

16:40 PM Karen Smillie, University of Edinburgh, "Presynaptic dysfunction in a mouse model of Huntington’s Disease results from huntingtin haploinsufficiency"

17:00 PM Drinks reception. 

After drinks we have space reserved at BrewYork Walmgate (directions here) for anyone wanting food with friends & colleagues before heading home.