In our lab, we are deeply passionate about unravelling the mysteries of mitochondria in neurodegenerative diseases, with a primary focus on Parkinson's Disease (PD). Our research spans various facets of mitochondrial biology, including function, DNA, morphology, and recycling, while exploring their intricate connections with other cellular pathways. 

We are committed to advancing the understanding of mitochondrial dysfunction in neurodegenerative conditions, striving to identify novel therapeutic targets and interventions. Through in vitro drug screening using patient tissue, we aim to uncover molecules capable of rescuing mitochondrial function, potentially offering new avenues for treatment. 

Recent endeavours have expanded our scope to include investigations into mitochondrial abnormalities in other neurodegenerative diseases, such as Alzheimer's Disease and Motor Neuron Disease. We find it particularly intriguing to explore the differing mitochondrial phenotypes between these conditions and the mechanisms driving neuronal vulnerability. 

Our current projects reflect our ongoing commitment to groundbreaking research in the field: 

1. Targeting mitochondrial dysfunction with novel small molecules in Parkinson's Disease and Alzheimer's Disease. 

2. Repurposing of compounds for the treatment of Parkinson's Disease. 

3. Exploring the connection between LRRK2 and mitochondria. 

4. Investigating differing types of mitophagy in neurons and astrocytes. 

5. Targeting mitophagy with small molecules in Parkinson's Disease. 

6. Studying mitochondrial morphological abnormalities in patient-derived models of Alzheimer's Disease. 

7. Compound screening in Alzheimer's Disease

8. Understanding metabolic abnormalities in Motor Neuron Disease.

9. Investigating best practices to model ageing in Parkinson's Disease.