On January 5, 1935, an experimental operation was performed on Sister Gertrude Korzendorfer on a malignant tumor in the pancreas. It was initially deemed to be inoperable. Thanks to the operation and prayers by other sisters, she was cured by February and returned to normal life by March. After her death, a biopsy was done on her pancreas and there was no evidence or scarring that showed the cancer was ever there. This is the first miracle attributed to the intercession of Elizabeth Ann Seton. 

One evening in January, 1952, Ann's mother  noticed she was especially irritable, and Mr. O'Neill took her to the doctor after dinner. Ann was taken home but she didn't look normal, her face was white and swollen and her head constantly shook. She got to a point where she was covered in sores and was struggling to breath. Ann was taken back to St. Agnes, where Sister Mary Alice Fowler was supervisor of pediatrics. She told Mrs. O'Neill about Mother Seton and began a novena of prayers. Prayer cards were distributed to nuns, priests, and relatives. Along with this, a relic, a cloth that had touched Mother Seton's remains, was pinned to Ann's gown. She seemed to improve instantly and her blood count built up. She was discharged and the family immediately made a trip to visit the site of Mother Seton's grave in Emmitsburg. Ann underwent a bone marrow test to prove the validity of her being cured. Her curing was unanimously deemed a miracle by both the reviewing clergy and medical professionals alike. 

Carl Kolin was admitted to the hospital on October 9, 1963. He had a disease of the brain that was only seen 5 times before, all others with the same diagnosis had died. They first pinned a relic to his gown but his health took a negative turn. They then brought in a first class relic that they placed on his head while the sisters and his wife prayed and asked for Mother Seton's intercession. 2 days later, a night nurse placed the relic on Carl's head and his convulsions stopped. Within 5-6 days, Carl was up and alert. Nine years later, the disease had not returned.