Publications

‡ = equal contribution; * = corresponding author

33.   V. Revazishvili‡, A. Morales‡, B. Baxter, J. Grim, A. Chakhrakia, A. Jimenez Salinas, A. M. Riestra, Y.K. Lee* "Quantitative Membrane Binding Assays Reveal an Inhibitory Role for the BRAF-Specific Region in CRD and Lipid Interaction" bioRxiv 2025, Link

32. A. Jimenez Salinas‡, K. Tevdorashvili‡, J. Grim, A. Morales, A. Chakhrakia, and Y.K. Lee* "Positive Cooperativity between RAS-Binding and Cysteine-Rich Domains Regulates RAF Membrane Binding Kinetics via Lateral Rebinding" bioRxiv 2025, Link

31. H. Lee, Jaehyuk Lee, M. Ko, K. Nam Lee, Y. Kim, B. Seo, Jungwon Lee, S. Jeong, K. Heo, Y.K. Lee, I. Jung, and Y. Rag Do* "Advanced Exosome Isolation through Electrophoretic Oscillation-Assisted Tangent-Flow Ultrafiltration with a PVDF-Fiber-Coated SiNx Nanofilter" ACS Appl. Bio Mater. 2025, 8 (4), 2965-2976. Link

30. G. Samaan‡, A. Jimenez Salinas‡, A. Bailie‡, J. Grim, J. Cizmic, A. Jones*, Y.K. Lee*, B.W. Purse* "Single-Molecule Detection of Oligonucleotides Using the Fluorescent Nucleobase Analogue ABN" Chem. Sci. 2025, 16, 4866. Link

29. M. Ko, H.J. Kim, J. Park, H. Lee, K.N. Lee, K. Kim, J. Lee, S.J. Yoon, T. Kim, S. Jeong, K. Heo, Y.K. Lee, Y. Rag. Do* "Isolation of Bovine Milk Exosome Using Electrophoretic Oscillation Assisted Tangential Flow Filtration with Antifouling of Micro-ultrafiltration Membrane Filters" ACS Appl. Mater. Interfaces 2023, 15, 26069. Link

28. A. Jimenez Salinas, Y.K. Lee* "In unity, there is strength: Phase Separation Controls Receptor Tyrosine Kinase Signal Transduction" Mol. Cell 2022, 82, 1081. Link

27. M.R. Packer, J.A. Parker, J.K. Chung, Z. Li, Y.K. Lee, T. Cookis, H. Guterres, S. Alvarez, M.A. Hossain, D.P. Donnelly, J.N. Agar, L. Makowski, M. Buck, J.T. Groves, C. Mattos* "Raf Promotes Dimerization of the Ras G-domain with Increased Allosteric Connections" PNAS 2021, 10, 118. Link

26. D. Karandur, M. Bhattacharyya, Z. Xia, Y.K. Lee, S. Muratcioglu, D. McAffee, E.D. McSpadden, B. Qiu, J.T. Groves, E.R. Williams, J. Kuriyan*. "Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase" eLife 2020, 9. Link

25. M. Bhattacharyya‡, Y.K. Lee‡, S. Muratcioglu, B. Qiu, P. Nyayapati, H. Schulman, J.T. Groves*, J. Kuriyan* "Flexible Linkers in CAMKII Control the Balance Between Activating and Inhibitory Autophosphorylation" eLife 2020, 9. ‡=Co-first author. Link

24. S.D. Hansen, W.Y.C. Huang, Y.K. Lee, P. Bieling, S.M. Christensen, J.T. Groves* "Stochastic Geometry Sensing and Polarization in a Lipid Kinase-Phosphatase Competitive Reaction" PNAS 2019, 10, 116. Link

23. W.Y.C. Huang, S. Alvarez, Y. Kondo, Y.K. Lee, J.K. Chung, H.Y.M. Lam, K.H. Biswas, J. Kuriyan, J.T. Groves* "A Molecular Assembly Phase Transition and Kinetic Proofreading Modulate Ras Activation by SOS" Science 2019, 363, 1098. Link

22. M. Dong , D. Spelke, Y.K. Lee, J. Chung, C.-H. Yu , D. Schaffer, J.T. Groves* "Spatiomechanical Modulation of EphB4:ephrin-B2 Signaling in Neural Stem Cell Differentiation" Biophys. J. 2018, 115, 865. Link

21. J. Chung‡, Y.K. Lee‡, J. Denson, W. Gillette, S. Alvarez, A. Stephen, J.T. Groves* "Membrane-reconstituted K-Ras4B Remains Monomeric Over a Wide Range of Surface Densities and Membrane Lipid Compositions" Biophys. J. 2018, 114, 137. ‡=Co-first author. Link

20. K. Kim, J.-W. Oh, Y.K. Lee, J. Son, J.-M. Nam* "Associating and Dissociating Nanodimer Analysis for Quantifying Ultra-Small Amounts of DNA" Angew. Chem. Int. Ed. 2017, 56, 9877. Link

19. Y.K. Lee, S. Low-Nam, Jean K. Chung, S.D. Hansen, S. Alvrez, H.Y.M. Lam, J.T. Groves* "Mechanism of SOS PR-domain Autoinhibition Revealed by Single Molecule Assay on Native Protein from Lysate" Nat. Commun. 2017, 8, 15061. Link

Highlighted in December 2017 Genetic Engineering and Biotechnology News (GENengnews.com)

18. S. Kim, J.-E. Park, W. Hwang, J. Seo, Y.K. Lee, J.-H. Hwang, J.-M. Nam* "Optokinetically Encoded Nanoprobe-Based Multiplexing Strategy for MicroRNA Profiling" J. Am. Chem. Soc. 2017, 139, 3558. Link

17. J.K. Chung‡, Y.K. Lee‡, H.Y.M. Lam‡, J.T. Groves* "Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation" J. Am. Chem. Soc. 2016, 138, 1800. ‡=Co-first author. Link

16. W. Li, J.K. Chung, Y.K. Lee, J.T. Groves* "Graphene-Templated Supported Lipid Bilayer Nanochannels" Nano Lett. 2016, 16, 5022. Link

15. Y.K. Lee‡, S. Kim‡, J.-M. Nam* "Dark-Field-Based Observation of Single-Nanoparticle Dynamics on a Supported Lipid Bilayer for In Situ Analysis of Interacting Molecules and Nanoparticles" ChemPhysChem 2015, 16, 77. ‡=Co-first author. Link

14. Y.K. Lee, S. Kim, J.-W. Oh, J.-M. Nam* "Massively Parallel and Highly Quantitative Single-Particle Analysis on Interactions between Nanoparticles on Supported Lipid Bilayer" J. Am. Chem. Soc. 2014, 136, 4081. Link

Selected as JACS spotlights: "Snapshots of Nanoparticles in Action Reveal Their Interactions" J. Am. Chem. Soc. 2014 136, 3321. Link

13. S.D. Chandradoss, A.C. Haagsma, Y.K. Lee, J.-H. Hwang, J.-M. Nam and C. Joo* "Surface Passivation for Single-Molecule Protein Studies" J. Vis. Exp. 2014, 86. Link

12. Y.K. Lee‡, H. Lee‡, J.-M. Nam* "Lipid-Nanostructure Hybrids and Their Applications in Nanobiotechnology" NPG Asia Mater. 2013, 5, e48 (). ‡=Co-first author. Link

11. Y.K. Lee, J.-M. Nam* "Electrofluidic Lipid Membrane Biosensor" Small 2012, 8, 832. Link

10. J.R. Oh, B.K. Park, Y.K. Lee, Y.-D. Huh, Y.R. Do* "Enhancement of Photoluminescence by Photonic Crystal Scattering and Nanocrystalline Surface Scattering from Y2O3:Tb3+ Film Phosphors" J. Electrochem Soc. 2011, 158, J316. Link

9. D.-H. Kim, H. Lee, Y.K. Lee, J.-M. Nam*, A. Levchenko* "Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells" Adv. Mater. 2010, 22, 4551. Link

8. J.R. Oh, Y.K. Lee, H.K. Park, Y.R. Do* "Effects of Symmetry, Shape and Structural Parameters of Two-Dimensional SiNx Photonic Crystal on the Extracted Light from Y2O3:Eu3+ Film" J. Appl. Phys. 2009, 105, 043103. Link

7. K.-Y. Ko, Y.K. Lee, H.K. Park, Y.-C. Kim, Y.R. Do* "The Variation of the Enhanced Photoluminescence Efficiency of Y2O3:Eu3+ Films with the Thickness to the Photonic Crystal Layer" Opt. Express 2008, 16, 5689. Link

6. S.K. Park, Y.K. Lee, H.T. Kwak, C.R. Park, J. Park, Y.R. Do* "Periodic Growth of ZnO Nanorod Arrays on Two-Dimensional SiNx Nanohole Templates by Electrochemical Deposition" J. Phys. Chem. C 2008, 112, 4129. Link

5. K.Y. Ko, K.N. Lee, Y.K. Lee, Y.R. Do* “Enhanced Light Extraction from SrGa2S4:Eu2+ Film Phosphors Coated with Various Sizes of Polystyrene Nanosphere Monolayers“ J. Phys. Chem. C 2008, 112, 7594. Link 

4. Y.K. Lee, J. R. Oh, Y.-D. Huh, Y. R. Do* "Strong Perturbation of the Guided Light within Y2O3:Eu3+ Thin-Film Phosphors Coated with Two-Dimensional Air-Hole Photonic Crystal Arrays" Appl. Phys. Lett. 2007, 91, 231908. Link 

3. Y.K. Lee, J. R. Oh, Y. R. Do* "Enhanced Extraction Efficiency of Y2O3:Eu3+ Thin-Film Phosphors Coated with Hexagonally Close-Packed Polystyrene Nanosphere Monolayers" Appl. Phys. Lett. 2007, 91, 041907. Link 

2. Y.K. Lee, J.Y. Cho, C.R. Park, Y.-D. Huh, Y.-C. Kim, Y.R. Do*, "Optical Properties of Y2O3:Eu3+ Thin-Film Phosphors Coated with 2D SiNx/Air Photonic Crystal Layers" Electrochem. Solid State Lett. 2007, 10, H82. Link

1. K.-Y. Ko, Y.K. Lee, Y.-D. Huh, Y.R. Do*, "Structural Effect of a Two-Dimensional SiO2 Photonic Crystal Layer on Extraction Efficiency in Sputter-Deposited Y2O3:Eu3+ Thin-Film Phosphors" J. Appl. Phys. 2007, 102, 013509. Link