Abstracts

6 July 11:00 5159.0062

Master program: Medical Pharmaceutical Sciences
Keywords: Health economics, market access, cost-utility analysis, pharmacoeconomic evaluation, fixed-dose combination analgesia treatment
Internship organization: Asc Academics
Type of organization: Health economics consultancy
Daily supervisor: Sharon Wolters (PharmD, Msc)
SBP supervisor: Dr. Samie Maqbool
Science supervisor: Dr. Nynke Schuiling-Veninga
Abstract:

Comparing the Dutch and the Belgian market access process to see if a pharmacoeconomic model made by Asc Academics for one country can be adapted to also fit the other.

When getting a new drug on the market, a company must get market authorization from the College ter Beoordeling van Geneesmiddelen (CBG) and reimbursement for admittance into the basic healthcare package by the Zorginstituut Nederland (ZiN). When applying for reimbursement for your drug at the ZiN, pharmacoeconomic (PE) evaluation dossiers must be submitted, usually including a budgetimpactanalysis or a cost-effectiveness or cost-utility analysis.

Asc Academics is a global market access and health economics consultancy, specifically focussed on making these PE models and dossiers for companies. For this project, they have asked me to look into the possibilities of expanding their services by offering their clients to adapt a PE model for either the Netherlands or Belgium to also fit the other, so the drug can get reimbursed in both countries simultaneously.

To form my advice, I will create a Standard Operating Procedure (SOP) of the Dutch market access process in the form of a flowchart. Next, I will use the case study of making a cost-utility model for an intravenous fixed-dose combination (FDC) for treating acute post-operative pain for Belgium. Then, I will use all the information collected to make an overview of the differences between the Dutch and Belgian process and advice Asc Academics on the possibilities of using this information to expand their services.

8 July 11:00 5159.0062

Master program: Energy and Environmental Sciences
Keywords: Certification service for H2
Internship organization: DNV
Type of organization: Consultancy company
Daily supervisor: Corin Taylor
SBP supervisor: Dr. Amtul Samie Maqbool
Science supervisor: MSc. Gideon A.H. Laugs
Abstract:
The aim of this project was to find a potential service for DNV in the hydrogen certification sector. The push for energy transition and the regulations from the EU to achieve that have led to the increase of renewable energy demand and specifically green hydrogen. Companies will be required to provide proof for the “greenness” of their products. The standards for such a certificate are set by the EU. The main issue is the lack of those rules at the moment. An analysis of the Renewable Energy Directive (RED II) and the EU Taxonomy, set a reference for what practices are considered green at the moment. A market analysis with hydrogen producers and users gave a clear idea of what is the market demand for a hydrogen certification service. From a scientific point of view, it was very important to set the right system boundaries when calculating the emissions that should be included in the certificate. The life cycle emissions for the available production methods had to be taken into account and compared. A final advice was delivered to DNV based on the elements that should be included in such a certificate but also based on the competences of the company to provide that type of service.

8 July 11:00 5159.0010

Master program: Biomedical Sciences

Keywords: Pre-clinical usability studies; Infusion pump

Internship organization: Ivy Medical

Type of organization: Company

Daily supervisors: Ymke Janse & Melcher Frankema

SBP supervisor: Gert-Jan Euverink

Science supervisor: Anton Scheurink

Abstract:

Many patients in the hospital receive infusion therapy, for example to ensure that they do not become dehydrated or to fight a disease with antibiotics or other medicines. Infusion therapy is currently given with different types of infusion pumps which unfortunately have many flaws. That’s why Ivy Medical has developed an innovative infusion pump: the Ivy Duo⁺, which has a superior infusion technique allowing patients to be mobilized and nurses to plan infusion therapy in advance.

However, before Ivy Medical can enter the market with their product, they need a CE certificate. They can achieve this by conducting a good clinical evaluation. Within this clinical evaluation, patient safety must be assured in both technical and usability tests. During my internship project, I have concerned myself with setting up these pre-clinical usability tests.

By using CE-certification standards, literature background and taking into account the wishes of Ivy Medical, I presented them with an advice in which I described what these studies should consist of. To conclude: I advise Ivy Medical to conduct a total of 4 different study (periods): two formative studies, one pre-summative study and one end summative study. The formative studies will show which adjustments still need to be made to the product. The pre-summative study ensures that the summative study is well designed. The final summative study is the most important and will assess whether the Ivy Duo⁺ is safe to use in terms of usability. During my presentation, I will go into detail about these studies.

7 July 11:00 5159.0062

Master program: Medical Pharmaceutical Sciences
Keywords: Putting the effectivity in CE-modelling
Internship organization: Asc Academics
Type of organization: HEOR consultancy
Daily supervisor: Bert Wolters MSc.
SBP supervisor: Jorien Zevenberg MSc.
Science supervisor: Prof. Dr. Talitaha Feenstra
Abstract:

If you participate in a triathlon, all three different sports must be executed to perfection to win. The same goes for model-building. It is a multistage process that can only maximize its profitability if all stages are performed as efficiently as possible. How effective is cost-effectiveness modelling? As it turns out: it’s not that efficient at all, and that needs to be changed. For instance: Why is a lot of research done multiple times for the same project? Or even better: why are frequently used calculations not centrally provided but investigated and validated each time? Why is a model, that takes a lot of time to create, only valuable for Asc as a one-time product?

These issues and others will be discussed and investigated during my presentation on a case study into the modelling process. Several interventions will be outlined and strategies for implementation are discussed using a case study form a disease called chikungunya and its upcoming treatment. The interventions will be analyzed, and points of improvement are provided to help Asc academics have a more streamlined modelling process. Developing a model has never been more interesting than it is right now! Want to know why? Come and see my presentation!.

7 July 14:00 5159.0062

Master program: Biology
Keywords: Market analysis on (climate change) projects, acquisition, framework
Internship organization: Royal HaskoningDHV
Type of organization: Consultancy company
Daily supervisor: MSc. Jens Schepers
SBP supervisor: MSc. Jorien Zevenberg
Science supervisor: Prof. dr. Theo Elzenga
Abstract:
Royal HaskoningDHV wants to increase its profit by reducing tender costs. For every tender on a project costs are made, this investment is lost when the tender is lost. The reduction of tender losses requires an analysis on the internal acquisition and the external market. In this case I chose the climate change problem. Due to climate change policy made by the EU and Dutch government has changed. I analyzed the policy made by the Dutch government and provinces to find out what the current and future projects will focus on. The internal structure of acquisition of projects will be analyzed. Based on those findings a framework will be made which can be used to get a clear picture on the project market. The framework will provide information on project demands, the project leaders and where profit can be made. This framework will be tested on one case-study and necessary adjustments will be made after evaluation. The ultimate advice is a plan of implementation of the framework, this could be adjustments in their current way of acquisition or something completely new. This will lead to more efficient acquisition with greatest possible sustainable contribution to society.

7 July 13:00 5159.0058

Master program: Biomedical Sciences
Keywords: Molecular biology, electronic lab notebooks
Internship organization: eLabNext
Type of organization: company
Daily supervisor: Jasper Dijkstra
SBP supervisor: Michiel Berger
Scientific supervisor: Bart Eggen
Abstract:
The lab notebook is an important tool for planning and documentation of scientific research. Today's laboratory contains a lot of computerized equipment that produces large amounts of data. An electronic lab notebook (ELN) offers many advantages that help planning and organizing experimental data over the paper version. Researchers working in different fields of life sciences are often looking for different functionalities when it comes to an ELN. By using a customizable ELN, users are able to add only the functions that they are interested in. eLabNext is a software company that offers customizable digital lab solutions to support research in different fields of life sciences. To better fit the needs of customers in molecular biology, development of tools useful in this field or research. But what is it that researchers in this field are looking for in an ELN? What functionalities do they need and how important are these functionalities in their decision-making process? These questions were important during my project at eLabNext, where I worked on the main question: ‘What specialized features can add to the general benefits of an ELN in biomolecular research and how can these specialized features give a competitive advantage in the ELN market?’

8 July 10:00 5159.0291

Master program: Energy and Environmental sciences
Keywords: Smart charging, electric vehicles, electricity grid

Intership organization: GreenFlux

Type of organization: Company

Daily supervisor: Lennart Verheijen

SBP supervisor: Gideon Laugs

Science supervisor: René Benders

Abstract:

To reach the goals of the Paris Climate Agreement, the world needs to transition to renewable energy sources. The mobility sector is responsible for more than 16% of the global greenhouse gas emissions. Therefore, a transition from internal combustion engine vehicles to zero-emission vehicles is necessary. Electric vehicles (EVs) are one form of zero-emission vehicles. The number of EVs on European roads has started to increase exponentially and is expected to keep increasing.

To support this, a network of charge points is necessary. The current electricity grid and network connections are insufficient to charge all EVs at maximum capacity at the same time. GreenFlux is a company that develops and licenses a platform to charge point operators. To prevent costly grid upgrades, GreenFlux has developed an algorithm called smart charging. The smart charging algorithm takes the local situation and user preferences into account to charge EVs. This way, the grid connection is secured, and more charge points can be installed at a location.

Smart charging is one of the services that can be licensed from GreenFlux. They have asked me what they can do to enhance the adoption of smart charging among their existing customers. During this presentation I will present my findings and advice to GreenFlux.

6 July 15:30 5159.0010

Master program: Biomedical Sciences

Keywords: Market access study for ddPCR technology

Internship organization: CC Diagnostics

Type of organization: Start-up company

Daily supervisor: Nutte van Belzen

SBP supervisor: Marion van Rijssel

Science supervisor: Frank Kruyt

Abstract:

CC diagnostics' vision is the prevention of cervical cancer in women by early detection using a very accurate test named Methica CC kit. The test is based on methylated genes using a quantitative PCR (qPCR). Currently, this PCR has a specificity of 74% for women with a CIN 3 abnormality (severe tissue abnormalities, but no cancer cells). Through a cut-off optimization CC Diagnostics could add more specificity to this qPCR, increasing it to 80%. Next to the qPCR there is also the droplet digital PCR (ddPCR) which is based on a water-oil emulsion droplet technology. This technology has a higher specificity than the qPCR technology. Besides, one single ddPCR sample can generate ten to twenty thousand data points, instead of one single result with qPCR. Due to these features CC Diagnostics may be able to add more sensitivity to their test through ddPCR. The goal of this project is to examine the feasibility of basing CC Diagnostics’ cervical cancer triage test on the ddPCR technology instead of the currently used qPCR technology. The research question associated with this goal is: ‘Is it feasible to base CC Diagnostics' cervical cancer triage test on ddPCR technology?’. The aimed end product is an advisory report for CC Diagnostics that concludes in a recommendation whether or not to enter the market with the ddPCR technology. This report contains a SWOT analysis in which the business aspects will be analyzed and a description of the scientific aspects of the ddPCR technology.

7 July 14:00 5159.0010

Master program: Biomedical Sciences
Keywords: lung cancer screening cost-effectiveness analysis in the Netherlands
Internship organization: institute of diagnostic accuracy (iDNA)
Type of organization: research and consultancy institute
Daily supervisor: Hilde ten Berge
SBP supervisor: Marion van Rijssel
Science supervisor: Anton Scheurink
Abstract:

Lung cancer is the leading cause of cancer deaths worldwide and is often detected in a late stage. This has a negative impact on the prognosis. For example, the 5-year survival rate for lung cancer patients is the lowest among all cancer types. Screening with low-dose CT has proven to be effective in detecting lung cancer in earlier stages, but has not yet been implemented in most countries.

iDNA is a research and consultancy institute that aims to accelerate lung cancer screening implementation and make it available for risk groups who can benefit from such a program. In this context, performs a variety of activities. For example, iDNA has recently developed a cost-effectiveness analysis (CEA) model adaptation for lung cancer screening in the Netherlands.

However, the current CEA model requires extra input in order to be optimized. During my internship I updated the CEA by collecting data for missing parameters, such as quality of life in different lung cancer stages and progression-free survival. Additionally, I also assessed the marketability of the CEA model and/or other healthcare economic related services that iDNA can offer in the Dutch market to healthcare decision makers and/or other target groups.

6 July 15:30 5159.0062

Master program: Biomedical Sciences
Keywords: Drug repurposing, glycogen storage disease type Ib, value-based health care, orphan disease
Internship organization: University Medical Center Groningen
Type of organization: Academic Hospital
Daily supervisor: Dr. Terry G.J. Derks
SBP supervisor: Dr. Amtul Samie Maqbool
Science supervisor: Prof. dr. Anton J.W. Scheurink
Abstract:

Optimizing the care for people with Glycogen Storage Disease type Ib: A value-based healthcare approach in the showcase of repurposing the drug empagliflozin

Value-based healthcare (VBHC) is the principle of delivering the best healthcare against the lowest possible costs while making the patients the protagonists of their own treatment. The current report applies a VBHC approach in tackling the problem of off-label prescription of empagliflozin to people with Glycogen Storage Disease type Ib (GSD-Ib). GSD-Ib is an inborn error of metabolism in which patients suffer from excessive storage of glycogen in the liver. This results in, among other things, hypoglycaemia during fasting. Therefore, people with GSD-Ib have to adhere strictly to a tailored diet. On top of that, people with GSD-Ib suffer from low neutrophil counts (neutropenia) and neutrophil dysfunction. Neutropenia and neutrophil dysfunction lead to recurrent infections throughout the gastrointestinal tract. The current standard of care for these symptoms is painful subcutaneous injections with Granulocyte-Colony Stimulating Factor (G-CSF).

Empagliflozin is a drug that has been on the market for a long time. Recently, repurposing of empagliflozin has been shown to alleviate the neutropenia and neutrophil dysfunction symptoms in people with GSD-Ib. Since empagliflozin is prescribed off-label, it is not reimbursed by healthcare insurance companies. This means that patients have to pay for it themselves.

The current report elucidated the benefits and drawbacks of empagliflozin compared to G-CSF. This provides evidence that empagliflozin should be reimbursed for people with GSD-Ib. In the end, this report advises the UMCG on how to pursue the path of getting empagliflozin on-label and reimbursed for people with GSD-Ib. This will make empagliflozin better available for future patients.

6 July 12:00 5159.0110

Master program: Biomedical Sciences

Keywords: Healthcare policy, Value Based Healthcare

Internship organization: BDO Accountants & Adviseurs

Type of organization: Accountancy and consultancy firm

Daily supervisor: Robin Schepers, MSc

SBP supervisor: Dr. Jacolien Graver & Saskia Grooters

Science supervisor: Dr. Johanna (Hannie) Westra

Abstract:

The Dutch healthcare expenses are expected to increase with an average of approximately 2.8% each year until 2060. It is important to reduce this rapid growth in healthcare costs, to ensure that healthcare in the Netherlands remains accessible and affordable.

A possible solution to reduce the increase in costs would be to shift from a fee-for-service system to a value-based healthcare system. The current system (fee-for-service) is based on a fixed price for every different type of treatment. It is ‘one size fits all’, and not tailored to the needs of the patient. In this system, healthcare providers are not being rewarded for quality. Instead, the system incentivizes volume rather than value. In a value-based system, treatments are based on the needs of a patient, with the ultimate aim of providing better healthcare at lower costs.

The application of these value-based principles in healthcare are encouraged by the Dutch government, health insurers, and healthcare institutions. However, in reality, these value-based concepts are not yet applied on a large scale, including in the field of rheumatology. This presentation will give an answer to the question “What are the potential strategies for the successful implementation of value based healthcare in the treatment of rheumatic diseases?”

7 July 13:00 5159.0010

Master program: Biomedical Sciences
Keywords: Healthcare policy, home-based postpartum care, parents with a low socioeconomic status
Internship organization: ROS Friesland
Type of organization: Policy organization
Daily supervisor: Maaike van der Meulen
SBP supervisor: Dr. M. (Marion) van Rijssel
Science supervisor: Prof. Dr. J.W. (Hans) Jonker
Abstract:

Around 16% of the children in the Netherlands do not have a good start in life. Therefore, the ministry of Health, Welfare and Sport started the action program ‘Solid Start’ (Kansrijke Start). This internship project is part of the Solid Start coalition ‘Frisian learning network Solid Start’.

In the field, it has been observed that people with a low socioeconomic status (SES) in Friesland make minimal use of home-based postpartum care (HPC; ‘kraamzorg’) due to a lack of money. In my project I gave advice about how and by whom the personal contribution for HPC can be financed for them. To this aim, factors present in the HPC weeks that could affect the child’s health at that moment and in later life were investigated. Furthermore, the effect of HPC on the child’s health was researched to be able to advise whether HPC should be financed. To determine how and by whom HPC could be financed, financial structures present in Friesland and other parts of the Netherlands suitable for financing HPC were investigated. Subsequently, scenarios for financing HPC for people with a low SES in Friesland were designed and evaluated to find the optimal scenario for implementation. Finally, the steps that need to be taken to make HPC affordable for people with a low SES were given.

Are you curious about how HPC can be financed for people with a low SES in Friesland? Please join my talk during this conference. Hope to see you there!

7 July 11:00 5159.0114

Master program: Biomedical Sciences

Keywords: Pathogens, surface water, microplastics, market research, risk assessment

Internship organization: Bioclear earth

Type of organization: Consultancy and innovation company

Daily supervisor: Alie Talen, MSc

SBP supervisor: Dr. Janneke Krooneman

Science supervisor: Prof. dr. Ingrid Molema

Abstract:

Pathogens remain a public health concern globally. Bacterial pathogens can be present in both marine and freshwater bodies. When humans or animals get in contact with pathogen polluted water, the microbes can be transmitted from water to host causing water borne disease. Once pathogens are present in water, they often form a biofilm layer around microplastics. This is due to the large surface area and hydrophobicity of the plastic particles. One characteristic trait of bacteria in biofilm is the increased ability of horizontal gene transfer. This can lead to an increased rate of bacteria becoming antibiotic resistance.

For this report, Bioclear earth had asked me to find out if there is a need for a pathogen risk assessment in surface water. To answer this question, desk research and interviews with experts from regional water authorities were conducted. The final advice for Bioclear earth contains a framework on how to identify and forecast the potential risk of antibiotic resistance bacteria on human health. The risk assessment is based on laboratory data, which means that Bioclear earth should have a joint venture with Microbial Analysis. Microbial Analysis is Bioclear earth's sister company, which has its own laboratory. In addition, the advice gives insight in the possible market scenarios for Bioclear earth to enter. These scenarios are provided with detailed short- and long-term recommendations on how to act on these market opportunities.

8 July 12:00 5159.0010

Master program: Biomedical Sciences
Keywords: Public health policy, diet, living environment
Internship organization: GGD Fryslân
Type of organization: Municipal healthcare organization
Daily supervisor: Marijke Teeuw

SBP supervisor: Gert-Jan Euverink

Science supervisor: Eva Corpeleijn

Abstract:

The Dutch (and the rest of the world) are gaining weight. If nothing is done to remedy this, approximately 62% of the population will be overweight in 2040. It does not help that the amount of fast-food establishments has been rising steadily over the previous decade. To put a stop to this overweight/ obesity epidemic, the “Nationaal Preventieakkoord” (NPA) was launched in 2018. In this agreement, various challenges and goals were formulated which should aid and support a more healthy food environment. In Fryslân, the NPA was further adapted and deepened with the “Friese Preventieaanpak” (FPA). In recent NPA progress reports, it became clear that further action needs to be taken to reduce the amount of overweight people in 2040.

The FPA has the goal to gain knowledge in the domain of public health and prevention, sharing this knowledge and implementing it in public health policy. Currently, it is unknown what municipalities and the GGD exactly can do to create a healthier food environment for their citizens.

This project has the goal to research which policies are effective and can be implemented in Fryslân so that the Frisian citizens have easy access to healthy food and are able to live healthier and longer lives. Some questions that will be answered in this project are: “What are the health effects of certain dietary patterns?”, “Who are involved in creating a healthier food environment?” and “Which policies/ programs towards a healthier food environment are the most effective?”

6 July 14:30 5159.0110

Master program: Biomedical Sciences

Keywords: Advisory boards, business, feasibility study

Internship organization: ASC Academics

Type of organization: A Market Access and Health Economics Consultancy

Daily supervisor: Auke van der Meij & Georgiana Badea

SBP supervisor: Jacolien Graver & Saskia Grooters

Science supervisor: Geert van den Bogaart

Abstract:

ASC Academics is a market access and health economics consultancy, who guides its clients through Health Technology Assessments (HTAs) for new health interventions. This assessment evaluates the clinical efficacy and cost-effectiveness of health care technologies. A thorough cost-effectiveness model is an important aspect of this assessment and therefore, validation of cost-effectiveness models is crucial. A valuable way of efficiently doing this is through advisory boards. External experts are brought in to give their opinion and share their experiences on data used in the cost-effectiveness model, in order to verify these.

Currently, ASC Academics is looking to expand their business by offering the facilitation of advisory boards as a new service to their clients. The aim of my internship was to find out what the market looks like considering this type of service, including competitive services and the market demand for advisory boards. Furthermore, I looked into how ASC Academics could market this service to effectively reach its clients. In order to implement this service, they needed a Standard Operating Procedure (SOP) which contains the necessary steps to organize an advisory board. Based on a case-study, I have constructed this manual for them.

An early external analysis indicated that the market is favourable for ASC Academics. Further research will point out if ASC Academics possesses the internal resources to consistently carry out this service, and how they can best reach their clients with this new service.

7 July 10:00 5159.0110

Master program: Biomedical sciences
Keywords: Laboratory professional shortage, CAR-T, Personalized medicine, Company expansion
Internship organization: OxfordCorp
Type of organization: Specialized HR and consultancy firm
Daily supervisor: Thijs Remijn
SBP supervisor: Maarten van den Nieuwenhof-Schilstra
Science supervisor: Dr. Maarten Linskens
Abstract:
The Netherlands is one of the leading nations in the Life-Sciences sector. We are a highly attractive country for foreign and domestic investments in Personalized Medicine and Biotechnology. This is partially due to the fact that we are the third highest educated country on the planet according to the World Economic Forum report of 2017. The successes and implementation of new treatments, like CAR-T cancer therapy, are contributing the rapid growth of our Life-Sciences sector. The Dutch labour market is starting to encounter a serious bottleneck however, as direct result of this growth: Laboratory professional shortage. To be able to continue the growth trends of our Life-sciences sector, this bottleneck requires an adaptive solution. Oxford is a specialized recruitment company, looking to adapt to the abovementioned developments by finding cooperative solutions to match the supply of laboratory professionals to the ever-growing demand. To provide adequate solutions, an in depth look is required, reviewing novel personalized medicine treatments, the biggest players, most poignant problems and opportunities associated with these developments. What is needed to maintain the lead on the international Life-Sciences market? Can the Netherlands become THE hub of Biotechnology in the world? These questions and many more will be answered during my final presentation.

8 July 10:00 5159.0010

Master program: Behavioural and Cognitive Neuroscience (N-track: Molecular and Clinical Neuroscience)

Keywords: Migraine product market entry preparation

Internship Organization: KetoSwiss AG

Type of Organization: Company (Aktiengesellschaft – AG)

Daily Supervisor: Dr. Elena Gross

SBP Supervisor: Prof. Gert-Jan Euverink

Science Supervisor: Prof. Gertjan van Dijk

Abstract:

Migraine is the most common neurological disease with about 1 billion patients across the world. Yet, to date there is no method of prevention and all treatments are symptomatic, causing not only suffering but also huge medical costs. As a response to this need, KetoSwiss has developed, and will soon launch, their flagship product – MigraKet^TM which addresses the root cause of (metabolic) migraines with a combination of vitamins, minerals and high-quality ketones. The product will launch in the US in the second half of 2022 and a later European launch is also planned. For both of these, a decision has to be made with regards to the qualification of the product as either a supplement or medical food. The crucial difference between the two is that the latter can be marketed to patients “for the dietary management of migraines”. In this project I have reviewed the regulatory aspects involved in this decision, as well as the connection with available scientific evidence behind the product. These, together with the analysis of the business consequences of either path will combine to form an advice as to which regulatory qualification will be more beneficial to the company and what next implementation steps should be undertaken.

7 July 14:00 5159.291

Master program: Energy and Environmental Sciences
Keywords: Energy transition, stakeholder approach, re-use of fossil fuel assets, renewable energy, innovative energy projects
Internship organization: Nederlandse Aardolie Maatschappij (NAM)
Type of organization: Oil and gas exploration company
Daily supervisor: Ingmar Hans, MSc
SBP supervisor: Gideon Laugs, MSc
Science supervisor: Johannes Miocic, PhD
Abstract:
The reason for this research stems from the ongoing climate change. A change is necessary in the way energy is produced, stored, and used. The term energy transition illustrates this transfer from a fossil fuel-based energy sector towards a more sustainable low carbon energy sector as part of a larger societal development.

This research contributes to innovation studies literature on re-use of fossil fuel assets and energy transition facilities. A case study is conducted at NAM where the possibilities were explored for such assets in combination with stakeholder management (e.g. local communities, landowners, municipalities).

The focus on re-use is motivated by cost-efficiency, prolonging the lifetime of assets, and the opportunity to create collaboration between sectors. NAM wants to create mutual gains by focusing on shared interests for all involved stakeholders.

With the energy transition, the Dutch landscape will look different. Support and acceptance among local citizens and businesses in the vicinity of energy projects are crucial in this regard. It is already known that many potential effective energy approaches and innovations are not realized, because of issues in public support.

My research covers the extent on creating a stakeholder approach assisting NAM with their decision-making when considering to re-use or decommission an existing built fossil fuel asset and what could be the policy on participation in certain situations. It consists of research into possibilities for NAM and the appurtenant social added value, to contribute to the energy transition.

Are you curious to the steps that are relevant to achieve an effective and efficient stakeholder approach in innovative energy projects? Then come to my presentation!

7 July 14:00 5159.0058

Master program: Biomedical Sciences
Keywords: elderly in nursing homes, general practitioners, nurses, cystitis, effective policy for treatment and diagnosis
Internship organization: ROS Friesland
Type of organization: consultancy
Daily supervisor: drs. Maaike van der Meulen
SBP supervisor: drs. Michiel Berger
Science supervisor: dr. Jan Kamps
Abstract:
The aging of the dutch population is increasing strongly and this is also noticeable in the province Friesland. More and more elderly people are ending up in nursing homes, which increases the workload for GPs and nurses. GPs associated with the nursing homes must learn to provide effective care. One of the most common diseases among the elderly in nursing homes is cystitis (bladder infection). The prevalence of cystitis among elderly is approximately 38%. Cystitis is regularly misdiagnosed and leads to unnecessary antibiotic treatment. This entails high healthcare costs and unnecessary treatment of the elderly with possible side effects. Since the prevalence of cystitis is high, its diagnosis and treatment require a lot of attention. That is why, the research question of this project is: 'What is the effective policy for the diagnosis and treatment of cystitis in frail elderly in nursing homes in Friesland?'. During this internship, literature research is performed to gain information about cystitis and best practices. Subsequently, interviews are conducted to find out which methods are used in GP practices for the treatment of cystitis. The different treatment methods are compared at the end and the best method is selected from this. Finally, several steps are described that are important for ROS Friesland for the implementation of the best treatment method in Friesland.

6 July 12:00 5159.0062

Master program: Biomedical Sciences

Keywords: Health literacy (cognition, stress, learning ability), low literacy, healthcare professional, policy strategy

Internship organisation: Healthy Ageing Network Northern Netherlands (HANNN)

Type of organisation: Policy organisation and network

Daily supervisor: Allette Snijder

SBP supervisor: Dr. Amtul Samie Maqbool

Science supervisor: Prof. Dr. Eddy van der Zee

Abstract:

A policy strategy for Healthy Ageing Network Northern Netherlands to enhance the interaction between people with low literacy (PWLL) and the healthcare professional (HCP)

About 2,5 million people in the Netherlands are considered low literate, of which 36% are individuals with Dutch as their mother tongue in the category between 16 and 65 years old. Low literacy is more than only encountering problems with writing and reading. Individuals who are considered low literate do not comply with the minimum level to function optimally in society. In recent years, it has become clear that equal inclusion is needed in healthcare, but also that there should be aimed for health equity. It is difficult for PWLL to optimally make use of health services if they encounter problems with understanding healthcare services or within the hospital. They often rely on family and friends and often take someone with them as a surrogate reader. Therefore, they are thought to have worsened health compared to someone with good health literacy.

Healthy Ageing Network Northern Netherlands (HANNN) is a foundation aiming for more healthy years for all citizens in the northern part of the Netherlands. Their role is to create and support a network of partners relevant to topics like personalised & customised health and healthy nutrition & health skills.

Although there is knowledge, there are tools and training materials available for healthcare professionals, it appeared that there is ample guidance from management levels. Together with biomedical input on correlations with cognition, stress and learning ability, we will examine the best policy strategy for HANNN to support the professional and come one step closer to health equity.

7 July 10:00 5159.0062

Master program: Biomedical Sciences
Keywords: Feasibility study cerebral palsy market
Internship organization: Reperio BV
Type of organization: Medical devices company (start-up)
Daily supervisor: Dr. A. (Alessandro) Grillini
SBP supervisor: J.C. (Jacolien) Graver & Saskia Grooters
Science supervisor: Dr. D.S. (Dineke) Verbeek
Abstract:

Reperio BV is a small start-up company in Groningen aiming to make the detection of different diseases affordable for everyone, everywhere. The company creates the new golden standard in visual field testing by combining eye-tracking and deep learning technologies.

Reperio BV works on a new project in collaboration with the Movement Disorders Centre of the University Medical Centre Groningen (UMCG), focused on dystonic cerebral palsy. The project goal is to have more consistent phenotyping of this paediatric movement disorder because the recognition of the disorder is difficult. Reliable phenotyping is important for the search for a cause and targeted therapy. Reperio BV aims to adapt its current eye-tracking technology, which is designed to diagnose glaucoma in adults, to phenotype dystonic cerebral palsy in children and to enter this market segment.

During my internship at Reperio BV, I was integrating scientific background (about adapting the existing technology to phenotype this paediatric movement disorder) with business aspects (exploring the market fit and capability of the company to market) to see whether it is feasible for Reperio BV to enter the dystonic cerebral palsy market with its existing technology to phenotype this disorder in children. I was investigating different scenarios to find the best business model for marketing the product and I worked on an implementation plan for Reperio BV. In the end, I advised the company about strategies to market their existing technology in this new market segment of dystonic cerebral palsy in children.

7 July 13:00 5159.0062

Master program: Marine Biology
Keywords: Monitoring, data assessment and environmental policy
Internship organization: Rijkswaterstaat Noord Nederland
Type of organization: RWS is part of the Dutch Ministry of Infrastructure and Water Management
Daily supervisor: Raven Cammenga
SBP supervisor: Jorien Zevenberg
Science supervisor: Laura Govers
Abstract:
Rijkswaterstaat (RWS) is part of the Dutch ministry of infrastructure and water management. Among other things, they have to protect the Wadden Sea as an ecological entity. Doing so, they collect an enormous pool of knowledge and experience. However, this data is fragmented and not easily assessable as it is stored in data bases, on websites or in reports. RWS wishes to improve their data collection by combining this into a water system report about the Wadden Sea. They want to answer the question: “How should a yearly report about the Wadden Sea be structured, considering the available data, related policy and all actors involved in maintaining a healthy Wadden Sea?”.

To analyse what kind of information is required in a report about the water system of the Wadden Sea a framework was developed. This framework was tested by three pilots namely; seagrass, salt marshes and fish. In this framework available data was analysed and optimized by gaining insight in available literature, policy, consultation of experts and comparisons. Eventually this led to an advice about the analysis of the data by the optimized framework containing an overview of all information necessary in a water system report about the of the Wadden Sea.

6 July 14:30 5159.0009

Master program: Marine Biology

Keywords: Cruise industry, Sustainability, Offshore wind, Marine biology

Internship organisation: ProSea

Type of organisation: NGO/foundation

Daily supervisor: Tim Haasnoot

SBP supervisor: Karin de Boer

Science supervisor: Tjisse van der Heide

Abstract:

Lowering the environmental impact of corporations is essential to help curb climate change and to preserve our natural environment. Similarly, companies operating in complex marine environments, do so in a complex web of social interactions, where peoples’ livelihood or wellbeing may directly be affected by the actions or presence of these companies. Evaluating to what extent these effects are detrimental to the people and what could be done to lessen this impact is vital for ensuring we move towards a socially responsible future. Not all corporations are equally aware of their impact or perhaps do not know what there is to gain from reducing their impact. For corporations, it is likely that a financial incentive may be necessary to promote these kinds of change. As such, determining what certifications they may achieve, or what fines they may avoid by undergoing sustainability training may be highly beneficial.

The foundation ProSea has noted that there are a variety of established and emerging industries, the specifics and impacts of which are not known to them or currently covered in their training courses. In order to branch out into different industries, they have asked me to look into the possibilities of the cruise ship and the offshore wind industries. The end product is an overview of the environmental and social impact, legislation, guidelines and stakeholders in each industry, where the focus lies mainly on the cruise industry. On the basis of these findings I provide a general indication whether or not these industries would benefit from the kinds of training ProSea provides in order to become more sustainable.

6 July 11:00 5159.0058

Master program: Biomedical sciences
Keywords: Mental healthcare, anxiety, depression, digital interventions, digitalization
Internship organization: BDO Advisory
Type of organization: Company
Daily supervisor: S. Groen
SBP supervisor: M.J. van den Nieuwenhof-Schilstra
Science supervisor: U.L.M. Eisel
Abstract:
The mental healthcare sector in the Netherlands has been under significant pressure for the past years, with waiting times far greater than the norm. The effects of the corona crisis has further contributed to increasing stress and decreasing the general mental well-being of the Dutch population. At this moment, the patient pool of the mental healthcare sector consists predominantly of patients suffering from depression and anxiety, often originating from stress-related causes. Most mental health institutions in its current form are unable to properly treat these patients in a timely and adequate manner. Therefore, significant changes need to be made. Digital interventions, such as online treatment options, have to ability to make mental healthcare more cost-effective, efficient and sustainable. However, there currently is a lack of vision by mental healthcare institutions on how to further digitalize their organization or how to implement new and promising digital interventions. This project aims to provide a scientific overview of the neurobiological pathways linking stress, anxiety, and depression. In addition, it reviews digital interventions currently being used in a clinical setting and their effectivity. Using qualitative and scientific data, an step-by-step implementation plan will be provided for mental health institutions with instruction on how to successfully implement new digital interventions. Finally, suggestions for future directions for BDO will be given on how to advice mental health institutions with this new-found knowledge.

6 July 14:30 5159.0058

Master program: Biomedical Science

Keywords: Chronic kidney disease, Kidney Screening, Primary Care, Study expansion strategy, Europe

Internship organisation: General Practitioners Research Institute

Type of organsiation: Research organization in primary care

Daily Supervisor: Aimée van de Maat, Bea Sloothaak

SBP supervisor: Maarten Nieuwenhof-Schilstra

Science supervisor: Dr. Jaap van den Born

Abstract:

In 2019 the World health organization reported kidney diseases to have risen to the 10^th leading cause of death in the world. Loss of kidney function is closely associated with hypertension, diabetes mellitus and cardiovascular disease, thereby contributing to a significant disease burden. Moreover, treatment of chronic kidney failure and transplantation are one of the most expensive interventions, accounting for most of the financial burden of the disease. Inadequate or late diagnosis and neglect of disease management are associated with complications in Chronic Kidney Disease (CKD) progression and kidney failure. Therefore, earlier identification can result into delay or even prevention of disease progression and kidney failure, subsequently improving treatment and disease outcome. The General Practitioners Research Institute (GPRI) aims improve CKD early identification and treatment, by determining the prevalence of kidney disease in high-risk populations.

GPRI is a research institute, located in Groningen, that provides research from primary care to primary care. Together with the UMCG, GPRI set up the ‘Screening for Albuminuria at the first LINE for early identification of chronic kidney disease: a pilot study’ (SALINE). Albuminuria is a protein that is normally found in the blood, but in damaged kidneys can be detected in urine. GPRI plans to expand this study from the Netherlands to Europe.

During this internship, I analysed the current SALINE Pilot, competitive CKD screenings and possible investors, to create an advisory implementation strategy to optimize and expand this study into Europe.

8 July 11:00 5159.0058

Master program: Biomedical Sciences
Keywords: Integrated care for vulnerable pregnant women
Internship organization: GGD Fryslân
Type of organization: Government organization
Daily supervisor: Marijke Teeuw
SBP supervisor: Michiel Berger
Science supervisor: Eva Corpeleijn
Abstract:
When women encounter stressful situations during pregnancy, this can have long-lasting consequences for their own and their child’s physical and mental health. Among other things, prenatal stress is correlated with depression (in both mother and child) and with increased chances of preterm birth and low birth weight. To prevent these problems, it is important to provide pregnant women with efficient, integrated care. An example of this is the care path for early identification of pregnant women in vulnerable situations. Within such a care path, both social and medical care professionals work together to cater to vulnerable women’s needs. It is a healthcare structure that has already been implemented in the Frisian municipalities of Smallingerland and De Fryske Marren. However, monitoring and evaluation of the care paths is lacking. To aid these and other Frisian municipalities, I have designed standardized protocols for these tasks. The protocols ensure complete evaluation and are therefore likely to identify factors which need to be improved. They also allow for comparisons between different care paths, even when there are organisational differences between the care paths which are being compared. In the long run, this will improve the care for pregnant women in vulnerable situations, allowing them to give their children a promising start in life.

7 July 11:00 5159.0291

Master program: Biomedical Sciences
Keywords: Health Economics, Systematic literature review, Cost-effectiveness model, e-procurement platforms
Internship organization: Asc Academics
Type of organization: Health Economics consultancy
Daily supervisor: Timon Louwsma (MSc)
SBP supervisor: Gideon Laugs (MSc)
Science supervisor: Dr. Bauke Buwalda
Abstract:

Asc Academics is a Health Economics consultancy based in the Netherlands. Because of their recent growth in size and capacity, they are looking at various options for expanding their customer base. Asc Academics has requested me to investigate whether e-procurement platforms can be used to attract new clients. E-procurement platforms are online platforms, where buyers and vendors can connect. Through previous investigations of e-procurement platforms, a possible client has asked Asc Academics to develop a Cost-Effectiveness Model for a drug agent to combat liver cirrhosis.

My internship consisted of two main projects. Firstly, all different e-procurement platforms are investigated and contacted, to assess whether they can be interesting for Asc Academics to join. This will result in a list of viable options for Asc Academics. Secondly, I have developed a Cost-Effectiveness for a client that has been acquired through an e-procurement platform. This project will be used as a case study, to assess whether these platforms are a viable option for Asc Academics. This case study also gives valuable insight on the workflow within these procurement platforms. These two projects will generate an advice report for Asc Academics, to see if and which e-procurement platforms are interesting for them to join.

8 July 10:00 5159.0114

Master program: Biomedical Sciences
Keywords: Dysphagia, 3D food printer, quality of life, implementation within healthcare institutions, 3D food printer niche market.
Internship organization: Health Hub Roden
Type of organization: NGO
Daily supervisor: ir ing. Egbert Wiltens
SBP supervisor: Jorien Zevenberg, Msc
Science supervisor: Jocelien Olivier, Prof
Abstract:
The non-governmental organization of Health Hub Roden has the vision to use innovations to increase the quality of life and the quality of the healthcare system.

Dysphagia is a common disorder in which patients have difficulties with swallowing. Dysphagia has a high impact on a person’s life, ranging from social behavior to the inability to consume food or drinks. To help these patients consume food, they must consume textured modified meals such as pureed food. This drastically decreases their enjoyment of food, thereby the quality of life and maybe even the will to live. On top of this, the overall recognition of the textured modified meals is decreased. The recognition is especially decreased in patients with Alzheimer’s disease. The relation between dysphagia and Alzheimer disease has a very high prevalence. This decrease in recognition and enjoyment results in a decrease in appetite, with the consequence of malnutrition, and even in the worst case, to death.

The idea of this project is to implement the innovation of the 3D food printer within healthcare to recreate the shapes of the meals with safe and texture-modified ingredients; thereby increasing recognition, appetite, food intake, enjoyment of eating, rehabilitation, and the general quality of life.

Health Hub Roden wants to get an indication of the demand/desire for this implementation within the healthcare institutions, an overview of the 3D food printer market for this niche market, and advice on how they can contribute by the creation of a possible implementation strategy.

6 July 11:00 5159.0114

Master program: Biology
Keywords: Biochemistry, enantiomers, racemic mixtures, racemic resolution, lipases, market research, biomedical research
Internship organization: Sulfateq (B.V.)
Type of organization: Biotechnology company
Daily supervisor: Daniël Swart
SBP supervisor: Gert-Jan Euverink
Science supervisor: Marco Fraaije
Abstract:
For optimal public health, it is important that drugs are as effective, efficient and safe as possible. However, many drugs currently in use are racemic mixtures, which are mixtures of two enantiomers in equal amounts (50/50). This may impact their efficacy and/or safety. Enantiomers are molecules with the same molecule formula, but with a different orientation of its molecule groups. Essentially, they are mirror images of each other, like the left and right hand. Two enantiomers of a drug can have large differences in pharmacological effects when present in a living body. This is because many biological molecules a drug reacts with are also enantiomers, but exist in only one of the two forms in the body.

Sulfateq is able to resolve racemic mixtures via enzymes (lipases), via which the pure, desired enantiomer can be produced. Sulfateq wants to produce these and sell them in the biomedical sector for research purposes.

In this internship I have performed literature research on the pharmacological differences between enantiomers and racemic resolution via lipases to investigate the technical relevance and feasibility. Moreover, I have investigated whether there are market opportunities for this business in terms of demand for pure enantiomers among researchers, competitiveness in this market and financial feasibility. Technical feasibility seems to be somewhat limited, yet there seems to be a demand among researchers for pure enantiomers rather than racemic mixtures. I have integrated everything to give advice on this to Sulfateq, which I will discuss in this presentation.

8 July 11:00 5159.0291

Master programme: Biomedical Sciences
Keywords: Military performance optimisation
Internship organisation: TNO
Type of organisation: Independent research organisation
Daily supervisor: Dr Olaf Binsch / Dr Koen Hogenelst
SBP supervisor: MSc Gideon Laugs
Science supervisor: Dr Prof. Jocelien Olivier
Abstract:
Complexity in military forces is growing, which requires higher physical and mental demands of its soldiers. To ensure military action in the future, it is important to ensure that soldiers become stronger and more capable of performing under demanding circumstances. A possible solution would be the introduction of human performance modification (HPM), such as pharmaceuticals or hardware. The Ministry of Defense has assigned TNO the task to look into possible HPM interventions that could help to withstand these demanding circumstances. HPM can result in many ethical consequences. Therefore, TNO advises the Ministry of Defense on which interventions could be applied in a justified ethical manner. One of the demanding factors is that military members experience sleep deprivation, especially during military operations. To ensure acceptable military performance, HPM could be introduced. TNO is interested in the possible (pharmaceutical) interventions to combat sleep deprivation during military operations. These interventions' ethical, legal, and societal consequences have been considered. Through this internship, TNO is advised on how to prevent and handle sleep deprivation in military operations. Furthermore, they are advised on how HPM use for other major issues in military action should be addressed using a framework from an ethical, legal and societal perspective.

8 July 10:00 5159.0058

Master programme: Biomedical Sciences
Keywords: healthcare policy, COPD, Positive Health
Internship organization: GGD Fryslân, Zorgbelang Fryslân
Type of organization: Governmental Organisation, Healthcare Association
Daily supervisors: drs. K. (Klaus) Boonstra, drs. P. (Pepi) Wadman
SBP supervisor: drs. M. R. (Michiel) Berger
Science Supervisor: prof. dr. A. J.W. (Anton) Scheurink
Abstract
COPD is a common chronic disease that affects around 600.000 people in the Netherlands. COPD is characterized by typical symptoms of wheeze, cough, chest tightness and shortness of breath. COPD is a complex disease with a huge health burden. COPD does not only affect bodily functions, but also other aspects of health, such as daily functioning and mental wellbeing. Despite the complexity and high disease burden, patients would like to be more in charge.

Current trends also push towards a more central role of the patient. The prevalence of COPD and other chronic diseases is increasing, as a result of an increase in life expectancy and an ageing population. This increase in chronic diseases and other processes, such a decrease of the number of young citizens, put more pressure on the healthcare system. Working with the ‘Positive Health’ concept may help in decreasing this pressure as proposed by GGD Fryslân, ZorgpleinNoord and Zorgbelang Fryslân. It is a broader perspective on health that puts the patients and his needs more central and can help in taking control and dealing with setbacks more resiliently, ultimately improving health.

Does Positive Health also have the potential to support people with COPD to take charge of their own health? Can it lead to healthier lifestyle choices and better health outcomes? What are the possibilities for implementation? By means of a literature study and semi-structured interviews, I aim to give an advice on the implementation of Positive Health for people with COPD.

6 July 12:00 5159.0058

Master program: Pharmacy
Internship organization: The Access to Medicine Foundation
Type of organization: non-profit organization
Daily supervisor: Claudia Martinez
SBP supervisor: Maarten van den Nieuwenhof-Schilstra
Science supervisor: Dr. C.C.M. (Nynke) Schuiling-Veninga
Abstract:
2 billion people living in low- and middle-income countries (LMICs) lack access to essential, affordable, and high-quality medicines. The Access to Medicine Foundation incentivises the pharmaceutical industry to do more in terms of access to medicines in these countries. Until now, the organisation has focussed on big innovative pharmaceutical companies. However, their new programme aims to identify tailored opportunities for Generic Medicine Manufacturers (GMMS).

GMMs are pharmaceutical companies that produce and market medicines of which the patent has been expired. These companies cover 60-80% of the medicine supply worldwide. As their products are generally cheaper compared to those of innovative pharma companies, GMMs could play a key role in improving the current state of the problem.

My project contributed to the new program of the Access to Medicine Foundation. I identified several tailored opportunities for the India-based GMM: Sun Pharmaceutical Industries Ltd. These opportunities provide the company with specific actions to improve access to their products in LMICs.

6 July 15:30 5159.0110

Master program: Biomedical Sciences

Keywords: Radiotracers, Alzheimer’s, clinical trials, standardization

Internship organization: GE Healthcare Radiopharmacy Zwolle

Type of organization: Company

Daily supervisor: Dr. Nanno Schreuder

SBP supervisor: Jacolien Graver Msc. & Saskia Grooters

Science supervisor: Prof. Dr. Uli Eisel

Abstract:

General Electric (GE) Healthcare Radiopharmacies produce radiopharmaceuticals used for diagnosis and therapy in nuclear medicine. GE Healthcare Radiopharmacies receive applications for clinical trials. The number of applications is increasing, especially those for Alzheimer’s Disease (AD). Positron Emission Tomography (PET) research and its application for studying AD has made progress over the past 20 years. Molecular imaging of neurofibrillary tangles and amyloid-β plaques with radiotracers and PET seems to be a powerful tool for the diagnosis of AD. The process from client request to delivery of the radiopharmaceutical takes a long time because requesting clinical trials by clients and processing these trial applications within GE Healthcare is not standardized. Because of this, the process is time-consuming and unclear which has an influence on both client satisfaction and working time spent in setting up a clinical trial. Therefore, standardization of the clinical trial process of GE Healthcare Radiopharmacies is important, because it will improve client satisfaction and decrease the time spent in setting up a clinical trial. To answer the main question ‘How can the clinical trial process of GE Healthcare Radiopharmacies be standardized?’, I interviewed stakeholders and analyzed GE Healthcare Radiopharmacies, the radiotracers to diagnose AD, current clinical trial process, related regulations, and documentation requirements. Based on this, I came up with an advice for GE Healthcare Radiopharmacies on how to standardize the process of setting up clinical trials.

6 July 15:30 5159.0114

Master program: Biomedical Sciences
Keywords: Public health policy
Internship organization: GGD Groningen & Drenthe
Type of organization: Governmental organization
Daily supervisor: Frans Greven, Rixt Botma
SBP supervisor: Prof. dr. Gert Jan Euverink
Science supervisor: Prof. dr. Barbro Melgert
Abstract:

Clean air is important for a healthy life. Worldwide, approximately three million people die each year as a result of exposure to ambient air pollution. Although the air in the Netherlands is relatively clean, negative health effects can occur even at low concentrations of air pollutants. In the National Air Quality Cooperation programme (Schone Lucht Akkoord), the Dutch State, provinces and municipalities want to work together to permanently improve the air quality in the Netherlands, with the aim of achieving 50 percent health gains from domestic sources by 2030 compared to 2016. To reach this goal, it is important that municipalities take measures to improve air quality.

The Municipal health service (GGD) advises municipalities on themes like air quality, for instance on measures that can be taken to improve air quality. For the GGD it is unclear whether advising to municipalities is effective and whether advices is taken into account in municipal decision-making. That is why GGD Groningen and Drenthe asked me to look into this. By means of literature research and interviews with employees of the GGD and municipalities I try to find out what an effective route for advice is and which information is important for municipalities to take advice into account in policy and decision making. Based on this information, I formulate an advice and implementation plan for the GGD to optimise the provision of advice to municipalities.

6 July 15:30 5159.0009

Master program: Biology
Keywords: Policy, closed areas, shrimp fishery, Wadden Sea
Internship organization: De Waddenvereniging
Type of organization: NGO
Daily supervisor: Wouter van der Heij, Eeke Haanstra & David Vertegaal
SBP supervisor: Karin de Boer
Science supervisor: Laura Govers
Abstract:
Worldwide, marine ecosystems on the coast are threatened, often due to human influences. The Wadden Sea is also threatened by these influences. As the largest tidal area in the world and a UNESCO World Heritage Site, the Wadden Sea has great ecological value, which is why protecting against harmful influences benefits nature. Bottom-touch fishing, such as shrimp fishing, is harmful to the seabed and therefore has a major impact on the benthic ecosystem. This is no different in the Dutch Wadden Sea, where shrimp fishing is among the disturbances.

Recently, two areas of the Dutch Wadden Sea have been closed for shrimp fishing. No management policy has yet been drawn up for these areas, and previously closed areas, and therefore there is no protection. This project aims to find the best management for the closed areas. Protection against bottom-disturbing fisheries and good management can help restore nature, which is necessary for endangered areas such as the Wadden Sea.

The Waddenvereniging wants this good management, and international proven concepts in marine nature management can help create this. The investigation of these proven concepts combined with multiple analyses, of both the Waddenvereniging and stakeholders involved, have helped me to formulate an advice for the Waddenvereniging. This advice regards the policy that can be applied to the recently closed areas in the Wadden Sea and ideally leads to a project plan for this policy.

7 July 10:00 5159.0010

Master program: Biology

Keywords: Stress-reducing intervention for poverty

Internship organization: Healthy Ageing Network Northern Netherlands

Type of organization: Independent foundation

Daily supervisor: Danielle Bekkering

SBP supervisor: Marion van Rijssel

Science supervisor: Peter Meerlo

Abstract:

Poverty is still present in the Netherlands, also in many areas in the north of the country (Groningen, Friesland and Drenthe). Adults living with money shortage, debt or poverty often have to deal with chronic stress, unhealthy lifestyle, chronic diseases. In order to reach the target group directly and address the aspect of unhealthy lifestyle, HANNN has set up the project "The Healthy Living Room". The Healthy Living Room is a place where people can get a free lifestyle check and can get advice about their lifestyle with the aim of improving their health in small steps. The Healthy Living Room is a van that can be driven around so that it can be used in various poorer places in the north of the Netherlands.

Because The Healthy Living Room is effective in reaching the target group, HANNN would like to know how they can tackle chronic stress in addition to the unhealthy lifestyle. Scientific literature research has shown that walking, cognitive behavioral therapy, and yoga effectively reduce stress. These three scenarios were compared resulting in one intervention that was most suitable. To find out if visitors to The Healthy Living Room had any desire at all to reduce their stress, people completed a questionnaire about stress. In the end, all the results are combined to come up with a recommendation for reducing stress among visitors of The Healthy Living Room.

8 July 12:00 5159.0062

Master program: Behaviour & Cognitive Neurosciences
Keywords: Healthcare policy, Research policy, implementation strategy, Patient involvement
Internship organization: UMCG
Type of organization: University Medical Hospital
Daily supervisor: Dr. Y. Lisman-van Leeuwen
SBP supervisor: Dr. A.S. Maqbool
Science supervisor: Prof. dr. H.W.G.M. Boddeke
Abstract:

You & Me Together: An Implementation Guide to Patient Involvement in the UMCG Research Institutes

The values in the healthcare sector are changing rapidly towards a culture in which the voice of the patient needs to be heard. Patient involvement can be seen as an example of incorporating the values and needs of patients in the different components of healthcare. Patient involvement is described as making use of the perspectives and experiences of patients, and/or their loved ones to improve the care they receive, as well as the research and policy related to this. The range of benefits of patient involvement in medical research is vast and can affect research projects, the experiences of researchers, and the well-being of patients. However, the actual implementation of patients as active co-researchers in the different phases of research still seems to be unsuccessfully realised so far. This is one of the problems the UMCG is facing too.

My project, therefore, focused on how the UMCG can provide the appropriate tools and support for researchers in the UMCG research institutes. An appropriate implementation strategy has been developed based on the science behind patient involvement and assessment of the external field and internal UMCG culture.

6 July 11:00 5159.0110

Master program: Biomedical Sciences
Keywords: Lung cancer, screening programs, health economics, healthcare policy
Internship organization: iDNA
Type of organization: Company
Daily supervisor: Evgeni Dvortsin/Xuanqi Pan
SBP supervisor: Jacolien Graver & Saskia Grooters
Science supervisor: J.H.M. van den Berg
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide. The challenge with lung cancer is that it is asymptomatic, meaning that the majority of people are diagnosed at later stages. The institute for DiagNostic Accuracy (iDNA) intends to implement lung cancer screening, which will result in more cases of lung cancer being identified and diagnosed early on, when treatment and surgery are still effective. The cost-effectiveness of such an intervention must be thoroughly evaluated prior to adoption. With the most recent advances in artificial intelligence (AI) and machine learning, iDNA wants to investigate if AI can increase the cost-effectiveness; AI can speed up the image reading process while also reducing costs and lowering the radiologists' workload. To answer the question, "How can iDNA incorporate Artificial Intelligence in their cost-effectiveness model for lung cancer screening adoption in the United Kingdom (UK)?" I first researched the worlds of lung cancer, AI, and the cost- effectiveness model to gain a better understanding of these topics. Then I used this information to adapt the UK's cost-effectiveness model. Along with a thorough examination of the laws and regulations that apply when implementing such a model, I concluded in an advice for iDNA how to incorporate AI in their cost-effectiveness model for lung cancer screening using the UK as an example.

6 July 15:30 5159.0058

Master program: Biomedical Sciences
Keywords: Cervical cancer, screening programme, DNA methylation analysis
Internship organization: Centre for Population Screening, RIVM
Type of organization: Governmental organisation
Daily supervisor: Esther Brouwer and Sandra van Dijk-de Bruin
SBP supervisor: Maarten van den Nieuwenhof - Schilstra
Science supervisor: Prof.dr. Steven de Jong
Abstract:
Every year, 800 women in the Netherlands are diagnosed with cervical cancer and an estimated 200 women die from this disease. Screening can detect early stages of cervical cancer, which can often be treated successfully. The Centre for Population Screening of the RIVM (RIVM-CvB) directs the cervical cancer screening programme in The Netherlands. Currently, the screening programme consists of primary HPV-screening with cytologic evaluation as triage. In light of previous evaluation, the RIVM – CvB wants to explore new technologies, with the aim of further innovating and optimising the screening programme.

This project investigates the possibilities of DNA methylation analysis for the Dutch cervical cancer screening programme. There are various incentives for looking into DNA methylation analysis, including high sensitivity and specificity and the prospect of automatic analysis, which could make the screening programme more (cost-) effective. This project answers the following question: In what way could DNA methylation tests improve the Dutch cervical cancer screening programme?

With the aim of giving the RIVM-CvB a meaningful advice, I used scientific literature and interviews with experts to explore DNA methylation-based biomarker panels and their performance in cervical cancer screening. Furthermore, I investigated whether DNA methylation tests could be implemented in the screening programme by looking into market availability, existing regulations, and the capacity of screening laboratories. Finally, I used the gathered information to compare potential screening strategies including DNA methylation tests with the current screening programme.

6 July 14:30 5159.0010

Master program: Biology
Keywords: Conservation, Monitoring, Programma Natuur
Internship organization: Provincie Drenthe
Type of organization: Government body
Daily supervisor: Jobien Veninga
SBP supervisor: Dr. Marion van Rijssel
Science supervisor: Prof. Dr. Theo Elzenga
Abstract:
How should provincie Drenthe adapt their monitoring activities in the ‘’Oude Diep’’ in accordance with ‘’Programma Natuur’’?

Currently a new programme to stimulate conservation and recovery of nature in the Netherlands is being formulated. This ‘’Programma Natuur’’ aims to realise most of the European Bird and Habitatguideline in the period 2021-2030. To achieve this, new measurements are being formulated by the Dutch provinces. In order to gain an understanding of the effects of these measurements, an expansion of monitoring activities is also necessary.

Provincie Drenthe oversees the preservation of Drenthe’s fourteen nature reserves. The new measurements from ‘’Programma Natuur’’ have steadily developed so far. However, there is still a lot of uncertainty on how monitoring should adapt to these new measurements. To solve this the interprovincial council formulated a businesscase in which they detail three scenarios to which the monitoring could be expanded.

This project has analysed and compared these scenarios based on the necessities, as well as costs and the necessary capacity to accomplish each scenario. Based on these findings a monitoring strategy was formulated for provincie Drenthe to implement in the Oude Diep nature reserve. This plan details the steps provincie Drenthe needs to undertake in order to realise this monitoring strategy.

8 July 12:00 5159.0291

Master Program: Medical Pharmaceutical Sciences
Keywords: ATMPs, Policy Evaluation, Government
Internship organization: Ministry of Health, Welfare and Sport
Type of organization: Government
Daily supervisor: M. van den Bosch-Vos
SBP-supervisor: G. Laugs
Science supervisor: I. Molema
Abstract:
Advanced therapy medicinal products (ATMPs) are medicines that are used to combat and potentially cure seriously life impeding and rare diseases that conventional approaches have proven to be inadequate. While the developments on ATMPs are promising for healthcare in the Netherlands, it simultaneously comes with challenges. Signals from hospitals that administer ATMPs address complications that arise on a capacity and organizational level, if the number of ATMPs on the market increase. The expertise, capacity, facilities and investments needed for ATMP administration is costly. To anticipate on (potential) bottlenecks and challenges in the future, the Ministry of Health, Welfare and Sport, has requested to inventory what specific problems arise at hospital level, what the thoughts are on (de)centralising of ATMP care, and investigate if it is possible to harmonise the regulatory procedures between the various ATMPs. This report aimed to give a clear overview of the relevant problems of ATMP care. Careful analyses of the healthcare system, the associated policies, and the existing literature, provided a foundation for the context of the existing challenges. Semi-structured interviews were conducted with various medical specialists, hospital pharmacists and pharmaceutical manufacturers, to get multiple perspectives on the topic. Insights gained from the interviews are interpreted in the context of relevant policy to determine if streamlining and optimization is possible. The result of the research should lead to a set of recommendations that are valuable to all relevant stakeholders active within the ATMP environment.

6 July 12:00 5159.0009

Master’s program: Marine biology
Keywords: Shellfish, aquaculture, offshore, wind farms, multi-use, ecosystem services
Internship organization: Stichting De Noordzee
Type of organization: NGO
Daily supervisor: Linda Planthof
SBP supervisor: Karin de Boer
Science supervisor: Laura Govers
Abstract:
Throughout the North Sea multiple countries, industries, and ecosystems vie for space and resources which makes spatial planning a challenging balance of various interests. There is public demand for renewable energy, food from fishing and aquaculture, shipping, recreational boating space, and nature conservation areas. Due to the limited space within the North Sea, multi-use areas such as combined wind farm and aquaculture areas are an attractive marine spatial planning technique. As an NGO that advocates for sustainable use of the North Sea, Stichting De Noordzee is interested in exploring multi-use because such a project could potentially provide renewable energy, sustainable food, and ecosystem services, all while taking up less space. Despite all of the possible benefits, there is still no clear implementation pathway for multi-use projects, and shellfish farmers as well as wind farms are warry of these ventures.

In order to help Stichting De Noordzee develop a plan of action for wind farm multi-use, I have researched the optimal method for implementing shellfish aquaculture amidst offshore wind farms that safely combines sustainable food production and restoration of wild shellfish beds. In my presentation I will explain which shellfish species offer the most ecosystem services, how aquaculture techniques can aid in marine restoration, and what policies may be needed to support multi-use installations and ensure that they maintain sustainable practices.

7 July 10:00 5159.0114

Master program: MSc Biology
Keywords: Seaweed, Italy, legislation, industrial applications, seaweed market
Internship organization: C.I.V. Offshore & Shipping, NorthSeaweed B.V.
Type of organization: Company
Daily supervisor: Joost Crommentuijn
SBP supervisor: Janneke Krooneman
Science supervisor: Karin de Boer
Abstract:
Marine seaweeds, characterized by high-valued bioactive compounds, are used worldwide for several applications, such as food, feed, pharmaceutics, bioplastics, etc. A growing seaweed market requires an enhanced supply chain. Other than farmed, macroalgae can be harvested or collected from the wild. In Europe, Italy has a high natural availability of seaweed biomass. Macroalgae proliferating at sea often get washed ashore, where they accumulate. This can damage tourism, hinder aquaculture activities, and interfere with traditional fisheries. Lacking proper market value in Italy, the overgrown biomass is often removed by municipalities and disposed of. Within my internship project for CIV Offshore & Shipping and NorthSeaweed BV, I aimed at determining the legal, technical, and financial possibilities for the two companies to source wild seaweed in Italy and re-use it for industrial applications. Three scenarios were laid down (i.e., harvesting from sea, collecting from beaches, farming) and some operational locations in the country were selected. Collaborations with local stakeholders were initiated to arrange the technical aspects, such as collecting/farming, processing the biomass, transportation, etc. Set of samples were analysed to assess quality and compound composition of the algae. This helped me determine the most suitable industrial use (e.g., feed, bioplastics, etc.) for the biomass, according to the specific EU quality requirements. Lastly, I performed an analysis of the seaweed market in Italy and the Netherlands, to assess the best market for my clients and their potential within it. Finally, I delivered an advice on the most suitable locations in Italy, the best seaweed species to harvest and farm, and the possible industrial applications for the sourced biomass.

8 July 10:00 5159.0062

Master Program: Medical Pharmaceutical Sciences

Keywords: Lung cancer, Therapeutics for early-stage NSCLC, Creating business opportunities

Internship organization: Institute of Diagnostic Accuracy (iDNA)

Type of Organization: Company

Daily Supervisor: Msc. Boudewijn Breens

SBP Supervisor: Dr. Amtul Samie Maqbool

Science Supervisor: Prof. dr. Frank Jansman

Abstract:

Cancer is the second leading cause of death worldwide. Of all cancer-related deaths, the majority are claimed by lung cancer. Lung cancer has one of the lowest five-year survival rates because cases are often diagnosed at later stages when the disease is less likely to be curable. Screening with annual low-dose computed tomography (CT) scans can significantly reduce the mortality rate by detecting lung cancer nodules while still in an early stage. At this stage, lung cancer can be highly curable, thereby increasing the patient’s survival rate significantly. With the ongoing implementation of national screening programs for lung cancer, the number of detected early-stage lung cancer will consequently rise, stressing the need for a validated early-stage treatment. Now, the first line of treatment for early-stage lung cancer consists of surgery, radiation therapy, and a combination of different types of chemotherapy drugs. However, extensive research is undergoing in the areas of lung cancer treatment, to develop better treatments, and improve survival and quality of life for patients. The rise in cancer awareness and advanced medical diagnostic equipment, coupled with the increasing investments in R&D activities, are boosting the lung cancer therapeutics market growth globally. iDNA is a small company that is looking for opportunities for business expansion; entering this market would increase its visibility and profit. The goal of my internship was to create potentially new business models that iDNA could use to access the market of early-stage lung cancer therapeutics.

6 July 14:30 5159.0114

Master program: Biomedical Sciences

Keywords: Cervical cancer, DNA methylation assay, urine, population screening

Internship organization: CC Diagnostics

Type of organization: Company

Daily supervisor: Nutte van Belzen

SBP supervisor: Gert-Jan Euverink

Science supervisor: Steven de Jong

Abstract:

Cervical cancer is a worldwide health concern, but with regular and decent screening it can be prevented. By screening women regularly, the early precancerous lesions in cervical cells can be detected and treated. Currently, the population based screening includes primary high-risk HPV screening with Pap testing as a triage test. CC Diagnostics wants to improve the population screening by making it accurate while also making it more accessible to women. In order to do this, CC Diagnostics has developed a novel methylation assay (Methica CC kit) making use of 3 epigenetic markers to screen for precancerous lesions. This test will replace the current triage test, the Pap test, making it more efficient, cheaper, and women friendly. The participation rate is an important factor in the effectiveness of the population screening and needs to be increased; the current screening rate is approximately 57%, which indicates that a considerable percentage of women with cervical cancers do not attend the screening. Recently, multiple studies have reported that urine is a potential liquid biopsy for cervical cancer screening. Urine is an attractive alternative compared to other sampling methods due to its non-invasiveness and easy accessible manner of sampling and may target non-responders. During this project I will provide CC Diagnostics with an advice whether urine sampling is a good direction for the company to go in.

7 July 13:00 5159.0110

Master program: Medical pharmaceutical sciences
Keywords: Metastatic castration-resistant prostate cancer, radiopharmaceuticals, integral costs
Internship organization: Bayer
Daily supervisor: Dr. Claudine de Meijer
SBP supervisor: Jacolien Graver & Saskia Grooters
Science supervisor: Prof. Dr. Talitha Feenstra
Abstract:
Prostate cancer is the most prevalent cancer amongst men in western countries. Despite several treatment options, metastatic castration-resistant prostate cancer (mCRPC), the progressed form of prostate cancer, remains fatal.
Radiopharmaceuticals can play a substantial role in the life-prolonging treatment of mCRPC. Radium-223 is an alpha-emitting radiopharmaceutical that targets bone metastases in mCRPC. Since 2013, radium-223 is used in the Netherlands as a second- or third-line treatment for mCRPC with bone metastases. Since 2022, also the pharmacy prepared, beta-emitting 177Lu-PSMA-I&T is reimbursed for mCRPC treatment. Moreover, recently, promising Phase III trial results have been published regarding 177Lu-PSMA-617.
Different factors (e.g. costs, registration, and hospital facilities) play a role in stakeholders’ choice between the different radiopharmaceuticals in the treatment of mCRPC.

The goal of this internship was to provide Bayer with advice regarding the business strategy for radium-223. To come to my advice, I performed a stakeholder analysis, established the costs associated with radiopharmaceutical treatment, and performed a product and market analysis.

8 July 12:00 5159.0114

Master program: Biomedical Sciences
Keywords: Clinical laboratory, Therapeutic Drug Monitoring, Toxicology, Value-Based, Patient-Oriented
Internship organization: Martini Ziekenhuis
Type of organization: Hospital
Daily supervisor: Marcel Kies
SBP supervisor: Jorien Zevenberg
Science supervisor: Klaas Poelstra
Abstract:
Clinical laboratory testing services such as Therapeutic Drug Monitoring (TDM) and toxicological screenings aid health care professionals directly in diagnosis, treatment, or prevention. Currently, it is estimated that laboratory test results affect 60-70% of clinical decision-making. The past few decades have contributed to great development in laboratory technology, which led to fundamental changes in laboratory testing services. Many laboratories invested in state-of-the-art analyzers, forcing them to achieve greater volumes in sample testing, reduce costs per test, and produce economies of scale. This led to a gap between clinical laboratories and clinicians or doctors involved. Restoring well-established communication between these parties is of vital importance for the patient, along with an evaluation of current processes regarding TDM and toxicology. Here, the focus will be on patient outcomes and test utilization, which includes the examination of turnaround times, price positioning, the efficiency of sample testing, and value-based laboratory testing. Laboratory testing services should be seen in the context of the whole patient journey, rather than it being a sole commodity. The ultimate goal is to promote TDM and toxicology testing services among health care providers, establish good communication between different relevant parties and evaluate the total testing process in a patient-oriented manner.

7 July 14:00 5159.0110

Master program: Biomedical Sciences
Keywords: Market access study for COVID-19 vaccine
Internship organization: Valneva
Type of organization: Biotech company
Daily supervisor: Gerard Vondeling
SBP supervisor: Maarten van Nieuwenhof-Schilstra
Science supervisor: Prof. Anke Huckriede
Abstract:
COVID-19 is a disease with a significant disease burden and high impact on our society. To date, the most efficient and safe way to protect us from the virus causing this disease is vaccination. Valneva is a specialized biotech company producing such a vaccine, called VLA2001. However, there are already may competitors on the market, especially in the EU, which is the target market for Valneva. Also, Valneva is still in the rolling review process of the EMA, and on top of that the demand for vaccines decreased in the last weeks. To see if there is a place for Valneva in the future market, this project focusses on the question: How Valneva can best prepare itself for the future European market with its vaccine candidate VLA2001?

To answer this question, I first identified 3 possible future scenarios for the development of COVID-19, amongst which the “flu-like” scenario appeared the most likely. This has certain implications for the vaccine market, such as a special focus on elderly as target population. It also gives the opportunity of combining a flu-vaccine with the Valneva vaccine. I defined important internal and external factors influencing the vaccine market and Valneva itself, to see how Valneva can respond to this potential future market.

This advice focuses on exploring potential opportunities for Valneva in the future COVID-19 vaccine market. Some points that will be highlighted is the importance of expanding their clinical trials to focus more on elderly data and look if their vaccine has the potential to induce an immune response against different virus variants. Thirdly, an interesting future investment could be to focus on a combined flu-VLA2001 shot, since this does not exist yet.

A general disclaimer here is that the virus is very dynamic. Changes can occur, also changing the relevance of the advice. This will also be discussed in the final presentation.

6 July 12:00 5159.0010

Master program: Biology
Keywords: Artificial intelligence, quality control, lung cancer screening
Internship organization: iDNA
Type of organization: Company
Daily supervisor: Erik Jippes
SBP supervisor: Marion van Rijssel
Science supervisor: Floris Foijer
Abstract:
Lung cancer is one of the most common and most deadly forms of cancer. It is proven that lung cancer screening amongst risk population can significantly reduce mortality. A new hype within the lung cancer (screening) world is the application of artificial intelligence. AI can be used for the detection and analysis of lung nodules in CT scans. There are however no strict rules regarding clinical validation and quality control for AI software to be FDA or CE approved. This project aimed to investigate how iDNA can position themselves as quality control service provider for AI that is used in lung cancer detection.

7 July 14:00 5159.0114

Master program: Biomedical Sciences
Keywords: Market opportunity, microbial production, bioplastic, medical implant
Internship organisation: EV Biotech
Type of organisation: Research, Development and Innovation Start-up
Daily supervisors: Ronja Wabeke, Debarun Dhali
SBP supervisor: Janneke Krooneman
Science supervisor: Rob Coppes
Abstract:
EV Biotech is Groningen-based start-up that develops microorganisms for the industry. With computational predictions and laboratory strain engineering, EV Biotech can develop these microorganisms in a sustainable manner and in a fraction of the time it would take with conventional methods. Next to this main business model, EV Biotech also has four proprietary strains. One of these strains produces polyhydroxyalkanoate (PHA), a type of bioplastic that has been gaining popularity as a substitute for plastics from petrochemical origin. Beneficial properties include its natural origin, biocompatibility, biodegradability, and endless modifiability.

PHAs may be particularly useful for medical and pharmaceutical purposes, as they degrade into biocompatible compounds in a predictable fashion. However, at present, PHAs have found limited applications in this sector mainly because of financial and regulatory constraints.

EV Biotech would like to evaluate the opportunity to further optimize its PHA producing MCF to produce a medical-grade PHA. Therefore, the technical aspects in this respect, along with the financial prospects, potential customers and the competitive landscape have been evaluated with the ultimate goal of providing a business strategy for EV Biotech’s PHA producing MCF.

6 July 11:00 5159.0009

Master program: Marine Biology
Keywords: Seaweed, algae, market entry, product development
Internship organization: Roquette Klötze GmbH & Co. KG
Type of Organization: Company
Daily supervisor: Jörg Ullmann
SBP supervisor: Karin de Boer
Science supervisor: Willem van de Poll
Abstract:
The growing world population paired with climate change demands for more alternative and sustainable food sources. Algae consumption offers despite some disadvantages multiple benefits for human nutrition, but the market in Europe is yet in its infancy stages.
Market barriers are found on multiple sides. The legislation around seaweed is strict (especially in Germany), biomass suppliers turned out to be often unresponsive and in the general population visibility and acceptance of macroalgae products are lacking. Still, the market holds great potential and can offer a promising business opportunity.
During my internship, I investigated the possibilities for the market entry of macroalgae products for the German company of Roquette Klötze GmbH & Co. KG, which are currently one of the biggest microalgae producers in Europe. To find possible suppliers of macroalgae biomass I analysed the external market and filtered all European companies dealing with macroalgae through multiple criteria. After, I designed different scenarios of how and which products could be derived from that. For the scenario fitting best into the market environment as well as the company, I mapped out a strategy for market entry. Based on this, I developed a suitable marketing and worked out implementation requirements for the company, which can all be found in my advice.

7 July 13:00 5159.0114

Master program: Biology

Keywords of internship: Agriculture, Potato, sustainability, data registration, cooperation

Internship organization: Royal Avebe

Type of organization: Company (cooperation)

Daily supervisor: dr. Johan Hopman

SBP supervisor: dr. Janneke Krooneman

Science supervisor: Prof. dr. J. Theo M. Elzenga

Abstract:

Stricter regulations regarding sustainability are being pushed towards almost all sectors. This also applies to the agricultural sector and therefore to my client, Avebe. In combination with the desire for more sustainable products from Avebe's customers, Avebe has started a “3x10=500” project; 10% reduction in CO₂ emissions, 10% reduced environmental pressure in combination with 10% more yield, will provide €500 extra per hectare. A large part of this “3x10=500” project is the registration of cultivation data from farmers. This data can then be analyzed. The results are used to develop benchmark reports. Farmers can use these reports to make their cultivation plan for the upcoming growing season more sustainable. However, the problem is that 65% of the data is of insufficient quality. This causes enormous delays in making the benchmark report since the data has to be checked, filtered and repaired. As a result, the benchmark reports are finished too late and the statistical quality is not sufficient. This results in the current situation in which farmers do not use the reports. But why do farmers not provide data of high quality? I will investigate this by interviewing dozens of farmers. I will also use literature research and PCA analyzes to determine which adjustments need to be made within the variables from which data is requested from Avebe. I will compare the results from the interviews with Avebe’s problems regarding the cultivation registration. With the help of a multi criteria analysis I hope to find the golden mean.

7 July 11:00 5159.0058

Master program: Biomedical sciences

Keywords: Socioeconomic status, Socioeconomic health differences, Motivation, Lifestyle

Internship organization: GGD Fryslân

Type of organization: Governmental organization

Daily supervisor: Drs. Klaus Boonstra

SBP supervisor: Drs Michiel Berger

Science supervisor: Prof. Dr. Jocelien Olivier

Abstract:

A low socioeconomic status is associated with a shorter life expectancy of about 6 years and living around 15 years in poorer health compared to a high socioeconomic status. People with a low socioeconomic status seem to be living an unhealthier lifestyle and could benefit by adding a few healthy lifestyle factors like a healthier diet or more movement. A lot of programs focus on decreasing these socioeconomic health differences by improving physical health and promoting healthy eating, however there are no programs focusing on young adults (18-25 years). This group is hard to reach but at the start of their life and this is an important stage of life regarding their health. This is the defining time of becoming obese and it is still relatively easy to start new habits. It is important to motivate this group to start living healthier and improve overall public health. In 2030 there is expected to be a shortage of 20.000 healthcare employers so this emphasis the urge to live healthier. This project focuses on the whishes and experiences of the target group itself. What do they want? What do they expect? After taking this into account, behavior change techniques are an important tool to keep motivating the target group. Lifestyle interventions could be set-up. Not as a remedy but as prevention.

7 July 10:00 5159.0058

Master Program: Biomedical sciences

Keywords: Gestational diabetes – Care pathway – Lifestyle interventions – Combining social and medical domain

Internship organization: Gemeente Westerwolde

Type of organization: Policy organization

Daily supervisor: Simonet Schroot & Rika Plat

SBP supervisor: drs. Michiel Berger

Science supervisor: dr. Marijke Faas

Abstract:

Gestational diabetes (GD) is the most common pregnancy-related complication and occurs in around 7% of pregnancies in the Netherlands. It not only influences mother and child during the pregnancy, but also in the years following delivery. For example, the mother has a 7 times increased chance of developing type 2 Diabetes Mellitus (T2DM) in the years after the delivery and the baby has an increased risk of obesity, diabetes and cardiovascular disease later on.

The care surrounding GD-patients and their babies is reflected in a protocol that hospitals, general practitioners and midwifery practices in the municipality use. This protocol is purely medical and looks only at screening, diagnosis and treatment of GD and screening for T2DM. However, GD is not a purely medical condition, since it is also influenced by socio-economic aspects. The current protocols surrounding GD could be improved by adding lifestyle interventions that target the prevention of both GD and T2DM, by tackling the socio-economic causes. These lifestyle interventions could reduce the risk of GD and T2DM by reducing weight, increasing activity and promoting a healthier diet in these women. A care pathway specifically for the screening, diagnosis, treatment and prevention of GD and T2DM in Westerwolde would be the result, by combining the social and medical domains.

But what should such a care pathway look like? Should it be implemented? And if so, how should it be implemented? That is what I have investigated during this internship.

8 July 12:00 5159.0058

Master program: Biomedical Sciences

Keywords: Healthy Ageing, Dementia, Activities, Checkers, Policy

Internship organization: Healthy Ageing Network Northern Netherlands (HANNN)

Type of organization: Independent foundation

Daily supervisor: Daan Bultje

SBP supervisor: Drs. M.R. (Michiel) Berger

Science supervisor: Prof. Dr. E.A. (Eddy) van der Zee

Abstract:

Dementia is a worldwide problem that not only has physical, mental and economic impacts on people with dementia but also their caregivers, family, neighbours and society. Although there are medicines available to relieve symptoms of dementia, there is no cure for dementia on the market yet. Besides, pharmaceutical medicines often have side effects. Therefore, there is currently also a focus on non-pharmaceutical interventions, such as social and intellectual activities. These activities might play a role in maintaining cognitive performance and the reduction of loneliness among people with dementia. According to national policies, municipalities should be more dementia friendly and are urged to listen to citizens’ initiatives to create opportunities for people with dementia.

Healthy Ageing Network Northern Netherlands (HANNN) would like to contribute to social and intellectual activities for people with dementia. They would like to do this within their current project called Fitter Brein. Fitter Brein organizes, together with checkers associations, checkers activities to stimulate cognitive activity and sociality among the elderly. These activities might have cognitive and social benefits for people with dementia as well, which will be investigated with a scientific analysis. In addition, the best strategy for HANNN regarding activities for people with dementia living at home and in nursing homes will be determined.

7 July 11:00 5159.0110

Master program: Medical Pharmaceutical Sciences
Keywords: Artificial Intelligence, Lung Cancer, Screening, Clinical validation, Health Assessment Technology (HTA) model, Impact, Laws, Regulations
Internship organization: Institute for DiagNostic Accuracy (iDNA)
Type of organization: Research and Consultancy Institute
Daily Supervisor: Xuanqi Pan, Dr. Erik Jippes, Evgeni Dvortsin
SBP supervisor: Maarten van den Nieuwenhof-Schilstra
Scientific supervisor: Dr. Reinoud Gossens
Abstract:
In 2020, lung cancer was responsible for 1.8 million deaths worldwide. The Dutch-Belgian Randomized Lung Cancer Screening Trial (Nederlands–Leuvens Longkanker Screenings Onderzoek [NELSON]) was a population-based, controlled trial proving that lung cancer-related mortality was 24% lower in current and past smokers who received low-dose CT screening compared to those who did not. As a result, iDNA's objective is to make LDCT screening the sole and most effective tool for the early detection of lung cancer. However, the introduction of LDCT screening is expected to result in a significant increase in radiologist workload, due to the production of an immense amount of CT scans. Artificial Intelligence can offer a solution. In the context of LCS, AI is critical for enabling large-scale and cost-effective LCS implementation, as it can interpret vast amounts of CT images. Nevertheless, AI still lacks clinical validation, a regulatory framework and cost-effectiveness data. Thus, AI companies that develop AI tools for pulmonary nodule detection often miss the right value judgment and assessment of health financing scenarios of their innovative software. To advise iDNA on how to expand their collaborations with AI companies, I developed an early phase Health Technology Assessment model that helps AI companies (or investors) to make evidence-based judgements. With this tool, iDNA can assess the AI software that will be used in LCS and further inform the client if it is promising or not. In the early HTA model, I compared the clinical and financial impact of AI as a first reader and as a parallel reader. The comparison arm was the standard reading method used in the NELSON trial. Furthermore, I created an overview of the current European laws that demand AI softwares to be clinically validated.

6 July 14:30 5159.0062

Master program: Medical Pharmaceutical Sciences

Keywords: Indirect Treatment Comparison

Internship organization: Asc Academics

Type of organization: Market access and health-economics consultancy

Daily supervisor: Bert Sloof

SBP supervisor: Dr. A.S. (Amtul Samie) Maqbool

Science supervisor: Dr. C.C.M. (Nynke) Schuiling-Veninga

Abstract:

The use of Indirect Treatment Comparison to assess novel therapies: A case study in breast cancer

For most diseases, there are numerous treatments available. Clinical trials are the main method to assess the safety and/or efficacy of these treatments. Because of a lack of money or time to properly conduct a clinical trial, pharmaceutical companies usually compare their novel drug with standard-of-cares or placebo, and only rarely include their direct competitors. For this reason, it can be difficult to establish which treatment is better for certain circumstances.

Fortunately, innovative technology can help us solve this problem. Researchers can use indirect network analyses, a type of statistical methods, to compare various trials with each other without actually having to perform expensive and lengthy head-to-head trials. It is therefore a fundamental tool to assess the differences between novel treatments for stakeholders. In this project, a novel drug for a specific subtype of breast cancer (HER2-low) has been assessed through one of these methods, a Network Meta-Analysis (NMA). This has allowed to compare it with other effective treatments for the same or similar indication and determine which is a better option. The requirements and the overall procedure of the NMA have been examined in order to identify how this technique can be improved and make a recommendation to Asc Academics on how they can offer a better service. These results have also been used to create a strategy in order to increase the acquisition of such projects and increase the market share of the company.

6 July 11:00 5159.0010

Master program: Biomedical Sciences

Keywords: Lifestyle intervention, overweight, healthy lifestyle, entering market

Internship organization: Healthcoin

Type of organization: Start-up company

Daily supervisor: Mike van Holsteijn

SBP supervisor: Marion van Rijssel

Science supervisor: Eva Corpeleijn

Abstract:

The number of people with overweight is increasing and poses many health risks. In addition, healthcare costs are increasing and overweight and the associated risks are contributing to these rising healthcare costs. However, the society is still focused on healing rather than preventing, which is something Healthcoin wants to see change. Healthcoin is aimed at prevention of health problems later in life by implementing a healthier lifestyle. She developed a lifestyle intervention consisting of an application, challenges, workshops and including the elements insight, gamification, reward, and social elements. Rewards are given in healthcoins to make the healthier choice more attractive and the healthcoins can be spent in the shop to buy products that improve lifestyle. This product of Healthcoin is now on the market for companies and employers buy this product with the intention of improving the lifestyle of employees with the aim of improving productivity and reducing absenteeism. The next step for Healthcoin is now to change to a new target group, namely people who are overweight, because in this group the most can be achieved in the field of prevention. The lifestyle intervention designed for overweight individuals is not on the market yet, so my advice consists of the most promising route to bring the lifestyle intervention for people with overweight on the market.

7 July 13:00 5159.0291

Master program: Physics
Keywords: Explainable AI, Automation, Natural Language Processing, Ethics
Internship organization: KPN
Type of organization: Company
Daily supervisor: Gianluigi Bardelloni, KPN AI Lead
SBP supervisor: Gideon Laugs
Science supervisor: Prof. dr. Marco Grzegorczyk
Abstract:
Deep learning opens the door to previously impossible analysis through the power of generalized model architectures and semi-autonomous learning regiments. This adaptability has brought black-box models to ubiquity in academic and corporate spaces; the power of these models comes with the trade-off of human-interpretability, which can have repercussions legally and ethically in decision-making scenarios. KPN currently deploys state-of-the-art natural language processing models to automate large portions of their customer contact analytics. While their models perform well there is room for improvement, without interpretability any future model improvement initiatives cannot be executed with confidence. We propose a novel two step interpretability technique devised to systematically diagnose and dissect KPN’s natural language models: stochastic methods are first deployed to disclose areas of weakness,these areas are then focused on with targeted interpretability techniques to create salient model performance statistics. The use of this procedure allows for more ethical, intelligent and competent usage of deep learning models within KPN.

8 July 11:00 5159.0114

Master Program: Medical Pharmaceutical Sciences

Keywords: Innovation in Healthcare, Global Lung cancer Screening Implementation, Low-Middle Income Countries

Internship organization: Institute of Diagnostic Accuracy (iDNA)

Type of Organization: Company

Daily Supervisor: Evgeni Dvortsin

SBP Supervisor: Jorien Zevenberg

Science Supervisor: Frank Jansman

Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide, which results in enormous impacts on families and endangers progress towards the Sustainable Development Goals set by the United Nations. Recent studies confirmed the potential of Low-dose CT Lung Cancer Screening for early detection, resulting in significant mortality reduction in high-risk individuals.

Nowadays, several Lung Cancer Screening pilots are initiated in high-income countries but not in low- or middle-income countries (LMICs), whilst a continuous increase in mortality rates and a significantly higher burden of risk factors can be found in LMICs. Lung Cancer Screening implementation is of great importance to prevent the endangerment of global health risks and ensure progress toward the SDGs. However, setting up business in LMICs is often hindered by limited resources and therefore requires a different strategic approach.

This project will investigate how to identify viable and sustainable business opportunities in LMICs for the company iDNA, and additionally recommend to iDNA how to pursue them. The identification starts with narrowing down the wide range of LMICs to a specific country, based on prioritized criteria in accordance with the results of both internal and external analyses. This resulted in the selection of Egypt, after which a strategy recommendation was formulated based on a drafted implementation reviewed by local stakeholders. Egypt showed to have high potential for Lung Cancer Screening Implementation but does not come without its’ risks, which iDNA should be aware of.

7 July 10:00 5159.0291

Master program: Biology

Keywords: Lung cancer screening, healthcare economics, medical consulting, healthcare policy

Internship organization: The Institute for Diagnostic Accuracy (iDNA)

Type of organization: Company

Daily supervisor: Msc. Xuanqi Pang

SBP supervisor: Msc. Gideon Laugs

Science supervisor: Prof. dr. Anton Scheurink
Abstract:
Lung cancer is currently the biggest cancer killer amongst all variants, accountable for almost a fifth of all global cancer deaths. With a higher mortality rate than breast-, colon-, and cervical cancer combined, for which are all population-based screening programs do exist, nevertheless, lung cancer remains without national preventive screening programs. The high mortality rates of lung cancer are the consequence of a late diagnose. Detection of this cancer in a very early stage leads to the opportunity to enable work that acts life-saving instead of the currently life-extending state of medicine. The company in which I performed my internship has developed an algorithm based on regular CT-scans that enables early detection of lung cancer. With this development, a lung cancer screening program is now an evidence-based reality and the focus should be directed towards the implementation of these programs. To evaluate and indicate the importance and feasibility of healthcare and medical interventions, health economical models are in place to enable the translation of research into practice for policy and decisionmakers. In my internship I focus on the implementation of a new high-risk profile within such an economical model to investigate the feasibility of lung cancer screening programs in Hong Kong. This incorporates the exploration of a new epidemiological profile of lung cancer in the Asian environment, healthcare modelling, integration science in an implementation policy and the delivery of the 9am message to pave the way for actual implementation of lung cancer screening programs.

7 July 11:00 5159.0010

Master program: Biomedical Sciences
Keywords: Wastewater analysis of illicit drugs
Internship organization: Trimbos-institute
Type of organization: Knowledge institute
Daily supervisor: Laura Smit-Rigter
SBP supervisor: Marion van Rijssel
Science supervisor: Anton Scheurink
Abstract:
My project is about illicit drugs, in particular MDMA, cocaine, amphetamine, methamphetamine, and THC (marijuana). To be able to form adequate drug policies, public institutions require up-to-date information on drug use. One of the upcoming methods for gathering drug use data is through wastewater analysis. Every drug that is consumed will leave the body and end up in the sewage at some point. By analysing the local wastewater it is possible to calculate which drugs were used in a municipality, and in which quantities. Measurements are typically done for 7 consecutive days and analysis gives insight in how usage patterns change throughout the week.

My internship is with the Trimbos-institute, the national knowledge institute for mental health, and addiction. Occasionally, Trimbos is consulted by municipalities who don’t know how to deal with the results of their wastewater analysis. What does it mean for a municipality if their methamphetamine usage appears to be twice as high as a neighbouring city? Or what happens if the media publishes the results?

The Trimbos-institute wants to take a more active role in guiding municipalities with their wastewater analysis. To reach that goal I interviewed several municipalities about their experiences with wastewater analysis. By identifying the issues and knowledge gaps, Trimbos can provide better assistance in the future. The final deliverable of this project will be a factsheet that gives a clear overview of all the pros and cons of wastewater analysis for drugs.

6 July 12:00 5159.0114

Master program: Chemistry
Keywords: Pharmaceuticals, market research
Internship organization: Sulfateq B.V.
Type of organization: Biotechnology company
Daily supervisor: Msc. Daniël Swart
SBP supervisor: Prof. Gert-Jan Euverink
Science supervisor: Prof. Wesley Browne
Abstract:

Sulfateq B.V. develops compounds to treat a wide range of therapeutic indications related to mitochondrial dysfunction. During this process, they have also developed a way to separate enantiomers using lipase enzyme in a method called kinetic resolution. Enantiomers are molecules that look the same but are not the same because they are mirror images of each other. A pair of enantiomers are physically inseparable but differ in biological functions and may cause adverse effects.

In kinetic resolution, only one of two enantiomers gets converted, leaving the other enantiomer unreacted which is then physically separable.

Sulfateq B.V. wants to know if there is a market to sell their separation service or sell separated enantiomers. The goal of this internship is to find that out.

To achieve this goal, scientific and business aspects were assessed.

For the science aspect, data collection was done on the different separation techniques being used to separate which enantiomers and what enzymes are involved.

For the business aspect, market analyses were performed alongside a questionnaire sent out to a multitude of chemical companies worldwide.

I advised Sulfateq B.V. on the challenges they would need to overcome in order to have a sustainable competitive advantage in this market.