Research

Research Interests

  • Synthetic Method Development

  • Total Synthesis of Natural Products

  • Development of Therapeutics

  • Chemoenzymatic Synthesis


Program 1. Vancomycin Heptapeptides and Derivatives

The first area of interest is the development of unnatural glycopeptides with antimicrobial activity. Antibiotic resistance is a major public health concern and the occurrence of drug-resistant, disease-causing bacteria has become more acute over the past six decades. The aim of our first study is to develop a chemoenzymatic synthesis of vancomycin and novel derivatives. This research will serve as a platform for the design of new antimicrobial glycopeptides.

Program 2. Aryl triflates as precursors to Morphine Derivatives

The second research program aims to address the opioid epidemic. The use of morphine for pain relief has led to misuse and drug dependence. The fluorine atom has been shown to improve lipophilicity, improve potency, lower basicity of nearby nitrogen atoms, and increase hydrogen bonding. Owing to the small size of fluorine, all of this is possible while maintaining the binding (activity) of the parent compound. These fluorinated morphines are hypothesized to be important tools for manipulation of morphine’s polypharmacology, warranted by its importance in pain treatment, but contrasted by its drawbacks: addiction, patient tolerance, and withdrawal.


Research in the Department of Chemistry and Biochemistry

"All undergraduate science students at Rowan University have the opportunity to participate with faculty in independent lab work and field research, a privilege often reserved for graduate students and professionals. In fact, the completion of a research project is a capstone requirement for graduation with the BS in Chemistry or BS in Biochemistry. Many students travel with faculty to regional and national conferences where they present and publish findings from their research. Visit the individual faculty websites for more details on possible research project areas."

Research Application Form


Photocatalytic Visible Light Reaction Setup

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Photocatalytic Visible Light Reaction Setup

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